JO

Journal of Clinical Oncology

Journal of Clinical Oncology is an ASCO journal covering clinical oncology research and publishing article types including original reports, clinical trial updates, special articles, correspondence, rapid communications, and ASCO special articles.

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Subject Oncology
Impact Factor 41.9
Quartile Q1
Open Access Type Hybrid
ISSN 0732-183X
eISSN 1527-7755
Invitation Only No
Cost Range A submission fee is mentioned for Case Reports submitted to Journal of Clinical Oncology and not refunded if withdrawn.

Submission Instructions

Journal of Clinical Oncology accepts the following article types. Click on an article type to view submission instructions.

Biology Of Neoplasia

Cover Letter A cover letter is required. Cover letter must describe the significance and uniqueness of the work and note any prior correspondence with the journal and any prior conference presentation, if applicable.
Abstract An abstract is required. Abstract must not exceed 275 words. Abstract must be structured. Abstract must use the headings PURPOSE, PATIENTS AND METHODS (or MATERIALS AND METHODS, METHODS, or a similar heading), RESULTS, and CONCLUSION.
Manuscript Manuscript must not exceed 4000 words, although initial submission may exceed this limit by up to 1000 words.
References References are limited to 150. References must be numbered in the order in which they are cited in the text.
Figures & Tables Figures and tables are limited to 6 combined. Tables must be placed at the end of the manuscript, and figures may be embedded in the manuscript instead of uploaded separately. Figure legends must be included in the manuscript file, and tables must be cited in numerical order using Arabic numerals.
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Original Reports

Cover Letter A cover letter is required. Cover letter must describe the significance and uniqueness of the work, note any similar work previously reported by the authors, disclose any prior correspondence with the journal, and be addressed to the Editor-in-Chief.
Abstract A structured abstract is required. Abstract must be 275 words. Abstract must be structured. Abstract must use the headings PURPOSE, PATIENTS AND METHODS or a similar methods heading, RESULTS, and CONCLUSION.
Manuscript Manuscript must not exceed 3000 words, although initial submission may exceed this limit by up to 1000 words. Manuscript must include a Context Summary following the title page at revision with Key objective, Knowledge generated, and Relevance sections. At revision, the manuscript must include a Context Summary of fewer than 100 words in which Key objective is a single question defining the content and novelty, Knowledge generated consists of two short result sentences without conclusions or interpretation, and Relevance explains clinical application.
References References must be numbered in the order in which they are cited in the text.
Figures & Tables Original Reports are limited to 6 figures and tables combined. Tables must be placed at the end of the manuscript, and figures may be embedded in the manuscript instead of uploaded separately. Figure legends must be included in the manuscript file, and extended patient demographic data should be presented in a table rather than in the text.
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Review Articles

Cover Letter A cover letter is required. Cover letter must describe the significance and uniqueness of the work, include any similar work previously reported by the authors, and note any prior correspondence with the journal about the manuscript.
Abstract An abstract is required. Abstract must be 275 words. Systematic reviews, consensus guidelines, and meta-analyses must use a structured abstract, while other Review Articles must use an unstructured abstract. Structured abstracts must use the headings PURPOSE, PATIENTS AND METHODS, RESULTS, and CONCLUSION, with DESIGN permitted instead of PATIENTS AND METHODS for Review Articles.
Manuscript Manuscript must not exceed 4000 words, although initial submission may exceed this limit by no more than 1,000 words. Review Articles should be disease-focused, examine new data in the field, and describe applications to practice. Review Articles may include one optional graphical abstract at revision, submitted separately, with text under 100 words and 1 to 3 figures.
References References are limited to 150. References must be numbered in the order in which they are cited in the text.
Figures & Tables Review Articles are limited to 6 figures and tables combined. Tables must be placed at the end of the manuscript, and figures may be embedded in the manuscript rather than uploaded separately if included there. Figure legends must be included in the manuscript file, and table pieces such as Table 1a and 1b are not allowed.
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Brief Reports

