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Gastroenterology

Gastroenterology is the flagship journal of the American Gastroenterological Association and publishes clinical, translational, and basic studies across the digestive system, including the liver, pancreas, and nutrition, along with original research, reviews, and perspectives in adult and pediatric gastroenterology and hepatology.

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Subject Gastroenterology & Hepatology
Impact Factor 25.1
Quartile Q1
Open Access Type Hybrid
ISSN 0016-5085
eISSN 1528-0012
Invitation Only No
Cost Range Supports open access.

Submission Instructions

Gastroenterology accepts the following article types. Click on an article type to view submission instructions.

Original Articles

Cover Letter A cover letter should be included with a concise introductory statement and suggested reviewers and associate editor. Cover letter should briefly describe the manuscript, provide relevant contextual information, suggest two to five reviewers with contact details and an associate editor, and explain any deviations from standard format.
Abstract A structured abstract is required for Original Articles. Abstract must not exceed 260 words. Abstract must be structured. Abstract must use the headings Background and Aims, Methods, Results, Conclusion, and include 4-5 keywords.
Manuscript Manuscript must not exceed 7,000 words inclusive of main text, references, and table/figure legends. Manuscript must include a title page and a "What You Need to Know" note with the headings BACKGROUND AND CONTEXT, NEW FINDINGS, LIMITATIONS, CLINICAL RESEARCH RELEVANCE, and BASIC RESEARCH RELEVANCE. Manuscript must include 4-5 keywords, a 25-30 word lay summary, a "What You Need to Know" note, a Data Transparency Statement on the title page, and any use of AI in writing must be disclosed before the References under the specified declaration heading.
References References must be cited with superscript Arabic numerals in order of appearance, include data references for underlying datasets, and end with the phrase "Author names in bold designate shared co-first authorship" with shared first authors shown in bold.
Figures & Tables Original Articles may include a total of seven tables with no panels and/or figures. Tables may be uploaded separately or included at the end of the manuscript, while figures must be submitted as separate attachments. Figures must be submitted as separate JPEG, TIFF, EPS, or PDF files at 300 PPI resolution.
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Brief And Full Reviews

Cover Letter Cover letter requirements are not explicitly stated for Brief and Full Reviews beyond invited review topic suggestions including a title and short summary. Invited review topic suggestions should include a title and a short summary.
Abstract Abstract is required. Abstract must not exceed 260 words. Structured abstract is required only if the article type specifically requires it; otherwise the abstract format is not explicitly stated. If a structured abstract is used, it must include Background and Aims, Methods, Results, Conclusions, and Keywords.
Manuscript Manuscript may be up to 6,000 words. Review articles are limited to a maximum of 4 authors.
References Review articles may include up to 150 references. References must be cited with superscript Arabic numerals in order of appearance in the text.
Figures & Tables Review articles may include up to 6 tables and figures. Tables may be uploaded separately or included at the end of the manuscript document, and figures must be submitted as separate attachments with legends at the end of the manuscript body.
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Full Length Original Research

Cover Letter A cover letter should be included with a concise introductory statement, relevant contextual information, suggested reviewers, and the associate editor best qualified to review the paper. Cover letter should include a concise introduction to the manuscript, relevant contextual information, two to five suggested reviewers with email addresses and phone numbers, the suggested associate editor, reasons for any deviations from standard format, and any potential conflicts related to exclusive publication.
Abstract An abstract is required for full-length original research submissions. Abstract must not exceed 260 words. Structured abstract is required only if applicable, using the headings Background and Aims, Methods, Results, Conclusions, and Keywords. When structured, abstract must include Background and Aims, Methods, Results, Conclusions, and Keywords.
Manuscript Manuscript must include Materials and Methods in the main text rather than in supplemental material. The manuscript must include a conflict of interest statement, 3–4 keywords if a structured abstract is used, figure and table captions if applicable, and any use of generative AI in writing must be disclosed before the References under the heading "Declaration of Generative AI and AI-assisted technologies in the writing process."
References References must be cited with superscript Arabic numerals in order of appearance. Reference list should use Index Medicus abbreviations, while personal communications and unpublished data must be cited only in the text and not numbered.
Figures & Tables Tables may be uploaded separately or placed at the end of the manuscript, while figures must be submitted as separate files and figure legends included at the end of the manuscript body. Full-length original research articles incur charges of $650 for the first printed color figure and $100 for each additional printed color figure, although authors may instead publish color figures online only and black-and-white versions in print at no charge.
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Reviews

