Overview Submission Instructions Recent Publications Frequently Asked Questions Research Topics

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EBioMedicine

eBioMedicine is a gold open access journal for translational biomedical research. It publishes original research, reviews, commentaries, and opinion pieces focused on disease pathways and mechanisms, determinants of human health and disease, therapeutic targets and treatments, biomarkers, diagnostic tools, and biomedical research spanning preclinical studies with human relevance through proof-of-concept studies and clinical trials.

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Subject Medicine, Research & Experimental

Impact Factor 10.8

Quartile Q1

Open Access Type Open

ISSN 2352-3964

eISSN 2352-3964

Invitation Only No

Cost Range Article Publishing Charge (APC): USD 6,810 (excluding taxes).

Submission Instructions

EBioMedicine accepts the following article types. Click on an article type to view submission instructions.

Articles

Cover Letter A cover letter is required at submission. The cover letter must explain why the paper should be published, briefly describe relevant literature, summarize the main findings, indicate how the work advances the field, and disclose any restrictions on the availability of materials or data.

Abstract A semi-structured abstract is required. Abstract must not exceed 250 words. Abstract must be semi-structured in five paragraphs. Abstract headings must be Background, Methods, Findings, Interpretation, and Funding.

Manuscript The Discussion must be no longer than 5 pages of A4 paper. Manuscript must follow the order Title, Abstract, Keywords, Research in Context, Introduction, Methods, Results, Discussion, Contributors, Declaration of Interests, Acknowledgments, Data Sharing Statement, References, and Figure Legends. Manuscript must include 4–6 keywords, a Research in Context panel with the sections “Evidence before this study,” “Added value of this study,” and “Implications of all the available evidence,” a Contributors section, declaration of interests, acknowledgments, a data sharing statement, and an AI disclosure statement in the Acknowledgment section if generative AI was used in writing.

References References must use Vancouver style. References must be cited sequentially in the text as superscript numbers after punctuation, with citations in tables, figures, and panels numbered according to first mention in the text.

Figures & Tables First submissions should include the manuscript with tables and panels and should also include figures, with tables provided in editable Word or Excel format. All figures and tables must be called out in sequential order, each table must fit on one A4 page, and figure legends must provide a title, briefly describe the experiment and display item, define all parts, state statistical tests, define error bars, and report the numbers of experiments and subjects.

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Systematic Reviews

Cover Letter A covering letter must be uploaded during submission. The covering letter must explain why the paper should be published, briefly describe relevant literature for context, summarize the main findings, and indicate how the work advances the field.

Abstract Abstract requirements are not specified.

Manuscript The manuscript must include a Research in Context panel with the sections “Evidence before this study”, “Added value of this study”, and “Implications of all the available evidence”. The Research in Context panel must contain no references, use clear simple language without jargon or abbreviations, and the “Evidence before this study” section must report the sources searched, inclusion and exclusion criteria with exact search dates, search terms, evidence quality or risk of bias, and pooled meta-analysis estimate if appropriate, while any use of generative AI in review development or writing must be disclosed in the Methods and Acknowledgment sections with the tool, version, prompts, and how it was used.

References References must be cited in Vancouver numbering style as superscript numbers after punctuation. References must be cited sequentially in the text, references in tables, figures, and panels must follow numerical order based on first citation in the text, online references must include URL and access date, in-press articles may be listed as “in press,” and personal communications and unpublished work must be cited only in the text.

Figures & Tables First submissions should include the manuscript with tables and panels and should also include figures.

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Meta-Analyses

Cover Letter A cover letter must be uploaded during submission. The cover letter must explain why the paper should be published, briefly describe relevant literature, summarize the main findings, and indicate how the work advances the field.

Abstract Abstract requirements are not specified.

Manuscript Manuscript must include a Research in Context panel with the sections “Evidence before this study”, “Added value of this study”, and “Implications of all the available evidence”. The Research in Context panel must contain no references, use clear simple language without jargon or abbreviations, and the “Evidence before this study” section must describe sources searched, inclusion and exclusion criteria with exact search dates, search terms, quality or risk of bias of the evidence, and pooled estimate if appropriate, and the manuscript must include an AI-use disclosure statement in the Acknowledgment section when generative AI or AI-assisted technologies were used in writing.

