Overview
Submission Instructions
Recent Publications
Frequently Asked Questions
Research Topics
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AJ
American Journal of Kidney Diseases is the official journal of the National Kidney Foundation, first published in 1981, and focuses on clinical nephrology research and practice. It publishes original research, reviews, editorials, case reports, and human interest pieces spanning kidney disease, hypertension, acid-base and electrolyte disorders, dialysis, transplantation, patient-centered outcomes, health care policy, socioeconomic aspects of kidney disease, and health care disparities.
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Subject
Urology & Nephrology
Impact Factor
8.2
Quartile
Q1
Open Access Type
Hybrid
ISSN
0272-6386
eISSN
1523-6838
Invitation Only
No
Cost Range
Open access APC: USD 4660 excluding taxes for all articles; subscription publication has no open access publication fee.
Submission Instructions
American Journal Of Kidney Diseases accepts the following article types. Click on an article type to view submission instructions.
Original Investigations
Cover Letter
Cover Letter requirements are not specified.
Abstract
A structured abstract is required for Original Investigations. The abstract must be no longer than 300 words. The abstract must be structured.
Manuscript
The manuscript is limited to 3,500 words excluding the abstract, references, article information section, tables, and figure legends. The manuscript body must be organized into Introduction, Methods, Results, and Discussion sections. The manuscript should include a subtitle stating the study design, a brief description of each author's contribution, a patient and public engagement summary in the Methods section of typically up to 100 words, and an AI declaration statement before the references if AI tools were used in manuscript preparation.
References
The manuscript should include no more than 50 references. References must use AMA style. References must be listed at the end of the manuscript in the order they are cited in the text.
Figures & Tables
The manuscript may include no more than 8 figures, tables, and boxes in total. Tables should ideally appear on separate pages after the references in the manuscript file, figure legends should ideally be placed at the end of the manuscript file, and figures should ideally be uploaded as separate files rather than embedded in the manuscript. Each table must be numbered and titled, and each figure must have a legend including a figure title and explanatory text.
Clinical Trial
Cover Letter
Cover Letter requirements are not specified.
Abstract
Abstract must be structured using article-type-specific headings. Abstract headings must be Rationale & Objective, Study Design, Setting & Participants, Intervention(s), Outcomes, Results, Limitations, Conclusions, Funding, and Trial Registration.
Manuscript
Manuscript body must not exceed 3,500 words excluding abstract, references, the article information section, tables, and figure legends. Manuscript body must be organized into Introduction, Methods, Results, and Discussion sections. Manuscript must include the study protocol with dated amendments for confidential review, a patient and public engagement summary of typically up to 100 words in the Methods section, and an AI declaration statement before the references if AI tools were used in manuscript preparation.
References
References should typically not exceed 50. References must use AMA style. References must be compiled at the end of the manuscript in the order of citation in the text.
Figures & Tables
No more than 8 figures, tables, and boxes may be included in total. Figures should ideally be uploaded as separate files, tables should ideally be placed on separate pages after the references in the manuscript file, and figure legends should ideally appear at the end of the manuscript file after the references or tables. Tables must be numbered and titled, and each figure must have a legend including a figure title and explanatory text.
Decision Analysis
Cover Letter
Cover Letter requirements are not specified.
Abstract
Abstract must be structured using article-type-specific headings. Abstract must include the headings Rationale & Objective, Study Design, Setting & Population, Intervention(s), Outcomes, Model, Perspective, & Timeframe, Results, Limitations, and Conclusions.
Manuscript
Manuscript must include a Declaration of Generative AI and AI-assisted technologies in the writing process in a new section before the references if AI tools were used in manuscript preparation.
References
References must use AMA style. References must be listed at the end of the manuscript in the order they are cited in the text.
Figures & Tables
Tables should ideally appear on separate pages after the references, figure legends should be placed at the end of the manuscript file after the references or tables, and figures should ideally be uploaded as separate files rather than embedded in the manuscript. Tables must be numbered and have titles, and each figure must have a legend including a figure title and explanatory text.
Cost-Effectiveness Analysis
Cover Letter
Cover Letter requirements are not specified.
Abstract
A structured abstract is required. Abstract must be no more than 300 words. Abstract must be structured using specified headings. Abstract headings must be Rationale & Objective, Study Design, Setting & Population, Intervention(s), Outcomes, Model, Perspective, & Timeframe, Results, Limitations, and Conclusions.
Manuscript
Manuscript body is limited to 3,500 words excluding the abstract, references, article information section, tables, and figure legends. The manuscript body must be organized into Introduction, Methods, Results, and Discussion sections. A patient and public engagement summary of typically up to 100 words must be included in the Methods section, and any use of AI tools in manuscript preparation must be disclosed in a new section before the references.
References
The manuscript typically may include no more than 50 references. References must use AMA style. References must be listed at the end of the manuscript in the order they are cited in the text.
