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Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration publishes research on motor neuron diseases, especially ALS and cognitive decline associated with frontotemporal degeneration. It is the official journal of the World Federation of Neurology Research Group on Motor Neuron Diseases and covers topics including cognitive decline, basic science, genetics, new treatments and clinical trials, epidemiology, and clinical neurophysiology.

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Subject Clinical Neurology
Impact Factor 2.8
Quartile Q2
Open Access Type Closed
ISSN 2167-8421
eISSN 2167-9223
Invitation Only No
Cost Range Institutional online-only subscription: USD 3,081.00; print and online subscription: USD 4,504.00.

Submission Instructions

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration accepts the following article types. Click on an article type to view submission instructions.

Original Articles

Cover Letter Cover Letter requirements are not specified.
Abstract A structured abstract is required for Original Articles. Abstract must be 250 words. Abstract must be structured. The structured abstract must cover Objective, Methods, Results, and Conclusions, and for Original Articles it should describe the method and procedures.
Manuscript Original Articles must not exceed 3000 words excluding the abstract and references. Manuscript should be compiled in the order of title page, abstract, keywords, main text with Introduction, Materials and methods, Results, and Discussion, acknowledgments, declaration of interest statement, references, appendices as appropriate, tables with captions, figures, and figure captions. Manuscript must include 3 to 5 keywords, a disclosure statement under the subheading “Disclosure of interest,” a statement disclosing whether and how generative AI was used, a short biographical note for each author of no more than 200 words, and a word count.
References References must use Vancouver style. References must be numbered consecutively in order of first citation, cited in the text as digits in parentheses, and entries with more than ten authors must list the first ten followed by “et al.”.
Figures & Tables Figures should be saved separately from the text. Tables must be supplied as editable files.
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Reviews

Cover Letter Cover Letter requirements are not specified.
Abstract A structured abstract is required for Reviews. Abstract must be 250 words. Abstract must be structured. Abstract must cover the primary objective of the review, the reasoning behind the choice of review, the main outcomes and results, and the conclusions including implications for further research, application, or practice.
Manuscript Reviews must not exceed 3000 words excluding the abstract and references. Manuscript should be compiled in the order title page, abstract, keywords, main text, acknowledgments, declaration of interest statement, references, appendices as appropriate, tables with captions on individual pages, figures, and figure captions as a list. Manuscript must include 3 to 5 keywords, a disclosure statement under the subheading “Disclosure of interest,” a generative AI use statement, a word count, and a short biographical note of no more than 200 words for each author.
References Vancouver referencing style must be used. References must be numbered consecutively in order of first citation and listed using the same number for repeated citations, with in-text citations given as digits in parentheses.
Figures & Tables Figures should be saved separately from the text. Tables must be supplied as editable files.
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Non-Systematic Reviews

Cover Letter Cover Letter requirements are not specified.
Abstract A 150-word maximum block-style non-structured abstract is required. Abstract must not exceed 150 words. Abstract must be block-style and non-structured. Abstract should state the primary objective of the review, the reasoning behind the choice of review, the main outcomes and results, and the conclusions including implications for further research, application, or practice.
Manuscript Manuscript should be compiled in the order of title page, abstract, keywords, main text, acknowledgments, disclosure of interest statement, references, appendices as appropriate, tables with captions, figures, and figure captions. Manuscript must include 3 to 5 keywords, a disclosure statement under the subheading “Disclosure of interest,” a generative AI use statement, a word count, and a short biographical note for each author of no more than 200 words.
References References must use Vancouver style. References must be numbered consecutively in order of first citation and list the first ten authors followed by “et al.” when there are more than ten authors.
Figures & Tables Figures should be saved separately from the text. Tables must be supplied as editable files and should present new information without duplicating the text.
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Reports

Cover Letter Cover Letter requirements are not specified.
Abstract A structured abstract is required. Abstract must be 250 words. Abstract must be structured. Abstract must include the headings Objective, Methods, Results, and Conclusions in that order.
Manuscript Reports must not exceed 3000 words, excluding the abstract and references. Manuscript should be organized in the order title page, abstract, keywords, main text with introduction, materials and methods, results, and discussion, acknowledgments, declaration of interest statement, references, appendices as appropriate, tables with captions, figures, and figure captions. Manuscript must include 3 to 5 keywords, a disclosure statement under the subheading “Disclosure of interest,” a statement disclosing whether and how generative AI was used, a word count, and a short biographical note of no more than 200 words for each author.
References References must use Vancouver style. References must be numbered consecutively in order of first citation and cited in the text using digits in parentheses.
Figures & Tables Figures should be saved separately from the text. Tables must be supplied as editable files.
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Case Reports

Cover Letter Cover Letter requirements are not specified.
Abstract A non-structured block-style abstract is required for Case Reports. The abstract must not exceed 150 words. The abstract must be non-structured and presented in block style. No abstract headings are required because the abstract must be non-structured.
Manuscript The manuscript should be approximately 750 words. The paper should be compiled in the order of title page, abstract, keywords, main text, acknowledgments, declaration of interest statement, references, appendices as appropriate, tables with captions on individual pages, figures, and figure captions as a list. The manuscript must include 3 to 5 keywords, a disclosure statement under the subheading “Disclosure of interest,” and a statement disclosing whether and how generative AI was used in the research and manuscript preparation process.
References Case Reports must have no more than 10 references. Vancouver referencing style must be used. References must be numbered consecutively in order of first citation in the text, cited using digits in parentheses, and list the first ten authors followed by “et al.” when there are more than ten authors.
Figures & Tables Figures should be saved separately from the text. Tables must be supplied as editable files.
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Other Short Reports

