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Nature Medicine

Nature Medicine is a medical journal publishing research, reviews, analysis, news and comment on translational and clinical research across medicine.

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Subject Medicine, Research & Experimental
Impact Factor 50
Quartile Q1
Open Access Type Hybrid
ISSN 1078-8956
eISSN 1546-170X
Invitation Only No
Cost Range Article Processing Charge applies for gold open access articles when the manuscript is accepted.

Submission Instructions

Nature Medicine accepts the following article types. Click on an article type to view submission instructions.

Article

Cover Letter A cover letter is required. Cover letter should explain the importance of the work, why it suits the journal’s broad readership, disclose related manuscripts under consideration or in press elsewhere, and state any prior discussions with an editor.
Abstract An abstract is required. Abstract must be no more than 150 words. Abstract must be unstructured and unreferenced.
Manuscript Main text must be up to 4,000 words excluding the abstract, Methods, references and figure legends. Manuscript must be organized as Introduction without a heading, Results, Discussion, and Online Methods, with topical subheadings in Results and Online Methods but not in Discussion. Manuscript file must include Methods, figures and any applicable Extended Data, include all elements needed for interpretation and replication, and document any use of a Large Language Model in the Methods section or a suitable alternative section if no Methods section is available.
References References are recommended to be up to 60. References must be numbered sequentially in citation order, include only one publication per reference, and include titles of cited articles.
Figures & Tables Article may include up to 6 display items and no more than 10 Extended Data display items or 10 Extended Data figures. Figures must be included in the manuscript file, while tables must be placed at the end of the text document and complex tables may be submitted separately as an Excel file. All figures must be cited sequentially in the text and each figure legend must include a brief title and short panel descriptions.
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Brief Communication

Cover Letter A cover letter is required. Cover letter should explain the importance of the work, why it suits the journal’s broad readership, disclose related manuscripts under consideration or in press elsewhere, and state any prior discussions with an editor about the work.
Abstract An abstract is required. Abstract must be unreferenced and no longer than 150 words. Abstract must be unstructured. No abstract headings are permitted because the article contains no headings.
Manuscript Main text must be no longer than 2,000 words including the abstract, references and figure legends. Manuscript must contain no headings and must include an Online Methods section. Use of a Large Language Model must be documented in the Methods section or, if no Methods section is available, in another suitable part of the manuscript.
References References are recommended to be limited to 20. References must be numbered sequentially in order of appearance, and article titles must be omitted from the reference list.
Figures & Tables Up to 2 display items are permitted, although this may be flexible at the editor’s discretion if the page limit is maintained. Tables must be included at the end of the text document.
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Resource

Cover Letter A cover letter is required. Cover letter should explain the importance of the work, why it suits the journal’s broad readership, disclose related manuscripts under consideration or in press elsewhere, and state any prior discussions with an editor.
Abstract An abstract is required. Abstract must be 150 words. Abstract must be unstructured and unreferenced.
Manuscript Main text must be up to 4,000 words excluding the abstract, online Methods, references and figure legends. Manuscript must be divided into Introduction (without heading), Results, Discussion and Online Methods, with topical subheadings in Results and Online Methods but not in Discussion. Manuscript file must include Methods, figures and Extended Data if applicable, and any use of a Large Language Model must be documented in the Methods section or another suitable part of the manuscript if no Methods section is available.
References References must be numbered sequentially in citation order, include only one publication per reference, and include titles of cited articles.
Figures & Tables Resource may include up to 6 display items and no more than 10 Extended Data display items. Tables must be included at the end of the text document, while figures are included in the manuscript file. Figure legends count outside the main-text word limit.
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Analysis

Cover Letter A cover letter is required. Cover letter should explain the importance of the work, why it suits the journal’s diverse readership, disclose related manuscripts under consideration or in press elsewhere, and state any prior discussions with an editor about the work.
Abstract An abstract is required. Abstract must be 150 words. Abstract must be unstructured and unreferenced.
Manuscript Main text must be up to 4,000 words excluding abstract, online Methods, references and figure legends. Manuscript must be divided into Introduction without a heading, Results, Discussion and Online Methods, with topical subheadings in Results and Online Methods but not in Discussion. Manuscript must include Methods and references, and any use of a Large Language Model must be documented in the Methods section or a suitable alternative part of the manuscript.
References References are recommended to be up to 60. References must be numbered sequentially in citation order, include only one publication per reference, include article titles, and continue numbering through Methods references if present.
Figures & Tables Analysis may include up to 6 display items, and a maximum of 10 Extended Data display items is permitted. Tables must be included at the end of the text document. Figures must be cited in sequence in the main text and each figure legend must include a brief title and panel descriptions.
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Review

Cover Letter A cover letter is required. Cover letter should explain the importance of the work, why it is appropriate for the diverse readership of Nature Medicine, disclose related manuscripts under consideration or in press elsewhere, and state any prior discussions with a Nature Medicine editor about the work.
Abstract Abstract requirements are not specified.
Manuscript Review main text must be 4,000 words. Review should not include original previously unpublished research findings and may contain only minimal new supporting data. Manuscript file must include Methods, figures and Extended Data if applicable, and any use of a Large Language Model must be documented in the Methods section or a suitable alternative part of the manuscript.
References Review references must not exceed 100. References must be numbered sequentially in citation order, include only one publication per reference, include article titles, and continue numbering through any Methods-only references.
Figures & Tables A maximum of ten Extended Data display items is permitted. Tables must be included at the end of the text document, while complex tables may be submitted as a separate Excel file. Illustrations are strongly encouraged, all figures must be cited in sequence in the main text, and figure legends must not exceed the article word limit.
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Correspondence