Cover Letter A cover letter is required. Cover letter must describe the significance and uniqueness of the work and note any prior correspondence with the journal and any prior conference presentation, if applicable.
Abstract A structured abstract is required. Abstract must be 275 words. Abstract must be structured. Abstract must use the headings PURPOSE, PATIENTS AND METHODS (or MATERIALS AND METHODS, METHODS, or a similar heading), RESULTS, and CONCLUSION.
Manuscript Manuscript must not exceed 1500 words, although initial submission may exceed this limit by no more than 1,000 words.
References References must be numbered in the order in which they are cited in the text.
Figures & Tables Brief Reports are limited to 3 figures and tables combined. Tables must be placed at the end of the manuscript, and figures may be embedded in the manuscript file rather than uploaded separately. Figure legends must be included in the manuscript file, and tables must be cited in the order in which they appear in the text using Arabic numerals.
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Case Reports

Cover Letter A cover letter is required. Cover letter must describe the significance and uniqueness of the work and note any prior correspondence with the journal.
Abstract Abstract is not required for Case Reports.
Manuscript Case Reports must not exceed 1500 words, although initial submission may exceed this limit by no more than 1000 words. Case Reports should provide a brief overview of the case and a concise literature review. Case Reports must be supported by data, should provide access to primary data, and should include clear evidence of exceptional response or resistance, a proposed mechanism linking genomic features to response or resistance to targeted therapy, and the variant, platform, and targeted therapy used.
References Case Reports are limited to 20 references. References must be numbered in the order in which they are cited in the text.
Figures & Tables Case Reports are limited to 3 figures and tables combined. If figures are included within the manuscript, they do not need to be uploaded separately, and tables must be placed at the end of the manuscript. Figure legends must be included in the manuscript file, and tables must be cited in the order in which they appear in the text using Arabic numerals.
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Clinical Trial Updates

Cover Letter A cover letter is required. Cover letter must describe the significance and uniqueness of the work, note any similar previously reported work and any prior correspondence with the journal, and be addressed to the Editor-in-Chief.
Abstract An abstract is required. Abstract must be 200 words. Abstract must be unstructured.
Manuscript Manuscript must not exceed 1200 words, although initial submission may exceed this limit by no more than 1,000 words. Clinical Trial Updates should include a brief description of the trial and a short summary of previous findings to provide context. Updates to randomized phase II and all phase III trials must include a redacted study protocol.
References References must be numbered in the order in which they are cited in the text.
Figures & Tables Clinical Trial Updates are limited to 3 figures and tables combined. Tables must be placed at the end of the manuscript, and figures may be embedded in the manuscript rather than uploaded separately. Table 1 must include information regarding the patient population, even if repeated from the original publication.
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Correspondence

Cover Letter A cover letter is required. Cover letter must describe the significance and uniqueness of the work, include any similar work previously reported by the authors, and note any prior correspondence with the journal about the manuscript.
Abstract Abstract requirements are not specified.
Manuscript Correspondence must not exceed 750 words. Correspondence responding to a JCO article must include the reference to that article and use an original title that differs from the article. Authors should not use artificial intelligence or large language models to generate Correspondence.
References Correspondence is limited to 10 references. References must be numbered in the order in which they are cited in the text.
Figures & Tables Tables must be placed at the end of the manuscript, and figures may be embedded in the manuscript file rather than uploaded separately. Figure legends must be included in the manuscript file.
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Special Articles

Cover Letter A cover letter is required. Cover letter must describe the significance and uniqueness of the work, include any similar work previously reported by the authors, note any prior correspondence with the journal, and disclose prior conference presentations if applicable.
Abstract An abstract is required. Abstract must not exceed 275 words. Abstract must be structured. Abstract must use the headings PURPOSE, PATIENTS AND METHODS (or MATERIALS AND METHODS, METHODS, or a similar heading), RESULTS, and CONCLUSION.
Manuscript Manuscript must not exceed 4000 words, although initial submission may exceed this limit by no more than 1,000 words. Special Articles should explicitly state the methods used to select committee membership, clearly describe deliberation processes, and explicitly state funding sources.
References References must be numbered in the order in which they are cited in the text.
Figures & Tables Special Articles are limited to 6 figures and tables combined. Tables must be placed at the end of the manuscript, and figures may be embedded in the manuscript file rather than uploaded separately if included there. Figure legends must be included in the manuscript file, and tables must be cited in the order in which they appear in the text using Arabic numerals.
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Recent Publications

Radiation Oncology at a Crossroads: Interpreting the Evidence on Proton Versus Photon Radiotherapy for Oropharyngeal Cancer

Sudarshan Ramanan, George Ashji, Khoi Nguyen, Danil Ratnikov, Eric J. Sherman, Sean M. McBride, Yingzhi Wu, Edward Christopher Dee, Nadeem Riaz, Nancy Y. Lee

