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Chemical Research In Toxicology

Chemical Research in Toxicology reports research on the chemical and molecular basis of toxicology for human and environmental health and safety.

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Subject Toxicology
Impact Factor 3.8
Quartile Q2
Open Access Type Hybrid
ISSN 0893-228X
eISSN 1520-5010
Invitation Only No
Cost Range Article publishing charges vary by journal and route; some options are free, some are discounted, and the article development charge is a flat fee of $2,500 USD for qualifying zero-embargo green open access.

Submission Instructions

Chemical Research In Toxicology accepts the following article types. Click on an article type to view submission instructions.

Articles

Cover Letter A cover letter must accompany every manuscript submission.
Abstract An abstract is required. The abstract must not exceed 300 words. Unstructured.
Manuscript Articles have no limit on length. Submissions for initial consideration must be complete with clearly identified standard sections used to report original research. Use of AI tools for text or image generation must be disclosed in the Acknowledgments section with a description of when and how the tools were used.
References Articles have no limit on references. ACS style. References must comply with the style in use for the journal and may be provided in any style for initial submission if they are complete and include titles.
Figures & Tables Articles have no limit on figures and tables. Figures should be embedded in the text at the point of relevance, and tables should be included in the manuscript. Tables must be numbered consecutively with Arabic numerals, have brief titles and column headings, indicate units of measure, and be cited in the text in consecutive order.
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Reviews

Cover Letter A cover letter is required. The cover letter must accompany every manuscript submission, and if the manuscript was deposited as a preprint it must state how it has been adjusted or updated between deposition and submission.
Abstract An abstract is required. The abstract must meet the journal's word count limit, typically 150-300 words maximum. Unstructured.
Manuscript Initial submissions must be complete with clearly identified standard sections used to report original research. A graphical summary for the table of contents must be included, all authors must provide a short biography of 100 words or less, author biographies and photos must be inserted below the reference list if provided, and use of AI tools for text or image generation must be disclosed in the Acknowledgments section with a description of when and how the tools were used.
References References must comply with the journal's style, may be provided in any style for initial submission if complete and including titles, and the list of references must be included within the LaTeX file.
Figures & Tables Figures should be embedded in the text at the point of relevance, and the graphical table-of-contents summary must be placed after the title page and before the abstract page. The table-of-contents graphic must fit within 8.47 cm by 4.76 cm, be entirely original, have no legend, avoid tables, photographs, people, stamps, currency, trademarked items, and duplicate figures from the text, while author photos must be at least 300 ppi and contain no logos.
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Communications

Cover Letter A cover letter is required. The cover letter must accompany every submission and should state how a preprint manuscript was adjusted or updated, if applicable.
Abstract An abstract is required. The abstract must not exceed 300 words. Unstructured.
Manuscript Communications are limited to 3000 words. Manuscripts should report original research with clearly identified standard sections and all numbered and labeled components. Use of AI tools for text or image generation must be disclosed in the Acknowledgments section with a description of when and how the tools were used.
References Communications should include about 30 references. ACS style. References must comply with the journal style and may be provided in any style for initial submission as long as they are complete and include titles.
Figures & Tables Communications should include about 5 or fewer figures and tables. Figures should be embedded in the text at the point of relevance. The graphical summary for the table of contents must be entirely original, have no legend, fit within 8.47 cm by 4.76 cm, and not be a table, photograph, drawing, caricature, stamp, currency, trademarked item, or a graphic already appearing in the text.
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Letters To The Editor

Cover Letter A cover letter must accompany every manuscript submission.
Abstract An abstract must not be included.
Manuscript Letters To The Editor must be limited to 2000 words.
References Letters To The Editor may include a maximum of 5 references.
Figures & Tables Letters To The Editor may include 0 to 1 figures and tables. Figures should be embedded in the text at the point of relevance.
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Recent Publications

Generation of Interstrand DNA Cross-Links under Conditions of Acid Stress

Mithila Farzana Mumu, Marjan Heidari, Md. Selim Mahbub, Kent S. Gates

10.1021/acs.chemrestox.6c00217
View Publication

Hemin Recapitulates the Labile Iron Pool in the Cellular Fenton Reaction with DNA

Aaron M. Fleming, Cynthia J. Burrows

10.1021/acs.chemrestox.6c00203
View Publication

Classification of Thyroid Peroxidase (TPO) Inhibitors Using Transfer Learning with SMILES Embeddings

Geven Piir, Sulev Sild, Eliana Spilioti, Dimitra Nikolopoulou, Effrosyni Katsanou, Ingrid Langezaal, Uko Maran

10.1021/acs.chemrestox.6c00058
View Publication

Ultrasensitive and Specific Detection of 8-Oxoguanine DNA Glycosylase via Locus-Specific Rolling Circle Amplification

Zi-Qin Huang, Jia-Hui Dong, Run-Hong Zhang, Ling-Li Zhao, Ying Liu, Ying-Lin Zhou, Xin-Xiang Zhang

10.1021/acs.chemrestox.6c00172
View Publication

Prediction of Ligand Binding to Transthyretin Using Machine Learning Algorithms and Low-Dimensional Molecular Descriptors: A Tox24 Challenge Study

Filip Stefaniak

10.1021/acs.chemrestox.6c00052
View Publication

Frequently asked questions

How long does it take to publish?

Communications aim for a decision within three weeks of receipt. Minor revisions are due within 10 days for Communications and 30 days for other manuscripts. Major revisions are due within 60 days for other manuscripts, and major revisions are not possible for Communications. Galley proofs should be returned within 48 hours. ASAP publication usually occurs within a few working days after proof corrections.

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Is a cover letter required?

A cover letter must accompany every manuscript submission. It may be typed or pasted into the submission system or attached as a file. For pre-submission inquiries, a cover letter and abstract are requested.

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What are the publication costs?

Immediate gold open access uses an APC; hybrid journals may offer reduced APCs for 12-month embargo open access; zero-embargo green open access uses a $2,500 USD article development charge; some journals and authors qualify for waivers, discounts, or institutional coverage.

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Research Topics

Carcinogens and Genotoxicity Assessment DNA and Nucleic Acid Chemistry Pharmacogenetics and Drug Metabolism DNA Repair Mechanisms Computational Drug Discovery Methods Chemistry and Chemical Engineering Genomics, phytochemicals, and oxidative stress History and advancements in chemistry Free Radicals and Antioxidants Synthesis and Biological Evaluation Effects and risks of endocrine disrupting chemicals Pesticide Exposure and Toxicity Toxic Organic Pollutants Impact Drug Transport and Resistance Mechanisms Metabolomics and Mass Spectrometry Studies Drug-Induced Hepatotoxicity and Protection Sulfur Compounds in Biology Analytical Chemistry and Chromatography Nitric Oxide and Endothelin Effects Air Quality and Health Impacts Glutathione Transferases and Polymorphisms Bioactive Compounds and Antitumor Agents Heavy Metal Exposure and Toxicity Cancer therapeutics and mechanisms Estrogen and related hormone effects

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