Overview Submission Instructions Recent Publications Frequently Asked Questions Research Topics

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Critical Reviews In Toxicology

Critical Reviews in Toxicology publishes review articles on toxicology and the application of toxicological information to assess human health hazards and risks. The journal covers mechanisms of action, responses, and assessment of health risks due to toxicant exposure across chemicals, pharmaceuticals, consumer products, environmental agents, and occupational exposures, and operates a single-anonymized peer review policy.

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Subject Toxicology

Impact Factor 4.1

Quartile Q1

Open Access Type Closed

ISSN 1040-8444

eISSN 1547-6898

Invitation Only No

Cost Range Institutional subscription: online only USD 6,459.00; print & online USD 9,436.00.

Submission Instructions

Critical Reviews In Toxicology accepts the following article types. Click on an article type to view submission instructions.

Review Articles

Cover Letter A cover letter is required. Cover letter must include a concise summary of the manuscript with its title and main objectives and 3–4 sentences explaining what the critical review adds to the current literature or knowledge base.

Abstract An abstract is required.

Manuscript Manuscript must be compiled in the order title page, abstract, keywords, abbreviation list, table of contents, main text with introduction, materials and methods, literature review methodology, results, discussion, acknowledgments, declaration of interest statement, references, appendices if applicable, tables with captions, figures, and figure captions. Manuscript must include a word count, 5–15 keywords, an alphabetical abbreviation list, a disclosure statement under the subheading "Disclosure of interest," funding details, and acknowledgment of any AI use in writing the paper.

References References must follow CSE style. References in Review Articles must be relevant, timely, verified, fair and balanced, and not unfairly biased toward any particular research group, organization, or journal.

Figures & Tables Figures must be saved separately from the text, and appendices must be included in the main manuscript file after the references. Tables must be supplied as editable files and should present new information rather than duplicating the text.

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Letter To The Editor

Cover Letter Cover letter is required for Letter To The Editor submissions. Cover letter must include a concise summary with the manuscript title and main objectives, and if more than six authors are listed it must justify this by outlining each author's contribution.

Abstract Abstract requirements are not specified.

Manuscript Letter To The Editor submissions are limited to 1500 words. Letters commenting on published articles must be titled "Comment on [Article Title]", and author replies must be titled "Authors' reply to Comment on [Title]" with "Comment" changed to "Comments" when replying to multiple letters. Letter To The Editor submissions must include affiliations for all authors, an email address for the corresponding author, and a full Disclosure of Interest statement acknowledging any relevant financial or non-financial interests.

References Letter To The Editor submissions must contain no more than 15 references. References must follow the CSE reference guide. One reference must be the article under discussion, and citations should support claims with relevant, timely, and verified literature.

Figures & Tables Letter To The Editor submissions must not contain any figures or tables.

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Recent Publications

The effect of antioxidants on antineoplastic-induced male reproductive system damage: a systematic review of experimental studies

Hale Bayram, Yaprak Dönmez Çakıl, Mustafa Erinç Sitar

10.1080/10408444.2026.2649599

View Publication

Letter to the Editor: Comprehensive review of octocrylene toxicology data and human exposure assessment for personal care products

Joseph C. DiNardo

10.1080/10408444.2026.2640891

View Publication

Response to Mr. DiNardo’s “Letter to the Editor: Comprehensive review of octocrylene toxicology data and human exposure assessment for personal care products”

Kimberly G. Norman, Lewis E. Kaufman, Peter Griem, Carl D’Ruiz, Linda Loretz, Alexandra Kowcz, Samuel M. Cohen, Anthony R. Scialli, Alan R. Boobis, David Jacobson-Kram, Rita Schoeny, Thomas J. Rosol, Gary M. Williams, Norbert E. Kaminski, F. Peter Guengerich, J. F. Nash

10.1080/10408444.2026.2640896

View Publication

The formaldehyde dispute – Part B: scientific critique of EPA’s formaldehyde occupational exposure values (OEVs) and proposed alternative occupational exposure limits (OELs)

Quincy Perry, Jacob Siracusa, Michael Stevens, Patricia Underwood, Dennis Paustenbach

10.1080/10408444.2026.2630662

View Publication

The formaldehyde dispute - Part A: acute and chronic inhalation toxicity and the evolution of scientific knowledge

Jacob Siracusa, Quincy Perry, Michael Stevens, Dennis J. Paustenbach

10.1080/10408444.2026.2630665

View Publication

Frequently asked questions

How long does it take to publish?

Speed from submission to first decision, speed from submission to first post-review decision, and speed from acceptance to online publication are reported as median numbers of days for recent journal activity. F1000Research is described as publishing submitted articles online in a fully citable format in 14 days.

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Is a cover letter required?

A cover letter is required for all submissions and must include a concise summary of the manuscript, including its title and main objectives, plus 3–4 sentences explaining what the critical review adds to the current literature or knowledge base.

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What are the publication costs?

Institutional subscription: online only USD 6,459.00; print & online USD 9,436.00.

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Research Topics

Carcinogens and Genotoxicity Assessment Effects and risks of endocrine disrupting chemicals Air Quality and Health Impacts Toxic Organic Pollutants Impact Pesticide Exposure and Toxicity Heavy Metal Exposure and Toxicity Animal testing and alternatives Environmental Toxicology and Ecotoxicology Occupational exposure and asthma Occupational and environmental lung diseases Pharmacogenetics and Drug Metabolism Pesticide and Herbicide Environmental Studies Indoor Air Quality and Microbial Exposure Immunotoxicology and immune responses Nanoparticles: synthesis and applications Pharmaceutical and Antibiotic Environmental Impacts Contact Dermatitis and Allergies Computational Drug Discovery Methods Trace Elements in Health Estrogen and related hormone effects Drug-Induced Hepatotoxicity and Protection Per- and polyfluoroalkyl substances research Drug Transport and Resistance Mechanisms Birth, Development, and Health Mercury impact and mitigation studies

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