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Annals of Internal Medicine

Annals of Internal Medicine is a medical journal published on the ACP Journals platform, featuring latest articles, most-read articles, specialty collections, and author information. It maintains social media channels including Facebook, X, and Instagram.

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Subject Medicine, General & Internal
Impact Factor 15.2
Quartile Q1
Open Access Type Closed
ISSN 0003-4819
eISSN 1539-3704
Invitation Only No
Cost Range Subscription-based journal; no article-level open-access option supported by article processing charges.

Submission Instructions

Annals of Internal Medicine accepts the following article types. Click on an article type to view submission instructions.

Original Research Articles

Cover Letter Cover letter is required only if artificial intelligence-assisted technologies were used, if justification is provided for requesting exclusion of reviewers, or if duplicate publication details and reuse-permission documentation apply. Cover letter must describe any use of artificial intelligence-assisted technologies, provide full details of possible previous or duplicate publication, justify any request to exclude reviewers, and include documentation granting permission to reuse previously published content when applicable.
Abstract Original Research Articles must include an abstract. Abstract must be structured and no longer than 275 words. Abstract must be structured. Abstract must use the headings Background, Objective, Design, Setting, Patients (or Participants), Interventions (if any), Measurements, Results, Limitations, Conclusion, and Primary Funding Source, except cost-effectiveness studies must use Background, Objective, Design, Data Sources, Target Population, Time Horizon, Perspective, Intervention, Outcome Measures, Results of Base-Case Analysis, Results of Sensitivity Analysis, Limitations, Conclusion, and Primary Funding Source, and registered studies must give the registry and unique registration number at the end of the Design section.
Manuscript Manuscript must be 3500 words or fewer excluding the abstract and references. Manuscript must be organized as Introduction, Methods, Results, and Discussion. Manuscript must identify the funding source and its role under the last Methods subheading titled "Role of the Funding source," and authors must attest in the submission and the work to any use of artificial intelligence-assisted technologies.
References Manuscript must include no more than 75 bibliographic references. References must follow National Library of Medicine style. References must be numbered in Arabic numerals in parentheses in order of first appearance, list all authors if there are 3 or fewer or the first 3 followed by "et al." if there are more than 3, and references cited in tables or figures must follow the numbering sequence of their first mention in the text.
Figures & Tables Manuscript must include no more than 4 to 6 tables or figures combined. Tables and figures must be numbered with Arabic numerals in the order they appear, tables must have concise titles and define abbreviations and units in footnotes, and each figure must include a legend beginning with a short title and explaining all abbreviations and symbols.
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Review Articles

Cover Letter A cover letter is required. The cover letter must confirm all authors approve the manuscript and, if artificial intelligence-assisted technologies were used, describe how they were used.
Abstract An abstract is required. The abstract must be unstructured and 275 words or fewer. The abstract must be unstructured.
Manuscript The manuscript text must be 3500 words or fewer, excluding the abstract and references. The title must include the subtitle "A narrative review." The manuscript must include a box with 3 to 7 take-home points that link back to the original questions the review set out to answer.
References The manuscript must include 75 or fewer bibliographic references. References must follow National Library of Medicine style. References must be numbered in Arabic numerals in parentheses in order of first appearance, list all authors when there are 3 or fewer, and list the first 3 authors followed by "et al." when there are more than 3.
Figures & Tables The manuscript may include no more than 4 tables or figures combined.
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Systematic Reviews

Cover Letter Cover letter is required only if artificial intelligence-assisted technologies were used, in which case it must describe how they were used. If artificial intelligence-assisted technologies were used, the cover letter must describe how they were used.
Abstract Abstract is required and must be no more than 275 words. Abstract must be 275 words or fewer. Abstract must be structured. Abstract must use the headings Background, Purpose, Data Sources, Study Selection, Data Extraction, Data Synthesis, Limitations, Conclusions, and Primary Funding Source, include start and end search dates in Data Sources, and give the registry and unique registration number at the end if the study is registered.
Manuscript Manuscript must be 4000 words or fewer, excluding the abstract and references. Manuscript must be structured as Introduction, Methods, Results, and Discussion, and the Methods section must use the subheadings Data Sources and Searches, Study Selection, Data Extraction and Quality Assessment, and Data Synthesis and Analysis. Systematic Review titles must add "A systematic review" as a subtitle, and the manuscript must identify the funding source and its role under the final Methods subheading titled "Role of the Funding source" and describe any use of artificial intelligence-assisted technologies in the submitted work.
References References must follow National Library of Medicine style. References must be numbered with Arabic numerals in parentheses in order of first appearance, list all authors if there are 3 or fewer or the first 3 followed by "et al." if there are more than 3, and must not use ibid. or op cit.
Figures & Tables Figures and tables must include a flow diagram depicting the search and selection processes and evidence tables.
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Meta-Analyses

