Top Researchers
Top Medicine Researchers at Case Western Reserve University for 2026
Case Western Reserve University’s recent work in Medicine spans a wide range of questions, from disease genetics and clinical decision-making to imaging, infectious disease, and care delivery. Looking across a large sample of works from the past year, a clear picture emerges of a research community that is connecting molecular insights with practical patient care.
Below, you’ll find a closer look at several researchers whose recent publications reflect that breadth. Their work shows how medicine at Case Western Reserve University is moving across basic science, data-driven methods, and clinical studies to address important problems in health and disease.
Featured Researchers
Jonathan L. Haines
Jonathan L. Haines has focused on genetics and physiology in Alzheimer's disease, including sequencing resources, ancestry-aware analyses, and gene–environment interaction studies.
Activity over the last year: 59 indexed journal articles.
Top publications:
- Alzheimer's Disease Sequencing Project release 4 whole genome sequencing dataset (May 2025)
- ABCA7 deletion lowers age at onset of Alzheimer's disease and interacts with APOE ε4 synergistically in African‐ancestry populations (Aug 2025)
- Alzheimer's disease multi‐ancestry genome‐wide interaction and stratified study with smoking (Nov 2025)
Daniel E. Spratt
Daniel E. Spratt’s recent work centers on prostate cancer, bringing together pulmonary and respiratory medicine, radiation, and cancer research through guidelines and radiotherapy outcomes.
Activity over the last year: 44 indexed journal articles.
Top publications:
- Germline and Somatic Genomic Testing for Metastatic Prostate Cancer: ASCO Guideline (Jan 2025)
- Prostate Cancer, Version 3.2026, NCCN Clinical Practice Guidelines In Oncology (Nov 2025)
- The interplay between acute and late toxicity among patients receiving prostate radiotherapy: an individual patient data meta-analysis of six randomised trials (Jan 2025)
Robert A. Bonomo
Robert A. Bonomo has been working across molecular medicine, pharmacology, and applied microbiology, with recent attention to antibiotic resistance and difficult-to-treat infections.
Activity over the last year: 38 indexed journal articles.
Top publications:
- How do I manage a patient with Stenotrophomonas maltophilia infection? (May 2025)
- A microbiological and structural analysis of the interplay between sulbactam/durlobactam and imipenem against penicillin-binding proteins (PBPs) of Acinetobacter spp. (Mar 2025)
- Cefiderocol “under siege”? Understanding the rise of NDM-mediated resistance to novel agents (Jan 2025)
Sanjay Rajagopalan
Sanjay Rajagopalan’s publications link cardiology, imaging, and toxicology, including studies of exposome-related risk, coronary assessment, and social determinants of health.
Activity over the last year: 27 indexed journal articles.
Top publications:
- Cardiovascular risk posed by the exposome (Apr 2025)
- Prediction of obstructive coronary artery disease using coronary calcification and epicardial adipose tissue assessments from CT calcium scoring scans (Feb 2025)
- The association between county-level social determinants of health and cardio-kidney-metabolic disease attributed all-cause mortality in the US: A cross sectional analysis (Jan 2025)
Rong Xu
Rong Xu’s recent research combines molecular biology, computational methods, and infectious disease topics, including vaccine effectiveness and real-world drug safety questions.
Activity over the last year: 21 indexed journal articles.
Top publications:
- Effectiveness and Safety of Respiratory Syncytial Virus Vaccine for US Adults Aged 60 Years or Older (May 2025)
- Semaglutide or Tirzepatide and Optic Nerve and Visual Pathway Disorders in Type 2 Diabetes (Aug 2025)
- Associations of semaglutide with Alzheimer's disease-related dementias in patients with type 2 diabetes: A real-world target trial emulation study (Jun 2025)
William S. Bush
William S. Bush has contributed to genetics, physiology, and molecular biology in Alzheimer's disease, with work on sequencing datasets and plasma biomarker performance across diverse ancestries.
Activity over the last year: 30 indexed journal articles.
Top publications:
- Alzheimer's Disease Sequencing Project release 4 whole genome sequencing dataset (May 2025)
- Generalizability of tau and amyloid plasma biomarkers in Alzheimer's disease cohorts of diverse genetic ancestries (Mar 2025)
- ABCA7 deletion lowers age at onset of Alzheimer's disease and interacts with APOE ε4 synergistically in African‐ancestry populations (Aug 2025)
Pingfu Fu
Pingfu Fu’s recent publications use artificial intelligence with radiology and pathology to predict outcomes in head and neck, cervical, and lung cancers.
Activity over the last year: 33 indexed journal articles.
Top publications:
- Deep learning informed multimodal fusion of radiology and pathology to predict outcomes in HPV-associated oropharyngeal squamous cell carcinoma (Mar 2025)
- Computationally integrating radiology and pathology image features for predicting treatment benefit and outcome in lung cancer (Jun 2025)
- Deep Learning Model of Primary Tumor and Metastatic Cervical Lymph Nodes From CT for Outcome Predictions in Oropharyngeal Cancer (May 2025)
Robert J. Trager
Robert J. Trager’s work spans pathology, pharmacology, and surgery, with retrospective cohort studies examining pain care, contraceptive use, and fracture risk.
Activity over the last year: 22 indexed journal articles.
Top publications:
- Association Between Spinal Manipulative Therapy for Low Back Pain With or Without Sciatica and Opioid Use Disorder: A Retrospective Cohort Study (Sep 2025)
- Association between combined oral contraceptive prescription and cervical artery dissection: A retrospective cohort study (Feb 2025)
- Is osteoporosis an independent risk factor for sacral fracture after lumbosacral spinal fusion in adults? A retrospective cohort study (May 2025)
What Case Western Reserve University's Medicine Community Is Working On
Across the most common subfields, the research community is actively blending physiology and genetics with pulmonary medicine, pharmacology, and imaging. That mix suggests strong interest in both biological mechanisms and clinical application, especially where patient outcomes can be improved through better risk prediction, more precise diagnostics, and evidence-guided treatment decisions. The repeated presence of genetics and physiology also points to a sustained focus on disease pathways, while radiology and pulmonary medicine show how often these questions are being studied in real clinical settings.- Physiology - seen across 2 of the featured researchers
- Genetics - seen across 2 of the featured researchers
- Pulmonary and Respiratory Medicine - seen across 2 of the featured researchers
- Pharmacology - seen across 2 of the featured researchers
- Radiology, Nuclear Medicine and Imaging - seen across 2 of the featured researchers
Together, these researchers illustrate the range of medical scholarship happening at Case Western Reserve University, with work that spans discovery, translation, and clinical application. If you’re exploring similar literature, this kind of overview can help you follow active areas of inquiry and identify useful collaborators or methods. For researchers managing their own publication workflows, Resub can also help streamline citation discovery, manuscript formatting, and submission preparation.
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