Overview
Submission Instructions
Recent Publications
Frequently Asked Questions
Research Topics
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PA
Pain and Therapy is an international, open access, peer-reviewed rapid publication journal focused on high-quality clinical, observational, real-world, and health outcomes research on the discovery, development, and use of pain therapies and pain-related devices. It also encourages studies related to diagnosis, pharmacoeconomics, public health, quality of life, and patient care, management, and education.
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Subject
Clinical Neurology
Impact Factor
3.3
Quartile
Q2
Open Access Type
Open
ISSN
2193-8237
eISSN
2193-651X
Invitation Only
No
Cost Range
£5120.00 GBP / $7675.00 USD / €5950.00 EUR APC; VAT or local taxes may apply.
Submission Instructions
Pain and Therapy accepts the following article types. Click on an article type to view submission instructions.
Original Research
Cover Letter
Cover Letter requirements are not specified.
Abstract
An abstract is required. Abstract must be no more than 300 words. Abstract must be structured. Abstract headings must be Introduction, Methods, Results, and Conclusion.
Manuscript
Original Research articles should be around 4000 words but are not limited to that length. Main text should use the headings Introduction, Methods, Results, and Conclusion. Manuscript must include 3 to 10 keywords, 4-5 single-sentence key summary points using 'Why carry out this study?' and 'What was learned from the study?', an author contribution statement, a Declarations section before the references, an acknowledgements section before the references, and documentation of any Large Language Model use in the Methods section.
References
References must use the Vancouver system. In-text citations must be Arabic numerals in square brackets, references must be listed in the order cited, and references with up to six authors list all authors while those with more than six list the first three followed by et al.
Figures & Tables
Tables must be included in the manuscript, figure legends must appear in the manuscript after the references, and each figure must be submitted as a separate file. Figures and tables must be cited in the text and numbered consecutively, figure parts should use lower-case roman letters, tables must have a concise title and be provided in an editable format, and figure legends must explain all abbreviations, colours, and symbols.
Reviews
Cover Letter
Cover Letter requirements are not specified.
Abstract
An abstract is required for Reviews and it does not need to be structured. The abstract must be no more than 300 words. The abstract may be unstructured for Reviews.
Manuscript
There is no word limit for Reviews. The title must indicate the format of the Review. The manuscript must include 4–5 single-sentence key summary points, a Declarations section before the references, an author contribution statement describing who had the idea for the article, who performed the literature search and data analysis, and who drafted and/or critically revised the work, and, if applicable, the sentence stating that the article is based on previously conducted studies and contains no new studies with human participants or animals performed by the authors.
References
References must use the Vancouver system. References must include only works cited in the text, list up to six authors in full or the first three followed by et al. if there are more than six, use Arabic numerals in square brackets for in-text citations, and be ordered to match the citation sequence in the text.
Figures & Tables
Tables and figure legends must be included in the manuscript, and each figure must be submitted as a separate file. Figures and tables must be cited and numbered consecutively in the text, and tables must be provided in an editable format rather than as images.
Narrative Review
Cover Letter
Cover Letter requirements are not specified.
Abstract
An abstract is required for Narrative Reviews. Abstract must be no more than 300 words. Review abstracts do not need to be structured.
Manuscript
There is no word limit for Reviews. The title must indicate the format of the Review. The manuscript must include 4-5 single-sentence key summary points, a disclosure statement, a Declarations section before the references, an author contribution statement indicating who conceived the article, performed the literature search and data analysis, and drafted and or critically revised the work, and for articles without author-conducted human or animal studies the exact sentence stating that the article is based on previously conducted studies and contains no new studies with human participants or animals performed by the authors.
References
References must use the Vancouver system. Only works cited in the text should appear in the reference list, references should be numbered in text with Arabic numerals in square brackets in sequential order, and references with up to six authors should list all authors while those with more than six should list the first three followed by et al.
Figures & Tables
Tables and figure legends must be included in the manuscript file, while each figure must be submitted as a separate file. All figures and tables must be cited in the text and numbered consecutively, with figure parts identified by lower-case roman letters and tables supplied in an editable format.
Systemic Review
Cover Letter
Cover Letter requirements are not specified.
Abstract
An abstract is required. Abstract must be no more than 300 words. Abstract does not need to be structured.
Manuscript
There is no word limit for Systemic Review articles. Title must indicate the review format. Manuscript must include 3 to 10 keywords, 4-5 single-sentence key summary points, a Declarations section before the references, an author contribution statement including who conceived the article, performed the literature search and data analysis, and drafted or critically revised the work, documentation of any Large Language Model use in the Methods or another suitable section, and the specified no-new-studies statement when applicable.
