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Nature Reviews Genetics

Nature Reviews Genetics covers the full scientific breadth of modern genetics, including genomics, functional genomics, evolutionary genetics, technology, gene expression, multifactorial genetics, disease, chromosome biology, epigenetics, developmental biology, systems and networks, and the ethical, legal and social implications of genetics and genomics.

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Subject Genetics & Heredity
Impact Factor 52
Quartile Q1
Open Access Type Closed
ISSN 1471-0056
eISSN 1471-0064
Invitation Only Yes
Cost Range We do not charge a fee for publication.

Submission Instructions

Nature Reviews Genetics is an invitation-only journal. Submissions are accepted by invitation from the editorial board only. The following article types are accepted:

Review

Cover Letter Cover Letter requirements are not specified.
Abstract A 200-word abstract is required for the synopsis and the manuscript abstract must be unstructured. Abstract should ideally be no more than 200 words. Abstract must be unstructured.
Manuscript The manuscript should open with an introduction without subheadings and end with a brief concluding summary section without subheadings. The synopsis must include a 200-word abstract, a brief description of the main article sections, a list of key references, and the list of authors and their affiliations, and any use of a Large Language Model must be documented in the Methods section or a suitable alternative section.
References References should be approximately 25 per 1,000 words. References must use Nature Reviews style. References must be cited sequentially as superscript numbers in the order of main text, tables, figures, and then boxes, and references with six or more authors should list only the first author followed by 'et al.'.
Figures & Tables Display items are limited to 7 or fewer tables, figures, and boxes combined. Tables must be provided as part of the article document, while tables containing graphical content must be provided as separate image files. Figures must be fully labelled and include brief legends with a short title, and tables must have a short title, contain entries in all cells, and define all abbreviations.
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Perspective

Cover Letter Cover Letter requirements are not specified.
Abstract Perspective articles must include an unstructured abstract. Perspective abstracts should ideally be no more than 200 words. Perspective abstracts must be unstructured.
Manuscript Perspective articles should open with an introduction without subheadings that ends with a guiding paragraph, may use no more than three heading levels, and must end with a brief concluding section without subheadings. The manuscript must document any use of a Large Language Model in the Methods section or another suitable section if no Methods section is available, declare competing interests within the manuscript file, and must not include key points.
References References must use Nature Reviews style. References must be cited as sequential superscript numbers in the order of main text, tables, figures, and then boxes, and references with six or more authors must list only the first author followed by 'et al.'.
Figures & Tables Perspective articles may include no more than 5 display items, including tables, figures, and boxes. Tables and boxes must be provided as part of the article document, while tables containing graphical content must be supplied as separate image files. Display items must be cited in the main text in order, tables must have a short title with all abbreviations defined and no legend, and figures must be fully labelled with a short title and a concise legend defining all abbreviations.
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Consensus Statement

Cover Letter Cover Letter requirements are not specified.
Abstract A 200-word unstructured abstract is required in the synopsis. Abstract should ideally be a maximum of 200 words. Abstract must be unstructured. Abstract must not contain headings, references, or display item citations.
Manuscript Manuscript must include an introductory section without subheadings, a Methods section describing the methodology and stakeholders, and a brief concluding summary section without subheadings. Manuscript must include competing interests and document any use of a Large Language Model in the Methods section or another suitable section if no Methods section is available.
References References should be approximately 25 per 1,000 words. References must use Nature Reviews style. References must be cited as sequential superscript numbers, listed in the order of main text, tables, figures and then boxes, and for works with six or more authors only the first author should be listed followed by 'et al.'.
Figures & Tables No more than 7 display items, including tables, figures and boxes, are allowed. Tables and boxes must be provided as part of the article document, while tables containing graphical content must be provided as separate image files. Tables must have a short title and defined abbreviations, and figures must be fully labelled with a short title and a concise legend of about 200 words defining all abbreviations.
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Evidence-Based Guidelines

Cover Letter Cover Letter requirements are not specified.
Abstract A synopsis for proposal submission must include an unstructured abstract. Abstract should ideally be a maximum of 200 words. Abstract must be unstructured.
Manuscript Synopsis proposals must include a brief description of the main article sections, the introduction must be a section without subheadings, articles must include a description of methodology and stakeholders, and the article must end with a brief concluding summary section without subheadings. The synopsis must include a list of key references and the manuscript must document any use of a large language model in the Methods section or another suitable section if no Methods section is available.
References References must use Nature Reviews style. Reference citations must be sequential superscript numbers, and for references with six or more authors only the first author should be listed followed by 'et al.'.
Figures & Tables No more than 7 display items, including tables, figures and boxes, are allowed. Tables and boxes must be provided as part of the article document, while tables containing graphical content must be provided as separate image files. Figures must be fully labelled, tables must have a short title with all abbreviations defined, and figures must have a short title with a concise legend defining all abbreviations.
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Correspondence

