Overview Submission Instructions Recent Publications Frequently Asked Questions Research Topics

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PLoS neglected tropical diseases

PLOS Neglected Tropical Diseases is an online journal focused on neglected tropical diseases and publishes content including research articles, viewpoints, and front matter articles. The journal has ISSN 1935-2735 (online) and provides submission instructions through its journal site and manuscript submission system.

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Subject Tropical Medicine

Impact Factor 3.4

Quartile Q1

Open Access Type Open

ISSN 1935-2735

eISSN 1935-2735

Invitation Only No

Cost Range Research Article: $2,670; Research4Life Group B fee for eligible authors: $940; free for eligible Research4Life Group A authors without external funding.

Submission Instructions

PLoS neglected tropical diseases accepts the following article types. Click on an article type to view submission instructions.

Original Research Papers

Cover Letter A cover letter is required as a separate file and must not exceed one page. The cover letter must summarize the study’s contribution to the literature, relate it to previously published work, specify the article type, describe any prior interactions with PLOS regarding the manuscript, suggest appropriate Academic Editors, and list any opposed reviewers.

Abstract An abstract is required and must appear after the title page. Abstract must be 250–300 words. Abstract must be structured. Abstract must use the headings Background, Methodology/Principal Findings, and Conclusions/Significance.

Manuscript Manuscripts can be any length. Manuscript must be organized as Title, Authors and Affiliations, Abstract, Author Summary, Introduction, Methods, Results, Discussion, Acknowledgments, References, and Supporting Information Captions, with Results and Discussion optionally combined and a 150–200 word non-technical Author Summary placed immediately after the Abstract. Manuscript must include a 150–200 word non-technical Author Summary written in the first person, and any AI tool use must be disclosed in a dedicated Methods section or in the Acknowledgments with the tool names, how they were used and validated, and what content was affected.

References References must use Vancouver style. References must be numbered in order of appearance, cited in square brackets, and formatted using the citation-sequence method listing the first six authors followed by et al.

Figures & Tables There are no restrictions on the number of figures. Figures must not be included in the main manuscript file, while tables must be inserted immediately after the first paragraph in which they are cited and must not be submitted as separate files. Figures and tables must be cited in ascending numeric order, and data must not be duplicated in graphs and tables.

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Review

Cover Letter A cover letter must be uploaded as a separate file and must not exceed 1 page. The cover letter must summarize the study’s contribution to the scientific literature, relate it to previously published work, specify the article type, describe any prior interactions with PLOS regarding the manuscript, suggest appropriate Academic Editors, and list any opposed reviewers.

Abstract Reviews must include a short abstract.

Manuscript Reviews must be 3,000–5,000 words and should not exceed 5,000 words except in very exceptional circumstances. Reviews must include a brief Methods section describing how the literature was searched and appraised. Reviews must include a box listing 3–5 key learning points and a box listing 5 key papers in the field.

References Reviews must include 50–80 references. References must use Vancouver style. References must be numbered in order of appearance, cited in square brackets, and formatted using the citation-sequence method with the first six authors followed by et al.

Figures & Tables Reviews should include 3–5 display items such as figures, tables, photos, or illustrations. Figures must not be included in the main manuscript file, whereas tables must be inserted immediately after the first paragraph in which they are cited and must not be submitted separately.

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Systematic Reviews

Cover Letter A cover letter is required for submission. The cover letter must state that the article is a systematic review or a meta-analysis.

Manuscript Manuscripts can be any length. Manuscript should be organized with Title, Authors and Affiliations, Abstract, Author Summary, Introduction, Methods, Results, Discussion, Acknowledgments, References, and Supporting Information Captions, with Results and Discussion allowed to be combined. The title subtitle should include the study design, the Methods section must state whether a protocol exists, the abstract must provide the registry number if a protocol exists or the review was prospectively registered, and a completed PRISMA checklist and flow diagram must accompany the main text as supporting information.

Figures & Tables There are no restrictions on the number of figures. Figures must not be included in the main manuscript file, the PRISMA flow diagram must be included as Fig 1 where applicable, tables must be inserted immediately after the first paragraph in which they are cited, and tables must not be submitted in separate files. Figures and tables must be cited in ascending numeric order and restricted to those needed to explain the argument of the paper and assess supporting data.

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Meta-Analyses

Cover Letter A cover letter must be uploaded as a separate file and must not exceed 1 page. The cover letter must state that the article is a systematic review or a meta-analysis, summarize the study’s contribution to the scientific literature, relate the study to previously published work, specify the article type, describe any prior interactions with PLOS regarding the manuscript, suggest appropriate Academic Editors, and list any opposed reviewers.

Abstract An abstract is required. Abstract must not exceed 250–300 words. Abstract should follow PRISMA for Abstracts using the PLOS structured abstract format. Abstract must use the headings Background, Methodology/Principal Findings, and Conclusions/Significance, and if the review was prospectively registered or a protocol exists, the registry number must be provided in the abstract.

