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EBioMedicine

eBioMedicine is a gold open access journal for translational biomedical research. It publishes original research, reviews, commentaries, and opinion pieces focused on disease pathways and mechanisms, determinants of human health and disease, therapeutic targets and treatments, biomarkers, diagnostic tools, and biomedical research spanning preclinical studies with human relevance through proof-of-concept studies and clinical trials.

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Subject Medicine, Research & Experimental
Impact Factor 10.8
Quartile Q1
Open Access Type Open
ISSN 2352-3964
eISSN 2352-3964
Invitation Only No
Cost Range Article Publishing Charge (APC): USD 6,810 (excluding taxes).

Submission Instructions

EBioMedicine accepts the following article types. Click on an article type to view submission instructions.

Articles

Cover Letter A cover letter is required at submission. The cover letter must explain why the paper should be published, briefly describe relevant literature, summarize the main findings, indicate how the work advances the field, and disclose any restrictions on the availability of materials or data.
Abstract A semi-structured abstract is required. Abstract must not exceed 250 words. Abstract must be semi-structured in five paragraphs. Abstract headings must be Background, Methods, Findings, Interpretation, and Funding.
Manuscript The Discussion must be no longer than 5 pages of A4 paper. Manuscript must follow the order Title, Abstract, Keywords, Research in Context, Introduction, Methods, Results, Discussion, Contributors, Declaration of Interests, Acknowledgments, Data Sharing Statement, References, and Figure Legends. Manuscript must include 4–6 keywords, a Research in Context panel with the sections “Evidence before this study,” “Added value of this study,” and “Implications of all the available evidence,” a Contributors section, declaration of interests, acknowledgments, a data sharing statement, and an AI disclosure statement in the Acknowledgment section if generative AI was used in writing.
References References must use Vancouver style. References must be cited sequentially in the text as superscript numbers after punctuation, with citations in tables, figures, and panels numbered according to first mention in the text.
Figures & Tables First submissions should include the manuscript with tables and panels and should also include figures, with tables provided in editable Word or Excel format. All figures and tables must be called out in sequential order, each table must fit on one A4 page, and figure legends must provide a title, briefly describe the experiment and display item, define all parts, state statistical tests, define error bars, and report the numbers of experiments and subjects.
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Systematic Reviews

Cover Letter A covering letter must be uploaded during submission. The covering letter must explain why the paper should be published, briefly describe relevant literature for context, summarize the main findings, and indicate how the work advances the field.
Abstract Abstract requirements are not specified.
Manuscript The manuscript must include a Research in Context panel with the sections “Evidence before this study”, “Added value of this study”, and “Implications of all the available evidence”. The Research in Context panel must contain no references, use clear simple language without jargon or abbreviations, and the “Evidence before this study” section must report the sources searched, inclusion and exclusion criteria with exact search dates, search terms, evidence quality or risk of bias, and pooled meta-analysis estimate if appropriate, while any use of generative AI in review development or writing must be disclosed in the Methods and Acknowledgment sections with the tool, version, prompts, and how it was used.
References References must be cited in Vancouver numbering style as superscript numbers after punctuation. References must be cited sequentially in the text, references in tables, figures, and panels must follow numerical order based on first citation in the text, online references must include URL and access date, in-press articles may be listed as “in press,” and personal communications and unpublished work must be cited only in the text.
Figures & Tables First submissions should include the manuscript with tables and panels and should also include figures.
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Meta-Analyses

Cover Letter A cover letter must be uploaded during submission. The cover letter must explain why the paper should be published, briefly describe relevant literature, summarize the main findings, and indicate how the work advances the field.
Abstract Abstract requirements are not specified.
Manuscript Manuscript must include a Research in Context panel with the sections “Evidence before this study”, “Added value of this study”, and “Implications of all the available evidence”. The Research in Context panel must contain no references, use clear simple language without jargon or abbreviations, and the “Evidence before this study” section must describe sources searched, inclusion and exclusion criteria with exact search dates, search terms, quality or risk of bias of the evidence, and pooled estimate if appropriate, and the manuscript must include an AI-use disclosure statement in the Acknowledgment section when generative AI or AI-assisted technologies were used in writing.
References References must be cited in Vancouver numbering style as superscript numbers after punctuation. References must be cited sequentially in the text, references in tables, figures, and panels must follow the order of first citation in the text, online references must include the URL and access date, in-press articles may be listed with “(in press)”, and personal communications and unpublished work must be cited only in the text.
Figures & Tables First submissions must include the manuscript with tables and panels and must also include figures.
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Reviews