References References must be cited in Vancouver numbering style as superscript numbers after punctuation. References must be cited sequentially in the text, references in tables, figures, and panels must follow the order of first citation in the text, online references must include the URL and access date, in-press articles may be listed with “(in press)”, and personal communications and unpublished work must be cited only in the text.

Figures & Tables First submissions must include the manuscript with tables and panels and must also include figures.

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Reviews

Abstract An abstract is required. Abstract must be no more than 150 words. Abstract should be unstructured.

Manuscript Main text must be up to 4500 words excluding references and tables. The manuscript must include a short paragraph entitled “Outstanding Questions” and a brief section entitled “Search strategy and selection criteria.” The manuscript must provide 4–6 descriptive keywords and include an AI disclosure statement in the Acknowledgment section if generative AI or AI-assisted technologies were used in writing, with additional Methods details if such tools were used in development of the Review.

References References may include no more than 75 items. Citations and references must use Vancouver style. References must be cited sequentially in the text using superscript numbers after punctuation.

Figures & Tables Reviews can contain up to 5 additional items including figures, tables, and text boxes. Figures must be included with the first submission, and the manuscript must include tables and panels with the first submission. Each figure, table, or text box must have a short explanatory title and be cited in the main text.

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Correspondence

Cover Letter A covering letter must be uploaded during submission. The covering letter must explain why the paper should be published, briefly describe relevant literature, summarize the main findings, and indicate how the work advances the field.

Abstract Abstract requirements are not specified.

Manuscript Correspondence responding to previous content must be no longer than 250 words, while correspondence of general interest unlinked to journal content may be up to 400 words. Correspondence should be written in response to previous content published in the journal. Use of generative AI in writing must be disclosed in a statement at the end of the article in the Acknowledgment section naming the model, version, exact prompt, and how and where it was used.

References Correspondence should include no more than 5 references. References must use Vancouver numbering style. References must be cited sequentially in the text as superscript numbers after punctuation, with references in tables, figures, and panels numbered according to first citation in the text.

Figures & Tables Correspondence may include only one table or figure. First submissions should include the manuscript with tables and panels and should also include figures.

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Recent Publications

Molecular mechanisms underlying the effectiveness of triiodothyroacetic acid (Triac) in patients with resistance to thyroid hormone β (RTHβ): a multicentre, international, retrospective cohort study

Wenjun Liao, Federica Marelli, Carla Moran, Irene Campi, Stefan Groeneweg, Zainaba Mohamed, Eman Kamaleldeen, Raja Padidela, Catharina Olivius, Luuk Oosterkamp, Selmar Leeuwenburgh, Greta Lyons, Robin P. Peeters, Krishna Chatterjee, Luca Persani, Marcel Meima, W. Edward Visser

10.1016/j.ebiom.2026.106512

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Exploration of the genetic architecture of ANCA-associated vasculitis

Jinyoung Byun, Vikram R. Shaw, Catherine Zhu, Younghun Han, Ryan Sun, Zhihui Zhang, Xiangjun Xiao, Benjamin D. Pinder, Jinyi Zhang, Yohannes Tadesse, Thomas R. Riley, Sharon Chung, David Cuthbertson, Paul F. Dellaripa, Anisha B. Dua, Ora Gewurz-Singer, Lindsy J. Forbess, Carol A. Langford, Nader Khalidi, Curry Koening, Alfred D. Mahr, Carol McAlear, Paul A. Monach, Larry Moreland, Christian Pagnoux, E. Philip Seo, Ulrich Specks, Robert F. Spiera, Antoine Sreih, Jason M. Springer, E. William St. Clair, Kenneth J. Warrington, Steven R. Ytterberg, Jeffrey C. Edberg, Peter C. Grayson, David Jayne, Rona Smith, Michael Walsh, Peter A. Merkel, Katherine A. Siminovitch, Christopher I. Amos, Simon Carette, Sharon Chung, Anisha Dua, Lindsy Forbess, Ora Gewurz-Singer, Nader Khalidi, Curry Koening, Carol A. Langford, Carol A. McAlear, Peter A. Merkel, Paul A. Monach, Larry Moreland, Christian Pagnoux, E. Philip Seo, Ulrich Specks, Robert F. Spiera, Jason Springer, Kenneth Warrington

