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Nature Biomedical Engineering

Nature Biomedical Engineering is a journal publishing research articles, reviews, analysis, news and comment in biomedical engineering, with a mix of subscription content and Open Access articles.

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Subject Engineering, Biomedical
Impact Factor 26.6
Quartile Q1
Open Access Type Hybrid
ISSN 2157-846X
eISSN 2157-846X
Invitation Only No
Cost Range Article Processing Charge (APC) applies for gold open access and is paid when the manuscript is accepted.

Submission Instructions

Nature Biomedical Engineering accepts the following article types. Click on an article type to view submission instructions.

Article

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract is required. Abstract must be unreferenced and no longer than 175 words. Abstract must be unstructured. Abstract must briefly present the background and rationale of the work followed by a statement of the main conclusions introduced by "Here, we show" or an equivalent phrase.
Manuscript Main text must not exceed 3,500 words, excluding the abstract, Methods, references, and figure and table legends. Manuscript must be organized into Introduction, Results, Discussion, Online Methods, Acknowledgements, Author contributions, and Competing interests, with the introduction presented without a heading and Results and Methods divided by one-level subheadings only.
References References should typically not exceed 50. References must be numbered in the order of first citation in the main text, then tables, and then figure captions.
Figures & Tables Articles may include up to 8 display items in total, including figures and tables.
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Review Article

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract is required and must be unreferenced. Abstract must be no more than 175 words. Abstract must be unstructured.
Manuscript Main text must be 4,000–8,000 words excluding abstract, references, boxes, and figure and table legends. Text must be organized into several sections, may include one-level subheadings, and may include an Outlook section at the end of the main text.
References References must not exceed 150, although exceptions can be granted by the Editor on a case-by-case basis. Reference list must be ordered according to citation numbers first appearing in the main text, then tables, figure captions, and boxes.
Figures & Tables No more than 8 display items, including figures, tables, and/or boxes, are allowed.
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Primary Research Articles

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract requirements are not specified.
Manuscript Research articles containing newly developed code central to the main claims must include code details for peer review evaluation and a software submission checklist.
References References requirements are not specified.
Figures & Tables Figures & Tables requirements are not specified.
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Correspondence

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract requirements are not specified.
Manuscript Main text must be 300–800 words. Correspondence cannot be used to present original research.
References References are limited to 10. Article titles must be omitted from the reference list, but book titles must be included.
Figures & Tables Only one display item is allowed.
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Matters Arising

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract requirements are not specified.
Manuscript Matters Arising are typically no longer than 1,200 words.
References References should typically not exceed 15.
Figures & Tables Matters Arising can include up to two display items, including figures and/or tables.
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Recent Publications

A three-dimensional multi-modal foundation model for optical coherence tomography

Zixuan Liu, Hanwen Xu, Addie Woicik, Linda G. Shapiro, Marian Blazes, Yue Wu, Verena Steffen, Catherine A. Cukras, Cecilia S. Lee, Miao Zhang, Aaron Y. Lee, Sheng Wang

10.1038/s41551-026-01662-2
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CAR-neutrophils produced in vivo to treat glioma

Yun Chang, Kunming Shao, Huiyang Li, Gyuhyung Jin, R. Timothy Bentley, Robyn R. McCain, Christa J. Crain, Jingqiao Shen, Yan Tan, Po-Yu Liang, Haley A. Harper, Sandra Torregrosa-Allen, Bennett D. Elzey, Isabelle F. Vanhaezebrouck, Aaron A. Cohen-Gadol, Cheng Dong, Yu Zhu, Yuewei Wang, Jie Luo, Xiaojun Lance Lian, Xiaoping Bao

10.1038/s41551-026-01656-0
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Whole cross-sectional human ultrasound tomography

David C. Garrett, Jinhua Xu, Donghyeon Oh, Yousuf Aborahama, Geng Ku, Konstantin Maslov, William W. Tseng, Lihong V. Wang

10.1038/s41551-026-01660-4
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DeepDrugDiscovery identifies blood–brain barrier permeable autophagy enhancers for Alzheimer’s disease

Yu Dong, Xianglu Xiao, Xu-Xu Zhuang, Wenfan Wu, Zi-Ying Wang, Shuang Zhang, Jin-Tao Li, Ke Zhang, Wen-Yu Fu, Jun-Ming Chen, Shi Hang Xiong, Shenglong Deng, Krinos Li, Chao Ma, Wangzhen Jin, Xurui Jin, Qiwei Cai, Han-Ming Shen, Min Li, Huanxing Su, Jian-Bo Wan, Hua Yu, Defang Ouyang, Keqiang Ye, Evandro F. Fang, Chris Soon Heng Tan, Guang Yang, Zhangming Niu, Jia-Hong Lu

10.1038/s41551-026-01667-x
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Towards a general-purpose foundation model for functional MRI analysis

Cheng Wang, Yu Jiang, Zhihao Peng, Chenxin Li, Chang-bae Bang, Lin Zhao, Wanyi Fu, Jinglei Lv, Jorge Sepulcre, Carl Yang, Lifang He, Tianming Liu, Xue-Jun Kong, Quanzheng Li, Daniel S. Barron, Anqi Qiu, Randy Hirschtick, Byung-Hoon Kim, Hongbin Han, Xiang Li, Yixuan Yuan

10.1038/s41551-026-01666-y
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Frequently asked questions

How long does it take to publish?

Articles are published as soon as they are ready.

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Is a cover letter required?

Review Articles, Perspectives and Comments advise submitting a presubmission enquiry before formal submission for unsolicited contributions. Review Articles and Perspectives advise a synopsis of about 1,000 words with references and figures. Comments advise a synopsis of about 300 words.

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What are the publication costs?

Article Processing Charge (APC) applies for gold open access and is paid when the manuscript is accepted.

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Research Topics

CRISPR and Genetic Engineering CAR-T cell therapy research Neuroscience and Neural Engineering 3D Printing in Biomedical Research Immunotherapy and Immune Responses Advanced biosensing and bioanalysis techniques Nanoplatforms for cancer theranostics RNA Interference and Gene Delivery Monoclonal and Polyclonal Antibodies Research Tissue Engineering and Regenerative Medicine Virus-based gene therapy research Cell Image Analysis Techniques Pluripotent Stem Cells Research Photoacoustic and Ultrasonic Imaging Single-cell and spatial transcriptomics Immune Cell Function and Interaction Cellular Mechanics and Interactions Radiomics and Machine Learning in Medical Imaging Extracellular vesicles in disease Advanced Sensor and Energy Harvesting Materials Biosensors and Analytical Detection EEG and Brain-Computer Interfaces AI in cancer detection Nanoparticle-Based Drug Delivery Cancer Cells and Metastasis

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