Overview
Submission Instructions
Recent Publications
Frequently Asked Questions
Research Topics
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AJ
American Journal of Physiology-Heart and Circulatory Physiology publishes research and reviews in cardiovascular physiology and pathophysiology, with content spanning heart, vascular, renal, and integrative cardiovascular mechanisms. The journal is edited by Merry L. Lindsey and includes calls for papers, podcasts, and online-first articles.
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Impact Factor
4.1
Quartile
Q1
Open Access Type
Closed
ISSN
0363-6135
eISSN
1522-1539
Invitation Only
No
Submission Instructions
American Journal of Physiology-Heart and Circulatory Physiology accepts the following article types. Click on an article type to view submission instructions.
Research Article
Cover Letter
Cover Letter requirements are not specified.
Abstract
Abstract is required for Research Articles. Abstract must not exceed 250 words. Abstract must be a one-paragraph unstructured summary.
Manuscript
Research Articles have no word limit. Manuscript must include an introduction, methods, results, and discussion. Manuscript must include a New & Noteworthy summary of no more than 75 words, up to 5 keywords without abbreviations, author contributions, and a Data Availability Statement.
References
Research Articles have no reference limit. References must use Vancouver style. References must be listed in numerical order as cited in the text and include only published, accepted, or preprint articles, while unpublished observations and personal communications are cited only in the text.
Figures & Tables
Research Articles have no figure or table limit. Tables must be provided in Word table format rather than tabbed text or embedded images.
Review Article
Cover Letter
Cover Letter requirements are not specified.
Abstract
Review Articles must include an abstract. Abstracts must not exceed 250 words. The abstract must be a one-paragraph unstructured summary.
Manuscript
Review Articles are limited to 6,000 words. The manuscript must include up to 5 keywords and an author contributions statement, and AI use in manuscript preparation should be disclosed in the Acknowledgments section.
References
Review Articles have no reference limit. References must use Vancouver style. References must be listed in numerical order as cited in the text.
Figures & Tables
Review Articles may include up to 6 figures. Tables must be submitted in Word table format rather than as tabbed text or embedded images.
Systematic Review
Cover Letter
Cover Letter requirements are not specified.
Abstract
Systematic Reviews must include an abstract. Abstract must not exceed 250 words.
Manuscript
Systematic Reviews have no word limit. Systematic Reviews must indicate in the title that the article is a systematic review or meta-analysis of the literature and must report the search strategy, inclusion and exclusion criteria, extracted information characteristics, risk of bias across studies, and limitations of the literature search and analysis. Manuscripts must include a title page, up to 5 keywords, author contributions, and an AI use disclosure in the Acknowledgments or Materials and Methods section when applicable.
References
References must use Vancouver style. References must be listed in numerical order as cited in the text and include only published, accepted, or preprint articles, while unpublished observations and personal communications may be cited only in the text.
Figures & Tables
Systematic Reviews have no figure or table limit. Tables must be submitted in Word table format rather than as tabbed text or embedded images.
Original Investigations
Cover Letter
Cover Letter requirements are not specified.
Abstract
A one-paragraph abstract is required for full-length manuscripts. Abstract must not exceed 250 words. Abstract must be unstructured and presented as a single paragraph.
Manuscript
Manuscript must include a title page, Materials and Methods, Results, Discussion, Acknowledgments, author contributions, references, and any SUPPLEMENTAL MATERIAL section after the Discussion. Manuscript must include up to 5 keywords, a New & Noteworthy summary of no more than 75 words, author contributions, and any required AI use disclosure in the Materials and Methods or Acknowledgments.
References
References must use Vancouver style. References must be listed in numerical order as cited in the text, include only published or accepted articles plus preprints, and exclude unpublished observations and personal communications from the reference list.
Figures & Tables
New submissions must include figures and tables. Tables must be submitted in Word table format rather than tabbed text or embedded images, and figure legends must clearly describe the content, define statistical symbols and abbreviations, include N values, and state P values where applicable.
Reviews
Cover Letter
Cover Letter requirements are not specified.
Abstract
A one-paragraph abstract is required. Abstract must not exceed 250 words. Abstract must be unstructured as a single paragraph.
Manuscript
Manuscript must include a title page and, for full-length manuscripts, an abstract. Manuscript may include up to 5 keywords, and any AI use in manuscript preparation should be disclosed in the Acknowledgments section.
References
References must use Vancouver style. References must be listed in numerical order as cited in the text, and only published or accepted articles should appear in the reference list.
Figures & Tables
New submissions must include figures and tables. Tables must be submitted in Word table format rather than tabbed text or embedded images.
Short Report
Cover Letter
Cover Letter requirements are not specified.
Abstract
Short Reports must include an abstract. Abstracts are limited to 250 words. Abstract must be a one-paragraph unstructured summary.
Manuscript
Short Reports are limited to 4,000 words excluding references and figure legends. Short Reports must include a Data Availability Statement and a link in the manuscript to repository-hosted supplemental material files.
References
Short Reports have no reference limit. References must use Vancouver style. References must be listed in numerical order as cited in the text.
Figures & Tables
Short Reports may include up to 4 figures or tables, excluding additional online materials. Tables must be submitted in Word table format and not as tabbed text or embedded images.
Mini-Review
Cover Letter
Cover Letter requirements are not specified.
Abstract
Mini-Reviews must include an abstract. Abstracts must not exceed 250 words. Abstract must be a one-paragraph abstract.
