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Drug Resistance Updates

Drug Resistance Updates publishes original research, commentary, and expert reviews on drug resistance in infectious disease and cancer, as well as novel drugs and strategies to overcome resistance. It covers both basic research and clinical aspects of drug resistance across disciplines including molecular biology, biochemistry, cell biology, pharmacology, microbiology, preclinical therapeutics, oncology, and clinical medicine. Original research articles are welcomed, while review articles are written by leaders in the field by invitation.

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Impact Factor 21.7
Quartile Q1
Open Access Type Hybrid
ISSN 1368-7646
eISSN 1532-2084
Invitation Only No
Cost Range USD 5320 APC for open access publication; no open access publication fee for subscription publication.

Submission Instructions

Drug Resistance Updates accepts the following article types. Click on an article type to view submission instructions.

Research Article

Cover Letter Cover Letter requirements are not specified.
Abstract A structured abstract is required for Research Articles. Abstract must not exceed 250 words. Abstract must be structured. Abstract must use the headings Aims, Methods, Results, Conclusions and Keywords.
Manuscript Manuscript must be a maximum of 10000 words, and this limit includes a combined total of eight figures or tables with legends while excluding references. Manuscript must be organized as Title Page, Structured Abstract, Introduction, Subjects, Materials and Methods, Results, Discussion, Acknowledgements, References, and figures and tables with legends. Research Articles must be designated as Basic Research, Clinical Research, or Epidemiology, and any use of generative AI in manuscript preparation must be declared in a new section before the references list.
References Research Articles may include up to 100 references. References must be cited as numbers in square brackets and listed in the order they appear in the article.
Figures & Tables A combined total of eight figures or tables with legends is permitted. Figures must be supplied as separate files, while the manuscript structure includes figures and tables with legends. Tables must be submitted as editable text with captions, and each figure or table must be cited and numbered consecutively in the text.
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Review Articles

Cover Letter Cover Letter requirements are not specified.
Abstract A summary is required for Review Articles. The summary must not exceed 200 words.
Manuscript Review Articles must be no more than 10000 words, and this limit includes a combined total of ten figures or tables with legends. Review Articles must use subheadings in the text to highlight the content of different sections. Authors must provide 1 to 7 keywords in English, and any use of generative AI in manuscript preparation must be declared in a new section before the references list.
References Review Articles may include up to 200 references, which are not included in the word limit. References must be cited using numbers in square brackets. References must be numbered in the order they appear in the article and may be submitted in any consistent style or format.
Figures & Tables The word limit includes a combined total of ten figures or tables with legends. Figures must be supplied as separate files, while tables are uploaded as editable text. Tables must include captions and figures must include a caption with a brief title and description.
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Research Brief

Cover Letter Cover Letter requirements are not specified.
Abstract Research Briefs must include a summary. The summary must be no more than 50 words.
Manuscript Research Briefs should not exceed 1100 words, excluding up to 10 references. Research Briefs must not use subsection titles such as “Abstract, Introduction, Materials and Methods, Results and Discussions”. Authors must declare any use of generative AI in manuscript preparation in a separate section before the references list.
References Research Briefs may include up to 10 references. References must be cited using numbers in square brackets in the text. References must be numbered in the order they appear in the article and may be submitted in any consistent style or format.
Figures & Tables Research Briefs may include only one figure or one table. The single figure or table is supplied with the manuscript, and any additional figures or tables should be included in the supplemental file. Tables must be submitted as editable text, and figures must be supplied as separate files with captions.
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Letters To The Editor

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must not exceed 250 words.
Manuscript Letters to the Editor should be no more than 1000 words. An AI declaration section must be included before the references list if generative AI was used in manuscript preparation.
References Letters to the Editor must include fewer than 10 references. References must be cited as numbers in square brackets and listed in the order they appear in the article.
Figures & Tables Letters to the Editor may include one figure. Figures must be supplied as separate files along with the manuscript. Tables must be submitted as editable text rather than images, and each figure or table must be cited in the manuscript and include a caption.
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Recent Publications

Activating ZBP1-centered PANoptosis and a collaborative innate-adaptive immune response sensitizes glioblastoma to PD-1 blockade

Yonghua Cai, Ziyi Luo, Zhengming Zhan, Heng Xiao, Jianfeng Li, Shuaishuai Xue, Hai Wang, Jie Lin, Cheng Xie, Jun Liu, Jing Du, Guanglong Huang, Binghui Qiu, Junxiang Peng, Xingyun Wang, Peng Li, Xi’an Zhang, Ye Song

10.1016/j.drup.2026.101395
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Local structural constraints and charge distribution in the protegrin-1 arginine loop govern activity against colistin-resistant Klebsiella pneumoniae.

Christina DeBarro, Sofia Assent, Hannah Makhecha, Rakesh Krishnan, Noor Radde, Justin Randall, Cesar de la Fuente-Nunez, Renee M. Fleeman

10.1016/j.drup.2026.101405
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The sRNA-encoded peptide TimP rewires the Escherichia coli envelope via LamB to sensitize bacteria to polymyxins

Hyejin Cho, Juyeon Jung, Soyeon Yi, Kwang-sun Kim

10.1016/j.drup.2026.101406
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The emerging role of AXL in pancreatic cancer: Biomarker potential and therapeutic targeting to counteract drug resistance

Benoit Immordino, Mafalda Angelica Rocco, Annalisa Comandatore, Gaby van der Zee, Mahrou Vahabi, Luca Morelli, Elisa Giovannetti

10.1016/j.drup.2026.101408
View Publication

ENO1 Lactylation Drives Bevacizumab Resistance through Metabolic Reprogramming and Angiogenesis in Ovarian Cancer

Tian Zeng, Qianqian Wang, Lei Li, Xiongjin Tan, Jing He, Yan Liu, Xiaodong Wang, Rongfang He, Gouping Ding, Xinyi Zeng, Xing Tang, Xun Chen, Hao Huang, Yukun Li

10.1016/j.drup.2026.101413
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Frequently asked questions

How long does it take to publish?

2 days submission to first decision; 33 days submission to decision after review; 88 days submission to acceptance; 3 days acceptance to online publication.

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What are the publication costs?

USD 5320 APC for open access publication; no open access publication fee for subscription publication.

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Research Topics

Human auditory perception and evaluation Educational Robotics and Engineering Diverse Scientific and Economic Studies Antibiotic Resistance in Bacteria Drug Transport and Resistance Mechanisms HIV/AIDS drug development and treatment Cancer, Hypoxia, and Metabolism Cancer therapeutics and mechanisms Cancer-related Molecular Pathways Cell death mechanisms and regulation RNA Interference and Gene Delivery Antifungal resistance and susceptibility Cancer Immunotherapy and Biomarkers Epigenetics and DNA Methylation Ferroptosis and cancer prognosis RNA modifications and cancer Cancer Cells and Metastasis Lung Cancer Treatments and Mutations Antibiotics Pharmacokinetics and Efficacy Cancer Mechanisms and Therapy HER2/EGFR in Cancer Research Nanoplatforms for cancer theranostics Protein Degradation and Inhibitors Ubiquitin and proteasome pathways Cancer Genomics and Diagnostics