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Gene Therapy

Gene Therapy is a key title for the exploration of new genetic and stem cell therapy techniques.

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Subject Genetics & Heredity, Medicine, Research & Experimental
Impact Factor 4.5
Quartile Q1
Open Access Type Hybrid
ISSN 0969-7128
eISSN 1476-5462
Invitation Only No
Cost Range Open access APC: £3890.00 / $5790.00 / €4690.00; traditional publishing model: no APC charges apply.

Submission Instructions

Gene Therapy accepts the following article types. Click on an article type to view submission instructions.

Article

Cover Letter Cover letter is required. Cover letter must include the corresponding author's affiliation and contact information, explain the importance of the work and its suitability for the journal's broad readership, and confirm that the manuscript reports original research not previously published or under consideration elsewhere.
Abstract An abstract is required. Abstract must not exceed 200 words. Abstract must be unstructured.
Manuscript Main body text must not exceed 8,000 words excluding the abstract, tables/figures, and references. Manuscript must include Title page, Abstract, Introduction, Materials (or Patients) and Methods, Results, Discussion, Data Availability Statement, References, Acknowledgments, Author Contributions, Ethical Approval, Competing Interests, Figure legends, Tables, and Figures. Manuscript must include Author Contributions and a funding section, be indexed with one to four unique subject terms, and document any use of a large language model in the Methods section or another suitable section if no Methods section is available.
References References must follow Vancouver format. References must be cited in text as numbered citations starting at 1 and listed in double-spaced numerical order, with up to six authors named in full or the first six followed by et al. if more than six authors.
Figures & Tables Composite figures containing more than three individual figures count as two figures. Figures must not be embedded in the text and must be uploaded as separate files, and each table must be uploaded separately. Figure legends must be provided on a separate manuscript page after the references, and tables must be editable and clearly labeled sequentially with a title or caption.
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Review Article

Cover Letter Cover letter is required. Cover letter must provide the corresponding author's affiliation and contact information, briefly explain the importance of the work and its suitability for the journal's diverse readership, and confirm that the material is original research, unpublished, and not under consideration elsewhere.
Abstract Abstract is required. Abstract must be no more than 200 words. Abstract must be unstructured.
Manuscript Main body text excluding abstract, tables/figures, and references must not exceed 4,000 words. Manuscript must contain Title page, Abstract, Introduction, Materials (or Patients) and Methods, Results, Discussion, Data Availability Statement, References, Acknowledgments, Author Contributions, Ethical Approval, Competing Interests, Figure legends, Tables, and Figures. Manuscript must include Author Contributions and a funding section, be indexed with one to four unique subject terms, and document any use of a large language model in the Methods section or a suitable alternative part of the manuscript.
References References must not exceed 100. References must follow Vancouver format. In-text citations must be numbered consecutively from 1, the reference list must be double-spaced and arranged in numerical order of citation, list all authors when there are up to six and the first six followed by et al. when there are more than six, and include first and last page numbers.
Figures & Tables Figures must not be embedded in the text and must be uploaded as separate files, and each table must be uploaded separately. Figure legends must be brief and specific and placed on a separate manuscript page after the references, tables must be editable and cited in sequence in the text, and figures and tables must be labelled sequentially.
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Brief Communication

Cover Letter Cover letter is required. Cover letter must provide the corresponding author's affiliation and contact information, explain the importance of the work and its suitability for the journal's diverse readership, and confirm that the submission is original research not previously published or under consideration elsewhere.
Abstract Abstract is required. Abstract must be unstructured and must not exceed 200 words. Abstract must be unstructured.
Manuscript Main body text excluding abstract, tables/figures, and references must not exceed 3,000 words. Manuscript should be arranged under the headings Abstract, Introduction, Materials & Methods, Results and Discussion where possible. Manuscript must include Author Contributions and a funding section, document any use of a large language model in the Methods section or another suitable part if no Methods section is available, and be indexed with one to four unique subject terms.
References References must not exceed 50. References must follow Vancouver format. In-text citations must be numbered consecutively from 1, references must be listed in numerical order of citation, papers with up to six authors must list all authors, and papers with more than six authors must list the first six authors followed by et al.
Figures & Tables Tables and figures combined must not exceed 6. Figures must not be embedded in the text and must be uploaded as separate files, and each table must be uploaded as a separate editable file. Figure legends must be brief and specific and placed on a separate manuscript page after the references, and tables must present only essential data without duplicating the text.
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Recent Publications

rAAV production cost analysis: Indication-specific cost per dose and reduction strategies

