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Metabolism and Target Organ Damage

Metabolism and Target Organ Damage is an open access journal with ISSN 2769-6375 (Online) that publishes research on metabolic disorders and their effects on organs, with emphasis on topics including metabolic syndrome, NAFLD/MASLD, diabetes, obesity, kidney disease, atherosclerosis, cardiovascular risk, insulin resistance, hypertension, metabolomics, and precision medicine.

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Subject Endocrinology & Metabolism
Impact Factor 3.9
Quartile Q2
Open Access Type Open
eISSN 2769-6375
Invitation Only No
Cost Range APC: $2600

Submission Instructions

Metabolism and Target Organ Damage accepts the following article types. Click on an article type to view submission instructions.

Original Article

Cover Letter A cover letter is required. It must include the manuscript title and article type, briefly describe the background, question, methods, main findings, and significance, explain fit with journal scope and reader interest, confirm no prior or concurrent publication, confirm all authors approved the submission, and mention any special topic, conference presentation details, nomenclature choice for NAFLD/NASH or MAFLD/MASLD if used, and any potential overlap or duplication.
Abstract An abstract is required. Abstract must not exceed 250 words. Structured. Aim, Methods, Results, and Conclusion.
Manuscript Original Article manuscripts should use Abstract, Keywords, Introduction, Methods, Results, Discussion, Declarations, and References, and the main text should include Introduction, Methods, Results, and Discussion. Three to eight keywords are required, and the manuscript must include Declarations covering authors' contributions, availability of data and materials, AI and AI-assisted tools, financial support and sponsorship, conflicts of interest, ethical approval and consent to participate, and consent for publication when applicable.
References Vancouver. References must be numbered in order of appearance, cited in square brackets in the text, list all authors when there are six or fewer and the first three authors plus et al. when there are more than six, use Index Medicus journal abbreviations, and include DOI numbers or website links when available.
Figures & Tables Figures and tables should be placed after the paragraph where they are first cited. Figures and tables must be cited in numeric order, figures should have captions under them, tables should have captions above them, tables must be editable rather than pictures, and figure and table legends or footnotes must explain abbreviations and symbols.
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Mini-Review

Cover Letter A cover letter is required. The cover letter must include the manuscript title, article type, a brief description of the background, question, methods, main findings, significance, journal scope fit, reader appeal, any special topic, any conference presentation details, and confirmation that the manuscript is unpublished, not under consideration elsewhere, and approved by all authors.
Abstract An abstract is required. The abstract must not exceed 250 words. The abstract must be unstructured.
Manuscript The manuscript must not exceed 3000 words. The manuscript should include an Introduction section at the beginning and a Conclusion section at the end. Three to eight keywords must be provided, and the manuscript must include a statement of AI and AI-assisted tools use if applicable.
References Vancouver. References must be numbered in order of appearance, cited with numbers in square brackets, and list all authors when there are six or fewer authors or the first three authors followed by et al. when there are more than six.
Figures & Tables Figures and tables must be placed after the paragraph where they are first cited. Figures must be cited in numeric order, and tables must be cited in numeric order with captions above tables and under figures.
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Review

Cover Letter A cover letter is required. The cover letter must include the manuscript title and article type, briefly describe the background, question, methods, main findings, and significance, explain why the manuscript fits the journal scope and will interest readers, confirm originality and that all authors approved the submission, mention any special topic or conference presentation, and disclose any potential overlap or duplication.
Abstract An abstract is required. Abstract must not exceed 250 words. Unstructured.
Manuscript Review articles should use the structure Abstract, Keywords, Introduction, Main Text, Conclusion, Declarations, and References. The manuscript must include 3-8 keywords, and if AI tools are integral to the research design or methodology, a Declaration of Generative AI Use must be included before the reference section.
References Vancouver. References must be numbered in order of appearance, cited in the text with square brackets, list all authors when there are six or fewer authors, list the first three authors followed by et al. when there are more than six, and use Index Medicus journal abbreviations.
Figures & Tables Figures and tables should be cited in numeric order and placed after the paragraph where they are first cited. Figures should be submitted in editable or standard image formats, tables should be editable and not pictures, captions must accompany each, and review figures and tables should avoid non-English information and use clear labels with any symbols explained in the legend or footnotes.
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Meta-Analysis

Cover Letter A cover letter is required. It must include the manuscript title and article type, briefly describe the background, question, methods, main findings, and significance, explain journal fit and reader interest, confirm exclusivity and all authors’ approval, mention any special topic or conference presentation, and disclose any potential overlap or duplication.
Abstract An abstract is required. It must not exceed 250 words. Structured. Aim, Methods, Results, and Conclusion.
Manuscript The main text must include Introduction, Methods, Results, and Discussion sections. It must include 3-8 keywords, a Declarations section, Authors’ contributions, Data source and availability, Financial support and sponsorship, Conflicts of interest, Ethics approval, and an AI and AI-assisted tools statement.
References Vancouver. References must be numbered in order of appearance, cited in the text with square brackets, and each reference must include a DOI number or website link.
Figures & Tables Figures and tables must be cited in numeric order and placed after the paragraph where they are first cited. Figures must have captions under them, tables must have captions above them, and any reused copyrighted figures or tables require permission.
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Systematic Review