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract requirements are not specified.
Manuscript Main text must not exceed 500 words. A maximum of two levels of headings is allowed, and the first paragraph must cite the original article. Competing interests must be declared within the text, and any use of a large language model must be documented in the Methods section or another suitable part of the manuscript if no Methods section is available.
References Articles may include a maximum of 10 references. References must use Nature Reviews reference style. References must be cited as superscript numbers and listed sequentially in the order of citation through the main text, tables, figures, and then boxes, with six or more authors shortened to the first author followed by 'et al.'.
Figures & Tables Only one display item can be included. Tables and boxes must be provided as part of the article document, while tables containing graphical content must be provided as separate image files. Tables must have a short title, contain at least three columns of data, include entries in all cells, omit legends, and define all abbreviations, while figures must be fully labelled with a short title and a concise legend defining all abbreviations.
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Comment

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract requirements are not specified.
Manuscript Comment articles are usually around 500–600 words or around 1,000–1,200 words. Comments must include a standfirst of no more than 50 words and may use only one level of heading. Competing interests must be declared within the manuscript, and any use of a Large Language Model must be documented in the Methods section or another suitable section if no Methods section is available.
References Comments may include a maximum of 10 references. Comments must use Nature Reviews reference style. References must be cited as superscript numbers in sequential order, and references with six or more authors should list only the first author followed by 'et al.'."
Figures & Tables Comments may include only one simple and concise display item, and supplementary information may be included at the editor's discretion. Tables and boxes must be provided as part of the article document, while supplementary information should be supplied as a single separate file if included. Tables must be simple, have a short title, no legend, at least three columns of data, and definitions for all abbreviations, while figures must be fully labelled with a short title and a concise legend defining all abbreviations.
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Recent Publications

Small variant calling in the era of long-read sequencing

Zhenxian Zheng, Fritz J. Sedlazeck, Ruibang Luo

10.1038/s41576-026-01020-7
View Publication

Towards equitable population epigenomics: implications for global health

Sarina Abrishamcar, Charles Agyemang, Habibul Ahsan, Marta E. Alarcón-Riquelme, Nicholas E. Banovich, Karisa R. Brina, Andres Cardenas, Elena Carnero-Montoro, Giriraj R. Chandak, Felix P. Chilunga, Shelley A. Cole, Murray P. Cox, Rajesh P. Dikshit, Aicha Djigal, William H. Dow, Hannah R. Elliott, Segun Fatumo, Irene Gallego Romero, Bizu Gelaye, Nicole Gladish, Roberto Gonzalez-Martin, Neil A. Hanchard, Fernando P. Hartwig, Peter Henneman, Anke Huels, Bernardo L. Horta, Prachand Issarapu, Diana L. Juvinao-Quintero, Gloria Kirabo, Michael S. Kobor, Ghattu V. Krishnaveni, Kalyanaraman Kumaran, Pradiptajati Kusuma, Gloria T. Larrabure Torrealva, James L. Li, Qing Li, Lilian Linda, Jun Lv, Sohail R. Mansuri, Sharayu S. Mhatre, Josine L. Min, Sinenhlanhla X. H. Mthembu, Ana Navas-Acien, Magatte Ndiaye, Shusuke Numata, Kazutaka Ohi, Omkar D. Patil, Brandon L. Pierce, Marlien Pieters, Luis F. R. Pinto, Elena Povedano, Andrew M. Prentice, David R. Rehkopf, Luis Rosero-Bixby, Sixto E. Sanchez, Jiahui Si, Matt J. Silver, Haotian Tang, Maria Tellez-Plaza, Teresa Tusie-Luna, Andrea Venema, Sarah H. Watkins, Jacqueline S. Womersley, Noha A. Yousri, Lizelle Zandberg, Heather J. Zar

10.1038/s41576-026-01027-0
View Publication

Towards a rational terminology for cell types

Yuanzhen Zhu, Guang Li, Peter W. H. Holland, Günter P. Wagner, Sebastian M. Shimeld

10.1038/s41576-026-01028-z
View Publication

Gene regulation at the early human maternal–fetal interface

Ana Paredes, Christina E. Kim, Roser Vento-Tormo

10.1038/s41576-026-01014-5
View Publication

Mapping genetic risk to regulatory networks at single-cell resolution

Yunlong Ma

10.1038/s41576-026-01025-2
View Publication

Frequently asked questions

How long does it take to publish?

Median time from submission to first editorial decision is 3 days. Median time from submission to acceptance is 21 days.

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What are the publication costs?

Institutional online access is available for purchase through a Springer Nature institutional licence.

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Research Topics

CRISPR and Genetic Engineering Genomics and Chromatin Dynamics RNA and protein synthesis mechanisms Epigenetics and DNA Methylation RNA modifications and cancer RNA Research and Splicing Chromosomal and Genetic Variations Genomics and Rare Diseases Genomics and Phylogenetic Studies Genetic Associations and Epidemiology Evolution and Genetic Dynamics Single-cell and spatial transcriptomics Animal Genetics and Reproduction Bioinformatics and Genomic Networks Genomic variations and chromosomal abnormalities Cancer Genomics and Diagnostics Genetic Mapping and Diversity in Plants and Animals Gene Regulatory Network Analysis Pluripotent Stem Cells Research Gene expression and cancer classification Genetics and Neurodevelopmental Disorders Developmental Biology and Gene Regulation Genetic diversity and population structure Genetics, Aging, and Longevity in Model Organisms Cancer-related molecular mechanisms research

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