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must not exceed 250 words. Abstract must be structured. Abstract must include the headings Objective, Methods, Results, and Conclusions.
Manuscript Manuscript should be approximately 750 words. Manuscript should be compiled in the order title page, abstract, keywords, main text with introduction, materials and methods, results, and discussion, acknowledgments, declaration of interest statement, references, appendices as appropriate, tables with captions, figures, and figure captions. Manuscript must include 3 to 5 keywords, a disclosure statement under the subheading “Disclosure of interest,” and a statement disclosing whether and how generative AI was used in the research and manuscript preparation process.
References References must not exceed 10. Vancouver style must be used. References must be numbered consecutively in order of first citation, cited in the text using digits in parentheses, and list the first 10 authors followed by “et al.” when there are more than 10 authors.
Figures & Tables Figures should be saved separately from the text. Tables must be supplied as editable files.
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Short Reports

Cover Letter Cover Letter requirements are not specified.
Abstract An abstract is required. The abstract must be a block-style non-structured abstract of no more than 150 words. The abstract must be non-structured and presented in block style. Abstract headings are not required because the abstract must be non-structured.
Manuscript The manuscript should be compiled in the order of title page, abstract, keywords, main text with introduction, materials and methods, results, and discussion, acknowledgments, declaration of interest statement, references, appendices as appropriate, tables with captions, figures, and figure captions. The manuscript must include 3 to 5 keywords, a disclosure statement under the subheading “Disclosure of interest,” and a statement disclosing whether and how generative AI was used in the research and manuscript preparation process.
References References must use Vancouver style. References must be cited in the text with digits in parentheses and numbered consecutively in the reference list according to first citation order.
Figures & Tables Figures should be saved separately from the text. Tables must be supplied as editable files.
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Correspondence

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract requirements are not specified.
Manuscript Correspondence should not exceed 750 words. A statement disclosing whether and how generative AI has been used in the research and manuscript preparation process must be included.
References Vancouver referencing style must be used. References must be numbered consecutively in order of first citation in the text.
Figures & Tables Correspondence may include 1 figure or table. Figures should be saved separately from the text.
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Recent Publications

Brain activity in an end-stage ALS patient suggests the presence of an unresponsive wakefulness syndrome

Sandra Frycz, Wiktor Więcławski, Marcin Skotniczny, Marek Binder

10.1080/21678421.2026.2688249
View Publication

Innate immune signaling as a potential pathomechanistic biomarker for distinct subtypes in amyotrophic lateral sclerosis

Marcel Naumann, Stefanie Kretschmer, Johannes Dorst, Hanna Lapp, Kevin Peikert, Susanne Petri, Burkhard Gess, Christine Wolf, Annekathrin Rödiger, Uta Smesny, Francisco Pan-Montojo, Philippe Kerschen, Torsten Grehl, Johannes Prudlo, Martin Regensburger, Albert Ludolph, René Günther, David Brenner, Min Ae Lee-Kirsch, Andreas Hermann

10.1080/21678421.2026.2663910
View Publication

Whole-body muscle MRI improves diagnostic certainty in amyotrophic lateral sclerosis

Vincent Fabry, Marie Faruch-Bilfeld, Rokia El Khalfi, Blandine Acket, Yassine Al Achram, Pascal Cintas

10.1080/21678421.2026.2685160
View Publication

Impact of treatment burden on medication adherence and quality of life in amyotrophic lateral sclerosis: a prospective multicentre study

Andrea Lizio, Matteo Farè, Francesca Gerardi, Marianna Collesi, Valeria Ada Sansone, Christian Lunetta, Luca Diamanti, Federica Cerri

10.1080/21678421.2026.2683691
View Publication

Oligogenic variants in NEK1 and ATXN2 in amyotrophic lateral sclerosis: report of two cases and review of the literature

Émy Roy, Mathieu Blais, Patrick Dion, Guy A. Rouleau, Nicolas Dupré, Vincent Picher-Martel

10.1080/21678421.2026.2685158
View Publication

Frequently asked questions

How long does it take to publish?

Average median timelines are tracked for submission to first decision, submission to first post-review decision, and acceptance to online publication, but no numerical values are stated.

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Is a cover letter required?

What are the publication costs?

Institutional online-only subscription: USD 3,081.00; print and online subscription: USD 4,504.00.

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Research Topics

Amyotrophic Lateral Sclerosis Research Neurogenetic and Muscular Disorders Research Parkinson's Disease Mechanisms and Treatments Genetic Neurodegenerative Diseases Neurological diseases and metabolism Prion Diseases and Protein Misfolding Alzheimer's disease research and treatments Cholinesterase and Neurodegenerative Diseases Multiple Sclerosis Research Studies Dysphagia Assessment and Management Parkinson's Disease and Spinal Disorders Neurological disorders and treatments Cervical and Thoracic Myelopathy Hereditary Neurological Disorders Palliative Care and End-of-Life Issues Biochemical Acid Research Studies Intracerebral and Subarachnoid Hemorrhage Research Fibromyalgia and Chronic Fatigue Syndrome Research Healthcare Decision-Making and Restraints Cerebral Palsy and Movement Disorders Dementia and Cognitive Impairment Research biodegradable polymer synthesis and properties Respiratory Support and Mechanisms Psychiatric care and mental health services Mitochondrial Function and Pathology

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