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Human Genetics and Genomics Advances

Human Genetics and Genomics Advances is an open-access journal publishing across the complete spectrum of human genetic and genomic research. The journal is part of the American Society for Human Genetics family of journals and emphasizes scientific rigor, validity, reproducibility, timely peer review, and continuous online publication.

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Subject Genetics & Heredity
Impact Factor 3.6
Quartile Q2
Open Access Type Open
ISSN 2666-2477
eISSN 2666-2477
Invitation Only No
Cost Range APCs start at US$1500 excluding tax and vary by journal; Human Genetics and Genomics Advances is listed at $3,300 for articles and reports and $1,250 for brief communications, with society member discounts.

Submission Instructions

Human Genetics and Genomics Advances accepts the following article types. Click on an article type to view submission instructions.

Articles

Cover Letter A cover letter is required. It must briefly explain what was previously known, the conceptual advance provided by the findings, and the significance of the findings to a broad readership.
Abstract An abstract is required. 250 words or fewer. Unstructured.
Manuscript The main text must include abstract, introduction, material and methods or subjects and methods or methods, results, and discussion. A Declaration of Interests section, a Web Resources section if applicable, a Data and Code Availability statement, and a supplemental information description titled "Supplemental Information" must be included when relevant.
References Only published articles may be included in the reference list.
Figures & Tables Each figure must be uploaded individually as a separate file, tables must be included after the figure titles and legends in the manuscript, and supplemental information may be uploaded as a single PDF except for very large tables of data or Excel files. Each figure must be numbered consecutively with whole numbers, figures may not exceed one page, figure titles must not contain parenthetical information, reference citations, or footnotes, and tables must not be saved as figures.
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Reviews

Cover Letter A cover letter is required. The cover letter must briefly explain what was previously known, the conceptual advance, and the significance of the findings to a broad readership.
Abstract An abstract is required. The abstract must be 250 words or fewer. The abstract must be unstructured and consist of a single paragraph.
Manuscript Reviews must be 5,000 to 8,000 words in length, including a brief abstract. The manuscript must include title, author list, affiliations, correspondence email(s), additional footnotes if any, abstract, main text, appendices if any, supplemental information description if any, acknowledgments, declaration of interests, web resources if any, references, figure titles and legends, and table titles and legends in that order. A Declaration of Interests section, a Web Resources section if applicable, and a Data and Code Availability statement must be included.
References References must include only published articles and may not be cited in the abstract.
Figures & Tables Reviews must have three to five display items. Each figure must be uploaded individually as a separate file, and all supplemental information other than very large tables of data or Excel files must be compiled into a single PDF file. Each figure must be numbered consecutively with whole numbers, figures may not exceed one page, and tables must appear in the manuscript after the figure titles and legends.
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Reports

Cover Letter A cover letter is required. It must briefly explain what was previously known, the conceptual advance provided by the findings, and the significance of the findings to a broad readership.
Abstract An abstract is required. The abstract must be 250 words or fewer. Unstructured.
Manuscript Reports must be 3,500 to 4,000 words. Reports must not have further subdivision of the manuscript. The manuscript must include an abstract, and the main text must include the Declaration of Interests section and the Web Resources section if applicable.
References Only published articles may be cited, and references must not be cited in the abstract.
Figures & Tables Figures must be uploaded individually as separate files and tables must be included in the submitted manuscript after the figure titles and legends. Figures must be numbered consecutively with whole numbers, may not exceed one page, and table files must not be saved as figures.
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Letters To The Editor

Cover Letter A cover letter is required. The cover letter must briefly explain what was previously known, the conceptual advance provided by the findings, and the significance of the findings to a broad readership.
Abstract An abstract is required. No more than 250 words. Unstructured.
Manuscript Letters To The Editor must be less than 900 words. The manuscript must be provided as one document containing, in order, title, author list, affiliations, correspondence email(s), additional footnotes if any, abstract, main text, appendices if any, supplemental information description if any, acknowledgments, declaration of interests, web resources if any, references, figure titles and legends, and table titles and legends. A Declaration of Interests section must be included and must state "The authors declare no competing interests." when there are no interests to declare, and a supplemental information description section must be titled "Supplemental Information."
References References must include only published articles and must not be cited in the abstract.
Figures & Tables Figures must be uploaded individually as separate files, and tables must be included in the submitted manuscript after the figure titles and legends. Each figure must be numbered consecutively with whole numbers, may not exceed one page, and figure titles must not contain parenthetical information, reference citations, or footnotes.
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Brief Communications

