CC

Clinical Colorectal Cancer

Clinical Colorectal Cancer publishes peer-reviewed manuscripts on early detection, screening, diagnosis, prevention, and treatment of colorectal cancer and other gastrointestinal cancers, including pancreatic, liver, gastric/gastroesophageal, and biliary cancers. The journal emphasizes recent scientific developments, original clinical and translational research, and translational correlative science related to clinical trials across multidisciplinary therapeutic fields. It also covers drug sensitivity and resistance, targeted therapies, immunotherapies, novel therapeutic approaches, pathology, predictive markers, prognostic indicators, chemoprevention, and multidisciplinary treatment integration, while giving lower priority to meta-analyses, pooled analyses, real-world analyses, and unsolicited reviews unless they provide substantial clinical value.

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Subject Oncology
Impact Factor 3.2
Quartile Q2
Open Access Type Hybrid
ISSN 1533-0028
eISSN 1938-0674
Invitation Only No
Cost Range USD 3630 APC for open access articles; no open access publication fee for subscription articles.

Submission Instructions

Clinical Colorectal Cancer accepts the following article types. Click on an article type to view submission instructions.

Original Study

Cover Letter Cover Letter requirements are not specified.
Abstract Original Study articles require both a structured abstract and an additional micro-abstract. The structured abstract may be up to 300 words, and the micro-abstract must be 3–4 sentences and no more than 60 words. The main abstract must be structured. The structured abstract must use the headings Introduction, Patients and Methods, Results, and Conclusion, and the micro-abstract must summarize the study’s rationale, methods and sample size, key findings, and significance.
Manuscript Original Study manuscripts have a recommended length of up to 4,000 words. The main manuscript should be organized as Introduction, Patients and Methods, Results, and Conclusion. If generative AI tools were used in manuscript preparation, a disclosure statement must be included in a new section at the end of the manuscript before the references list.
References Original Study manuscripts may include up to 80 references. References should follow AMA Manual of Style, 11th Edition. References should be numbered in the order they appear in the article, and journal names in the reference list must be abbreviated according to the List of Title Word Abbreviations.
Figures & Tables Original Study manuscripts may include up to 8 figures and/or tables. Tables should be placed next to the relevant text or on separate pages at the end of the article, while figures and other artwork must be supplied as separate files along with the manuscript. Tables must be submitted as editable text rather than images, all tables and figures must be cited in the text and numbered consecutively, and each must include a caption.
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Systematic Review

Cover Letter Cover Letter requirements are not specified.
Abstract A structured abstract is required. Abstract must be no more than 250 words. Abstract must be structured.
Manuscript Main manuscript has a recommended length of up to 4,000 words. Main manuscript should be structured into Introduction, Methods, Results, and Discussion. An AI use disclosure statement must be included at the end of the manuscript before the references if generative AI tools were used in manuscript preparation.
References Manuscript may include up to 80 references. References should follow AMA Manual of Style, 11th Edition. References should be numbered in the order in which they appear in the article.
Figures & Tables Manuscript may include up to 8 figures and/or tables. Tables should be placed next to the relevant text or on separate pages at the end of the article, and figures must be supplied as separate files along with the manuscript. Tables must be submitted as editable text rather than images, and all figures and tables must be cited in the manuscript text and include captions.
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Invited Review

Cover Letter Cover Letter requirements are not specified.
Abstract An unstructured abstract is required for Invited Reviews. The abstract must be up to 250 words. The abstract must be unstructured.
Manuscript The manuscript should be 2,000–10,000 words. The manuscript must begin with an Introduction, organize sections under concise informative subheadings, and conclude with a summary section delivering a strong take-home message. A generative AI disclosure statement must be included at the end of the manuscript before the references if AI tools were used in manuscript preparation.
References The manuscript should contain 50–120 references. References should follow AMA Manual of Style, 11th Edition. References should be numbered in the order they appear in the article and journal names in the reference list must be abbreviated according to the List of Title Word Abbreviations.
Figures & Tables The manuscript may include up to 7 figures and/or tables. Tables should be placed next to the relevant text or on separate pages at the end of the article, and figures must be supplied as separate files along with the manuscript. Tables must be submitted as editable text rather than images, and all figures and tables must be cited in the manuscript and include captions.
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Case Report

Cover Letter Cover Letter requirements are not specified.
Abstract Case Report articles require both a structured abstract and an additional micro-abstract. The structured abstract must be up to 250 words, and the micro-abstract must be 3–4 sentences and no more than 60 words. The main abstract must be structured. The abstract must use the headings Background, Case Presentation, and Conclusion.
Manuscript The main manuscript should be 500–1,500 words. The main manuscript should follow the sections Background, Case Presentation, and Conclusion, followed by a Clinical Practice Points statement after the Conclusion. A Clinical Practice Points statement of up to 250 words addressing what is already known, the new findings, and the foreseeable impact on clinical practice must be included after the Conclusion, and any generative AI use in manuscript preparation must be disclosed in a new section before the references list.
References The manuscript should contain 15–30 references. References should follow AMA Manual of Style, 11th Edition. References should be numbered in the order of appearance in the article, and journal names in the reference list should be abbreviated according to the List of Title Word Abbreviations.
Figures & Tables The manuscript may include 1–2 figures and/or tables. Tables should be placed next to the relevant text or on separate pages at the end of the article, while figures and other artwork must be supplied as separate files along with the manuscript. Tables must be submitted as editable text rather than images, all figures and tables must be cited in the text and numbered consecutively, and each must include a caption.
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Case Series