Manuscript
Mini-Reviews should be approximately 3,000 words excluding references. Manuscripts must include up to 5 keywords without abbreviations, author contributions, and an AI use disclosure in the Acknowledgments if AI tools were used in manuscript preparation.
References
Mini-Reviews may include up to 50 references. References must use Vancouver style. References must be listed in numerical order as cited in the text.
Figures & Tables
Mini-Reviews may include 1-3 figures and/or tables. Previously published figures are permitted only with copyright-holder permission and acknowledgment of the source.
Letter To The Editor
Cover Letter
Cover Letter requirements are not specified.
Abstract
Abstract requirements are not specified.
Manuscript
Letters To The Editor are limited to 1,000 words excluding references. Letters To The Editor must respond to work previously published in the journal. Letters To The Editor must have a clear and unique title that does not quote or reuse the original article's title.
References
Letters To The Editor may include up to 10 references, including the highlighted article. References must use Vancouver style. References must be listed in numerical order as cited in the text.
Figures & Tables
Letters To The Editor must not include figures or tables. Letters To The Editor must not include figures or tables.
Reviews For Physiological Reviews
Cover Letter
Cover Letter requirements are not specified.
Abstract
Abstract is required. Abstract must not exceed 250 words.
Manuscript
Manuscript must be 10,000-25,000 words. Manuscript may include up to 5 keywords, and any AI-assisted manuscript preparation should be disclosed in the Acknowledgments.
References
There is no reference limit. References must use Vancouver style. References must be listed in numerical order as cited in the text.
Figures & Tables
Manuscript must include at least 10 figures, and tables are encouraged. Tables must be submitted in Word table format and not as tabbed text or embedded images.
Reviews For Physiology
Cover Letter
Cover Letter requirements are not specified.
Abstract
Abstract is required. Abstract must not exceed 250 words.
Manuscript
Manuscript must be 6,000-8,000 words. Manuscript may include up to 5 keywords, and any use of AI tools in manuscript preparation should be disclosed in the Acknowledgments section.
References
References must use Vancouver style. References must be listed in numerical order as cited in the text.
Figures & Tables
There is no figure or table limit. Tables must be submitted in Word table format and not as tabbed text or embedded images.
Recent Publications
Interpreting AIM2 dependency in CAWS-induced vasculitis in the context of prior inflammasome studies
Chie Miyabe, Yoshishige Miyabe
10.1152/ajpheart.00409.2026
View Publication
Beyond Cancer: Breast Cancer Gene 2 Emerges as a New Player in Atherosclerosis
David C. R. Michels, Aman Singh, Margi Patel, Berk Rasheed, Sepideh Nikfarjam, Shuhan Bu, Mehroz Ehsan, Biao Feng, Liliana German-Castelan, Robert Gros, Jefferson C. Frisbee, krishna K. Singh
10.1152/ajpheart.00790.2025
View Publication
Myeloid PD-1/PD-L1 Signaling: An Unexpected Regulator of Heart Integrity
Dinender K. Singla, Jonatas M. Rolando
10.1152/ajpheart.00525.2026
View Publication
“Heart Failure Through the Lens of Complexity”
Dirk L. Brutsaert, Andrew Xanthopoulos, Filippos Triposkiadis
10.1152/ajpheart.00341.2026
View Publication
Potential role of tryptophan metabolites in the sex-based differences in doxorubicin-induced chronic cardiotoxicity in a rat model
Klaudia Kupecz, Zsolt Galla, Réka Losonczi, Dávid Volford, Andrea Siska, Anita Sejben, Moska Kohistani, Merse Kis, Réka Somogyi, Zsombor András Greschik, András Kriston, Ferenc Kovács, Péter Horváth, Péter Bencsik, Imre Földesi, Péter Monostori, Gábor Cserni, Zsuzsanna Kahán, Márta Sárközy
10.1152/ajpheart.00026.2026
View Publication
Frequently asked questions
How long does it take to publish?
Transferred manuscripts to Physiological Reports must be transferred within 120 days of the decision.
Reformat to American Journal of Physiology-Heart and Circulatory Physiology using Livewrite PremiumIs a cover letter required?
A cover letter is required for NPRC transfers and should state that the submission is an NPRC paper; no general cover letter requirement is stated.
Reformat to American Journal of Physiology-Heart and Circulatory Physiology using Livewrite PremiumResearch Topics
Cardiac electrophysiology and arrhythmias
Nitric Oxide and Endothelin Effects
Heart Rate Variability and Autonomic Control
Cardiovascular Function and Risk Factors
Ion channel regulation and function
Cardiac Ischemia and Reperfusion
Cardiovascular and exercise physiology
Cardiomyopathy and Myosin Studies
Receptor Mechanisms and Signaling
Cardiac Imaging and Diagnostics
Neuroscience of respiration and sleep
Cardiovascular Health and Disease Prevention
Renin-Angiotensin System Studies
Cardiovascular Effects of Exercise
Cardiac Arrest and Resuscitation
Cardiac Arrhythmias and Treatments
Advanced MRI Techniques and Applications
Eicosanoids and Hypertension Pharmacology
Cardiac Fibrosis and Remodeling
Neuroscience and Neural Engineering
Adipose Tissue and Metabolism
Pulmonary Hypertension Research and Treatments
Mitochondrial Function and Pathology
Hormonal Regulation and Hypertension
Neuropeptides and Animal Physiology
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