Cover Letter Cover letter must describe any use of artificial intelligence-assisted technologies in producing the submitted work. Cover letter must include a description of how artificial intelligence-assisted technologies were used, if used.
Abstract Abstract is required. Abstract must be 275 words or fewer. Abstract must be structured. Abstract must use the headings Background, Purpose, Data Sources, Study Selection, Data Extraction, Data Synthesis, Limitations, Conclusions, and Primary Funding Source, and the Data Sources section must include the start and end search dates.
Manuscript Manuscript must be 4000 words or fewer, excluding the abstract and references. Manuscript must be structured as Introduction, Methods, Results, and Discussion, and the Methods section must include the subheadings Data Sources and Searches; Study Selection; Data Extraction and Quality Assessment; Data Synthesis and Analysis; and Role of the Funding source. Title must add the subtitle "A systematic review and meta-analysis," the abstract must give the registry and unique registration number at the end if the study is registered, the manuscript must identify the funding source and its role under the last Methods subheading titled "Role of the Funding source," it must include a flow diagram and evidence tables among the figures and tables, and authors must attest whether artificial intelligence-assisted technologies were used and describe their use in the submitted work if used.
References References must follow National Library of Medicine style. References must be numbered with Arabic numerals in parentheses in order of first appearance, list all authors when there are 3 or fewer and the first 3 followed by "et al." when there are more than 3, and must not use ibid. or op cit.
Figures & Tables Manuscript must include a flow diagram depicting the search and selection processes and evidence tables among the tables and figures.
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Clinical Guidelines

Cover Letter Cover letter is required if disclosing AI-assisted technology use, possible previous or duplicate publication, or requesting exclusion of specific reviewers. Cover letter must describe any AI-assisted technology use, give full details on any possible previous or duplicate publication, include documentation for reused published content, and justify any request to exclude reviewers.
Abstract Abstract is required and must be structured. Abstract must be 275 words or fewer. Abstract must be structured. Abstract must use the headings Description, Methods, and Recommendations.
Manuscript Manuscripts longer than 4000 words may require an executive summary, with the full document published as an online-only appendix. Title must include the name of the responsible organization and identify the article as a clinical guideline, and the article must include standard reporting elements suggested by guideline groups. Manuscript should include a concise table or concise graphic summarizing the recommendations and other key points, and authors must disclose any AI-assisted technology use in the submitted work.
References References must follow National Library of Medicine style. References must be numbered with Arabic numerals in parentheses in order of first appearance, list all authors if there are 3 or fewer or the first 3 followed by "et al." if there are more than 3, and must not use ibid. or op cit.
Figures & Tables A concise table or concise graphic summarizing the recommendations and other key points should be included.
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Rapid Review

Cover Letter A cover letter is required when artificial intelligence-assisted technologies were used, when requesting exclusion of reviewers, or when submitting permissions documentation for reused content. The cover letter must describe any use of artificial intelligence-assisted technologies, justify any request to exclude reviewers, and include addenda with documentation granting permission to reuse previously published content when applicable.
Abstract Abstract requirements are not specified.
Manuscript Rapid Reviews must follow the general format requirements for Systematic Reviews and Meta-Analyses and include clearly formulated questions, methods describing sources and searches, selection criteria, data extraction and assessment, and synthesis methods, results that synthesize rather than catalog evidence, and a discussion that mentions review limitations. Rapid Reviews must include the registry name and dated protocol or submit the protocol with the manuscript if it cannot be posted, and the Methods section must specify any modified methods used, such as language or database limits, preprint searching, crowd-distributed screening or extraction, automation for screening, date restrictions, or single-reviewer extraction or assessment.
References References must follow National Library of Medicine style. References must be numbered with Arabic numerals in parentheses in order of first appearance, list all authors when there are 3 or fewer or the first 3 followed by et al. when there are more than 3, and not use ibid. or op cit.
Figures & Tables Tables and figures must be numbered with Arabic numerals in the order cited, tables must have concise titles and explain abbreviations and units in footnotes, and each figure must include a legend beginning with a short title that explains all abbreviations and symbols.
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Living Review