10.1016/j.ebiom.2026.106502

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CNPY3 variants associated with a recessive developmental and epileptic encephalopathy affect inflammasome and TLR function

Vera Garloff, Mona Grimmel, Reza Maroofian, Stephanie Efthymiou, Sven Stengel, Dolores Bello, Carolin Tille, Mohamed Ghait, Oliver Ohlenschläger, Andrea Dieckmann, Heike de Vries, Matthias Waginger, Seba Nadeef, Ehsan Barkhordari, Rauan Kaiyrzhanov, Sarah Bühler, Irisa Pjeci, Stefanie Beck-Wödl, Javeria Raza Alvi, Tipu Sultan, Anna Chassevent, Constance Smith-Hicks, Irina Mishina, Agustí Rodríguez-Palmero, Evangeline Wassmer, Julie Vogt, Christopher Manuel Meudt, Rami Abou Jamra, Mohammad Reza Abbaszadegan, Naser Ajami, Reza Azizimalamiri, Hamid Galehdari, Niloofar Chamanrou, Mina Zamani, Gholamreza Shariati, Pardis Nourbakhsh, Farhan Bahadar Ali, Ambrin Fatima, Sohana Nadeem Hashmi, Zafar Iqbal, Sidra Kaleem, Mathias Toft, Erum Afzal, Shazia Maqbool, Fatima Rahman, Vincenzo Salpietro, Margot Grisval, Caroline Racine, Louis Januel, David Cheillan, Cecile Acquaviva-Bourdain, Chadi Al Alam, Majid Alfadhel, Muhammad Umair, Barbara Oehl-Jaschkowitz, Shahzad Haider, Vivek Jain, Bhuvandeep Narang, Fawzia Amer, Nour Elkhateeb, Carolina Alvarez, Eduardo Pérez-Palma, Loreto Ríos-Pohl, Rikke S. Møller, Debangana Baruah, Lokesh Lingappa, Ahmad Farooq, Maha S. Zaki, Gulnara Svyatova, Alexandra Murtazalieva, Asem Burabayeva, Kamran Salayev, Ulviyya Guliyeva, Kimia Kahrizi, Hossein Najmabadi, Anya Revah-Politi, Maureen S. Mulhern, Tristan Timothy Sands, Hafiz Muhammad Mustafa, Hani Akbar Rao, Gabriela Oprea, Aboulfazl Rad, Mohammad Miryounesi, Ali Mardi, Vykuntaraju K. Gowda, Varunvenkat M. Srinivasan, Rola Mohammed Alanazi, Iman Sabri Abumansour, Bader Alhaddad, Khadijah Bakur, Michael Bauer, Fowzan S. Alkuraya, Peter Huppke, Henry Houlden, Tobias B. Haack, Ignacio Rubio, Ralf A. Husain

10.1016/j.ebiom.2026.106506

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Sustained type I interferon activity and N-antigenemia form a vicious cycle during severe COVID-19