Min Tae Park, Dan Matuszek, Angela Andaluz, Seyed Pouria Motevalian

10.1038/s41434-026-00631-3
View Publication

Gene augmentation therapy successfully treats mice with complete congenital stationary night blindness (cCSNB), improving retinal function and visual acuity

Nazarul Hasan, Cecilia A. Attaway, Mattia Di Paolo, Maureen A. McCall, Ronald G. Gregg

10.1038/s41434-026-00633-1
View Publication

Reversing cancer cell behavior using AI-guided CRISPR and quantum nanobiology: a systems-based approach to epigenetic reprogramming

Bakr Ahmed Taha, Ali J. Addie, Adawiya J. Haider, Khalid Ibnaouf, Norhana Arsad

10.1038/s41434-026-00632-2
View Publication

FMR1 gene therapy restores translationally relevant phenotypes in a mouse model for fragile X syndrome

Richard K. Lacher, Kari Henson, Lindsay N. Wathen, Caitlin Jones, Tiffany Arnold, McKenzie R. Rice, Heather M. Carles, Angela R. White, Elizabeth Ramsuchit, Darren Murrey, Rebecca Raig, Austen Fisher, Kaitlin Bucher, Grace C. Westerkamp, Adam L. Fritz, Brooke M. Gollaway, Sebastian Piloto, David Dismuke, J Elliott Robinson, Michael T. Williams, Charles V. Vorhees, Erandi K. De Silva, Durgesh Tiwari, Craig A. Erickson, Ernest V. Pedapati, Christina Gross

10.1038/s41434-026-00630-4
View Publication

Improving the precision of AAV lung gene therapy for SP-B deficiency using computationally derived lung-specific promoters

Nicole Zielinska, Erin. L. Howard, Brenna A. Y. Stevens, Melanie M. Goens, Elena S. B. Campbell, Madison E. Hughes, Yanlong Pei, Liqun Xu, Adithya Achuthan, Arul Vadivel, Arnold Apostol, Xiaolin He, Dinghai Zheng, D. Benjamin Gordon, Raja R. Srinivas, Alec A. K. Nielsen, Jeff L. Caswell, Luis G. Arroyo, Darren A. Yuen, Bernard Thebaud, Sarah K. Wootton

10.1038/s41434-026-00629-x
View Publication

Frequently asked questions

How long does it take to publish?

Submission to first editorial decision (median days): 7. Submission to acceptance (median days): 163.

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Is a cover letter required?

A cover letter is required. It should include the affiliation and contact information for the corresponding author, explain the importance of the work and its suitability for the journal's readership, confirm originality and exclusive submission, and include previous reviewer comments if the manuscript was previously considered by another journal.

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What are the publication costs?

Open access APC is £3890.00 / $5790.00 / €4690.00, subject to VAT or local taxes where applicable. Traditional publishing is available with no APC charges.

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Research Topics

Virus-based gene therapy research RNA Interference and Gene Delivery CRISPR and Genetic Engineering CAR-T cell therapy research Viral Infectious Diseases and Gene Expression in Insects Immunotherapy and Immune Responses Herpesvirus Infections and Treatments Viral gastroenteritis research and epidemiology Advanced biosensing and bioanalysis techniques Cancer Research and Treatments Viral Infections and Immunology Research Immune Cell Function and Interaction Retinal Development and Disorders Nerve injury and regeneration Muscle Physiology and Disorders Pluripotent Stem Cells Research Cytomegalovirus and herpesvirus research Animal Genetics and Reproduction T-cell and B-cell Immunology HIV Research and Treatment Mesenchymal stem cell research Animal Virus Infections Studies Angiogenesis and VEGF in Cancer Neurogenetic and Muscular Disorders Research Monoclonal and Polyclonal Antibodies Research

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