References
References must use the Vancouver system. In-text citations must be Arabic numerals in square brackets, references must be listed in citation order, and references with up to six authors list all authors while those with more than six list the first three followed by et al.
Figures & Tables
Tables must be included in the manuscript, figure legends must appear in the manuscript after the references, and each figure must be submitted as a separate file. Figures and tables must be cited in the text and numbered consecutively, figure parts should use lower-case roman letters, tables must have a concise title, and tables must be provided in an editable format rather than as images.
Brief Reports
Cover Letter
The cover letter must mention any unpublished material included in the manuscript and provide transparency on any re-use of material.
Abstract
An abstract is required. The abstract must be no more than 300 words. The abstract must be structured. The abstract should use the headings Introduction, Methods, Results, and Conclusion.
Manuscript
Brief Reports should be around 2000-3000 words. The main text should use the headings Introduction, Methods, Results, and Conclusion. The manuscript must include 3 to 10 keywords, 4-5 single-sentence bullet-point key summary points below the abstract, an author contribution statement, a Declarations section before the references, and documentation of any Large Language Model use in the Methods section or another suitable section if no Methods section is available.
References
References must use the Vancouver system. In-text citations must be Arabic numerals in square brackets, the reference list must follow citation order, and references with up to six authors list all authors while those with more than six list the first three followed by et al.
Figures & Tables
Tables and figure legends must be included in the manuscript, while each figure must be submitted as a separate file. Figures and tables must be cited in the text and numbered consecutively, figure parts should use lower-case roman letters, tables must be editable rather than images, and legends or titles are required.
Case Series
Cover Letter
Cover Letter requirements are not specified.
Abstract
An abstract is required. Abstract must be up to 300 words.
Manuscript
Case Series should be around 3000 words. Case Series should follow the structure Abstract; Introduction; Case presentations; Discussion; Conclusion(s); Acknowledgements; References. The manuscript must include 4-5 single-sentence key summary points below the abstract stating what is unique about the case and what it adds to the current literature, an author contribution statement, a Declarations section before the references, and 3 to 10 keywords.
References
References must use the Vancouver system. In-text citations must be Arabic numerals in square brackets, references must be listed in citation order, and references with up to six authors list all authors while those with more than six list the first three followed by et al.
Figures & Tables
Tables must be included in the manuscript, figure legends must appear in the manuscript after the references, and each figure must be submitted as a separate file. Figures and tables must be cited in the text and numbered consecutively, figure parts should use lower-case roman letters, tables must be editable rather than images, and figure legends must explain all abbreviations, colours, and symbols.
Case Report
Cover Letter
Cover Letter requirements are not specified.
Abstract
An abstract is required. Abstract must be up to 300 words.
Manuscript
Case Reports should be around 2000 words. The manuscript must include 3 to 10 keywords, 4 to 5 single-sentence key summary points stating what is unique about the case and what it adds to the current literature, an acknowledgements section, and a Declarations section before the references.
References
References must use the Vancouver system. In-text citations must be Arabic numerals in square brackets, the reference list must follow citation order, and references with more than six authors must list the first three followed by et al.
Figures & Tables
Tables must be included in the manuscript, figure legends must appear in the manuscript after the references, and each figure must be submitted as a separate file. All figures and tables must be cited in the text and numbered consecutively, and tables must be provided in an editable format.
Guidelines
Cover Letter
Cover letter must mention any unpublished material included in the manuscript and provide transparency on any re-use of material.
Abstract
Abstract is required. Abstract must be no more than 300 words.
Manuscript
Guidelines should be around 10,000–15,000 words. Manuscript must include 3 to 10 keywords, 4–5 single-sentence bullet-point key summary points below the abstract, an author contribution statement, a Declarations section before the references, an Acknowledgements section, and the disclaimer "Springer Healthcare is not responsible for the validity of guidelines it publishes."
References
References must use the Vancouver system. In-text citations must be Arabic numerals in square brackets, references must be listed in citation order, and references with more than six authors must list the first three followed by et al.
Figures & Tables
Tables must be included in the manuscript, figure legends must appear in the manuscript after the references, and each figure must be submitted as a separate file. Figures and tables must be cited in the text and numbered consecutively throughout.
Letter To The Editor
Cover Letter
Cover letter should mention any unpublished material included in the manuscript and provide transparency on any re-use of material.