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract is required. Abstract must not exceed 260 words.
Manuscript Submission must include manuscript text and a conflict of interest statement, and any use of generative AI or AI-assisted technologies in writing must be disclosed before the References under the heading "Declaration of Generative AI and AI-assisted technologies in the writing process."
References References must be cited with superscript Arabic numerals in order of appearance in the text.
Figures & Tables Figures must be submitted as separate attachments, while tables may be uploaded separately or included at the end of the manuscript document. Figures and tables with captions must be included if applicable, and figure legends must appear at the end of the manuscript body.
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Reviews In Basic And Clinical Gastroenterology And Hepatology

Cover Letter A cover letter should be included with a concise introductory statement, and review topic suggestions should include a title and a short summary. The cover letter should concisely describe the manuscript, include relevant contextual information, suggest two to five reviewers with contact details and an associate editor, explain any deviations from standard format, and disclose publication of abstracts or posters.
Abstract An abstract should be included after the title page. Abstract must not exceed 260 words. Structured abstract is required only if applicable; otherwise the abstract format is not explicitly specified for this article type. If structured, the abstract should use the headings Background and Aims, Methods, Results, Conclusions, and Keywords.
Manuscript Review articles may be up to 6,000 words. Materials and Methods must be included in the main text and not provided as supplemental information. Keywords should include 3-4 terms separated by semicolons, and any use of generative AI in writing must be disclosed before the References under the heading "Declaration of Generative AI and AI-assisted technologies in the writing process."
References Review articles may include up to 150 references. References must use superscripted Arabic numerals in order of appearance. References should be numbered by order of appearance, personal communications and unpublished data should be cited only in the text, and journal abbreviations should follow Index Medicus.
Figures & Tables Review articles may include up to 6 tables and figures. Tables may be uploaded separately or included at the end of the manuscript, while figures must be submitted as separate attachments and figure legends included at the end of the manuscript body. Multiple-panel figures must be submitted as a single attachment with all panels together, and figures must not span more than one journal page.
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Research Letters

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must not be included.
Manuscript Article text must not exceed 1000 words excluding table or figure legends and references, and up to 1000 additional words of supplemental text may be used only to describe methods. Manuscript must not include section headings such as Methods or Results. Title page must include title, authors' names and institutions, corresponding author contact information, conflict of interest statements for all authors, author contributions, and a statement on whether data, analytic methods, and study materials will be available to other researchers, with location specified if study materials will be shared.
References References are limited to 10. References must follow the format "Jones RS, et al. Gastroenterology 2011; 2: 373-380" without article titles, list only the first author unless joint first authors are cited, include shared first-author names in bold, and end with the phrase "Author names in bold designate shared co-first authorship."
Figures & Tables Manuscript may include up to 1 table or figure. Figures must be submitted as separate attachments. Figures may be multi-panel and must be submitted in JPEG, TIFF, EPS, or PDF format at 300 PPI resolution.
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Aga Clinical Practice Updates

Cover Letter Cover Letter requirements are not specified.
Abstract An abstract should be included after the title page. Abstract must not exceed 260 words. A structured abstract is required only if the article type specifically requires it; otherwise no abstract structure is stated. If a structured abstract is required, it must use the headings Background and Aims, Methods, Results, Conclusions, and Keywords.
Manuscript Materials and Methods must be included in the main text and not provided as supplemental information. A declaration of generative AI and AI-assisted technologies in the writing process must be placed at the end of the manuscript before the References if such tools were used.
References References must be cited with superscript Arabic numerals in order of appearance. Reference abbreviations must follow Index Medicus abbreviations, and personal communications or unpublished data must be cited directly in the text without numbering.
Figures & Tables Tables may be uploaded separately or included at the end of the manuscript document, while figures must be submitted as separate attachments and figure legends included at the end of the manuscript body. Multiple-panel figures must be submitted as a single attachment with all panels together, and figures may not exceed one journal page.
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Letters To The Editor

