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Alzheimer s & Dementia Translational Research & Clinical Interventions

Alzheimer's & Dementia: Translational Research & Clinical Interventions (TRCI) is an open access journal that seeks to bridge drug discovery research and clinical studies for dementia and Alzheimer's disease. It publishes preclinical and clinical translational research, including disease biology, therapeutic development, observational and interventional human studies, precision medicine approaches, clinical trial design and outcomes, and related health economics focused on therapeutic development and treatment.

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Subject Clinical Neurology, Neurosciences
Impact Factor 6.8
Quartile Q1
Open Access Type Open
eISSN 2352-8737
Invitation Only No
Cost Range No submission fee; APC applies for open access publication, with a 50% discount for ISTAART members and additional waivers and discounts for authors in developing countries.

Submission Instructions

Alzheimer s & Dementia Translational Research & Clinical Interventions accepts the following article types. Click on an article type to view submission instructions.

Review Articles

Cover Letter Cover Letter requirements are not specified.
Abstract An abstract is required for Review Articles. The abstract should be approximately 300 words.
Manuscript Review Articles may not exceed 10,000 words, excluding the abstract, references, figures, and tables. Articles must be divided into clearly defined and numbered sections with hierarchical subsection numbering where applicable. The manuscript must include keywords, mandatory highlights submitted in a separate editable file, a competing interests statement, and disclosure of any AI-assisted tool use in the Methods or Acknowledgments section.
References There is no reference limit for Review Articles. References must be cited by number in square brackets in the text and listed in numbered order of first appearance.
Figures & Tables Review Articles may include no more than six figures or tables. Figures and tables must be uploaded separately from the manuscript. Figures must include captions and tables must include titles, descriptions, and footnotes.
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Systematic Reviews

Cover Letter Cover Letter requirements are not specified.
Abstract An abstract is required. Abstract must not exceed 300 words.
Manuscript Articles must be divided into clearly defined and numbered sections with hierarchical subsection numbering. The manuscript must include keywords and a competing interests statement, and mandatory highlights must be submitted in a separate editable file; any use of AI-assisted tools must be disclosed in the Methods or Acknowledgments section.
References References must be cited by number in square brackets. The reference list must be numbered in the order of appearance in the text, journal names should be abbreviated according to the List of Title Word Abbreviations, and references cited in the abstract must be given in full.
Figures & Tables All figures and all tables must be uploaded, with each illustration submitted as a separate file. Figures must include separate captions and be numbered in sequence in the text, while tables must include titles, descriptions, and footnotes and be numbered consecutively in the order cited.
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Meta-Analyses

Cover Letter Cover Letter requirements are not specified.
Abstract An abstract is required. Abstract must not exceed 300 words.
Manuscript Articles must be divided into clearly defined and numbered sections with hierarchical subsection numbering. The manuscript must include keywords, mandatory highlights submitted in a separate editable file, a competing interests statement, and disclosure of any AI-assisted tools used in the Methods or Acknowledgments section.
References References must be cited by number in square brackets. The reference list must be numbered in the order of first appearance in the text and journal names should be abbreviated according to the List of Title Word Abbreviations.
Figures & Tables All figures and tables must be uploaded, with each illustration submitted as a separate file and captions provided separately for figures. Figures must be numbered in sequence with matching in-text citations, and tables must be numbered consecutively with titles, descriptions, and footnotes.
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Narrative Reviews

Cover Letter Cover Letter requirements are not specified.
Abstract An abstract is required. Abstract must be 300 words or less.
Manuscript Articles must be divided into clearly defined and numbered sections with hierarchical subsection numbering. The manuscript must include keywords and a competing interests statement, highlights must be submitted in a separate editable file, and any use of AI-assisted tools must be disclosed in the Methods or Acknowledgments section.
References References must be cited by number in square brackets. The reference list must be numbered in the order of first appearance in the text and journal names should be abbreviated according to the List of Title Word Abbreviations.
Figures & Tables All figures and tables must be uploaded, with each illustration submitted as a separate file and captions provided separately for illustrations. Figures must be numbered according to their sequence in the text, and tables must be numbered consecutively in accordance with their appearance in the text.
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Research Articles

Cover Letter Cover Letter requirements are not specified.
Abstract A structured abstract is required for Research Articles. Abstract must not exceed 300 words. Abstract must be structured.
Manuscript Manuscript must not exceed 3,500 words excluding the abstract, references, figures, and tables. Manuscript must include the sections Background, Methods, Results, Discussion, References, Acknowledgements/Conflicts/Funding Sources, Key Words, and a Research in Context section with the subheadings systematic review, interpretation, and future directions. Manuscript must include keywords, mandatory highlights in a separate editable file, and disclosure of any use of AI or AI-assisted tools in the Methods or Acknowledgments section.
References References are limited to a maximum of 50. References must be cited by number in square brackets. Reference list must be numbered in the order of first appearance in the text, and journal names should be abbreviated according to the List of Title Word Abbreviations.
Figures & Tables No more than six figures, boxes, or tables may be included. Figures and tables must be uploaded separately, with each illustration submitted as a separate file. Figures must include captions, tables must include titles, descriptions, and footnotes, and all figure and table citations in the text must match the files provided.
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Short Reports