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must not exceed 250 words.
Manuscript Case Series manuscripts may be up to 2,000 words. Manuscripts must be divided into clearly defined sections covering all essential elements using headings. The manuscript must include 1 to 7 keywords in English and, if generative AI tools were used in manuscript preparation, a disclosure statement in a new section before the references list.
References Case Series manuscripts may include up to 40 references. References should follow AMA Manual of Style, 11th Edition. References must be numbered in the order in which they appear in the article, and journal names in the reference list must be abbreviated according to the List of Title Word Abbreviations.
Figures & Tables Case Series manuscripts may include up to 4 figures/tables. Tables should be placed next to the relevant text or on separate pages at the end of the article, while figures, images, diagrams and other artwork must be supplied as separate files along with the manuscript. Tables must be submitted as editable text rather than images, and all figures and tables must be cited in the manuscript text, numbered consecutively, and accompanied by captions.
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Letter To The Editor

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must not exceed 250 words.
Manuscript Letter to the Editor should be 500–1,000 words in length. Letter to the Editor should comment directly on work published in the journal within the last 6 months. Letter must include an AI disclosure if AI tools were used in its preparation, with the disclosure statement added at the end of the manuscript before the references list.
References Letter may contain up to 12 references. References should follow AMA Manual of Style, 11th Edition. References should be numbered in the order in which they appear in the article, and journal names in the reference list must be abbreviated according to the List of Title Word Abbreviations.
Figures & Tables Letters to the Editor must not include figures or tables.
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Recent Publications

Fruquintinib or Regorafenib? A Weighted Toxicity Score Analysis to Facilitate Better Discussions on Toxicity and Benefits in Later-line Colorectal Cancer Treatment

Salvatore Corallo, Francesco Agustoni, Anna Pagani, Francesco Serra, Alessandra Ferrari, Nicola Personeni, Paolo Pedrazzoli, Chiara Citterio

10.1016/j.clcc.2026.05.002
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Discordant Dynamics Between Absolute ctDNA and Tumor Fraction During Treatment Monitoring in Metastatic Colorectal Cancer: Evidence of a Dilution Phenomenon

Yuji Takayama, Kosuke Ichida, Taro Fukui, Nao Kakizawa, Fumiaki Watanabe, Koichi Suzuki, Toshiki Rikiyama

10.1016/j.clcc.2026.05.001
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Resource use and costs of the low-risk arm of a risk-stratified colorectal cancer screening approach based on previous negative FIT values: comparative analyses with the standard approach

Andrea Buron, Merce Comas, Carmen Guirado-Fuentes, Cristina Barrufet, Cristina Alvarez-Urturi, Xavier Bessa, Josep M Auge, Isabel Torá-Rocamora, Jaume Grau, Oswaldo Ortiz, Teresa Puig, Monica Pardo, Xavier Castells, Carlo Senore, Maria Sala

10.1016/j.clcc.2026.05.005
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Optimizing Systemic Therapy in Advanced Gastrointestinal Malignancies: Strategies to Minimize Toxicity and Maximize Tolerability

Sabrina Bulancea, Udhayvir S Grewal, Marta Wronska, Deepak Vadehra, Nicholas Hornstein, Timothy J Brown, Michael Shusterman

10.1016/j.clcc.2026.05.004
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Dual CTLA-4/PD-1 blockade versus anti–PD-1 in MSI-H metastatic colorectal cancer: early survival benefit and exploratory clinical predictors

Lea Jehanno, Julie Henriques, Thomas Samaille, Camille Loisel, Baptiste Cervantes, Raphaël Colle, Dewi Vernerey, Thierry André, Romain Cohen

10.1016/j.clcc.2026.05.003
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Frequently asked questions

How long does it take to publish?

6 days submission to first decision; 50 days submission to decision after review; 85 days submission to acceptance; 5 days acceptance to online publication.

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What are the publication costs?

Open access APC: USD 3630 excluding taxes for all articles. Subscription publication has no open access publication fee.

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Research Topics

Colorectal Cancer Treatments and Studies Colorectal Cancer Surgical Treatments Colorectal and Anal Carcinomas Gastric Cancer Management and Outcomes Genetic factors in colorectal cancer Cancer Treatment and Pharmacology Colorectal Cancer Screening and Detection Hepatocellular Carcinoma Treatment and Prognosis Diverse Scientific and Economic Studies Cancer Genomics and Diagnostics Cancer Immunotherapy and Biomarkers Pancreatic and Hepatic Oncology Research Lung Cancer Treatments and Mutations Human auditory perception and evaluation Educational Robotics and Engineering Ferroelectric and Negative Capacitance Devices Intraperitoneal and Appendiceal Malignancies HER2/EGFR in Cancer Research Cholangiocarcinoma and Gallbladder Cancer Studies Cancer Cells and Metastasis Cancer therapeutics and mechanisms Economic and Financial Impacts of Cancer Advanced Breast Cancer Therapies Big Data and Digital Economy Angiogenesis and VEGF in Cancer

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