William Mouton, Kahina Saker, Priscille Franc, Marine Mommert-Tripon, Guy Oriol, Laurence Generenaz, Valérie Cheynet, Antonin Bal, Léa Pons, Brice Wittmann, David Bussy, Paul Bastard, Jean-Laurent Casanova, Sarah Sebai, Amel Chebel, Fabrice Chatonnet, Dominique Costagliola, Jose Arribas, Hans-Kittil Viermyr, Julien Poissy, Aleksander Rygh Holten, Aliou Baldé, Emmanuel Roux, Inge C. Olsen, Karen Brengel-Pesce, Sylvie Pons, Cécile Barnel, Bouchra Mokdad, Florent Wallet, Laurent Genestier, Olivier Terrier, Marius Trøseid, Jean-Christophe Richard, Sophie Trouillet-Assant, Mehdi Mezidi, Hodane Yonis, Laurent Bitker, Guillaume Deniel, Florent Wallet, Donatien De Marignan, Auguste Dargent, Marius Trøseid, José Arribas, Lambert Assoumou, Aleksander Rygh Holten, Julien Poissy, Vida Terzić, Fulvia Mazzaferri, Jesús Rodríguez Baño, Joe Eustace, Maya Hites, Michael Joannidis, José-Artur Paiva, Jean Reuter, Isabel Püntmann, Thale Patrick-Brown, Elin Westerheim, Katerina Nezvalova-Henriksen, Lydie Beniguel, Tuva Børresdatter Dahl, Maude Bouscambert, Monika Halanova, Zoltán Péterfi, Sotirios Tsiodras, Michael Rezek, Matthias Briel, Serhat Ünal, Martin Schlegel, Florence Ader, Karine Lacombe, Cecilie Delphin Amdal, Serge Rodrigues, Kristian Tonby, Alexandre Gaudet, Lars Heggelund, Joy Mootien, Asgeir Johannessen, Jannicke Horjen Møller, Beatriz Diaz Pollan, Anders Aune Tveita, Anders Benjamin Kildal, Jean-Christophe Richard, Olav Dalgard, Victoria Charlotte Simensen, Aliou Baldé, Lucie de Gastines, Marta del Álamo, Burç Aydin, Fridtjof Lund-Johansen, Mary-Anne Trabaud, Alpha Diallo, Bente Halvorsen, John-Arne Røttingen, Evelina Tacconelli, Yazdan Yazdanpanah, Inge C. Olsen, Dominique Costagliola, Anne Ma Dyrhol-Riise, Birgitte Stiksrud, Synne Jenum, Magnhild Eide Macpherson, Nikolai Ravn Aarskog, Kjerstin Røstad, Linda Gail Skeie, Åsne Dahl, Jeanette Konstance Steen, Sarah Nur, Filip Segers, Katrine Andersen Korsan, Ashwini Sethupathy, Ann Jorunn Sandstå, Gunn-Janne Paulsen, Thor Ueland, Annika Michelsen, Pål Aukrust, Jan Erik Berdal, Ingunn Melkeraaen, Merete Moen Tollefsen, Jessica Andreassen, Jannicke Dokken, Karl Erik Müller, Bjørn Martin Woll, Hanne Opsand, Mette Bogen, Linn-Therese Rød, Trude Steinsvik, Bjørn Åsheim-Hansen, Randi Haukaas Bjerkreim, Åse Berg, Solfrid Moen, Stina Kvalheim, Kristian Strand, Berit Gravrok, Vegard Skogen, Elias Myrvoll Lorentzen, Simen Walberg Schive, Lasse Rossvoll, Hedda Hoel, Simon Engebråten, Mia Schie Martinsson, Monica Thallinger, Elise Ådnanes, Raisa Hannula, Nina Bremnes, Kristin Liyanarachi, Birgitta Ehrnström, Martin Kvalshaug, Kari Berge, Marte Bygdås, Linda Gustafsson, Saad Aballib, Marianne Strand, Britt Andersen, Pål Aukrust, Andreas Barratt-Due, Katerina Nezvalova Henriksen, Trine Kåsine, Anne Ma Dyrhol-Riise, Jan Erik Berdal, Raphaël Favory, Saad Nseir, Sebastien Preau, Mercé Jourdain, Geoffrey Ledoux, Arthur Durand, Marion Houard, Anne-Sophie Moreau, Anahita Rouzé, Romain Tortuyaux, Guillaume Degouy, Clémentin Levy, Vincent Liu, Nicolas Dognon, Laure Mariller, Claire Delcourte, Zineb Reguig, Amélie Cerf, Marie Cuvelliez, Eric Kipnis, Marielle Boyer-Beysserre, Anne Bignon, Laurie Parmentier, Damia Meddour, Sarah Frade, Jean-François Timsit, Nathan Peiffer-Smadja, Paul-Henri Wicky, Etienne de Montmollin, Lila Bouadma, Julien Dessajan, Romain Sonneville, Juliette Patrier, Simona Presente, Zmihi Sylia, Christophe Rioux, Michaël Thy, Lio Collias, Yasmine Bouaraba, Nikita Dobremel, Anne-Florence Dureau, Pierre Oudeville, Valentin Pointurier, Yannick Rabouel, Laure Stiel, Camille Alzina, Camille Ramstein, Hafid Ait-Oufella, Fatima Hamoudi, Thomas Urbina, Yoann Zerbib, Julien Maizel, Celine Wilpotte, Lionel Piroth, Mathieu Blot, Thibault Sixt, Florian Moretto, Carole Charles, Sandrine Gohier, Damien Roux, Camille Le Breton, Coralie Gernez, Ingrid Thiry, Loredana Baboi, Denis Malvy, Alexandre Boyer, Pauline Perreau, Maddalena Armellini, Giulia de Luca, Ospedale Di Pietro, Benedetta Romanin, Michela