Cover Letter A cover letter is required. It must briefly explain what was previously known, the conceptual advance, and the significance of the findings to a broad readership.
Abstract An abstract is required. No more than 200 words. Unstructured.
Manuscript The main text from introduction through discussion, excluding figure legends and references, must not exceed 2,500 words. The manuscript must be organized into introduction, materials and methods, results, and discussion. A declaration of interests section and, if applicable, a supplemental information description section titled "Supplemental Information" must be included.
References No more than 30 references. References must include only published articles.
Figures & Tables No more than four display items. Figures and tables are uploaded separately from the manuscript, with figures submitted individually as separate files and tables included in the manuscript. Each figure may contain no more than four subpanels, and a provisional Mendelian gene discovery submission must include a table mapping phenotypic findings to HPO terms or IDs as one of the four display items.
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Recent Publications

Gene-environment interactions contribute to blood pressure variation across global populations

Khushi Goda, Noah Klimkowski Arango, Francesco Tiezzi, Trudy F.C. Mackay, Fabio Morgante

10.1016/j.xhgg.2026.100656
View Publication

Identification of genetic variants associated with idiopathic inflammatory myopathies via cross-trait analysis with B-cell lymphomas

Weng Ian Che, James N. Jarvis, Anton Öberg Sysojev, Catherine Zhu, Karina Patasova, Karin E. Smedby, Ingrid E. Lundberg, Helga Westerlind, Janine A. Lamb, Marie Holmqvist

10.1016/j.xhgg.2026.100658
View Publication

Leveraging the genetics of human face shape boosts the discovery of orofacial cleft risk loci

Noah Herrick, Seppe Goovaerts, Alexandra Manchel, Myoung Keun Lee, Xinyi Zhang, Amy Davies, Jenna C. Carlson, Elizabeth J. Leslie-Clarkson, Sarah J. Lewis, Mary L. Marazita, Justin Cotney, Peter Claes, John R. Shaffer, Seth M. Weinberg

10.1016/j.xhgg.2026.100655
View Publication

Aggregate variant calling using short reads enables population and disease studies for paralogous genes

Timofey Prodanov, Sang Yoon Byun, Vikas Bansal

10.1016/j.xhgg.2026.100653
View Publication

Expanding the Clinical and Molecular Spectrum of TUBB2B Through Distinct Variants Identified Across Multiple Families

Shaghayegh T. Beheshti, Angad Jolly, Ahmed K. Saad, Haowei Du, Lauren E. Westerfield, Chloe Munderloh, Divya Kalra, Yifan Wu, Yi Chen, Marie-Claude Gingras, Shalini N. Jhangiani, Sarenur Yilmaz, Maha S. Zaki, Daniel G. Calame, Davut Pehlivan, Richard A. Gibbs, Richard A. Lewis, James R. Lupski, Jennifer E. Posey

10.1016/j.xhgg.2026.100654
View Publication

Frequently asked questions

How long does it take to publish?

Timely editorial decisions; rapid publication; continuous publication.

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Is a cover letter required?

A cover letter is required with each submission. It should briefly explain prior knowledge, the conceptual advance, and the significance for a broad readership. It may include reviewer suggestions and up to three reviewer exclusion requests. Fast-track review may be requested in the cover letter.

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What are the publication costs?

Open access publication is funded by APCs; Cell Press APCs start at US$1500 excluding tax and are set per journal.

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Research Topics

Genomics and Rare Diseases Genetic Associations and Epidemiology Genomic variations and chromosomal abnormalities BRCA gene mutations in cancer RNA modifications and cancer Epigenetics and DNA Methylation Genetics and Neurodevelopmental Disorders Congenital heart defects research RNA Research and Splicing Bioinformatics and Genomic Networks Genetic Mapping and Diversity in Plants and Animals Genetic factors in colorectal cancer RNA and protein synthesis mechanisms Cancer Genomics and Diagnostics RNA regulation and disease Ethics in Clinical Research Race, Genetics, and Society Genomics and Phylogenetic Studies Genetic Neurodegenerative Diseases Prenatal Screening and Diagnostics Genetic Syndromes and Imprinting Mitochondrial Function and Pathology Genetic and phenotypic traits in livestock CRISPR and Genetic Engineering Connective tissue disorders research

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