Overview
Submission Instructions
Recent Publications
Frequently Asked Questions
Research Topics
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Cancer Discovery publishes high-impact articles featuring major advances in research and clinical trials. Topics span the spectrum of cancer research and medicine from the laboratory to the clinic to epidemiologic studies. The journal also publishes News and Research Watch sections.
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Subject
Oncology
Impact Factor
33.3
Quartile
Q1
Open Access Type
Closed
ISSN
2159-8274
eISSN
2159-8290
Invitation Only
No
Cost Range
Publication involves a base publication fee and an additional fee for each display item; authors without financial support may apply for a waiver of the fixed publication fee at submission.
Submission Instructions
Cancer Discovery accepts the following article types. Click on an article type to view submission instructions.
Original Research Articles
Cover Letter
Cover letter is strongly encouraged. Cover letter must describe how any associated manuscript is related to the submission and must detail any use of AI to produce new text, images, or other material for the manuscript.
Abstract
Abstract requirements are not specified.
Manuscript
Initial submissions do not have strict length restrictions, and the methods section is excluded when calculating manuscript length. Manuscript must be arranged in the order of title page, text and references, tables, figure legends, and figures, and it must include a Data Availability subsection at the end of the Materials and Methods section. Manuscript must include a conflict of interest disclosure on the title page, funding information and acknowledgments, a declaration of any AI use in the acknowledgments and appropriate manuscript section, and a Code Availability Statement if custom computer code was used.
References
References must be numbered in order of first mention and cited in the text by number only. For references with more than 6 authors, list the first 6 followed by et al., and for references with 6 or fewer authors, list all authors.
Figures & Tables
For initial submission, figures should appear in sequential order adjacent to their legends, ideally where first cited, and supplementary files must be uploaded separately rather than appended to the main manuscript. Each figure must have a legend, figures and tables must be cited in sequential order, and the title page must state the total number of figures and tables.
Review Manuscript
Cover Letter
Cover letter is strongly encouraged for initial submission. Cover letter must describe how any associated manuscript is related to the current submission and detail any use of AI to produce new text, images, or other material for the manuscript.
Abstract
Abstract is required.
Manuscript
Initial submissions do not have strict length restrictions, and the methods section is excluded when calculating manuscript length. Manuscript must be arranged in the following order: title page, text and references, tables, figure legends, and figures. Manuscript must include funding information, an Acknowledgments section naming nonauthor contributors and any generative AI technologies involved, a title page with word count and total number of figures and tables, a detailed conflict of interest disclosure statement, and declarations of any AI use in the manuscript and acknowledgments.
References
References must be numbered in the order of first mention in the text, cited in the text by number only, and list the first 6 authors followed by et al. when there are more than 6 authors or all authors when there are 6 or fewer.
Figures & Tables
For initial submission, figures should appear in sequential order adjacent to their legends and ideally where first cited in the text, while supplementary files must be uploaded separately and not appended to the main manuscript file. Each figure must include a legend with a short title sentence and description, multi-panel figures must have labeled panels described in the legend, figures and tables must be cited sequentially in the text, and every table must have a descriptive title and enough explanatory information to stand alone.
Meta-Analysis
Cover Letter
Cover letter is strongly encouraged but not required. Cover letter must describe how any associated manuscript is related to the current submission and must describe in detail any use of AI to produce new text, images, or other material.
Abstract
Abstract requirements are not specified.
Manuscript
Initial submissions do not have strict length restrictions, and the methods section is excluded when calculating manuscript length. The manuscript must include funding information, acknowledgments for nonauthor contributors and any generative AI technologies used, a detailed conflict of interest disclosure on the title page, and an appropriate manuscript section declaring AI use.
References
References must be numbered in order of first mention in the text and cited by number only, listing all authors when there are 6 or fewer and the first 6 followed by et al. when there are more than 6.
Figures & Tables
For initial submission, figures should be presented in sequential order adjacent to their legends, ideally where first cited in the text, while supplementary files must be uploaded separately and not appended to the main manuscript. Each table must be cited in sequential order and have a descriptive title, and each figure must be cited and numbered in order and accompanied by a legend with a short title sentence and panel descriptions if applicable.
Systematic Reviews
Cover Letter
Cover letter is strongly encouraged. Any use of AI to produce new text, images, or other material for the manuscript must be described in detail in the cover letter.
Abstract
Abstract requirements are not specified.
Manuscript
Initial submissions do not have strict length restrictions, and the methods section is excluded when calculating manuscript length. The manuscript must include funding information, acknowledgments for nonauthor contributors and any generative artificial intelligence technologies used, a detailed conflict of interest statement on the title page, and an AI declaration in the acknowledgments and appropriate manuscript section when applicable.
References
References must be numbered in the order of first mention in the text, cited in the text by number only, and list the first 6 authors followed by et al. when there are more than 6 authors.
Figures & Tables
For initial submission, figures should be placed in sequential order adjacent to their legends, ideally where first cited in the text, while supplementary files must be uploaded separately and not appended to the main manuscript. Each figure must have a legend, figures and tables must be cited in sequential order, and the title page must report the total number of figures and tables.
Recent Publications
Blood Protein Test Predicts Lung Cancer Years before Diagnosis
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10.1158/2159-8290.cd-nw2026-0070
View Publication
Modular Platform Curbs CAR T-Cell Exhaustion by Tuning Receptor Shedding
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10.1158/2159-8290.cd-rw2026-059
View Publication
PROTEUS May Mean New SOC for Some Prostate Cancers
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10.1158/2159-8290.cd-nw2026-0068
View Publication
In Vivo CAR T-Cell Therapy Spurs 100% ORR in Phase I
-
10.1158/2159-8290.cd-nw2026-0067
View Publication
Frequently asked questions
How long does it take to publish?
Decisions are typically returned within 35 days of submission. Accepted author manuscripts are usually posted OnlineFirst within 48 hours following formal acceptance.
Reformat to Cancer Discovery using Livewrite PremiumIs a cover letter required?
A cover letter is strongly encouraged for initial submission.
Reformat to Cancer Discovery using Livewrite PremiumWhat are the publication costs?
Publication involves a base publication fee and an additional fee for each display item; authors without financial support may apply for a waiver of the fixed publication fee at submission.
Reformat to Cancer Discovery using Livewrite PremiumResearch Topics
Cancer Genomics and Diagnostics
Cancer Immunotherapy and Biomarkers
CAR-T cell therapy research
Lung Cancer Treatments and Mutations
Epigenetics and DNA Methylation
Immunotherapy and Immune Responses
Immune Cell Function and Interaction
RNA modifications and cancer
Protein Degradation and Inhibitors
Cancer, Hypoxia, and Metabolism
Immune cells in cancer
Melanoma and MAPK Pathways
Acute Myeloid Leukemia Research
PI3K/AKT/mTOR signaling in cancer
Cancer Cells and Metastasis
Pancreatic and Hepatic Oncology Research
Colorectal Cancer Treatments and Studies
Chronic Lymphocytic Leukemia Research
Cancer-related Molecular Pathways
HER2/EGFR in Cancer Research
Monoclonal and Polyclonal Antibodies Research
Cancer-related gene regulation
Peptidase Inhibition and Analysis
DNA Repair Mechanisms
Ubiquitin and proteasome pathways