Figures & Tables
No more than 8 figures, tables, and boxes in total may be included. Tables should ideally appear on separate pages after the references in the manuscript file, figure legends should be placed at the end of the manuscript file, and figures should ideally be uploaded as separate files rather than embedded. Tables must be numbered and have titles, and each figure must have a legend.
Diagnostic Test Study
Cover Letter
Cover Letter requirements are not specified.
Abstract
Abstract must be structured. Abstract must use the headings Rationale & Objective, Study Design, Setting & Participants, Tests Compared, Outcome(s), Results, Limitations, and Conclusions.
Manuscript
Manuscript body is limited to 3,500 words excluding the abstract, references, article information section, tables, and figure legends. Manuscript body must be organized into Introduction, Methods, Results, and Discussion sections. Methods section must include a patient and public engagement summary of typically up to 100 words, and if AI tools were used in manuscript preparation, a declaration statement must be added in a new section before the references.
References
References should typically not exceed 50. References must use AMA style. References must be compiled at the end of the manuscript in the order they are cited in the text.
Figures & Tables
No more than 8 figures, tables, and boxes in total may be included. Figures should ideally be uploaded as separate files, figure legends should be placed at the end of the manuscript file, and each table should ideally appear on a separate page after the references. Each table must be numbered and have a title, and each figure must have a legend including a figure title and explanatory text.
Observational Study
Cover Letter
Cover Letter requirements are not specified.
Abstract
Abstract must be structured. Abstract headings must be Rationale & Objective, Study Design, Setting & Participants, Exposure(s) or Predictor(s), Outcome(s), Analytical Approach, Results, Limitations, and Conclusions.
Manuscript
Manuscript body is limited to 3,500 words excluding abstract, references, the article information section, tables, and figure legends. Manuscript body must be organized into Introduction, Methods, Results, and Discussion sections. Methods section must include a patient and public engagement summary of typically up to 100 words, and if AI tools were used in manuscript preparation a declaration statement must be included in a new section before the references list.
References
References should typically not exceed 50. References must use AMA style. References must be compiled at the end of the manuscript in the order of citation in the text.
Figures & Tables
No more than 8 figures, tables, and boxes in total may be included. Tables should ideally appear on separate pages after the references, figure legends should be placed at the end of the manuscript file, and figures should ideally be uploaded as separate files rather than embedded in the manuscript. Tables must be numbered and have titles, and each figure must have a legend including a figure title and explanatory text.
Cohort Study
Cover Letter
Cover Letter requirements are not specified.
Abstract
A structured abstract is required. The abstract must be no more than 300 words. The abstract must be structured. Observational Study abstracts must use the headings Rationale & Objective, Study Design, Setting & Participants, Exposure(s) or Predictor(s), Outcome(s), Analytical Approach, Results, Limitations, and Conclusions.
Manuscript
The manuscript is limited to 3,500 words excluding the abstract, references, article information section, tables, and figure legends. The body of the manuscript must be organized into Introduction, Methods, Results, and Discussion sections. The Methods section must include a patient and public engagement summary of typically up to 100 words, and if AI tools were used in manuscript preparation, a declaration statement must be added in a new section before the references.
References
The manuscript should typically have no more than 50 references. AMA reference style must be used. References must be compiled at the end of the manuscript in the order of citation in the text.
Figures & Tables
The submission may include no more than 8 figures, tables, and boxes in total. Tables should ideally appear on separate pages after the references in the manuscript file, figure legends should be placed at the end of the manuscript file, and figures should ideally be uploaded as separate files rather than embedded. Tables must be numbered and have titles, and each figure must have a legend including a figure title and explanatory text.
Case-Control Study
Cover Letter
Cover Letter requirements are not specified.
Abstract
Abstract must be structured for observational studies. Abstract must use the headings Rationale & Objective, Study Design, Setting & Participants, Exposure(s) or Predictor(s), Outcome(s), Analytical Approach, Results, Limitations, and Conclusions.
Manuscript
Manuscript must not exceed 3,500 words excluding the abstract, references, article information section, tables, and figure legends. Manuscript body must be organized into Introduction, Methods, Results, and Discussion sections. Methods section must include a patient and public engagement summary of typically up to 100 words, and if AI tools were used in manuscript preparation an AI declaration statement must be included in a new section before the references.
References
Original Investigations typically have no more than 50 references. References must use AMA style. References must be listed at the end of the manuscript in the order cited in the text.
Figures & Tables
No more than 8 figures, tables, and boxes in total may be included. Tables should ideally appear on separate pages after the references, figure legends should ideally be placed at the end of the manuscript file, and figures should ideally be uploaded as separate files rather than embedded in the manuscript. Tables must be numbered and titled, and each figure must have a legend including a figure title and explanatory text.
