CM

Clinical Medicine

Clinical Medicine is a peer-reviewed journal of the Royal College of Physicians that publishes advances in general and specialist medicine, authoritative reviews, original research, guideline summaries, and clinically focused reviews, with a dedicated CME section and six issues per year. From January 1, 2024, it operates as a full gold open access journal, with accepted articles published online ahead of each issue.

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Subject Medicine, General & Internal
Impact Factor 3.9
Quartile Q1
Open Access Type Open
ISSN 1470-2118
eISSN 1473-4893
Invitation Only No
Cost Range Article Publishing Charge: USD 2500 for Full Length Articles and Reviews; USD 1250 for Short Articles and Case Reports; paying members and fellows of the Royal College of Physicians who are named authors are eligible for a 100% discount.

Submission Instructions

Clinical Medicine accepts the following article types. Click on an article type to view submission instructions.

Full Length Articles (Original Research)

Cover Letter A cover letter must be included with the submission. The cover letter must confirm approval for publication by all authors and by the responsible authorities where the work was carried out.
Abstract A structured abstract is required. Abstract must be 250 words. Abstract must be structured. Abstract headings must be Study Objective, Design, Setting, Participants, Interventions, Main Outcome Measure(s), Results, and Conclusions.
Manuscript Main text must be up to 3,000 words excluding tables, figure legends, and references. Manuscript must include, in order, Title Page, Structured Abstract and Keywords, Introduction, Materials and Methods, Results, Discussion, and References. Manuscript must include keywords, mandatory highlights submitted separately as 3 to 5 bullet points, a mandatory graphical abstract submitted separately, an AI disclosure section before the references if generative AI was used in manuscript preparation, and explicit study limitations.
References References are limited to 30. References must follow AMA style. References must be cited by numbers in square brackets and listed in the order of appearance, and AMA references with one to six authors list all authors while those with seven or more list the first three followed by et al.
Figures & Tables A maximum of 4 figures and/or tables is allowed. Figures, tables, and the graphical abstract must be submitted as separate files rather than embedded only in the manuscript. Figures and tables must be numbered in numerical order, all legends or captions must be included in the manuscript, figures require relevant captions, and tables must be editable and include titles, descriptions, and footnotes.
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Review

Cover Letter A cover letter is required.
Abstract An abstract is required. Abstract must be up to 150 words.
Manuscript Manuscript must be up to 3,000 words. Review must address a question relevant to a general medical audience. Manuscript must include a box summarising key practice implications, mandatory highlights, up to 6 keywords after the abstract, a declaration of generative AI use before the references if applicable, and a graphical abstract submitted as a separate file.
References Reference list may include up to 50 references. AMA style is required. References must be cited in numerical order in the text and listed in the same order, with one to six authors listed in full and seven or more shortened after the third author with et al.
Figures & Tables A total of up to 4 figures and or tables is allowed. Figures must be uploaded as separate files, high-resolution artwork must not be included in the Word manuscript, captions must be included in the manuscript, and the graphical abstract must be submitted as a separate file. Figures and tables must be numbered and cited in numerical order in the text, figures must include captions, and tables must include titles, descriptions, footnotes, and editable text format.
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Narrative Reviews

Cover Letter A cover letter is required. The cover letter must confirm approval for publication by all authors and by the responsible authorities where the work was carried out.
Abstract An abstract is required. Abstract must be up to 150 words. Abstract must be unstructured.
Manuscript Manuscript must be up to 3,000 words. Manuscript must address a question relevant to a general medical audience and include a box summarising key practice implications. The submission must include highlights, 3 to 8 keywords, a competing interests statement, an AI-use disclosure section before the references if generative AI was used in manuscript preparation, and a mandatory graphical abstract submitted as a separate file.
References References may include up to 50 entries. References must follow AMA style. References must be cited in the text by numbers in square brackets and listed in numerical order of first appearance, with all authors listed for one to six authors and the first three authors followed by et al for seven or more authors.
Figures & Tables The article may include up to 4 figures and or tables. Figures, tables, and the graphical abstract must be uploaded as separate files rather than embedded in the manuscript. All figures and tables must have captions or legends and be cited in the text in numerical order, and tables must be provided in editable text format.
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Systematic Reviews

