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Digestive and Liver Disease

Digestive and Liver Disease is an international journal of gastroenterology and hepatology and the official journal of AISF, AISP, AIGO, SIGE, SIGENP, and IG-IBD. It publishes basic and clinical research in gastroenterology and hepatology, including original papers, correspondence, editorials, reviews, special articles, position papers, guidelines, progress reports, image of the month, congress proceedings, symposia, and mini-symposia.

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Subject Gastroenterology & Hepatology
Impact Factor 3.8
Quartile Q2
Open Access Type Open
ISSN 1590-8658
eISSN 1878-3562
Invitation Only No
Cost Range Article Publishing Charge: EUR 2700 excluding taxes; corresponding authors who are members of affiliated Scientific Societies receive a 25% discount.

Submission Instructions

Digestive and Liver Disease accepts the following article types. Click on an article type to view submission instructions.

Original Papers

Cover Letter A cover letter is required. The cover letter must summarize the strengths of the study.
Abstract An abstract is required. Abstract must not exceed 200 words. Structured.
Manuscript Original Papers must not exceed 3,500 words, excluding the abstract, references, tables and figures. Introduction/Background/Aims, Materials and methods, Results, Discussion, Appendices, Acknowledgements, References, and Figure legends. The manuscript must include two to four key words.
References Vancouver. References must be numbered consecutively in the order cited in the text, and for works with four or more authors only the first three authors are listed followed by et al.
Figures & Tables Tables must be submitted separately and not included in the text, and illustrations must be submitted as separate files. Tables must be numbered consecutively with Arabic numerals and contain only horizontal lines, while illustrations must be numbered in sequence and have legends.
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Reviews

Cover Letter A cover letter is required. The cover letter must summarize the strengths of the study.
Abstract An abstract is required. No more than 200 words. Unstructured.
Manuscript No more than 5,000 words, excluding the abstract, references, tables and figures. The manuscript must include Introduction/Background/Aims, Materials and methods, Results, Discussion, Appendices, Acknowledgements, References, and Figure legends. The manuscript must include two to four key words.
References Vancouver. References must be numbered consecutively in the order cited in the text and formatted according to the New England Journal of Medicine example, with only the first three authors listed when there are four or more authors.
Figures & Tables Illustrations must be submitted as separate files, and tables must not be included in the text. Reviews must not exceed 6 authors, and figures and tables must be numbered consecutively with legends on separate pages; tables require brief self-explanatory titles, while illustrations must have legends and may require separate black-and-white versions for color figures.
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Correspondence To The Editor

Cover Letter A cover letter is required. The cover letter must summarize the strengths of the study and, for resubmissions, state that the revised manuscript has been modified according to the Editor's and reviewers' comments.
Abstract Abstract requirements are not specified.
Manuscript Correspondence To The Editor must be up to 1,500 words long. The manuscript must include two to four key words.
References Correspondence To The Editor must have no more than 10 references. New England Journal of Medicine style. References must be numbered consecutively in the order cited in the text, and for works with four or more authors only the first three authors are listed followed by et al.
Figures & Tables Correspondence To The Editor must include only 1 or 2 images and/or 1 or 2 tables. Figures and tables must be submitted as separate files rather than embedded in the text. Illustrations must be numbered in sequence, each table must have a brief self-explanatory title, and legends must be provided for all illustrations.
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Position Papers

Cover Letter A cover letter is required. The cover letter must summarize the strengths of the study.
Abstract An abstract is required. The abstract must not exceed 200 words. The abstract must be non-structured.
Manuscript Guidelines and Position Papers must not exceed 6,000 words excluding the abstract, references, tables and figures. The manuscript should include Introduction/Background/Aims, Materials and methods, Results, Discussion, Appendices, Acknowledgements, References, and Figure legends. The manuscript must include two to four key words, and the article must attribute authorship to the reference society or societies with participating contributors listed in an Appendix.
References The reference list must follow the New England Journal of Medicine style. References must be numbered consecutively in the order cited in the text, and for works with four or more authors only the first three authors are listed followed by et al.
Figures & Tables Tables must be submitted separately from the text, and illustrations must be submitted as separate files. Each table must have a brief title and only horizontal lines, and each illustration must be numbered in sequence with a legend.
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Guidelines

