Overview Submission Instructions Recent Publications Frequently Asked Questions Research Topics

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Cell Reports Medicine

Cell Reports Medicine is a premium open-access Cell Press journal publishing translational and clinical biomedical research that informs human health and medicine. It publishes original research across human biology, health, disease, clinical work, translational studies, clinical trials, genomics, biomarker discovery, diagnostic and healthcare technologies, and directly relevant vertebrate model organism studies, along with reports, articles, tools, datasets, and reviews.

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Subject Medicine, Research & Experimental

Impact Factor 10.6

Quartile Q1

Open Access Type Open

ISSN 2666-3791

eISSN 2666-3791

Invitation Only No

Cost Range Elsevier APCs are set on a per-journal basis and range between approximately $200 and $11,400 USD excluding tax.

Submission Instructions

Cell Reports Medicine accepts the following article types. Click on an article type to view submission instructions.

Report

Cover Letter A cover letter is required. Cover letter must explain what was previously known, the conceptual advance, the significance and potential impact of the work, and whether the paper is part of a consortium.

Abstract A single-paragraph summary is required. Summary must be 150 words or fewer. The summary must be unstructured and presented as a single paragraph.

Manuscript The Report main document must contain no more than 25,000 characters including spaces and the total word count must be under 4,000 words, including figure legends but excluding STAR Methods text, supplemental item legends, and references. The manuscript must include title, author list and affiliations, Lead Contact footnote, corresponding author email address(es), Summary, Introduction, Results, Discussion, Resource Availability, Acknowledgments, Author Contributions, Declaration of Interests, main figure titles and legends, main tables and legends, STAR Methods text, supplemental video and Excel table titles and legends, and References in that order.

References References must use consecutive numbered superscript citations. References must be numbered by first citation order, only include published or in-press items, use "et al." only after 10 author names, and provide for articles the author list, year, title, journal abbreviation, volume, page range, and DOI when applicable.

Figures & Tables A Report may contain no more than four main figures and/or tables. For final submission, main figures must be uploaded individually as separate files and figure titles and legends and main-text tables must appear in the main manuscript, while for initial submission figures may be interspersed in the manuscript or uploaded separately. Figures must include a descriptive title with all panels together on one page and tables must be editable Word tables with a descriptive title and no panel subdivisions.

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Research Article

Cover Letter Cover letter is required and must explain what was previously known, the conceptual advance, the significance and potential impact of the work, and whether the paper is part of a consortium. Cover letter must explain prior knowledge, the conceptual advance, the significance and potential impact of the work, and whether the paper is part of a consortium.

Abstract A summary is required. Summary must be a single paragraph of no more than 150 words. Summary must be unstructured as a single paragraph. No headings are specified for the summary.

Manuscript Main document must be under 7,000 words including figure legends but excluding STAR Methods text, supplemental item legends, and references. Manuscript should include Title, Author list, Author affiliations and footnotes, Contact information, Summary, Keywords, Introduction, Results, Discussion, Limitations, Resource availability, Acknowledgments, Author contributions, Declaration of interests, Declaration of generative AI and AI-assisted technologies, Supplemental information titles and legends, Figure or scheme titles and legends, Tables, STAR Methods, Resource identification initiative, and References. Manuscript should include keywords, a Resource Availability section with lead contact, materials availability, and data and code availability subsections, an author contributions section using initials, a declaration of interests section, a declaration of generative AI and AI-assisted technologies section, supplemental information titles and legends, and a resource identification initiative section.

References References must use numbered superscript citations in consecutive order. References must be numbered by first citation order, include only published or in-press works, and list article references with author list, year, title, journal abbreviation, volume, page range, and DOI when applicable.

Figures & Tables Research Articles may contain no more than seven main figures and or tables. Figure titles and legends, tables, and supplemental information titles and legends must be included in the manuscript, while main figures must be uploaded individually as separate files. Tables must be editable Word tables with descriptive titles and no panels, and figures must include descriptive titles with all panels together on a single page.

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Review

Cover Letter A cover letter is required. Cover letter should explain what was previously known, the conceptual advance provided by the work, the significance and potential impact of the work, and whether the paper is part of a consortium.

Abstract Reviews must include an abstract. Abstract must be no more than 150 words. Abstract must be unstructured as a single paragraph.

Manuscript Reviews are usually 5,000–7,000 words in length. Main document must include title, author list and affiliations, Lead Contact footnote, corresponding author email address(es), Summary, Introduction, Results, Discussion, Resource Availability, Acknowledgments, Author Contributions, Declaration of Interests, main figure titles and legends, main tables and legends, STAR Methods text, supplemental video and Excel table titles and legends, and References in that order. Manuscript must also include Highlights of 3–4 bullet points.

