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Molecular Neurodegeneration

Molecular Neurodegeneration is an open access neuroscience journal focused on neurodegeneration research at the molecular and cellular levels. As the official journal of the BrightFocus Foundation, it highlights advances in the molecular and cellular mechanisms underlying the pathogenesis of neurodegenerative disorders associated with aging.

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Subject Neurosciences
Impact Factor 17.5
Quartile Q1
Open Access Type Open
eISSN 1750-1326
Invitation Only No
Cost Range £2590.00 GBP / $3190.00 USD / €2990.00 EUR; Perspective: £1215.00 GBP / $1720.00 USD / €1495.00 EUR

Submission Instructions

Molecular Neurodegeneration accepts the following article types. Click on an article type to view submission instructions.

Research

Cover Letter A cover letter is required. The cover letter must explain any issues relating to journal policies, declare any potential competing interests, confirm all authors approved the submission, confirm the manuscript has not been published or submitted elsewhere, and name the special issue if applicable.
Abstract An abstract is required. Abstract must not exceed 350 words. Abstract must be structured. Abstract must include the headings Background, Methods, Results, Conclusions, and Trial registration.
Manuscript Manuscript must include the sections Background, Methods, Results, Discussion, Conclusions, and a Declarations section. Manuscript must include three to ten keywords, a Declarations section with the specified subheadings using 'Not applicable' when a subheading is irrelevant, a list of abbreviations if abbreviations are used, and documentation of any Large Language Model use in the Methods section or suitable alternative part.
References References must use Vancouver style. Only published or publicly available articles, clinical trial registration records, abstracts, and preprints may be cited, unpublished abstracts/data/personal communications must not appear in the reference list, journal abbreviations must follow Index Medicus/MEDLINE, and URLs must be numbered and included in the reference list in full with site title and access date.
Figures & Tables Figure titles and legends must be provided in the main manuscript rather than in the graphic file, tables shorter than one page may be placed within the manuscript, and tables longer than one page may be placed at the end of the document with their placement indicated in the text. Multi-panel figures must be uploaded as single composite files, figures must be uploaded separately in citation order, and tables must not be embedded as figures or spreadsheet files.
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Review

Cover Letter A cover letter is required. The cover letter must explain any issues relating to journal policies, declare any potential competing interests, confirm that all authors approved the manuscript for submission, confirm that the manuscript has not been published or submitted elsewhere, and name the special issue if applicable.
Abstract An abstract is required. Abstract must not exceed 350 words. Abstract must be structured. Abstract must include Background, Main body of the abstract, and short Conclusion.
Manuscript Manuscript must include Background, Main text, Conclusions, Declarations, and an Availability of data and materials statement. Manuscript must include three to ten keywords, a list of abbreviations if abbreviations are used, and a Declarations section with the subheadings Ethics approval and consent to participate, Consent for publication, Availability of data and materials, Competing interests, Funding, Authors' contributions, and Acknowledgements, using 'Not applicable' for any irrelevant section.
References References must follow Vancouver style. Only published or in-press articles, clinical trial registration records, abstracts, and publicly available preprints may be cited, unpublished abstracts, unpublished data, and personal communications must not appear in the reference list, journal abbreviations must follow Index Medicus/MEDLINE, and web links and URLs must be numbered and included in the reference list with the site title, full URL, and access date.
Figures & Tables Figure titles and legends must be provided in the main manuscript rather than in the graphic file, tables shorter than one page may be placed within the manuscript, and tables longer than one page may be placed at the end of the document with in-text placement indicated. Figures must be numbered and uploaded in the order first cited, multi-panel figures must be submitted as a single composite file, and tables must be numbered and cited sequentially and created using the word processor's table function rather than embedded as figures or spreadsheet files.
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Letter To The Editor