Cover Letter A cover letter is required. It must include the manuscript title and article type, briefly describe the background, question, methods, main findings, and significance, explain why the manuscript fits the journal scope and appeals to readers, confirm non-publication and sole consideration elsewhere, confirm all authors approved the submission, mention any special topic or conference presentation details, and briefly justify any NAFLD/NASH or MAFLD/MASLD nomenclature choice if used.
Abstract An abstract is required. Abstract must not exceed 250 words. Structured. Aim, Methods, Results, and Conclusion.
Manuscript Introduction, Methods, Results, and Discussion sections are required. Three to eight keywords are required, and the manuscript must include Declarations, Authors’ contributions, Data source and availability, Financial support and sponsorship, Patient consent, and Ethics approval statements, plus an AI and AI-assisted tools statement if applicable.
References Vancouver. References must be numbered in order of appearance, cited in square brackets in the text, and each reference should include all authors if six or fewer or the first three authors followed by et al. if more than six, with journal abbreviations following Index Medicus and a DOI or website link included.
Figures & Tables Figures and tables should be cited in sequence in the main text near their first appearance. Figures should be in TIFF, PSD, AI, or JPEG format at 300-600 dpi, tables should be editable and not images, non-English words should be avoided, and copyrighted reused material requires permission.
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Letter To Editor

Cover Letter A cover letter is required. It must include the manuscript title and article type, briefly describe the background, question, rationale, methods, main findings, and significance, explain the fit with journal scope and reader appeal, confirm originality and exclusive submission, state authors’ approval, mention any special topic, conference presentation details if applicable, and disclose any potential overlap or duplication.
Abstract An abstract is optional. Abstracts must not exceed 250 words. Abstracts must be unstructured.
Manuscript Letters to the Editor should use the structure Main Text, Declarations, and References. The manuscript must include keywords, an Authors' Contributions section, an Availability of Data and Materials section, an AI and AI-assisted tools Statement section, financial support and conflicts of interest declarations, and any required ethics or consent statements.
References Vancouver References must be numbered in order of appearance, cited in the text with square brackets, list all authors when there are six or fewer and the first three plus et al. when there are more than six, and include a DOI number or website link.
Figures & Tables Figures and tables should be cited in numeric order and placed after the paragraph where they are first cited. Table pictures are not allowed, figures and tables must be editable where applicable, and titles should be concise without abbreviations except standardized ones.
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Short Communication

Cover Letter A cover letter is required. The cover letter must include the manuscript title and article type, briefly describe the study background, question, methods, main findings, and significance, explain fit with journal scope and reader interest, confirm originality and that all authors approved submission, mention any special topic or conference presentation details, and disclose any potential overlap or duplication.
Abstract An abstract is required. Abstract must not exceed 250 words. Structured. Aim, Methods, Results, and Conclusion.
Manuscript The main text must include Introduction, Methods, Results, and Discussion sections. The manuscript must include 3-8 keywords, an Authors' Contributions section, an Availability of Data and Materials section, an AI and AI-assisted tools Statement section, and relevant ethics, consent, and funding disclosures where applicable.
References Vancouver. References must be numbered in order of appearance, cited with square-bracketed numbers in the text, and formatted with full author lists for six or fewer authors or the first three authors followed by et al. for more than six authors.
Figures & Tables Figures and tables must be cited in numeric order and placed after the paragraph where they are first cited. Figures and tables must be clear, editable where required, and prepared with captions and explanatory notes as appropriate, with figures in numeric order and tables labeled sequentially.
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Communication

Cover Letter A cover letter is required. It must include the manuscript title and article type, briefly describe the study background, question, methods, main findings, significance, explain why the manuscript fits the journal scope and would attract readers, confirm it has not been published elsewhere or submitted elsewhere, confirm all authors approved the submission, mention any special topic or conference presentation details if applicable, and briefly justify any NAFLD/NASH or MAFLD/MASLD nomenclature choice if used.
Abstract Abstract requirements are not specified.
Manuscript The manuscript must include authors' full names, institutional addresses and email addresses, at least one corresponding author, three to eight keywords, Authors' Contributions, Availability of Data and Materials, AI and AI-assisted tools Statement, Financial Support and Sponsorship, Conflicts of Interest, Ethical Approval and Consent to Participate where applicable, and Consent for Publication where applicable.
References References must be numbered in order of appearance, cited in the text with square brackets, list all authors when there are six or fewer authors, list the first three authors followed by et al. when there are more than six authors, and use Index Medicus journal abbreviations.
Figures & Tables Figures and tables should be cited in numeric order and placed after the paragraph where they are first cited. Figures must be clear and cited numerically, with captions under figures; tables must have captions above them and be editable, and any reused copyrighted figures or tables require permission.
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Letter

