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Free Radical Biology and Medicine

Free Radical Biology and Medicine publishes research in the redox biology of health and disease, including signal transduction and redox signaling, oxidative and reductive stress, aging, metabolic regulation, mitochondrial function, homeostatic mechanisms, redox chemistry, materials and nanomaterials, non-thermal plasmas, and redox biology across microorganisms, plants, animals, and humans. It welcomes full-length and short Research Communications, Hypothesis Papers, Reviews, Mini Reviews, Graphical Reviews, and Critical Methods Papers, and is the official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe, and an affiliate journal of the International Society for Free Radical Research.

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Subject Endocrinology & Metabolism
Impact Factor 8.2
Quartile Q1
Open Access Type Hybrid
ISSN 0891-5849
eISSN 1873-4596
Invitation Only No
Cost Range Open Access APC: USD 4,030 (excluding taxes). Subscription: no publication fee charged to authors.

Submission Instructions

Free Radical Biology and Medicine accepts the following article types. Click on an article type to view submission instructions.

Review Articles

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract is required. Abstract must not exceed 200 words.
Manuscript Review Articles are usually 16,320 words in length excluding references and figure legends. Manuscript must be divided into clearly defined sections using headings. Submission must include 1 to 7 keywords in English, 3 to 5 highlights provided as a separate editable file, a graphical abstract, a declarations tool completion, and an AI disclosure statement at the end of the manuscript before the references if generative AI was used in manuscript preparation.
References Review Articles normally include 75 to 250 references. References must be cited using numbered square brackets in the text. References must be numbered in order of appearance, journal names must be abbreviated according to the List of Title Word Abbreviations, and Review Article references should include titles.
Figures & Tables Review Articles must include at least three figures or illustrations and summary table(s) of relevant literature. Figures and other graphical media must be supplied as separate files along with the manuscript. Tables must be submitted as editable text rather than images, and all figures and tables must be cited in the manuscript text and provided with captions.
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Research Articles

Cover Letter Cover Letter requirements are not specified.
Abstract An abstract is required for Research Articles. Abstract must not exceed 250 words. Abstract must be unstructured and concise and factual. Abstract must briefly state the purpose of the research, principal results, and major conclusions.
Manuscript Manuscript must be divided into clearly defined sections using headings, including an introduction stating the objectives and a methods section with enough detail to allow reproduction. The submission must include 1 to 7 English keywords, 3 to 5 highlights submitted as a separate editable file, a graphical abstract, a declarations tool, and an AI disclosure statement at the end of the manuscript before the references if generative AI was used in manuscript preparation.
References References must use a numbered square-bracket citation style. References must be numbered in the order they appear in the article and include applicable bibliographic details, with journal names abbreviated according to the List of Title Word Abbreviations.
Figures & Tables Tables must be included as editable text, while figures and other graphical media must be supplied as separate files along with the manuscript. All tables and figures must be cited in the text, numbered according to their order of appearance, and provided with captions.
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Short Communications

Cover Letter Cover Letter requirements are not specified.
Abstract An abstract is required. Abstract must not exceed 250 words.
Manuscript Short Communications must not exceed 2000 words excluding the graphical abstract, highlights, references, abstract, and figure legends. Manuscript must be divided into clearly defined sections using headings, including an introduction stating the objectives and a methods section with sufficient detail to allow reproduction. The submission must include 1 to 7 English keywords, 3 to 5 highlights provided as a separate editable file, a graphical abstract, and an AI-use disclosure section before the references if generative AI was used in manuscript preparation.
References References must be cited using numbered square brackets in the text. References must be numbered in order of appearance and include applicable bibliographic details, with journal names abbreviated according to the List of Title Word Abbreviations.
Figures & Tables Short Communications may include a maximum of four figures, and each figure may contain no more than six panels. Figures must be supplied as separate files along with the manuscript, and tables must be submitted as editable text. All figures and tables must be cited in the text, numbered according to their order of appearance, and provided with captions.
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Mini-Review Articles

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract is required for Mini-Review Articles. Abstract must be no more than 150 words.
Manuscript Mini-Review Articles are usually 2000 to 4000 words long excluding references and figure legends. Manuscript must be divided into clearly defined sections using headings. Manuscript must include 1 to 7 keywords in English, article highlights of 3 to 5 bullet points submitted as a separate editable file, a graphical abstract submitted as a separate file, completion of the declarations tool, and an AI disclosure section before the references if generative AI was used in manuscript preparation.
References Mini-Review Articles may include up to 50 references. References must be cited as numbers in square brackets in the text. References must be numbered in the order of appearance and should include titles.
Figures & Tables Mini-Review Articles must include one to three figures or illustrations. Figures must be supplied as separate files along with the manuscript, while tables must be submitted as editable text. All figures and tables must be cited in the text, numbered consecutively, and provided with captions.
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Unsolicited Reviews