Cover Letter A cover letter is required.
Abstract An abstract is required. Abstract must be no more than 150 words.
Manuscript Manuscript must be no more than 3,000 words. Manuscript must address a question relevant to a general medical audience. Manuscript must include a box summarising key practice implications, highlights, up to 6 keywords, an AI disclosure section before the references if generative AI was used in manuscript preparation, and a graphical abstract submitted as a separate file.
References References must not exceed 50. References must follow AMA style. References must be cited in the text by numbers in square brackets and listed in the order of appearance, with all authors listed for one to six authors and the fourth and subsequent authors replaced by et al for seven or more authors.
Figures & Tables A maximum of 4 figures and or tables is permitted. Figures must be submitted as separate files, legends or captions for all figures and tables must be included in the manuscript, and high-resolution artwork must not be included in the Word document. All figures and tables must be numbered and cited in numerical order in the text, figures must include relevant captions, and tables must include titles, descriptions, and footnotes.
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Quality Improvement

Cover Letter A cover letter is required. Publication must be approved by all authors.
Abstract An abstract is required. Abstract must be no more than 150 words.
Manuscript Manuscript must be no more than 1,500 words. Manuscript must describe and evaluate a healthcare process or system improvement intervention, outline how the quality improvement programme was set up, report measurable benefits and lessons learnt, follow SQUIRE guidelines, and explicitly include study limitations. Highlights are mandatory and must be provided as 3 to 5 bullet points in a separate editable file, authors must provide 3 to 8 keywords, and any use of generative AI in manuscript preparation must be disclosed in a section placed before the references.
References References may include up to 15 sources. AMA style is required. References must be cited in the text by numbers in square brackets and listed in numerical order of appearance, with all authors listed for one to six authors and the first three authors followed by et al for seven or more authors.
Figures & Tables Figures must be submitted as separate files rather than included in the manuscript, while tables must be provided in editable text format. Figures and tables must be numbered in the order cited in the text, figures must include captions, and tables must include titles, descriptions, footnotes, and legends or captions in the manuscript.
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Case Reports

Cover Letter A cover letter is required. Cover letter content is not explicitly specified.
Abstract A concise and factual abstract is required.
Manuscript Articles must be divided into clearly defined and numbered sections. The manuscript must include highlights in a separate editable file with 3 to 5 bullet points, 3 to 8 keywords, and an AI disclosure section before the references if generative AI was used in manuscript preparation.
References AMA reference style is required. References must be cited in the text by numbers in square brackets and listed in the order of first appearance, with up to 6 authors listed and 7 or more shortened after the third author with et al.
Figures & Tables Figures must be uploaded as separate files, while figure and table legends or captions must be included in the manuscript. All figures and tables must be cited in the text in numerical order, figures must include relevant captions, and tables must include titles, descriptions, and footnotes.
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Acute Medical Care (Amc)

Cover Letter Cover letter is required.
Abstract Abstract is required. Abstract must be no more than 150 words.
Manuscript Manuscript must be 1,000 words. Manuscript must use a case-based discussion format with sections for Case presentation, Diagnosis, Initial management and prognosis, Case progression and outcome, and Discussion. Manuscript must include 4 to 6 key learning points, keywords, highlights, a competing interests statement, an AI disclosure section before the references if generative AI was used in preparation, and a statement of written informed consent.
References References are limited to 5. AMA style is required. References must be cited numerically in the text and listed in the order of appearance, with all authors listed for one to six authors and the first three authors followed by et al for seven or more authors.
Figures & Tables A maximum of 1 figure and/or table is permitted. Figures must be uploaded as separate files, while legends or captions for figures and tables must be included in the manuscript. Figures and tables must be numbered in numerical order and cited in the text, with tables submitted in editable format rather than as images.
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Lessons Of The Month

Cover Letter A cover letter must be included with the submission.
Abstract An abstract is required. Abstract must be no more than 150 words.
Manuscript Manuscript must be no more than 1,000 words. The manuscript must include keywords, mandatory highlights of 3 to 5 bullet points, and an AI disclosure statement before the references if generative AI was used in manuscript preparation.
References References are limited to a maximum of 10. AMA style is required. References must be cited in the text using numbers in square brackets and listed in numerical order of appearance, with AMA author listing of all authors for one to six authors and et al for seven or more authors.
Figures & Tables A maximum of 4 figures and/or tables may be included. Figures must be uploaded as separate files rather than embedded in the manuscript, and legends or captions for all figures and tables must be included in the manuscript. Figures and tables must be numbered in the order cited in the text, figures must include captions, and tables must include titles, descriptions, and footnotes.
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Letters To The Editor