Cover Letter A cover letter is required. It must include the manuscript title and article type, briefly describe the background, question, methods, main findings, and significance, explain why the manuscript fits the journal scope and would interest readers, confirm no prior publication or concurrent consideration, confirm all authors approved submission, mention any special topic or conference presentation details, and briefly justify any NAFLD/NASH or MAFLD/MASLD nomenclature choice if used.
Abstract Abstract requirements are not specified.
Manuscript The manuscript must include an Authors' Contributions section, an Availability of Data and Materials section, an AI and AI-assisted tools Statement section, and a separate Ethical Approval and Consent to Participate statement where applicable. Three to eight keywords must be provided, all abbreviations must be defined at first use, and if AI tools are integral to the research design or methodology a Declaration of Generative AI Use must be included before the reference section.
References References must be numbered in order of appearance, cited with bracketed numbers in the text, and formatted so that all authors are listed when there are six or fewer authors and the first three authors are followed by et al. when there are more than six.
Figures & Tables Figures and tables must be cited in numeric order and placed after the paragraph where they are first cited. Figures and tables must follow the journal's standard content rules, including editable tables and legible figure labeling, but no article-type-specific count limit is stated.
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Recent Publications

Thrombospondin 1 is associated with MASH and hepatic macrophage inflammatory responses via CD47

Qiling Liu, Chenmin Fan, Binger Xu, Xinyu Yang, Xiaoyang Sun, Yuying Zhang, Shuqi Li, Miao Zhang, Xilei Ban, Guligeina Aikebaier, Ziping Bai, Wenfei Duan, Yang He, Hongmei Yan, Xinxia Chang, Mingfeng Xia, Xiaopeng Zhu, Xin Gao, Hua Bian

10.20517/mtod.2026.11
View Publication

Genetic predisposition to diabetes mellitus causally increases acute pancreatitis risk

Yi-Man Wang, Wei-Yi Zhou, Yi-Xian Lu, Bo-Juan Li, Yong-Quan Shi, Tuo Li

10.20517/mtod.2025.221
View Publication

The impact of phthalate exposure on cardiometabolic risk progression in children and the modifying role of movement behaviors

Ruolin Wang, Di Gao, Xinli Song, Jianuo Jiang, Yi Zhang, Jieyu Liu, Ziqi Dong, Yang Qin, Dengcheng Zhang, Zhenting Lu, Li Chen, Jinghong Liang, Zhiying Song, Yi Song, Jun Ma, Yanhui Dong

10.20517/mtod.2025.229
View Publication

Alterations in the serum lipid profile predict incident diabetes in obese individuals

Juan Du, Yubin Tang, Lili Xia, Xiaoxu Ge, Liuqing Xi, Wenyi Li, Wenfang Peng, Xiaohong Jiang, Lei Feng, Xirong Guo, Jianfang Gao, Zhou Peng, Shan Huang

10.20517/mtod.2025.206
View Publication

Application and interpretation of non-invasive testing in MetALD

Wah-Kheong Chan, Ken Liu, George Boon-Bee Goh, Vincent Wai-Sun Wong

10.20517/mtod.2026.30
View Publication

Frequently asked questions

How long does it take to publish?

Median time to first editorial decision: 6 days

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Is a cover letter required?

A cover letter is required with each manuscript. It should explain significance, scope fit, reader interest, and confirm the manuscript has not been published elsewhere or under consideration elsewhere.

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What are the publication costs?

The article processing charge is $2600 per submission.

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Research Topics

Liver Disease Diagnosis and Treatment Diet, Metabolism, and Disease Liver Disease and Transplantation Alcohol Consumption and Health Effects Bariatric Surgery and Outcomes Diet and metabolism studies Liver Diseases and Immunity Diabetes Treatment and Management Liver physiology and pathology Pancreatic function and diabetes Diabetes Management and Research Hormonal and reproductive studies Endoplasmic Reticulum Stress and Disease Metabolism, Diabetes, and Cancer Diabetes, Cardiovascular Risks, and Lipoproteins Genetic Associations and Epidemiology Pancreatitis Pathology and Treatment Diabetes and associated disorders Folate and B Vitamins Research Adipokines, Inflammation, and Metabolic Diseases Trace Elements in Health Adipose Tissue and Metabolism Drug-Induced Hepatotoxicity and Protection Cancer, Lipids, and Metabolism Pharmacology and Obesity Treatment

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