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Cancer Cell

Cancer Cell advances a systemic understanding of cancer as a dynamic interplay between tumor cells, microenvironment, microbiota, nervous system, and host physiology. It bridges foundational discoveries and clinical innovation through bidirectional translation, integrating disciplines and transformative technologies including AI, spatial multi-omics, single-cell sequencing, and functional genomics to decode cancer's complexity.

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Subject Oncology
Impact Factor 44.5
Quartile Q1
Open Access Type Hybrid
ISSN 1535-6108
eISSN 1878-3686
Invitation Only No
Cost Range Article publishing charge: $10,400 for open access publication.

Submission Instructions

Cancer Cell accepts the following article types. Click on an article type to view submission instructions.

Article

Cover Letter A cover letter is required. Cover letter must explain what was previously known, the conceptual advance provided by the work, the significance and potential impact of the work, and whether the paper is part of a consortium.
Abstract A summary is required. Summary must be a single paragraph of no more than 150 words. Summary must be unstructured as a single paragraph. Summary must include the background or purpose, principal results, approaches or model systems, major conclusions, and broader significance, and it must not include references.
Manuscript Article manuscripts must contain no more than 7,000 words, including main figure legends but excluding STAR Methods text, supplemental item legends, and references. Manuscript must include an Introduction without subheadings, a Results section divided into short informative subsections, a required Resource Availability section with the subsections Lead Contact, Materials Availability, and Data and Code Availability, and STAR Methods for acceptance. Manuscript must include up to 10 comma-separated keywords after the summary, highlights in a separate Word document with up to four bullet points of no more than 85 characters each, an eTOC blurb of no more than 50 words in up to two sentences, required author contributions and declaration of interests sections, a generative AI declaration section only if applicable, a supplemental information heading listing supplemental files, a figures section containing all figure titles and legends, and a separate Graphical Abstract and Key Resources Table.
References References must be numbered sequentially by first citation, cited in the text as superscript numbers, use et al. only after 10 author names, and each reference must contain only one article.
Figures & Tables Article manuscripts must include no more than eight figures and/or tables. Figure titles and legends must appear in a single figures section within the main-text manuscript, tables must appear at the end of the manuscript after the figure legends, and main figures must also be uploaded individually. Each figure must have a descriptive title and legend with all panels together on one page, and tables must be editable Word tables with titles and no panel subdivisions such as Table 1A or Table 1B.
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Report

Cover Letter A cover letter is required. The cover letter must explain what was previously known, the conceptual advance provided by the work, the significance and potential impact of the work, and whether the paper is part of a consortium.
Abstract A summary abstract is required. The summary must be a single paragraph of no more than 150 words. The summary must be unstructured as a single paragraph. The summary must include the background or purpose, principal results, approaches or model systems, major conclusions, and broader significance, and it must not include reference citations.
Manuscript Report manuscripts must contain no more than 4,000 words, including main figure legends but excluding STAR Methods text, supplemental item legends, and the references section. The manuscript must include an introduction without subheadings, a results section divided into short informative subsections, a required Resource Availability section with the subsections Lead Contact, Materials Availability, and Data and Code Availability, and STAR Methods for acceptance. Up to 10 keywords may be included after the summary, highlights and an eTOC blurb must be provided in a separate Word document, the manuscript must include author contributions and a declaration of interests, and a declaration of generative AI and AI-assisted technologies in the writing process is required only if such tools were used.
References References must be numbered sequentially by first citation, cited in the text as numbered superscripts, use "et al." only after 10 author names, and include only published or in-press items in the reference list.
Figures & Tables Report manuscripts must include no more than four figures and/or tables. Figure titles and legends must appear in a single figures section within the main-text manuscript, main-text tables must appear at the end of the manuscript after the figure and scheme legends, and additional figure files must be uploaded individually. Each figure must have a descriptive title and legend and be cited in numerical order, and tables must be editable, numbered consecutively, include a title, and not be divided into panels.
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Review

Cover Letter A cover letter is required. Cover letter must explain what was previously known, the conceptual advance provided by the work, the significance and potential impact of the work, and whether the paper is part of a consortium.
Abstract An abstract is required. Abstract must be no more than 150 words. Abstract should consist of a single paragraph.
Manuscript Review articles are usually 5,000 to 8,000 words in length, including the abstract. Manuscript must include highlights, an eTOC blurb, an author contributions section, a declaration of interests section, a Graphical Abstract, and a declaration of generative AI and AI-assisted technologies in the writing process if such tools were used.
References Review articles must include no more than 150 references. References must be sequentially numbered by first citation and cited in the text using numbered superscripts, with "et al." used only after 10 author names.
Figures & Tables Review articles must include three to five display items, defined as figures or tables. Figure titles and legends must appear in a single figures section within the main-text manuscript, tables must appear at the end of the manuscript after the figure and scheme legends, and main figures must also be uploaded individually. Figures and tables must be cited in numerical order, each figure must have a descriptive title and legend, and tables must be editable, numbered, titled, and not divided into panels.
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Recent Publications

