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Nature Cardiovascular Research

Nature Cardiovascular Research publishes cardiovascular research and related content including Articles, Review Articles, Perspectives, Technical Reports, Research Highlights, News & Views, Comments and Research Briefings. The journal is open for submissions of original research articles and Reviews/Perspectives.

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Subject Cardiac & Cardiovascular Systems
Impact Factor 10.8
Quartile Q1
Open Access Type Hybrid
eISSN 2731-0590
Invitation Only No
Cost Range Article Processing Charge applies for gold open access publication.

Submission Instructions

Nature Cardiovascular Research accepts the following article types. Click on an article type to view submission instructions.

Article

Cover Letter A cover letter must be included with the submission. Cover letter should explain the importance of the work and its suitability for the journal’s diverse readership, and if double-blind peer review is chosen it must include all authors’ affiliations and contact information.
Abstract An abstract is required. Abstract must be up to 150 words. Abstract must be unstructured and unreferenced. Abstract should briefly describe the background and rationale and then state the main conclusions introduced by the phrase 'Here we show' or an equivalent.
Manuscript Main text must be up to 4,500 words excluding the abstract, Methods, references and figure legends. Manuscript should be divided into Introduction without a heading, Results, Discussion and Online Methods, with topical subheadings in Results and Online Methods only and none in Discussion. Manuscript file must include Methods, figures and Extended Data if applicable, and any use of a Large Language Model must be documented in the Methods section or a suitable alternative section if no Methods section is available.
References References are typically recommended up to 60. References must be numerical. References must be numbered sequentially and cited articles must include article titles, with Methods-only references continuing the numbering from the main text.
Figures & Tables Display items are limited to 8 figures and/or tables, with up to 10 additional Extended Data display items allowed. Tables must be included at the end of the text document. All figures must be cited in sequence within the main text.
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Analysis

Cover Letter A cover letter is required. Cover letter should explain the importance of the work, why it suits the journal’s broad readership, and state whether there have been prior discussions with an editor about the work.
Abstract An abstract is required. Abstract must be 100–150 words. Abstract must be unstructured. Abstract must briefly present the background and rationale followed by the main conclusions introduced by the phrase 'Here we show' or an equivalent.
Manuscript Main text must be up to 4,000 words excluding the abstract, online Methods, references and figure legends. Manuscript must be organized as Introduction without a heading, Results, Discussion and Online Methods, with subheadings allowed in Results and Online Methods but not in Discussion. Methods must contain enough detail for interpretation and replication, use of a Large Language Model must be documented in Methods or a suitable alternative section, and Supplementary Information may be included.
References References are typically recommended up to 50. References must be numerical. References must be numbered sequentially in the order they appear, with Methods-only references continuing from the end of the main text reference list.
Figures & Tables Manuscript may include up to 6 display items and up to 10 Extended Data display items. Tables must be included at the end of the text document. All figures must be cited in sequence in the main text.
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Letter

Cover Letter A cover letter must be included with the submission. Cover letter should explain the importance of the work, why it suits the journal’s broad readership, and if double-blind peer review is chosen, include all authors’ affiliations and contact information.
Abstract An abstract is not permitted because a Letter must include an introductory paragraph instead. The introductory paragraph must be no longer than 150 words. The summary must be provided as an unstructured introductory paragraph that is referenced and counted as part of the main text. The introductory paragraph must summarize the background, rationale, main results and implications, and should introduce the main conclusions with 'Here we show' or equivalent.
Manuscript Main text must not exceed 2,500 words, excluding the introductory paragraph, online Methods, references and figure legends. Letters must not be divided by headings, except that the online Methods may use up to two levels of headings. Use of a Large Language Model must be documented in the Methods section or another suitable section if no Methods section is available.
References References are typically recommended up to 40. References must be numbered sequentially and cited article references must include article titles.
Figures & Tables Letters must include 2–4 display items and may include up to 10 Extended Data display items. Tables must be included at the end of the text document, while complex tables may be submitted as a separate Excel file.
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Resource

Cover Letter A cover letter is required. Cover letter should explain the importance of the work, why it suits the journal’s diverse readership, and whether there have been prior discussions with an editor.
Abstract An abstract is required. Abstract must be up to 150 words. Abstract must be unstructured and unreferenced. Abstract must briefly state the background and rationale and then the main conclusions introduced by the phrase 'Here we show' or an equivalent.
Manuscript Main text must be up to 4,500 words, excluding the abstract, Online Methods, references and figure legends. Manuscript must be divided into Introduction without a heading, Results, Discussion and Online Methods, with Results and Online Methods divided by topical subheadings and no subheadings in the Discussion. Manuscript file must include Methods, figures and Extended Data if applicable, a reference list, and documentation of any Large Language Model use in the Methods section or a suitable alternative section.
References References are typically recommended up to 60. References must be numbered sequentially in the order of Main Text, Methods, Data Availability Section, Tables, Figure Legends, Box and Extended Data Figures, with only one publication given for each reference.
Figures & Tables Display items are limited to 8 figures and/or tables, and up to 10 Extended Data display items are allowed. Tables must be included at the end of the text document.
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Technical Report