Cross-Sectional Study
Cover Letter
Cover Letter requirements are not specified.
Abstract
A structured abstract is required. The abstract must be no more than 300 words. The abstract must be structured. Observational Study abstracts must use the headings Rationale & Objective, Study Design, Setting & Participants, Exposure(s) or Predictor(s), Outcome(s), Analytical Approach, Results, Limitations, and Conclusions.
Manuscript
The manuscript is limited to 3,500 words excluding the abstract, references, article information section, tables, and figure legends. The body of the manuscript must be organized into Introduction, Methods, Results, and Discussion sections. The Methods section must include a patient and public engagement summary of typically up to 100 words, and if AI tools were used in manuscript preparation, a declaration statement must be added in a new section before the references.
References
The manuscript should typically have no more than 50 references. References must use AMA style. References must be compiled at the end of the manuscript in the order of citation in the text.
Figures & Tables
The manuscript may include no more than 8 figures, tables, and boxes in total. Each table should ideally appear on a separate page after the references, figure legends should ideally be placed at the end of the manuscript file after the references or tables, and figures should ideally be uploaded as separate files rather than embedded in the manuscript. Tables must be numbered and have titles, and each figure must have a legend including a figure title and explanatory text.
Case-Cohort Study
Cover Letter
Cover Letter requirements are not specified.
Abstract
Abstract must be structured for this observational study article type. Abstract must use the headings Rationale & Objective, Study Design, Setting & Participants, Exposure(s) or Predictor(s), Outcome(s), Analytical Approach, Results, Limitations, and Conclusions.
Manuscript
Manuscript must include a patient and public engagement summary in the Methods section, typically up to 100 words, and if AI tools were used in manuscript preparation, a Declaration of Generative AI and AI-assisted technologies in the writing process must appear before the references.
References
References must use AMA style. References must be compiled at the end of the manuscript in the order they are cited in the text.
Figures & Tables
Tables should ideally appear on separate pages after the references in the manuscript file, figure legends should be placed at the end of the manuscript file, and figures should ideally be uploaded as separate files rather than embedded. Tables must be numbered and have titles, and each figure must have a legend including a figure title and explanatory text.
Ecological Studies
Cover Letter
Cover Letter requirements are not specified.
Abstract
Abstract requirements are not specified.
Manuscript
Manuscript must not exceed 3,500 words excluding the abstract, references, article information section, tables, and figure legends. Manuscript body must be organized into Introduction, Methods, Results, and Discussion sections. The Methods section must include a patient and public engagement summary of typically up to 100 words, and any use of AI tools in manuscript preparation must be disclosed in a declaration section placed immediately before the references.
References
References should typically not exceed 50. References must use AMA style. References must be compiled at the end of the manuscript in the order they are cited in the text.
Figures & Tables
No more than 8 figures, tables, and boxes in total may be included. Figures should ideally be uploaded as separate files, tables should ideally be placed on separate pages after the references in the manuscript file, and figure legends should ideally appear at the end of the manuscript file. Each table must be numbered and titled, and each figure must have a legend including a figure title and explanatory text.
Genetic Association Study
Cover Letter
Cover Letter requirements are not specified.
Abstract
Abstract requirements are not specified.
Manuscript
Manuscript body is limited to 3,500 words excluding abstract, references, the article information section, tables, and figure legends. Manuscript body must be organized into Introduction, Methods, Results, and Discussion sections. The Methods section must include a patient and public engagement summary typically up to 100 words, and if AI tools were used in manuscript preparation, a declaration section must be added immediately before the references specifying the tool and reason for use.
References
References should typically not exceed 50. References must use AMA style. References must be compiled at the end of the manuscript in the order of citation in the text.
Figures & Tables
No more than 8 figures, tables, and boxes may be included in total. Figures should ideally be uploaded as separate files, figure legends placed at the end of the manuscript file after the references or tables, and each table ideally placed on a separate page immediately after the references. Each table must be numbered and have a title, and each figure must have a legend including a figure title and explanatory text.
Prediction Study
Cover Letter
Cover Letter requirements are not specified.
Abstract
Prediction Study abstracts must use the heading “New Predictors & Established Predictors” in place of “Exposure(s) or Predictor(s).”
Manuscript
The manuscript must include a patient and public engagement summary in the Methods section, typically up to 100 words, and if AI tools were used in manuscript preparation an AI declaration statement must appear in a new section before the references.
References
References must use AMA style. References must be compiled at the end of the manuscript in the order they are cited in the text.
Figures & Tables
Tables should ideally be placed on separate pages after the references, figure legends should be placed at the end of the manuscript file after the references or tables, and figures should ideally be uploaded as separate files rather than embedded in the manuscript. Tables must be numbered and have titles, and each figure must have a legend with a figure title and explanatory text.