Brogi, Francesco Castelli, Silvia Amadasi, Francesco Barchiesi, Benedetta Canovari, Nicola Coppola, Mariantonietta Pisaturo, Antonio Russo, Laura Occhiello, Francesco Cataldo, Marta Mora Rillo, Javier Queiruga, Enrique Seco, Stefan Stewart, Alberto Borobia, Paloma Moraga, Rocío Prieto, Irene García, Carlota Rivera, José Luis Narro, Natalia Chacón, Sandra de la Rosa, María Macías, Lydia Barrera, Almudena Serna, Virginia Palomo, Maria Isabel García Sánchez, David Gutiérrez, Ana Silva Campos, Miguel Ángel Gómez Garfia, Elvira Bonilla Toyos, Judith Sanabria Cabrera, María Isabel Lucena, Eva Larranaga Lapique, Pierre Englert, Zineb Khalil, Frédérique Jacobs, Justine Malaise, Odette Mukangenzi, Cinderella Smissaert, Marc Hildebrand, Delphine Martiny, Audrey Vervacke, Axelle Scarnière, Nicolas Yin, Charlotte Michel, Lucie Seyler, Sabine Allard, Johan van Laethem, Gil Verschelden, Annelies Meeuwissen, Alex de Waele, Virgini van Buggenhout, Dora Monteyne, Nils Noppe, Leila Belkhir, Jean Cyr Yombi, Julien de Greef, Jean Baptiste Mesland, Léopold de Ghellinck, Valérie Kin, Céline D’aoust, Anne Bouvier, Anne- Charlotte Dekeister, Estelle Hawia, Adeline Gaillet, Hélène Deshorme, Severine Halleux, Vanessa Galand, Roberto Roncon-Albuquerque, Luís Linhares Santos, César Burgi Vieira, Rosana Magalhaes, Sónia Ferreira, Mariana Bernardo, Arthur Jackson, Corinna Sadlier, Sarah O’connell, Matthew Blair, Edmund Manning, Fiona Cusack, Niamh Kelly, Hannah Stephenson, Ruben Keane, Aisling Murphy, Michele Cunnane, Fionnuala Keane, Mary-Claire O’regan, Eoghan de Barra, Aimee Mcgreal Bellone, Siobhan O’regan, Patrick Carey, Jeffrey Harte, Peter Coakley, Aoife Heeney, Dorothy Ryan, Gerard Curley, Samuel Mcconkey, Imran Sulaiman, Richard Costello, Cora Mcnally, Claire Foley, Sophie Trainor, Benson Jacob, Suchitra Vengathodi, Brian Kent, Colm Bergin, Liam Townsend, Colm Kerr, Nalini Panti, Alberto Garcia Sanz, Binny Benny, Edel Dea, Niamh Galvin, Claire Burke, Aisling Galvin, Sara Aisiyabi, Deepanjali Lobo, John Laffey, Bairbre Mcnicolas, David Cosgrave, J. Sheehan, Ciprian Nita, Ciara Hanley, Claire Kelly, Maeve Kernan, Jonathan Murray, Thérèse Staub, Thomas Henin, Gaelle Damilot, Tania Bintener, Joelle Colling, Christian Ferretti, Christophe Werer, Pascal Stammet, Pierre Braquet, Vic Arendt, Esther Calvo, Christian Michaux, Chouaib Mediouni, Ali Znati, Gloria Montanes, Laetitia Garcia, Claudius Thomé, Robert Breitkopf, Andreas Peer, Georg Lehner, Romuald Bellman, Adelheid Ditlbacher, Armin Finkenstedt, Klemens Zotter, Christian Preuss Hernandez, Sasa Rajsic, Barbara Lanthaler, Richard Greil, Kiss Tamás, Szilvia Kovácsné-Levang, David Sipos, Agnes Kappéter, Bernadett Halda-Kiss, Edit Madarassi-Papp, Edit Hajdu, Balázs Bende, Thomas Konstantinos, Charalambos Moschopoulos, Eleni Labrou, Maria Tsakona, Ioannis Grigoropoulos, Anastasia Kotanidou, Paraskevi Fragkou, Maria Theodorakopoulou, Eugenia Pantazi, Edison Jahai, Maria Moukouli, Dimitrios Siafakas, Bernd Mühlbauer, Rolf Dembinski, Kathrin Stich, Gerhard Schneider, Andrej Nagy, Karolína Grodová, Michaela Kubelová, Lenka Součková, Helena Kartáková Švábová, Regina Demlová, Simona Sonderlichová, Serhat Unal, A. Inkaya, Stephanie de Bono, Cynthia Kartman, David Adams, Brenda Crowe, Yazdan Yazdanapanah, Serhat Unal, Gerhard Schneider, Bernd Mühlbauer, Tone Ødegård, Gine Bakkehøi, Brigitte Autran, Magnar Bjørås, Xavier de Lamballerie, Fulvia Mezzarri, Jeremie Guedj, Helene Esperou, Julia Lumbroso, Tobias Welte, Alexandra Calmy, Søren Pischke, Shaun Treweek, Els Goetghebeur, Adelaide Doussau, Laurence Weiss, Frank Hulstaert, Radu Botgros, Marta del Alamo, Florence Chung, Julia Lumbroso, Markus Zeitlinger, Begonya Escalera, Chantal Csajka, Clare Williams, Alain Amstutz, Corina Silvia Rüegg, Charles Burdet, Clement Massonnaud, Drifa Belhadi, France Mentré, Massinissa Aroun, France Mentré, Stephan Ehrmann, Helene Espoerou, Charles Burdet, Ragnhild Sørum Falk, Kristin Bjordal, Gina Bakkehøi, Tone Ødegård, Andreas Barratt-Due