Cover Letter A cover letter is required if artificial intelligence-assisted technologies were used, because their use must be described there. The cover letter must describe any use of artificial intelligence-assisted technologies.
Abstract Abstract requirements are not specified.
Manuscript The manuscript must follow the general format requirements for Systematic Reviews and Meta-Analyses, define the review as a living review in the Methods section, and include search methods describing ongoing surveillance and update procedures. The manuscript must include the registry name and dated protocol, describe any use of artificial intelligence-assisted technologies in the submitted work, and specify any modified review methods used.
References References must follow National Library of Medicine style. References must be numbered in Arabic numerals in order of first appearance, list all authors when there are 3 or fewer or the first 3 followed by "et al." when there are more than 3, and unpublished material must be cited in the text rather than the reference list.
Figures & Tables Tables and figures must be numbered with Arabic numerals in the order first cited, and each figure must include a legend beginning with a short title.
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Living Guidelines

Cover Letter Cover letter is required because authors who used artificial intelligence-assisted technologies must describe that use in the cover letter. Cover letter must describe any use of artificial intelligence-assisted technologies in producing the submitted work.
Abstract Abstract requirements are not specified.
Manuscript Initial methods section must describe the planned updating methodology. Manuscript must describe any use of artificial intelligence-assisted technologies in the submitted work.
References References must follow National Library of Medicine style. References must be numbered with Arabic numerals in parentheses in order of first appearance, list all authors if there are 3 or fewer or the first 3 followed by et al. if there are more than 3, and must not use ibid. or op cit.
Figures & Tables Tables and figures must be numbered with Arabic numerals in the order first cited, tables must have concise titles and explain abbreviations in footnotes, and figure legends must begin with a short title and explain all abbreviations and symbols.
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Narrative

Cover Letter If artificial intelligence-assisted technologies were used, the cover letter must describe how they were used.
Abstract An abstract is required. The abstract must be unstructured and no more than 275 words. The abstract must be unstructured.
Manuscript The manuscript must be 3500 words or fewer, excluding the abstract and references. The title must include the subtitle "A narrative review." The manuscript must include a box with 3 to 7 take-home points that link back to the original questions the review set out to answer.
References The manuscript must include 75 or fewer references. References must follow National Library of Medicine style. References must be numbered in Arabic numerals in order of first appearance and list all authors if there are 3 or fewer or the first 3 followed by "et al." if there are more than 3.
Figures & Tables The manuscript may include no more than 4 tables or figures combined.
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Brief Research Reports

Cover Letter A cover letter is required if authors need to disclose use of artificial intelligence-assisted technologies, possible previous or duplicate publication, reuse-permission documentation, or reviewer exclusions. The cover letter must describe any use of artificial intelligence-assisted technologies and include full details of any possible previous or duplicate publication, plus reuse-permission documentation when applicable.
Abstract Abstract requirements are not specified.
Manuscript Manuscript text must not exceed 700 words, excluding references. Manuscript must be organized as Background, Objective, Methods and Findings, Discussion, and References. Authors must attest whether artificial intelligence-assisted technologies were used and, if so, describe their use in the submitted work.
References No more than 5 bibliographic references are allowed. References must follow National Library of Medicine style. References must be numbered with Arabic numerals in parentheses in order of first appearance, list all authors if there are 3 or fewer or the first 3 followed by et al. if there are more than 3, and must not use ibid. or op cit.
Figures & Tables No more than 2 tables or figures combined are allowed. Tables and figures must be numbered with Arabic numerals in the order cited, tables must have concise titles, and each figure must include a legend beginning with a short title.
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Case Reports

