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Trends in Molecular Medicine

Trends in Molecular Medicine publishes concise and contextualized reviews and opinions on research at the interface between basic biology and clinical research, with emphasis on mechanisms of human biology and pathology that have implications for diagnostics, therapeutics, prevention, and human disease. The journal covers themes including disease mechanisms, tools and technologies, diagnostics, therapeutics, clinical trial landscape, science policy, and medical ethics, with a goal of bridging bench and bedside for a broad audience.

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Subject Medicine, Research & Experimental
Impact Factor 13.8
Quartile Q1
Open Access Type Hybrid
ISSN 1471-4914
eISSN 1471-499X
Invitation Only No
Cost Range APC fees start at US$1500 excluding tax; Trends review journals are listed at US$7,030 for hybrid open access.

Submission Instructions

Trends in Molecular Medicine accepts the following article types. Click on an article type to view submission instructions.

Review

Cover Letter Cover Letter requirements are not specified.
Abstract Review articles must include an abstract. Review abstracts must be 100–120 words.
Manuscript Review main text must be 3000–3500 words. Review articles should begin with a short introductory section of one or two paragraphs under a descriptive heading other than “Introduction” and end with a section entitled “Concluding Remarks.” Review articles must include at least four descriptive keywords, Highlights of 3–5 bullet points not exceeding 900 characters in a separate Word file, an Outstanding Questions box not exceeding 2000 characters in a separate Word file, a 200–400 word Clinician’s Corner of 4–5 bullet points, a declaration of interests section, and an AI declaration statement if generative AI was used in writing.
References Review articles must include no more than 100 references. References must be numbered in square brackets in order of appearance in the text, while websites should be cited in the main text in parentheses rather than included in the reference list.
Figures & Tables Review articles may contain up to six display elements, and only one Key Figure or one Key Table may be included, not both. Figures must be uploaded as separate files rather than embedded in the main text document, while tables must be included in the main manuscript file in Word format and not submitted as separate image files. Figure legends must have a short explanatory title, fully explain the figure without reference to the text, and be no more than 250 words, while tables must have a single-sentence title and no legend.
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Letters

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract requirements are not specified.
Manuscript Letters must be 700–800 words. Letters must include at least two descriptive keywords and the manuscript must include a declaration of interests section plus a separate AI declaration statement if generative AI or AI-assisted writing tools were used.
References Letters must include no more than 12 references. References must be numbered and cited in the text in square brackets in the order they appear.
Figures & Tables Letters may contain one display element. Letter figures must be supplied as separate files rather than embedded in the main text document, while Letter tables must be submitted as part of the main document. Letter figure legends must have a short explanatory title and fully explain the figure without reference to the text, and Letter tables must have a single-sentence title with abbreviations explained in footnotes using superscript lowercase letters.
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Recent Publications

The niche–metabolism axis: reprogramming tumor-associated macrophages for precision immunotherapy

Lijun Zhao, Xuyun Li, Wenyue Liu, Wanru Zhao, Miao Qi, Meiqi Lin, Tao Zhang, Baile Zuo, Huilong Yin, Junjie Li, Angang Yang, Rui Zhang

10.1016/j.molmed.2026.07.008
View Publication

Emerging therapeutic opportunities targeting nonclassical MHC-I molecules

Yan-Ruide Li, Yuning Chen, Lili Yang

10.1016/j.molmed.2026.07.012
View Publication

Tumor metaboception: local PGE2 signals global decline

Ming-Zhu Jin, Hao-Ran Dang, Wei-Lin Jin

10.1016/j.molmed.2026.07.011
View Publication

Formicitoxins: membrane-targeting antifungal peptides from carpenter ant venoms

Wei Zhang, Melina Sarabandi, Vinit Kumar

10.1016/j.molmed.2026.07.010
View Publication

RNA translational control in skeletal development, homeostasis, and disease

Denghao Huang, Siyuan Hu, Qiwen Li, Quan Yuan

10.1016/j.molmed.2026.07.005
View Publication

Frequently asked questions

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What are the publication costs?

APCs start at US$1500 excluding tax. Trends review journals are listed at US$7,030 for hybrid open access, excluding taxes.

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Research Topics

Diverse Scientific and Economic Studies Human auditory perception and evaluation Legal Cases and Commentary Immune Cell Function and Interaction Legal case studies and regulations Immunotherapy and Immune Responses CRISPR and Genetic Engineering Epigenetics and DNA Methylation T-cell and B-cell Immunology Virus-based gene therapy research Mitochondrial Function and Pathology RNA Interference and Gene Delivery RNA modifications and cancer Pluripotent Stem Cells Research Educational Robotics and Engineering CAR-T cell therapy research Alzheimer's disease research and treatments MicroRNA in disease regulation Neuroinflammation and Neurodegeneration Mechanisms Pharmacy and Medical Practices RNA Research and Splicing Cancer-related Molecular Pathways Cancer, Hypoxia, and Metabolism Ubiquitin and proteasome pathways Cancer Genomics and Diagnostics

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