Cover Letter A cover letter is required for Unsolicited Reviews. The cover letter must briefly summarize the submission’s relevance to the field of Free Radical Biology and Medicine and, if a similar review was published in the journal within the last two years, explain how the article differs in scope, perspective, and/or content.
Abstract An abstract is required. The abstract must not exceed 250 words. The abstract must be concise and factual and is not described as structured under named headings.
Manuscript The manuscript must be divided into clearly defined sections using headings. The submission must include 1 to 7 keywords in English, 3 to 5 highlights submitted as a separate editable file, a graphical abstract submitted as a separate file, completion of the declarations tool, and an AI-use disclosure statement at the end of the manuscript before the references if generative AI was used in manuscript preparation.
References References must use a numbered style with citations indicated in square brackets. References must be numbered in the order they appear in the article and include applicable bibliographic details, with journal names abbreviated according to the List of Title Word Abbreviations.
Figures & Tables Tables must be submitted as editable text and figures must be supplied as separate files along with the manuscript. All tables and figures must be cited in the text, numbered according to their order of appearance, and provided with captions.
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Recent Publications

Editorial Board

-

10.1016/s0891-5849(26)01200-1
View Publication

Nicotine modulates α7nAChR associated ceramide-mitochondrial stress responses in Parkinsonian models

Gaoge Wang, Zhen Ni, Jingzheng Zhang, Qian Li, Yunfu Tan, Hao Yu, Enliang Hong, Chunmei Guang, Shu Wang, Huan Chen, Hongwei Hou

10.1016/j.freeradbiomed.2026.09.010
View Publication

Editorial Board

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10.1016/s0891-5849(26)01142-1
View Publication

Proximal tubular EZH2 inhibits diabetic kidney disease by suppressing SHC1-mediated oxidative stress

Qiming Xu, Pinglan Lin, Sijun Chen, Jianrao Lu, Lin Li, Reza Moghadasali, Xuejun Yang, Jing Hu, Ming Wu, Dongping Chen

10.1016/j.freeradbiomed.2026.08.019
View Publication

Ferroptotic vulnerability drives cardiac fibrosis and diastolic dysfunction in diabetic HFpEF via a gut-associated Proline–PPARγ axis

Kai Huang, Jie Lu, Yizhi Yu, Xiangyang Xu, Hua Wen, Chuyi Wang, Haowen Xie, Xiaotian Sun, Mengwei Tan, Lin Han

10.1016/j.freeradbiomed.2026.07.020
View Publication

Frequently asked questions

How long does it take to publish?

4 days from submission to first decision; 26 days from submission to decision after review; 65 days from submission to acceptance; 2 days from acceptance to first online publication.

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Is a cover letter required?

A cover letter is required for unsolicited reviews and should briefly summarize the relevance of the submission to the field. If a similar review was published in the journal within the last two years, authors should explain how the submission differs in scope, perspective, or content.

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What are the publication costs?

Open Access APC: USD 4,030 excluding taxes. Subscription option: no publication fee charged to authors.

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Research Topics

Nitric Oxide and Endothelin Effects Redox biology and oxidative stress Mitochondrial Function and Pathology Genomics, phytochemicals, and oxidative stress Antioxidant Activity and Oxidative Stress Free Radicals and Antioxidants Neutrophil, Myeloperoxidase and Oxidative Mechanisms Electron Spin Resonance Studies Sulfur Compounds in Biology Diverse Scientific and Economic Studies Adipose Tissue and Metabolism Human auditory perception and evaluation Vitamin C and Antioxidants Research Glutathione Transferases and Polymorphisms Heme Oxygenase-1 and Carbon Monoxide Eicosanoids and Hypertension Pharmacology Biochemical effects in animals Trace Elements in Health Cancer, Hypoxia, and Metabolism Advanced Glycation End Products research Educational Robotics and Engineering Cardiac Ischemia and Reperfusion Autophagy in Disease and Therapy Endoplasmic Reticulum Stress and Disease Neuroinflammation and Neurodegeneration Mechanisms

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