Abstract
Abstract is not mandatory for this article type. If included, the abstract may be up to 300 words.
Manuscript
Letter to the Editor should be around, but is not limited to, 1000 words. Letter to the Editor should comment on a recently published article in the journal. Manuscript must include a Declarations section before the references, an author contribution statement, 3 to 10 keywords, and key summary points are not mandatory.
References
References must use the Vancouver system. In-text citations must be Arabic numerals in square brackets, references must be listed in the order cited, and references with up to six authors list all authors while those with more than six list the first three followed by et al.
Figures & Tables
Tables and figure legends must be included in the manuscript, while each figure must be submitted as a separate file. Figures and tables must be cited in the text and numbered consecutively throughout.
Recent Publications
Comparative Efficacy of Non-invasive Brain Stimulation for Pain, Anxiety, and Depression: A Systematic Review and Network Meta-analysis
Yan Li, Xiangyin Ye, Shufang Li, Jing Xu, Hongyuan Wang, Lina Pang, Yuanlin Li, Song Jin
10.1007/s40122-026-00860-9
View Publication
Real-World Complication Profiles of Fully and Semi-Implanted Intrathecal Drug Delivery Systems for Cancer Pain: A Large Single-Center Chinese Cohort
Zikun Ning, Zheng Zou, Shunxin Liu, Hui Pan, Huaiming Wang, Pengjiu Feng, Aimin Zhang
10.1007/s40122-026-00862-7
View Publication
Durable Outcomes and Intervention Avoidance in Low Back Pain Up to 5 Years After Percutaneous 60-Day Peripheral Nerve Stimulation
Samir J. Sheth, Denise D. Lester, Jaudat Mahmood, Sarah E. Trampota, G. Lawson Smith, Raheleh Rahimi Darabad, Brandon D. Swan, Meredith J. McGee, Joseph W. Boggs
10.1007/s40122-026-00858-3
View Publication
French National Guidelines for the Appropriate Use of Opioids: Analgesia, Opioid Use Disorder, and Overdose Prevention—Part 1: Methodology and Pain Management
Célian Bertin, Julie Dupouy, Nicolas Authier, Nathalie Michenot, Sidonie Verdier, Mathieu Chappuy, Anne-Priscille Trouvin
10.1007/s40122-026-00853-8
View Publication
French National Guidelines for the Appropriate Use of Opioids: Analgesia, Opioid Use Disorder, and Overdose Prevention—Part 2: Prevention and Management of Opioid Use Disorder and Overdose
Célian Bertin, Julie Dupouy, Nicolas Authier, Nathalie Michenot, Sidonie Verdier, Mathieu Chappuy, Anne-Priscille Trouvin
10.1007/s40122-026-00852-9
View Publication
Frequently asked questions
How long does it take to publish?
The journal aims for a 2-week peer review, 3-4 weeks from acceptance to online publication, and a median submission-to-first-decision time of 2 days.
Reformat to Pain and Therapy using Livewrite PremiumIs a cover letter required?
A cover letter may include information on unpublished material and transparency on re-use of material, and authors can suggest peer reviewers in the cover letter.
Reformat to Pain and Therapy using Livewrite PremiumWhat are the publication costs?
The current APC is £5120.00 GBP / $7675.00 USD / €5950.00 EUR for each accepted article; VAT or local taxes may apply.
Reformat to Pain and Therapy using Livewrite PremiumResearch Topics
Anesthesia and Pain Management
Pain Management and Opioid Use
Pain Mechanisms and Treatments
Musculoskeletal pain and rehabilitation
Spine and Intervertebral Disc Pathology
Migraine and Headache Studies
Pain Management and Treatment
Opioid Use Disorder Treatment
Pediatric Pain Management Techniques
Nausea and vomiting management
Myofascial pain diagnosis and treatment
Trigeminal Neuralgia and Treatments
Cancer, Stress, Anesthesia, and Immune Response
Anesthesia and Sedative Agents
Enhanced Recovery After Surgery
Fibromyalgia and Chronic Fatigue Syndrome Research
Neurological Complications and Syndromes
Pain Management and Placebo Effect
Herpesvirus Infections and Treatments
Inflammatory mediators and NSAID effects
Shoulder Injury and Treatment
Cardiac, Anesthesia and Surgical Outcomes
Traumatic Brain Injury Research
Botulinum Toxin and Related Neurological Disorders
Cervical and Thoracic Myelopathy