Qualitative Study
Cover Letter
Cover Letter requirements are not specified.
Abstract
Abstracts must omit the headings “Exposure(s) or Predictor(s)” and “Outcome(s).”
Manuscript
Methods section must include a patient and public engagement summary of typically up to 100 words. If AI tools were used in manuscript preparation, a declaration statement naming the tool and reason for use must be included in a new section immediately before the references.
References
References must use AMA style. References must be compiled at the end of the manuscript in the order they are cited in the text.
Figures & Tables
Tables should ideally appear on separate pages after the references, figure legends should be placed at the end of the manuscript file, and figures should ideally be uploaded as separate files rather than embedded in the manuscript. Tables must be numbered and titled, and each figure must have a legend including a figure title and explanatory text.
Registry Or Health Care Database Study
Cover Letter
Cover Letter requirements are not specified.
Abstract
Abstract must be structured for observational studies. Abstract headings must be Rationale & Objective, Study Design, Setting & Participants, Exposure(s) or Predictor(s), Outcome(s), Analytical Approach, Results, Limitations, and Conclusions.
Manuscript
Methods section must include a patient and public engagement summary of typically up to 100 words, and if AI tools were used in manuscript preparation a declaration statement must be added in a new section before the references.
References
References must use AMA style. References must be listed at the end of the manuscript in the order they are cited in the text.
Figures & Tables
Tables should ideally appear on separate pages after the references, figure legends should be placed at the end of the manuscript file, and figures should ideally be uploaded as separate files rather than embedded in the manuscript. Tables must be numbered and have titles, and each figure must have a legend.
Recent Publications
Utility of Risk Scores for Predicting Stroke and Intracranial Bleeding Across Levels of Kidney Function in Two Large Community-Based Cohorts of Older Adults With Atrial Fibrillation
Nisha Bansal, Grace H. Tabada, Yuguang Kang, Kathryn Stirling, Leila R. Zelnick, Elisha A. Garcia, Sara Bota, Jaejin An, Teresa N. Harrison, Daniel E. Singer, Manish Sood, Amit X. Garg, Alan S. Go
10.1053/j.ajkd.2026.03.038
View Publication
Podocyte-Targeted Therapy in Focal Segmental Glomerulosclerosis: Insights from a Phase 2 Trial of TRPC6 Inhibition
Luis Sanchez-Russo, George Vasquez-Rios, Kirk N. Campbell
10.1053/j.ajkd.2026.04.006
View Publication
Advice for Living With Hemodialysis: A Qualitative Study of Older Patients and Their Care Partners
Nicole DePasquale, Casey J. Powell, Francisca A. Hammond, Jessica M. Alvarez, Rasheeda K. Hall, C. Barrett Bowling
10.1053/j.ajkd.2026.04.004
View Publication
Prevalence Estimates of Predicted Pathogenic COL4A3-COL4A5 Variants in the Chinese Population and Its Implications for Clinical Practice
Mengyao Zeng, Changming Zhang, Xingjian Gao, Jiahui Zhang, Song Jiang, Yanan Cao, Zhi-Hong Liu
10.1053/j.ajkd.2026.03.039
View Publication
Weight Loss-Independent Mechanisms of Kidney Protection with Glucagon-Like Peptide-1 Receptor Agonists and Implications for Clinical Practice
Allon N. Friedman, Ilyas Oultache, Robert Hovey
10.1053/j.ajkd.2026.03.037
View Publication
Frequently asked questions
How long does it take to publish?
8 days from submission to first decision; 42 days from submission to decision after review; 158 days from submission to acceptance.
Reformat to American Journal Of Kidney Diseases using Livewrite PremiumWhat are the publication costs?
Open access APC is USD 4660 excluding taxes for all articles. Subscription publication has no open access publication fee.
Reformat to American Journal Of Kidney Diseases using Livewrite PremiumResearch Topics
Dialysis and Renal Disease Management
Chronic Kidney Disease and Diabetes
Renal Diseases and Glomerulopathies
Renal Transplantation Outcomes and Treatments
Acute Kidney Injury Research
Parathyroid Disorders and Treatments
Central Venous Catheters and Hemodialysis
Renal and Vascular Pathologies
Diverse Scientific and Economic Studies
Organ Donation and Transplantation
Electrolyte and hormonal disorders
Erythropoietin and Anemia Treatment
Blood Pressure and Hypertension Studies
Vasculitis and related conditions
Amyloidosis: Diagnosis, Treatment, Outcomes
Potassium and Related Disorders
Educational Robotics and Engineering
Human auditory perception and evaluation
Muscle and Compartmental Disorders
Renal function and acid-base balance
Pharmacological Effects and Toxicity Studies
Health Systems, Economic Evaluations, Quality of Life
Systemic Lupus Erythematosus Research
Genetic and Kidney Cyst Diseases
Complement system in diseases