Cover Letter A cover letter is required. Cover letter should explain the importance of the work, why it is appropriate for the diverse readership of Nature Medicine, disclose related manuscripts under consideration or in press elsewhere, and state any prior discussions with a Nature Medicine editor.
Abstract Abstract requirements are not specified.
Manuscript Correspondence main text must be up to 1,000 words. Correspondence should not contain new research data and must not serve as a venue for technical comments on peer-reviewed research papers. Manuscript file must include the names and affiliations of all co-authors, a reference list, and documentation of any Large Language Model use in a suitable part of the manuscript if no Methods section is available.
References Correspondence may include up to 10 references. References must be numbered sequentially in the order of citation, with only one publication given for each reference.
Figures & Tables Correspondence may include up to 2 display items. Tables must be included at the end of the text document.
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Recent Publications

Hidden race disparities in cancer treatment toxicity

Karen O’Leary

10.1038/d41591-026-00050-2
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Optogenetic therapy shows early promise for treating retinitis pigmentosa

Karen O’Leary

10.1038/d41591-026-00051-1
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Personalized neoantigen-targeting cancer vaccines in ovarian cancer: a phase 1 trial

MacLean C. Sellars, Jessica A. Frank, Bohoon Shim, Allison Vanasse, Ruolin Liu, Cleo Forman, Chloe R. Tu, Kyohei K. Tabata, Antonia Kowelewski, Su-Chun Cheng, Catherine Song, Kan Xiong, Pia Jain, Andjela Crnjac, Haley E. Sax, Vipheaviny Chea, Wesley Lu, J. Thomas Janes, Micah Rickles-Young, Amit Sud, Savni Sarolkar, Martin Hayes, Oriol Olive, Haley Greenslade, Carrie Cibulskis, Nir Hacohen, Edward F. Fritsch, Shuqiang Li, Kenneth J. Livak, Nabihah Tayob, Elizabeth H. Stover, Carolyn Krasner, Rebecca Porter, Ursula Matulonis, Gad Getz, Giacomo Oliveira, Patrick A. Ott, Jeremy M. Simon, Viktor A. Adalsteinsson, Derin B. Keskin, Panagiotis A. Konstantinopoulos, Catherine J. Wu

10.1038/s41591-026-04717-8
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Talazoparib plus enzalutamide in high-volume metastatic hormone-naive prostate cancer: a randomized phase 2 trial

Francesca Zacchi, Elena Castro, Kathleen Imbach, Alejo Rodriguez-Vida, Sara Simonetti, Begoña Mellado, Gisela Mir Arnau, Daniel Aguilar, Daniel Castellano, Miguel Angel Climent, Manuel J. Ramos, Angel Borque-Fernando, Jose Antonio Guerrero, Paula Gonzalez-Alonso, Jhudit Perez-Escuredo, Vanessa Izquierdo, Maria Isabel Saez, Heura Domenech, Sara Arce-Gallego, Bernardo Herrera-Imbroda, Jacques Planas, David Lorente, Albert Font, Anna Oliveira, Pablo Cresta Morgado, Victor Esquefa, Julian Brandariz, Nicolas Anselmino, Keyi Zhu, Patricia Troncoso, Monica Aguilera, Ana Vivancos, Paolo Nuciforo, Irene Casanova-Salas, Eduard Porta, Joan Carles, Amado J. Zurita, Joaquin Mateo

10.1038/s41591-026-04671-5
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Editorial Expression of Concern: Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function

Guoying Yu, Argyris Tzouvelekis, Rong Wang, Jose D. Herazo-Maya, Gabriel H. Ibarra, Anup Srivastava, Joao Pedro Werneck de Castro, Giuseppe DeIuliis, Farida Ahangari, Tony Woolard, Nachelle Aurelien, Rafael Arrojo e Drigo, Ye Gan, Morven Graham, Xinran Liu, Robert J. Homer, Thomas S. Scanlan, Praveen Mannam, Patty J. Lee, Erica L. Herzog, Antonio C. Bianco, Naftali Kaminski

10.1038/s41591-026-04733-8
View Publication

Frequently asked questions

How long does it take to publish?

Median time from submission to first editorial decision is 4 days. Median time from submission to acceptance is 117 days.

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Is a cover letter required?

A cover letter is expected for revised manuscripts invited for revise and resubmit and should provide any additional information requested by the editors.

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What are the publication costs?

Article Processing Charge applies for gold open access articles when the manuscript is accepted; subscription publishing is also available for eligible article types.

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Research Topics

Science, Research, and Medicine Immune Cell Function and Interaction Immunotherapy and Immune Responses Biotechnology and Related Fields HIV Research and Treatment Biomedical Ethics and Regulation T-cell and B-cell Immunology Health and Medical Research Impacts CAR-T cell therapy research Cancer Genomics and Diagnostics Virus-based gene therapy research Cancer Immunotherapy and Biomarkers SARS-CoV-2 and COVID-19 Research CRISPR and Genetic Engineering Alzheimer's disease research and treatments Adipose Tissue and Metabolism Health Systems, Economic Evaluations, Quality of Life Diet and metabolism studies Epigenetics and DNA Methylation Pancreatic function and diabetes RNA Interference and Gene Delivery HIV/AIDS Research and Interventions Global Public Health Policies and Epidemiology Immune Response and Inflammation Gut microbiota and health

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