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract is required. Abstract must not exceed 300 words.
Manuscript Manuscript must not exceed 1,500 words excluding the abstract, references, figures, and tables. Manuscript must use IMRAD format with the headings INTRODUCTION, METHODS, RESULTS, and DISCUSSION in uppercase letters followed by a colon and space. Manuscript must include keywords, mandatory highlights submitted in a separate editable file, a competing interests statement, AI tool use disclosures in the Methods or Acknowledgments section when applicable, and a Research in Context section with the subheadings systematic review, interpretation, and future directions, with a Research in Context summary for online submission of 150 words or less.
References References are limited to a maximum of 20. References must be cited by number in square brackets in the text and listed in numerical order of first appearance, with journal names abbreviated according to the List of Title Word Abbreviations.
Figures & Tables No more than two figures, boxes, or tables may be included. Figures and tables must be uploaded, with each illustration submitted as a separate file and captions for illustrations provided separately. Figures and tables must be numbered consecutively in the order cited in the text, figure citations and table citations must match the files provided, figures must include captions, and tables must include titles, descriptions, and footnotes.
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Letters To The Editor

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract is required. Abstract must not exceed 300 words.
Manuscript Manuscript must not exceed 750 words. Letter must relate to content of earlier issues of the journal. Manuscript must include keywords, mandatory highlights submitted in a separate editable file, a competing interests statement, and disclosure of any AI-assisted tools used in the Methods or Acknowledgments section.
References References are limited to a maximum of 10. References must be cited by number in square brackets. Reference list must be numbered in the order of first appearance in the text, and journal names should be abbreviated according to the List of Title Word Abbreviations.
Figures & Tables No more than one figure may be included. Figures and tables must be uploaded separately from the manuscript. Figures must include captions, tables must include titles, descriptions, and footnotes, and all figure and table citations in the text must match the files provided.
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Recent Publications

Association of Excessive Daytime Sleepiness With Long‐Term Incident Dementia: The Role of β‐Amyloid and White Matter Injury

Xiaowen Zhou, Guangshi Zhang, Qili Hu, Hanyu Shao, Tao Yang, Jie Wang, Xiaoniu Liang, Qianhua Zhao, Ding Ding

10.1002/trc2.70272
View Publication

Peripheral immune markers in dementia: A systematic review and meta‐analysis of risk, severity, and pathological correlates

Ahmad A. Toubasi, Thuraya N. Al‐Sayegh

10.1002/trc2.70270
View Publication

Virtual reality‐based cognitive‐motor training in middle‐aged adults at high Alzheimer's disease risk improves frontal cortex cerebral blood flow: A randomized controlled trial

Maayan Harel, Anat Leibovici, Nofar Itzhaki, Ramit Ravona‐Springer, Erin Moshier, Glen M. Doniger, Amihai Gottlieb, Yotam Bahat, Barbara B. Bendlin, Gabi Zeilig, Meir Plotnik, Michal Schneider Beeri, Abigail Livny

10.1002/trc2.70265
View Publication

APOE ‐associated disease risk and sex‐specific effects in Egyptian Alzheimer's disease: an exploratory study

Mai Othman, Eman Khedr, Shimaa Heikal, Mohamed H. Yousef, Gharib Fawi, Sara El Farrash, Samer Salama, Muhammad Abdelshafi, Nesma G. Elsheikh, Heba M. Tawfik, Hany I. Hassanin, Nourelhoda A. Haridy, Gellan K. Ahmed, Noha Abo Elftoh, Amna Ibrahim, Ahmed Qayaty, Eman M. Ali, Agsha Atputhavadivel, Samir Shamma, Noha A. Yousri, Mie Rizig, Mohamed Salama

10.1002/trc2.70268
View Publication

Reframing Alzheimer's disease as a complex adaptive system: More than an amyloid beta–tau connection

Maurizio Giorelli

10.1002/trc2.70256
View Publication

Frequently asked questions

How long does it take to publish?

Median submission to first decision is 19 days, median submission to acceptance is 104 days, and median acceptance to publication is 36 days.

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Is a cover letter required?

A submission letter should include the names, mailing addresses, phone and fax numbers, and e-mail addresses of 5-7 potential reviewers with appropriate expertise.

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What are the publication costs?

The journal operates an open access model and does not charge submission fees. APCs apply, with a 50% discount for ISTAART members and additional waivers and discounts for eligible authors in developing countries.

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Research Topics

Dementia and Cognitive Impairment Research Alzheimer's disease research and treatments Geriatric Care and Nursing Homes Functional Brain Connectivity Studies Cholinesterase and Neurodegenerative Diseases Ethics in Clinical Research Health Systems, Economic Evaluations, Quality of Life Neurological Disease Mechanisms and Treatments Traumatic Brain Injury Research Cancer-related cognitive impairment studies Intensive Care Unit Cognitive Disorders Palliative Care and End-of-Life Issues Health, Environment, Cognitive Aging Schizophrenia research and treatment Neuroinflammation and Neurodegeneration Mechanisms Older Adults Driving Studies Frailty in Older Adults Mental Health and Patient Involvement Phosphodiesterase function and regulation Diverse Scientific and Economic Studies Human auditory perception and evaluation Amyotrophic Lateral Sclerosis Research Neurological Disorders and Treatments Nutritional Studies and Diet Intracerebral and Subarachnoid Hemorrhage Research

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