References Reviews may include up to 150 references. References must use numbered superscript citations. References must be numbered sequentially by first citation, use "et al." only after 10 author names, and article references must include the author list, year, article title, journal abbreviation, volume, page range, and DOI when applicable.

Figures & Tables Reviews may include three or four display items total, consisting of figures and/or tables. For final submission, main figures must be uploaded separately and figure titles and legends and main-text tables must appear at the end of the manuscript, although for initial submission figures may be interspersed in the manuscript or uploaded separately. Tables must be editable Word tables with descriptive titles and no panels, and each figure must include all panels together on a single page with a descriptive title.

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Recent Publications

Orally delivered metabolically reprogrammed probiotics for cascade-activated antitumor immunity in colorectal cancer

Lexuan Wang, Yang Chen, Yanyu Shang, Jia Liu, Muyuan Zhao, Lei Jin, Yichenxi Shi, Ruili Zhang, Zhuang Chen, Ting Yin, Chaoqiang Qiao, Zhongliang Wang

10.1016/j.xcrm.2026.103111

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Microbiota-regulated TCDCA associates with Parkinson’s disease severity and promotes BBB dysfunction through VSMC TGR5 signaling in mice

Zhe Zhao, Yixuan Liu, Wen Ma, Gaofei Hu, Jincen Hao, Chaobo Bai, Jing Chen, Qi Zhang, Huanhuan Cao, Xiaoyi Liu, Yujie Zhu, Manyuan Dong, Zheng Zhang, Shenge Su, Rui Zhan, Huibo Li, Rongsheng Zhao, Junliang Yuan

10.1016/j.xcrm.2026.103098

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Anti-HDGFL2 cryptic protein antibodies provide a sensitive readout of TDP-43 pathology and clinical disease features

Kathryn J. Citrano, Vidhya Bharathi Maheswari Jawahar, Madison M. Reeves, Leonardo Petrucelli, Yari Carlomagno, Mei Yue, Jorge Alaiz Noya, Lillian M. Daughrity, Raul Baena Tomé, Karen Jansen-West, Bailey Rawlinson, Michael DeTure, Erica Engelberg-Cook, Alpana Singh, Neill R. Graff-Radford, Gregory S. Day, Bradley F. Boeve, Adam L. Boxer, David S. Knopman, Keith A. Josephs, Ronald C. Petersen, Björn Oskarsson, Nicholas J. Ashton, Dennis W. Dickson, Tania F. Gendron, Mercedes Prudencio, Yong-Jie Zhang, Leonard Petrucelli

10.1016/j.xcrm.2026.103105

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AI-integrated RNA therapeutics in precision oncology

William S.O. Symmans, Ziyi Li, George A. Calin, Akanksha Samuel

10.1016/j.xcrm.2026.103100

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Breastfeeding and maternal microbial reservoirs are associated with infant gut phageome development during the first year of life

Elena Cabello-Yeves, Anna Samarra, Kimberley Summers, Iñaki Comas, Elizabeth Wellington, Andrew Millard, María Carmen Collado, Alberto Marina

10.1016/j.xcrm.2026.103107

View Publication

Frequently asked questions

How long does it take to publish?

6 days submission to first decision; 43 days submission to decision after review; 205 days submission to acceptance; 27 days acceptance to online publication.

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Is a cover letter required?

A cover letter is included among the materials to prepare for submission.

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What are the publication costs?

Elsevier journals publish under subscription and open access models. APCs are set per journal and range between approximately $200 and $11,400 USD excluding tax, with waivers and discounts available in some cases.

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Research Topics

Cancer Immunotherapy and Biomarkers Immune Cell Function and Interaction SARS-CoV-2 and COVID-19 Research CAR-T cell therapy research Immunotherapy and Immune Responses COVID-19 Clinical Research Studies Gut microbiota and health Immune cells in cancer Cancer Genomics and Diagnostics Single-cell and spatial transcriptomics T-cell and B-cell Immunology Ferroptosis and cancer prognosis Pancreatic and Hepatic Oncology Research Virus-based gene therapy research Monoclonal and Polyclonal Antibodies Research Cancer Cells and Metastasis Cancer Research and Treatments Pancreatic function and diabetes Glioma Diagnosis and Treatment Diet and metabolism studies Radiomics and Machine Learning in Medical Imaging Epigenetics and DNA Methylation Cancer, Hypoxia, and Metabolism CRISPR and Genetic Engineering Adipose Tissue and Metabolism

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