10.1016/j.ebiom.2026.106508

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The time has come: integrating vaccination and vector control for Aedes-borne disease prevention

Henry Puerta-Guardo, Pablo Manrique-Saide

10.1016/j.ebiom.2026.106514

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Frequently asked questions

How long does it take to publish?

2 days from submission to first decision; 161 days from submission to acceptance.

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Is a cover letter required?

A covering letter should be uploaded at the Enter Comments stage of online submission and should explain why the paper should be published in eBioMedicine, summarize the main findings, provide relevant literature context, and indicate how the work advances the field and relates to human health.

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What are the publication costs?

Article Publishing Charge (APC): USD 6,810 (excluding taxes).

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Research Topics

SARS-CoV-2 and COVID-19 Research Gut microbiota and health COVID-19 Clinical Research Studies HIV Research and Treatment Epigenetics and DNA Methylation Cancer Immunotherapy and Biomarkers Immune Cell Function and Interaction Genetic Associations and Epidemiology vaccines and immunoinformatics approaches Ferroptosis and cancer prognosis MicroRNA in disease regulation Immunotherapy and Immune Responses Immune responses and vaccinations Mosquito-borne diseases and control Cancer Genomics and Diagnostics Long-Term Effects of COVID-19 Tuberculosis Research and Epidemiology Immune cells in cancer T-cell and B-cell Immunology Liver Disease Diagnosis and Treatment Alzheimer's disease research and treatments Cancer Cells and Metastasis Cancer, Hypoxia, and Metabolism Metabolomics and Mass Spectrometry Studies Respiratory viral infections research

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