Cover Letter A cover letter must be included.
Abstract Abstract must not be included.
Manuscript Manuscript must be up to 350 words. Keywords and highlights are required, and any use of generative AI in manuscript preparation must be disclosed in a new section before the references list.
References References may include up to 5 items. AMA style is required. References must be cited in the text by numbers in square brackets and listed in the order of appearance, with all authors listed for one to six authors and the fourth and subsequent authors replaced by et al for seven or more authors.
Figures & Tables Figures and tables must not be included.
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Concise Guidance

Cover Letter A cover letter is required.
Abstract An abstract is required. Abstract must be no more than 150 words.
Manuscript Manuscript must be no more than 3,000 words. Manuscript must be organized as a sequence of subheadings related to the clinical questions addressed and include an explicit link to the guideline, the scope as it relates to general medical practice and disease burden, what is out of scope where relevant, and a conclusion focusing on what is new with health economics and research recommendations highlighted where relevant. Manuscript must include a box summarising key practice implications from the guideline, mandatory highlights, up to 6 keywords after the abstract, and an AI disclosure section before the references if generative AI was used in manuscript preparation.
References References may include up to 50 entries. References must use AMA style. References must be cited by number in square brackets and listed in the order of appearance, with all authors listed for one to six authors and the fourth and subsequent authors replaced by et al for seven or more authors.
Figures & Tables Figures must be submitted as separate files rather than embedded in the manuscript, while legends or captions for all figures and tables must be included in the manuscript. Figures and tables must be numbered in the order cited in the text, figures must include relevant captions, and tables must include titles, descriptions, footnotes, and be submitted as editable text.
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Recent Publications

Investigation of suspected pulmonary embolus - imaging frequency and diagnostic yield over 10 years in a major UK teaching hospital

Filipa Mendes, Robert J.B. Goudie, Sarah L. Cowan

10.1016/j.clinme.2026.100641
View Publication

Promoting Clinical Academic Careers and Medical Research Skills through a Dedicated Research Training Programme: Outcomes from the MEDICORE Programme

Ranya V Kumar, Jacob Vincent, Caleb Cole, Prakrit R Kumar, Nicholas R Evans

10.1016/j.clinme.2026.100640
View Publication

Sink or Swim: Making sense of the NICE Intravenous Fluid Guidelines as a Foundation Year Doctor

Talia Patel, Calum R.A. Heslop, Milap Rajpara, Shivaali Karelia, Rakesh Patel

10.1016/j.clinme.2026.100639
View Publication

The Economic Imperative for an AI Productivity Index in Healthcare: Beyond Clinical Promise to Fiscal Accountability

Yazan A. Al-Ajlouni, Basile Njei

10.1016/j.clinme.2026.100638
View Publication

What is new in Tuberculosis?

Ye Myat, Maddalena Cerrone, Onn Min Kon

10.1016/j.clinme.2026.100634
View Publication

Frequently asked questions

How long does it take to publish?

Proof corrections are requested within two days after acceptance.

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Is a cover letter required?

A cover letter is included in the submission checklist. CME submissions should include three possible self-assessment questions in the cover letter.

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What are the publication costs?

Article Publishing Charge: USD 2500 for Full Length Articles and Reviews; USD 1250 for Short Articles and Case Reports; paying members and fellows of the Royal College of Physicians who are named authors are eligible for a 100% discount.

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Research Topics

Primary Care and Health Outcomes Innovations in Medical Education Palliative Care and End-of-Life Issues Healthcare cost, quality, practices Respiratory Support and Mechanisms Emergency and Acute Care Studies Venous Thromboembolism Diagnosis and Management Healthcare Policy and Management Liver Disease Diagnosis and Treatment Sepsis Diagnosis and Treatment Acute Ischemic Stroke Management Cardiac, Anesthesia and Surgical Outcomes Health Systems, Economic Evaluations, Quality of Life Clinical practice guidelines implementation Global Health Workforce Issues Healthcare Quality and Management Medical Research and Treatments Health and Medical Research Impacts COVID-19 Clinical Research Studies Clinical Reasoning and Diagnostic Skills Frailty in Older Adults Cardiac Imaging and Diagnostics Diabetes Management and Research Chronic Obstructive Pulmonary Disease (COPD) Research Atrial Fibrillation Management and Outcomes

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