Cover Letter A cover letter must be uploaded during submission. The cover letter must explain why the paper should be published, briefly describe relevant literature, summarize the main findings, and indicate how the work advances the field.
Abstract An abstract is required. Abstract must be no more than 150 words. Abstract should be unstructured.
Manuscript Main text must be up to 4500 words excluding references and tables. The manuscript must include a short paragraph entitled “Outstanding Questions” and a brief section entitled “Search strategy and selection criteria.” The manuscript must provide 4–6 descriptive keywords and include an AI disclosure statement in the Acknowledgment section if generative AI or AI-assisted technologies were used in writing, with additional Methods details if such tools were used in development of the Review.
References References may include no more than 75 items. Citations and references must use Vancouver style. References must be cited sequentially in the text using superscript numbers after punctuation.
Figures & Tables Reviews can contain up to 5 additional items including figures, tables, and text boxes. Figures must be included with the first submission, and the manuscript must include tables and panels with the first submission. Each figure, table, or text box must have a short explanatory title and be cited in the main text.
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Correspondence

Cover Letter A covering letter must be uploaded during submission. The covering letter must explain why the paper should be published, briefly describe relevant literature, summarize the main findings, and indicate how the work advances the field.
Abstract Abstract requirements are not specified.
Manuscript Correspondence responding to previous content must be no longer than 250 words, while correspondence of general interest unlinked to journal content may be up to 400 words. Correspondence should be written in response to previous content published in the journal. Use of generative AI in writing must be disclosed in a statement at the end of the article in the Acknowledgment section naming the model, version, exact prompt, and how and where it was used.
References Correspondence should include no more than 5 references. References must use Vancouver numbering style. References must be cited sequentially in the text as superscript numbers after punctuation, with references in tables, figures, and panels numbered according to first citation in the text.
Figures & Tables Correspondence may include only one table or figure. First submissions should include the manuscript with tables and panels and should also include figures.
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Recent Publications

Characterisation of a human monoclonal antibody targeting a conserved epitope at the base of the HA head of influenza A(H3N2) virus

Seiya Yamayoshi, Taiki Hamabata, Yuka Inoue, Maki Kiso, Moe Okuda, Hiroaki Akasaka, Wataru Shihoya, Takeaki Imamura, Yukimasa Matsuzawa, Daisuke Jubishi, Kiyoko Iwatsuki-Horimoto, Patrick C. Wilson, Osamu Nureki, Yoshihiro Kawaoka

10.1016/j.ebiom.2026.106450
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Infradian rhythms of human heart rate reveal distinct multiday cycle periods in healthy adults

Rochelle I. De Silva, Rachel E. Stirling, Jodie Naim-Feil, Shivam Puri, Elizabeth Paratz, Philippa J. Karoly

10.1016/j.ebiom.2026.106444
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Epigenetic ageing is accelerated in drug-resistant epilepsy and dynamically modulated during ketogenic diet therapy

Kristina Gervin, Magnhild Kverneland, Karl Otto Nakken, Knut Rudi, Per Ole Iversen, Kaja Kristine Selmer

10.1016/j.ebiom.2026.106449
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Determining intracellular and extracellular activities of azithromycin against azithromycin-resistant Salmonella Typhi and their association with clinical treatment responses

Ngo Ngoc Phuong Thuy, Voong Vinh Phat, Sabina Dongol, Nguyen Hoang Thu Trang, Sumit Bista, Quynh Nguyen, Chau Vinh, Guy E. Thwaites, Buddha Basnyat, Christopher M. Parry, Stephen Baker, Maia A. Rabaa, Jay C.D. Hinton, Abhilasha Karkey, Pham Thanh Duy

10.1016/j.ebiom.2026.106447
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Insulin resistance and brain health in midlife: a potential dementia prevention target

Rohith Erukulla, Graham Reid, Courtney Yotter, Maria-Elini Dounavi, Audrey Low, John T. O'Brien, Craig Ritchie, Brian Lawlor, Lorina Naci, Paresh Malhotra, Ivan Koychev

10.1016/j.ebiom.2026.106448
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Frequently asked questions

How long does it take to publish?

2 days from submission to first decision; 161 days from submission to acceptance.

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Is a cover letter required?

A covering letter should be uploaded at the Enter Comments stage of online submission and should explain why the paper should be published in eBioMedicine, summarize the main findings, provide relevant literature context, and indicate how the work advances the field and relates to human health.

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What are the publication costs?

Article Publishing Charge (APC): USD 6,810 (excluding taxes).

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Research Topics

SARS-CoV-2 and COVID-19 Research Gut microbiota and health COVID-19 Clinical Research Studies HIV Research and Treatment Epigenetics and DNA Methylation Cancer Immunotherapy and Biomarkers Immune Cell Function and Interaction Genetic Associations and Epidemiology vaccines and immunoinformatics approaches Ferroptosis and cancer prognosis MicroRNA in disease regulation Immunotherapy and Immune Responses Immune responses and vaccinations Mosquito-borne diseases and control Cancer Genomics and Diagnostics Long-Term Effects of COVID-19 Tuberculosis Research and Epidemiology Immune cells in cancer T-cell and B-cell Immunology Liver Disease Diagnosis and Treatment Alzheimer's disease research and treatments Cancer Cells and Metastasis Cancer, Hypoxia, and Metabolism Metabolomics and Mass Spectrometry Studies Respiratory viral infections research

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