Cover Letter A cover letter is required. The cover letter must be typed in the online submission system and include a summary of the study's strengths.
Abstract An abstract is required. The abstract must not exceed 200 words. The abstract must be unstructured.
Manuscript The manuscript must not exceed 6,000 words, excluding the abstract, references, tables and figures. The manuscript should include Introduction/Background/Aims, Materials and methods, Results, Discussion, Appendices, Acknowledgements, References, and Figure legends. Two to four keywords must be included, and Guidelines and Position Papers must attribute authorship to the reference society or societies with the society name placed below the title.
References Vancouver style. References must be numbered consecutively in the order cited in the text, and for works with four or more authors only the first three authors are listed followed by et al.
Figures & Tables Tables must be separate from the text, figures must be submitted as separate files, and figure legends must be placed on separate pages at the end of the manuscript. Tables and illustrations must be numbered consecutively, tables must use only horizontal lines and no vertical rules, and figures and tables must include legends or titles as specified.
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Recent Publications

Full Title Page /Editorial Board

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10.1016/s1590-8658(26)00797-8
View Publication

Evaluation and interpretation of Hawthorne and other trial-related effects in Celiac Disease: A systematic review and meta-analysis

Dorina Pjetraj, Elena Lionetti, Alfredo Pulvirenti, Rosaria Gesuita, Carlo Catassi

10.1016/j.dld.2026.06.014
View Publication

Is it always necessary to wait until day 5 for second line treatment in children with acute severe ulcerative colitis?

Luca Scarallo, Arianna Bedeschi, Martina Di Benedetto, Sara Renzo, Irene Dalpiaz, Flavio Labriola, Patrizia Alvisi, Paolo Lionetti

10.1016/j.dld.2026.07.002
View Publication

AISF practice guidance on the treatment of primary biliary cholangitis: A 2026 update

Alessio Aghemo, Vincenza Calvaruso, Marco Carbone, Nora Cazzagon, Laura Cristoferi, Daphne D’Amato, Roberta D’ambrosio, Francesca Fianchi, Giacomo Germani, Edoardo Giovanni Giannini, Stefano Gitto, Pietro Invernizzi, Sara Labanca, Ana Lleo, Giuseppe Marrone, Marco Marzioni, Grazia Pennisi, Francesca Romana Ponziani, Cristina Rigamonti, Vincenzo Ronca, Francesca Terracciani, Francesco Tovoli, Alessandro Valsecchi, Umberto Vespasiani Gentilucci, Mauro Viganò

10.1016/j.dld.2026.06.019
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Functional dyspepsia: A new hypothesis on its pathophysiology and comments on efficacy of exercise therapies

Jorge Gonzalez-Calvin, Francisco J. Casado-Caballero, Jose L. Martin-Rodriguez, Jorge L. Gonzalez-Cantero

10.1016/j.dld.2026.07.003
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Frequently asked questions

How long does it take to publish?

3 days submission to first decision; 40 days submission to decision after review; 33 days submission to acceptance

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Is a cover letter required?

A cover letter is required in the online submission system. It should include a summary of the study strengths and statements that the manuscript has not been published previously, is not under consideration elsewhere, is approved by all authors, and will transfer copyright to Digestive and Liver Disease if accepted.

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What are the publication costs?

All articles require an APC of EUR 2700 excluding taxes. The journal is open access with no subscription charges. A 25% discount applies for corresponding authors who are members of affiliated Scientific Societies.

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Research Topics

Liver Disease Diagnosis and Treatment Inflammatory Bowel Disease Liver Disease and Transplantation Microscopic Colitis Hepatitis C virus research Helicobacter pylori-related gastroenterology studies Esophageal and GI Pathology Gastric Cancer Management and Outcomes Celiac Disease Research and Management Eosinophilic Esophagitis Colorectal Cancer Screening and Detection Gastrointestinal disorders and treatments Gastroesophageal reflux and treatments Hepatocellular Carcinoma Treatment and Prognosis Gallbladder and Bile Duct Disorders Pancreatic and Hepatic Oncology Research Liver Diseases and Immunity Pancreatitis Pathology and Treatment Hepatitis B Virus Studies Gastrointestinal motility and disorders Gastrointestinal Bleeding Diagnosis and Treatment Organ Transplantation Techniques and Outcomes Pediatric Hepatobiliary Diseases and Treatments Diverticular Disease and Complications Gastrointestinal Tumor Research and Treatment

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