AJ

American Journal Of Pathology

The American Journal of Pathology is the official journal of the American Society for Investigative Pathology and publishes high-quality original research reports, reviews, and commentaries related to the molecular and cellular basis of disease, including basic, translational, and clinical investigations that address mechanisms of pathogenesis or provide a foundation for future mechanistic inquiry.

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Subject Pathology
Impact Factor 3.6
Quartile Q1
Open Access Type Hybrid
ISSN 0002-9440
eISSN 1525-2191
Invitation Only No
Cost Range Article Publishing Charge (APC) for all articles: USD 3500 excl. taxes; ASIP corresponding-author discounts may apply.

Submission Instructions

American Journal Of Pathology accepts the following article types. Click on an article type to view submission instructions.

Regular Articles

Cover Letter A cover letter is required. It must state any financial and personal conflicts of interest and affirm that the manuscript has not been published previously, is not under concurrent consideration elsewhere, and has been approved by all authors and acknowledged contributors.
Abstract An abstract is required. 220 words or less. Unstructured.
Manuscript Regular Articles have no official limits to word count. The text should be organized as Introduction, Materials and Methods, Results, and Discussion in that order. First-person personal pronouns should be kept to a minimum.
References References should begin on a new page.
Figures & Tables Regular Articles have no official limits to the number of tables and figures that can be included. All labels in figures must be sized so they are legible in print.
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Reviews

Cover Letter A cover letter is required. The cover letter must disclose financial and personal conflicts of interest and affirm that the manuscript has not been published previously, is not under concurrent consideration, and has been approved by all authors and acknowledged contributors.
Abstract An abstract is required. 220 words or less. Unstructured.
Manuscript Reviews have a maximum of 6,000 words. Reviews should include Introduction, Materials and Methods, Results, and Discussion in that order. The manuscript must include a separate AI declaration statement if AI tools were used for manuscript preparation.
References Reviews have a maximum of 150 references. References should begin on a new page.
Figures & Tables Reviews have a maximum of 4 tables or figures and must include one mechanistic table or figure. All labels in figures must be sized so they are legible in print.
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Mini-Reviews

Cover Letter A cover letter is required. The cover letter must state any financial and personal conflicts of interest, affirm that the manuscript has not been published previously, affirm that it is not being considered concurrently elsewhere, and affirm that all authors and acknowledged contributors have read and approved the manuscript.
Abstract An abstract is required. Abstract must be 220 words or less. Unstructured.
Manuscript Mini-Reviews must not exceed 4,000 words. The text should include Introduction, Materials and Methods, Results, and Discussion in this order. Mini-Reviews must include one mechanistic table or figure, and supplemental data should not be used to expand beyond the listed parameters.
References References requirements are not specified.
Figures & Tables Mini-Reviews must include one mechanistic table or figure. All labels in figures must be sized so they are legible in print.
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Short Communications

Cover Letter A cover letter is required. The cover letter must state any financial and personal conflicts of interest, affirm that the manuscript has not been published previously, affirm that it is not being considered concurrently by another publication, and affirm that all authors and acknowledged contributors have read and approved the manuscript.
Abstract An abstract is required. The abstract must be 220 words or less. The abstract must be unstructured.
Manuscript Short Communications must not exceed 12 double-spaced typed pages, excluding references and legends. The text should include Introduction, Materials and Methods, Results, and Discussion in that order. The manuscript must include a title page, and authors who use AI tools for manuscript preparation must include a separate AI declaration statement in the manuscript upon submission.
References References should begin on a new page.
Figures & Tables Short Communications are limited to a maximum of 4 combined figures and tables. Figures and tables should not circumvent length limits by excessive supplemental data.
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Letters To The Editor