Cover Letter A cover letter must be included with the submission. The cover letter should explain the importance of the work and why it is appropriate for the diverse readership of Nature Cardiovascular Research.
Abstract An abstract is required. The abstract should be unstructured as a brief account of the background and rationale followed by a statement of the main conclusions introduced by 'Here we show' or an equivalent phrase.
Manuscript The manuscript must include separate sections for Introduction, Results, Discussion and Methods. Use of a Large Language Model must be documented in the Methods section or in a suitable alternative section if no Methods section is available.
References References are typically recommended up to 60. References must be numerical. References must be numbered sequentially in the order of Main Text, Methods, Data Availability Section, Tables, Figure Legends, Box and Extended Data Figures, with only one publication given for each reference.
Figures & Tables Up to 10 Extended Data display items, including figures and/or tables, are allowed. Tables must be included at the end of the text document.
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Review

Cover Letter A cover letter is required with the submission. The cover letter should explain the importance of the work, why it suits a diverse readership, disclose related manuscripts and prior editorial discussions, and include all authors’ affiliations and contact information if double-blind peer review is chosen.
Abstract An abstract is required and must be unreferenced. Abstract must be no more than 150 words. Abstract must be unstructured.
Manuscript Main text must be 4,000–6,000 words. The article should not include original unpublished research findings except minimal new supporting data, and up to three subheading levels are allowed. Use of a Large Language Model must be documented in the Methods section or another suitable section if no Methods section is available.
References References must not exceed 150. References and in-text citations must use numerical citation style. Citations should be selective, references for cited articles must include article titles, and brief annotations for particularly important studies comprising no more than 10% of references are encouraged.
Figures & Tables Display items, including figures, tables and boxes, must total 4–8. Tables must be included at the end of the text document.
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Recent Publications

A world of possibilities for cardiac simulations

Andrea Tavosanis

10.1038/s44161-026-00830-6
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Genome-wide association study of coronary flow reserve assessed by cardiac perfusion PET suggests a role for NF-κB pathway

Rasika Venkatesh, Tess Cherlin, Nicole Wayne, Rachit Kumar, Lindsay Guare, Venkata P. Singamneni, Brett Irving, Scott Dudek, Michael G. Levin, Shefali Setia-Verma, Marie A. Guerraty

10.1038/s44161-026-00819-1
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Lipoprotein(a) and oxidized phospholipids are associated with myocardial inflammation after acute myocardial infarction

Mark Atallah, Nadim Nasrallah, Tarek Harb, Ines Valenta, Thomas H. Schindler, Amelia S. Wallace, Sotirios Tsimikas, Gary Gerstenblith, Thorsten M. Leucker

10.1038/s44161-026-00821-7
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Consensus statement on mass spectrometry-based proteomic analysis of cardiac tissue

Alicia Lundby, Jennifer E. Van Eyk, Manuel Mayr, Melanie Y. White, Jonathan A. Kirk, Jonathan S. Achter, Justyna Fert-Bober, Michael Wierer, Philipp Mertins, Maggie P. Y. Lam, Sean J. Humphrey, Edward Lau, Anthony O. Gramolini, Ying Ge, Rebekah L. Gundry

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CAMK2 inhibition treats genetic dilated cardiomyopathy in mice

-

10.1038/s44161-026-00826-2
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Frequently asked questions

How long does it take to publish?

Median submission to first editorial decision is 5 days. Median submission to acceptance is 232 days.

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Is a cover letter required?

A cover letter is required for revised manuscripts when additional information is requested by the editors.

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What are the publication costs?

Article Processing Charge applies for gold open access publication.

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Research Topics

Congenital heart defects research Cardiac Fibrosis and Remodeling Atherosclerosis and Cardiovascular Diseases Cardiac electrophysiology and arrhythmias Cardiovascular Function and Risk Factors Cardiomyopathy and Myosin Studies Single-cell and spatial transcriptomics RNA modifications and cancer Tissue Engineering and Regenerative Medicine Viral Infections and Immunology Research Immune cells in cancer Ion channel regulation and function RNA Research and Splicing Sex and Gender in Healthcare Adipokines, Inflammation, and Metabolic Diseases Signaling Pathways in Disease Mitochondrial Function and Pathology Cardiac Arrhythmias and Treatments Angiogenesis and VEGF in Cancer Neutrophil, Myeloperoxidase and Oxidative Mechanisms Cardiac Valve Diseases and Treatments Congenital Heart Disease Studies Cardiovascular Effects of Exercise Heart Failure Treatment and Management Neuroinflammation and Neurodegeneration Mechanisms

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