Cover Letter Cover letter is required. Cover letter must explain any issues relating to journal policies, declare any potential competing interests, confirm that all authors have approved the manuscript for submission, confirm that the manuscript content has not been published or submitted elsewhere, and name the special issue if applicable.
Abstract Abstract is optional. If included, the abstract must be limited to one sentence. Abstract structure is not specified.
Manuscript Body text must be no more than 1000 words, excluding figure legends and references. Manuscript must start with "To the Editor" and the main text must not be divided into sections. Manuscript must include a Declarations section containing Ethics approval and consent to participate, Consent for publication, Availability of data and materials, Competing interests, Funding, Authors' contributions, Acknowledgements, and optional Authors' information, with "Not applicable" used for any non-relevant section.
References Manuscript must include no more than 10 references. References must use Vancouver style. Web links and URLs must be assigned a reference number and included in the reference list in full with the site title, URL, and access date.
Figures & Tables Manuscript may include a maximum of 1 figure or table at submission. Tables shorter than one page may be placed within the manuscript, while larger tables may be placed at the end of the document and must be cited in the text. Figure titles and legends must be provided in the main manuscript rather than in the graphic file.
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Recent Publications

Insulin resistance alters cortical inhibitory neurons and microglia to exacerbate Alzheimer’s knock-in mouse phenotypes

LaShae Nicholson, Si Jie Tang, Tejaswini Karra, Habiba Abouelatta, Stephen M. Strittmatter

10.1186/s13024-026-00946-0
View Publication

3’UTR regulation of axon translation and optic nerve regeneration

Minjuan Bian, Emma L. Huie, Xin Xia, Michael Nahmou, Savana A. Maxfield, Liang Li, Liang Liu, Ziming Luo, Christina Tsien, Katherine J. Healzer, Heather V. Chang, Kristina Russano, Jeffrey L. Goldberg

10.1186/s13024-026-00952-2
View Publication

Cholesterol metabolism in neurodegenerative diseases: mechanisms and therapeutic advances

Dezhen Tu, Yuxiao Zheng, Pingping Ding, Miao Shen, Wangyang Tang, Bin Wei, Hongyan Wang

10.1186/s13024-026-00951-3
View Publication

Temporal single-cell atlas of full-length Huntington’s disease mouse model defines stage-specific signatures of corticostriatal dysfunction

Ashley B. Robbins, Paul T. Ranum, Icnelia Huerta-Ocampo, Michael Kuckyr, Beverly L. Davidson

10.1186/s13024-026-00960-2
View Publication

Correction: Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis

Laura Pasetto, Stefano Callegaro, Alessandro Corbelli, Fabio Fiordaliso, Deborah Ferrara, Laura Brunelli, Giovanna Sestito, Roberta Pastorelli, Elisa Bianchi, Marina Cretich, Marcella Chiari, Cristina Potrich, Cristina Moglia, Massimo Corbo, Gianni Sorarù, Christian Lunetta, Andrea Calvo, Adriano Chiò, Gabriele Mora, Maria Pennuto, Alessandro Quattrone, Francesco Rinaldi, Vito Giuseppe D’Agostino, Manuela Basso, Valentina Bonetto

10.1186/s13024-026-00955-z
View Publication

Frequently asked questions

How long does it take to publish?

Submission to first decision (median): 20 days

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Is a cover letter required?

A cover letter is required. It should explain why the manuscript should be published in Molecular Neurodegeneration, address any issues relating to journal policies, declare any potential competing interests, confirm that all authors approved the submission, confirm that the content has not been published or submitted elsewhere, and identify the special issue if applicable. Authors may also suggest preferred and non-preferred peer reviewers in the cover letter.

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What are the publication costs?

An article processing charge applies for each accepted article. The current APC is £2590.00 GBP / $3190.00 USD / €2990.00 EUR. The current APC for a Perspective is £1215.00 GBP / $1720.00 USD / €1495.00 EUR. VAT or local taxes may apply.

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Research Topics

Alzheimer's disease research and treatments Neuroinflammation and Neurodegeneration Mechanisms Parkinson's Disease Mechanisms and Treatments Amyotrophic Lateral Sclerosis Research Dementia and Cognitive Impairment Research Genetic Neurodegenerative Diseases Neurogenesis and neuroplasticity mechanisms Nuclear Receptors and Signaling Neuroscience and Neuropharmacology Research Cholinesterase and Neurodegenerative Diseases Neurological Disease Mechanisms and Treatments Mitochondrial Function and Pathology Nerve injury and regeneration Autophagy in Disease and Therapy Cellular transport and secretion Neurogenetic and Muscular Disorders Research Neurological disorders and treatments Tryptophan and brain disorders Neurological diseases and metabolism Lysosomal Storage Disorders Research Prion Diseases and Protein Misfolding RNA Research and Splicing Computational Drug Discovery Methods Endoplasmic Reticulum Stress and Disease S100 Proteins and Annexins

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