Bridging clinical gaps in personalized cancer neoantigen vaccines

Karam Khaddour, Patrick A Ott

10.1016/j.ccell.2026.04.002
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Extracellular vesicles: Whisperers of tumor immune evasion

An Hendrix, Olivier De Wever

10.1016/j.ccell.2026.03.010
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Cancer stem cells orchestrate immune evasion through extracellular vesicle-mediated non-canonical signaling pathways

Guangjian Fan, Juan Jin, Jie Wang, Jingxuan Xu, Weiyu Ge, Suling Liu, Lei Tang, Wumaier Reziya, Xiaoyi Yang, Junjian Li, Lai Guan Ng, Lijun Di, Yuanting Zheng, Fei Lan, Shizhuo Chen, Yan Zhang, Xin Wang, Dong Gao, Xindong Liu, Haoyu Sun, Yinbing Liu, Ting Li, Yiqun Cao, Zhonghua Tao, Wenting Liu, Hongxia Wang

10.1016/j.ccell.2026.04.004
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Whole-genome doubling drives immune evasion by silencing antigen presentation

Pierre Foidart, Zheqi Li, Xinran Cai, Marco Seehawer, Daniel D. Brown, Amatullah Tawawalla, Pilar Baldominos, Salma Parvin, Jun Nishida, Ernesto Rojas-Jimenez, Triet M. Bui, Benedetto Diciaccio, Rahul Kumar, Brent T. Schlegel, Marie-Anne Goyette, TashJae Scales, Pengze Yan, Xintao Qiu, Rong Li, Yijia Jiang, Yingtian Xie, Mahmoud Aarabi, Xiao-Yun Huang, Laura E. Stevens, Paloma Cejas, Lise Mangiante, Cristina Irene Sotomayor Vivas, Kathleen E. Houlahan, Christina Curtis, Steffi Oesterreich, Isaac S. Harris, Anthony G. Letai, Adrian V. Lee, Henry W. Long, Judith Agudo, Kornelia Polyak

10.1016/j.ccell.2026.04.007
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Dendritic cell redundancy enables priming of anti-tumor CD4+ T cells in pancreatic cancer

Courtney T.S. Kureshi, Michael J. Walsh, Rakeeb Kureshi, Victoire Cardot-Ruffino, Dennis A. Agardy, Lestat R. Ali, James M. Dougan, Li Qiang, Jiao Shen, Chong Zuo, Patrick J. Lenehan, S. Jennifer Wang, Eugena Chang, Joshua Remland, Lauren Brais, Thomas E. Clancy, James M. Cleary, Jason L. Hornick, Brandon M. Huffman, Joseph D. Mancias, George Molina, Mark Fairweather, Jonathan A. Nowak, Kimberly J. Perez, Douglas A. Rubinson, Sarah Slater, Ritchell van Dams, Jiping Wang, Brian M. Wolpin, Lei Zhao, Katharine Barrientos, Ruslan Novosiadly, Miranda Broz, Harshabad Singh, Michael Dougan, Stephanie K. Dougan

10.1016/j.ccell.2026.04.005
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Frequently asked questions

How long does it take to publish?

Median 5 days from submission to first editorial decision and median 23 days from acceptance to online publication.

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Is a cover letter required?

A cover letter is included among the required materials to prepare for submission.

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What are the publication costs?

Article publishing charge: $10,400 for open access publication.

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Research Topics

Epigenetics and DNA Methylation Cancer Immunotherapy and Biomarkers Cancer Genomics and Diagnostics Cancer-related Molecular Pathways CAR-T cell therapy research Cancer, Hypoxia, and Metabolism Immunotherapy and Immune Responses Ubiquitin and proteasome pathways Cancer Cells and Metastasis Immune cells in cancer Acute Myeloid Leukemia Research Immune Cell Function and Interaction RNA modifications and cancer Glioma Diagnosis and Treatment Protein Degradation and Inhibitors PI3K/AKT/mTOR signaling in cancer Cancer-related gene regulation Pancreatic and Hepatic Oncology Research Chronic Lymphocytic Leukemia Research Angiogenesis and VEGF in Cancer Microtubule and mitosis dynamics Single-cell and spatial transcriptomics Histone Deacetylase Inhibitors Research Melanoma and MAPK Pathways Cancer Research and Treatments

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