Manuscript Manuscripts can be any length. Manuscript should be organized as Title, Authors and Affiliations, Abstract, Author Summary, Introduction, Methods, Results, Discussion, Acknowledgments, References, and Supporting Information Captions, with Results and Discussion allowed to be combined and the title subtitle including the study design. The manuscript must include an Author Summary, a dedicated AI disclosure section in the Methods or Acknowledgments if AI tools were used, a Methods statement on whether a protocol exists, and the submission must include a completed PRISMA checklist and flow diagram with the PRISMA flow diagram included as Fig 1 where applicable.

References References must use Vancouver style. References must be listed at the end of the manuscript, numbered in order of first appearance, cited in square brackets, and formatted using the numbered citation-sequence method with the first six authors followed by et al.

Figures & Tables There are no restrictions on the number of figures. Figures must not be included in the main manuscript file and the PRISMA flow diagram must be included as Fig 1 where applicable, while tables must be inserted immediately after the first paragraph in which they are cited and must not be submitted in separate files. Tables must be editable cell-based objects with a label and brief descriptive title above the table, and figure captions must appear in the manuscript text immediately after the paragraph where the figure is first cited.

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Formal Comment

Cover Letter Cover letter must be uploaded as a separate file and must not exceed 1 page. Cover letter must summarize the study’s contribution, relate it to previously published work, specify the article type, describe any prior interactions with PLOS, suggest appropriate Academic Editors, and list any opposed reviewers.

Abstract Abstract requirements are not specified.

Manuscript Formal Comment must be 1,500 words.

References Formal Comment should cite up to 15 references in support of key assertions. References must use Vancouver style. References must be listed at the end of the manuscript, numbered in order of first appearance, cited in square brackets, and formatted with the first six authors followed by et al.

Figures & Tables There are no restrictions on the number of figures. Figures must not be included in the main manuscript file, while tables must be inserted immediately after the first paragraph in which they are cited. Figures and tables must be cited in ascending numeric order.

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Recent Publications

Ecological signature on the epidemiological dynamics of severe fever with thrombocytopenia syndrome

Zhe Lou, Jing Lu, Shuyi Liang, Wei Zhao, Ling Huang, Haowei Wang, Xiang Li, Jianli Hu, Ruiyun Li

10.1371/journal.pntd.0014408

View Publication

Plasma proteomics improves risk prediction in heart failure and reveals unique biology in chronic chagas cardiomyopathy

José S. L. Patané, Fernando R. Giugni, Rogério S. Rosa, Fabiana G. Marcondes-Braga, Alfredo J. Mansur, Alexandre C. Pereira, Jose E. Krieger

10.1371/journal.pntd.0014370

View Publication

Beneficiary feedback mechanisms: Exploring ways to systematically integrate community feedback in mass drug administration delivery for NTDs

Jake D. Mathewson, Charlie Aardewijn, Sake J. de Vlas, Dunstan J. Matungwa, Mirjam I. Bakker

10.1371/journal.pntd.0014373

View Publication

Discovery of a novel coltivirus in a newly identified Bat Bug Species (Heteroptera: Cimicidae) in Cambodia

Jurre Y. Siegers, Heidi Auerswald, Pierre-Olivier Maquart, Tamara Szentiványi, Julia Guillebaud, Thavry Hoem, Xiang Li, Kimhuor Suor, Leakhena Pum, Limmey Khun, Sithun Nuon, Kimlay Chea, Vireak Heang, Kathrina Mae Bienes, Yvonne C.F. Su, Veasna Duong, Janin Nouhin, Sébastien Boyer, Erik A. Karlsson

10.1371/journal.pntd.0014372

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Preclinical animal models for onchocerciasis and loiasis: A systematic review of applications in drug screening

Rene Bilingwe Ayiseh, Blendin Serri Gemuh, Glory Enjong Mbah, Stephen Mbigha Ghogomu, Fidelis Cho-Ngwa

10.1371/journal.pntd.0014401

View Publication

Frequently asked questions

How long does it take to publish?

Formatting requirements are waived until the manuscript has received a provisional Editorial Accept decision. Original uncropped and minimally adjusted blot and gel images are required before a manuscript can be accepted for submissions on or after April 1 2026.

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Is a cover letter required?

A cover letter must be uploaded as a separate file in the online system and should explain why the manuscript is suitable for PLOS Neglected Tropical Diseases and why the study will inspire the NTDs community and advance understanding of NTD pathobiology, epidemiology, prevention, treatment, control, or policy.

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What are the publication costs?

Research Article APC: $2,670. Eligible Research4Life Group B authors may pay $940, and eligible Research4Life Group A authors without external funding may publish free.

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Research Topics

Parasites and Host Interactions Mosquito-borne diseases and control Research on Leishmaniasis Studies Trypanosoma species research and implications Viral Infections and Vectors Parasitic Diseases Research and Treatment Malaria Research and Control Parasite Biology and Host Interactions Viral Infections and Outbreaks Research Zoonotic diseases and public health Vector-borne infectious diseases Insect symbiosis and bacterial influences Parasitic Infections and Diagnostics Rabies epidemiology and control Helminth infection and control Parasitic infections in humans and animals Leprosy Research and Treatment Amoebic Infections and Treatments Mycobacterium research and diagnosis Insects and Parasite Interactions Virology and Viral Diseases Leptospirosis research and findings Vector-Borne Animal Diseases Child Nutrition and Water Access Venomous Animal Envenomation and Studies

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