10.1200/jco-26-01434
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Treatment of Advanced Biliary Tract Cancer: ASCO Living Guideline, Version 2026.1.0

Rachna T. Shroff, Erin B. Kennedy, Ashley Efrain Alarcon Rozas, Rajiv Agarwal, Melinda Bachini, Marina Baretti, Gagandeep Brar, Allen L. Cohn, Madhu Eluri, Olumide B. Gbolahan, John D. Gordan, Lipika Goyal, James J. Harding, Ishmael Jaiyesimi, Adel Kardosh, Robin Kate Kelley, Angela Lamarca, Arun Nagarajan, Vikas Ostwal, Michal Rose, Ardaman Shergill, Changqing Xie, Tim F. Greten

10.1200/jco-26-02462
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Erratum: Circulating Tumor DNA Profiling Defines Risk Classification in Patients With Ewing Sarcoma: A Report From the Children's Oncology Group and the LEOPARD Study

David S. Shulman, Kelly Klega, Nan Chen, Allen Buxton, Elliot Gohn, Sarah Sexton, Catherine Clinton, Mohammad Tanhaemami, Carrie Cibulskis, Edwin Choy, Thomas Cash, Kris Ann P. Schultz, Leo Mascarenhas, Rochelle Bagatell, Christopher Kuo, Brian K. Turpin, Bhuvana A. Setty, Bradley D. DeNardo, Douglas S. Hawkins, Michael W. Bishop, Avanthi Tayi Shah, Luke D. Maese, Julia L. Glade Bender, Damon Reed, Mark D. Krailo, Natalie DelRocco, Wendy B. London, Katherine A. Janeway, Steven G. DuBois, Brian D. Crompton

10.1200/jco-26-02524
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Selpercatinib in Pediatric and Adolescent Patients With RET -Altered Solid Tumors: Safety and Efficacy Results From the Phase I/II LIBRETTO-121 Study

Theodore W. Laetsch, Hyoung Jin Kang, Michela Casanova, Antoinette Anazodo, Steven G. DuBois, Atsushi Manabe, Fariba Navid, Alberto Pappo, Adrienne M. Gilligan, Olivera Grbovic-Huezo, Dan Liu, Subha Suriyapperuma, Nivedita Sharma, Patrick Peterson, Jennifer Wright, Cornelis M. van Tilburg, Daniel Morgenstern, Birgit Geoerger, Charlotte Rigaud, Raquel Hladun Alvaro, Lorena Valero, Martin Campbell, David Ziegler, Douglas Hawkins, Catherine Albert, Tanya Watt, Frank Balis, Leo Mascarenhas, Stephanie Fetzko, Samara Potter, Ayumu Arakawa, Karsten Nysom

10.1200/jco-25-03013
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Prescription Does Not Ensure Patient Access: Progress and Remaining Challenges in Addressing Access Barriers to Specialty Oral Anticancer Medications

Aryana Sepassi, A. Mark Fendrick

10.1200/jco-26-02192
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Frequently asked questions

How long does it take to publish?

Published three times per month — a total of 36 issues per year.

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Is a cover letter required?

A cover letter is required as part of the required information for submission under the format-free EZSubmit policy.

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What are the publication costs?

Journal of Clinical Oncology charges an $80 USD submission fee for Original Reports.

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Research Topics

Lung Cancer Treatments and Mutations Cancer Treatment and Pharmacology Colorectal Cancer Treatments and Studies Cancer Genomics and Diagnostics Cancer Immunotherapy and Biomarkers Gastric Cancer Management and Outcomes Prostate Cancer Treatment and Research Lung Cancer Research Studies Breast Cancer Treatment Studies Economic and Financial Impacts of Cancer Lymphoma Diagnosis and Treatment Cancer Diagnosis and Treatment Pancreatic and Hepatic Oncology Research HER2/EGFR in Cancer Research Radiomics and Machine Learning in Medical Imaging Multiple and Secondary Primary Cancers Renal cell carcinoma treatment Advanced Breast Cancer Therapies Bladder and Urothelial Cancer Treatments Chronic Lymphocytic Leukemia Research Hepatocellular Carcinoma Treatment and Prognosis Lung Cancer Diagnosis and Treatment Radiopharmaceutical Chemistry and Applications Cholangiocarcinoma and Gallbladder Cancer Studies Sarcoma Diagnosis and Treatment

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