Cover Letter A cover letter is required only if artificial intelligence-assisted technologies were used or if authors request exclusion of reviewers. The cover letter must describe any use of artificial intelligence-assisted technologies and justify any request to exclude specific reviewers.
Abstract Abstract requirements are not specified.
Manuscript Manuscript must not exceed 700 words, excluding references. Manuscript must use the sections Background, Objective, Case Report, Discussion, and References. Manuscript must be descriptive in nature, must not include inferential analyses, and must disclose any use of artificial intelligence-assisted technologies in the submitted work.
References References are limited to 5 or fewer bibliographic entries. References must follow National Library of Medicine style. References must be numbered with Arabic numerals in parentheses in order of first appearance, list all authors if there are 3 or fewer or the first 3 followed by "et al." if there are more than 3, and must not use ibid. or op cit.
Figures & Tables A maximum of 2 tables or figures combined is permitted. Tables and figures must be numbered with Arabic numerals in order of appearance, tables must have concise titles, and each figure must include a legend beginning with a short title.
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Recent Publications

In adults unresponsive after cardiac arrest, conservative vs. liberal oxygen therapy did not improve outcomes at 180 d

Greg S. Martin

10.7326/annals-26-03500-jc
View Publication

Visual Guideline - Pharmacologic Treatments for Females With Menopausal Vasomotor Symptoms: A Visual Clinical Guideline From the American College of Physicians

-

10.7326/annals-26-01205-vg
View Publication

Pharmacologic Treatments for Females With Menopausal Vasomotor Symptoms: A Clinical Guideline From the American College of Physicians

Amir Qaseem, Katherine Mackey, Jennifer Yost, Paul G. Shekelle, Tatyana A. Shamliyan, J. Thomas Cross, J. Thomas Cross, Ethan M. Balk, Nick Fitterman, Matthew Gibson, Johanna Lewis, Katherine Mackey, Matthew C. Miller, Adam J. Obley, Douglas K. Owens, Paul G. Shekelle, Kate Carroll, Itziar Etxeandia-Ikobaltzeta, Curtis S. Harrod, Amir Qaseem, Tatyana Shamliyan, Jennifer Yost, Ethan M. Balk, Nick Fitterman, Matthew Gibson, Johanna Lewis, Matthew C. Miller, Adam J. Obley, Douglas K. Owens, Kate Carroll, Itziar Etxeandia-Ikobaltzeta, Curtis S. Harrod

10.7326/annals-26-01205
View Publication

Annals On Call - Tirzepatide Versus Intensified Conventional Care for Poorly Controlled Type 2 Diabetes

Robert M. Centor, Bryan C. Batch

10.7326/annals-26-03906-oc
View Publication

After PCI in patients with ACS, short-duration DAPT followed by P2Y12 inhibitor monotherapy vs. standard DAPT reduces NACE

Ayman R. Fath, Islam Y. Elgendy

10.7326/annals-26-03606-jc
View Publication

Frequently asked questions

How long does it take to publish?

Comments on published articles can be submitted any time after publication; comments submitted within 8 weeks of publication are considered for print publication; editors review posted comments 2 months after publication.

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Is a cover letter required?

Cover letters are referenced for On Being a Doctor and On Being a Patient essays to explain whether the essay is nonfiction, fiction, or a fictionalized account of true events and, when applicable, to explain absence of subject permission.

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What are the publication costs?

Subscription-based journal; no article-level open-access option supported by article processing charges.

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Research Topics

Healthcare Policy and Management Primary Care and Health Outcomes Health Systems, Economic Evaluations, Quality of Life Venous Thromboembolism Diagnosis and Management Liver Disease Diagnosis and Treatment Atrial Fibrillation Management and Outcomes Empathy and Medical Education Innovations in Medical Education Diet and metabolism studies Healthcare cost, quality, practices Cardiac Imaging and Diagnostics Cardiac electrophysiology and arrhythmias Health Sciences Research and Education Cardiac Arrhythmias and Treatments Blood Pressure and Hypertension Studies Ethics in medical practice Cardiac, Anesthesia and Surgical Outcomes Hepatitis C virus research Pharmaceutical studies and practices Lipoproteins and Cardiovascular Health Hepatitis B Virus Studies Colorectal Cancer Screening and Detection Hemoglobinopathies and Related Disorders Diabetes Treatment and Management Pneumocystis jirovecii pneumonia detection and treatment

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