Cover Letter A cover letter is required. The cover letter must state financial and personal conflicts of interest, affirm that the manuscript has not been published previously, affirm that it is not being considered concurrently elsewhere, and affirm that all authors and acknowledged contributors have read and approved the manuscript.
Abstract Abstract requirements are not specified.
Manuscript The text should include Introduction, Materials and Methods, Results, and Discussion in that order. A separate AI declaration statement is required if AI tools are used for manuscript preparation.
References References should begin on a new page.
Figures & Tables All labels in figures must be legible in print, and tables should be typed double-spaced.
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Recent Publications

REGγ Links Inflammation to Fibrosis in Post-Necrotizing Enterocolitis Intestinal Strictures by Activating TGF-β/Smad3 Signaling

Xiangzhan Zhu, Ya Li, Hongyan Wu, Lihua He, Chengbo Wang, Rui Jia, Minglei Yang, Xianliang Wang, Faisal Aziz, Bianhong Zhang, Deng pan, Jingyu Cao

10.1016/j.ajpath.2026.05.003
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Macrophage polarization and spatial architecture characterize the tumor immune microenvironment and prognosis in hepatoblastoma

Ville J. Väyrynen, Katja Eloranta, Markus Talka, Antti Tuhkala, Jouko Lohi, Markku Varjosalo, Antti Kyrönlahti, Sirpa Jalkanen, Maija Hollmén, Marjut Pihlajoki, Markku Heikinheimo

10.1016/j.ajpath.2026.05.006
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Low-Dose Radiotherapy Attenuates Pulmonary Granulomas involving ATM-Dependent Modulation of the IFN-β Response: A Host-Directed Therapeutic Strategy for Tuberculosis

Ha-Yeon Song, Bo-Gyeong Yoo, Jang Woo Park, Eui-Baek Byun

10.1016/j.ajpath.2026.05.005
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APOE4 Increases Systemic Inflammation and Alters Metabolic and Neuroprotective Pathways following Multi-Agent Chemotherapy in Older Human APOE Knock-In Mice

Aisha Naeem, Michaela McCormack, Ryan Lein, Maria Sanchez Perez, Grace Knoer, Salma Garcia, Madelyn Kausch, Yichien Lee, Judith Carroll, Steve Cole, Jaeil Ahn, Ruzong Fan, Jeff Dage, Adrian Oblak, Naazneen Khan, G. William Rebeck, Maria Laura Avantaggiati, Jeanne Mandelblatt, Christopher Albanese, Olga Rodriguez

10.1016/j.ajpath.2026.05.004
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Editorial Board

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10.1016/s0002-9440(26)00109-4
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Frequently asked questions

How long does it take to publish?

Average time to desk rejection was 2.4 days in 2023. External review is targeted for completion within 35 days of receipt. Appeals must be submitted within 60 days.

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Is a cover letter required?

A cover letter is required and must state conflicts of interest, affirm that the manuscript has not been published previously or submitted concurrently elsewhere, and affirm that all authors and acknowledged contributors have read and approved the manuscript.

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What are the publication costs?

Open access publication requires an APC of USD 3500 excl. taxes for all articles. Subscription publication has no open access publication fee.

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Research Topics

Cell Adhesion Molecules Research Angiogenesis and VEGF in Cancer Alzheimer's disease research and treatments Liver physiology and pathology Protease and Inhibitor Mechanisms Immune Response and Inflammation Immune Cell Function and Interaction Cancer Cells and Metastasis Wnt/β-catenin signaling in development and cancer Liver Disease Diagnosis and Treatment Cancer-related Molecular Pathways Epigenetics and DNA Methylation Cancer, Hypoxia, and Metabolism Neuroinflammation and Neurodegeneration Mechanisms Muscle Physiology and Disorders Neonatal Respiratory Health Research Immunotherapy and Immune Responses Renal and related cancers Cancer-related gene regulation T-cell and B-cell Immunology Health Sciences Research and Education Child and Adolescent Health Nursing Education, Practice, and Leadership Renal Diseases and Glomerulopathies Genetic factors in colorectal cancer

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