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract is not required for Letters to the Editor.
Manuscript Letters to the Editor must not exceed 750 words. Letters to the Editor must include a title page with the title, authors’ names, authors’ institutions, corresponding author contact information, and a conflict of interest statement for all authors.
References Letters to the Editor are limited to 8 references. References must follow the format "Jones RS, et al. Gastroenterology 2011; 2: 373-380," omit the article title, and list only the first author unless joint first authors are cited.
Figures & Tables Tables and figures are not permitted in Letters to the Editor.
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Correspondence

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract requirements are not specified.
Manuscript Manuscript must not exceed 750 words. Manuscript must include a title page with the title, authors' names, authors' institutions, corresponding author contact information, and a conflict of interest statement for all authors.
References References are limited to 8. References must follow the format "Jones RS, et al. Gastroenterology 2011; 2: 373-380," omit the article title, and list only the first author unless joint first authors are cited.
Figures & Tables Figures and tables are not permitted.
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Recent Publications

IBDome: An integrated molecular, histopathological, and clinical atlas of inflammatory bowel diseases

Christina Plattner, Gregor Sturm, Anja A. Kühl, Raja Atreya, Sandro Carollo, Dietmar Rieder, Raphael Gronauer, Michael Günther, Steffen Ormanns, Claudia Manzl, Stefan Wirtz, Asier Rabasco Meneghetti, Ahmed N. Hegazy, Jay V. Patankar, Zunamys I. Carrero, Felix Grabherr, Moritz Meyer, Imke Atreya, Raja Atreya, Petra Bacher, Christoph Becker, Christian Bojarski, Nathalie Britzen-Laurent, Caroline Voskens, Hyun-Dong Chang, Andreas Diefenbach, Claudia Günther, Ahmed N. Hegazy, Kai Hildner, Christoph S.N. Klose, Kristina Koop, Susanne M. Krug, Anja A. Kühl, Moritz Leppkes, Rocío López-Posadas, Leif S. Ludwig, Clemens Neufert, Markus Neurath, Jay V. Patankar, Christina Plattner, Magdalena S. Prüß, Andreas Radbruch, Chiara Romagnani, Francesca Ronchi, Ashley D. Sanders, Alexander Scheffold, Jörg-Dieter Schulzke, Michael Schumann, Sebastian Schürmann, Britta Siegmund, Michael Stürzl, Zlatko Trajanoski, Antigoni Triantafyllopoulou, Maximilian Waldner, Carl Weidinger, Stefan Wirtz, Sebastian Zundler, Timon E. Adolph, Herbert Tilg, Markus F. Neurath, Jakob Nikolas Kather, Christoph Becker, Britta Siegmund, Zlatko Trajanoski

10.1053/j.gastro.2026.05.023
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DREAM Promotes Intestinal Adaptation and Restores Enterohepatic Signaling in Short Bowel Syndrome

Shaurya Mehta, Kento Kurashima, Chandrashekhara Manithody, Takahiro Ohkura, Sylvia Morfin, Ashlesha Bagwe, Marzena Syn, Austin Sims, Sree Kolli, Connor Whalen, Aditya Jain, Miguel Guzman, Sherri Besmer, Sonali Jain, Paula Buchanan, Keith Pereira, Chien-Jung Lin, Bolette Hartmann, Jens J. Holst, John Long, Shin Miyata, Matthew McHale, Chelsea Hutchinson, Ajay Kumar Jain

10.1053/j.gastro.2026.05.024
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Beyond Calorie Counting: Is Circadian Alignment Key to Metabolic Health in Crohn’s Disease?

Lei Sun, Wei Ye

10.1053/j.gastro.2026.02.056
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Generalizability of the MetALD-ALD Prediction Index in Asian populations

Hideki Fujii, Hiroshi Tobita, Atsushi Nakajima

10.1053/j.gastro.2026.04.043
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Acute Liver Failure in a Patient with Myasthenia Gravis

Tianzhi Tang, Dhanpat Jain, Peter D. Block

10.1053/j.gastro.2026.05.025
View Publication

Frequently asked questions

How long does it take to publish?

Median 4 days from submission to first decision and median 21 days from acceptance to online publication.

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Is a cover letter required?

A concise cover letter is strongly encouraged. It should describe the manuscript and relevant context, suggest 2-5 reviewers and the associate editor best qualified to review the paper, note any non-preferred editors or reviewers, explain deviations from standard format, and clarify potential conflicts. Fast-track requests should be indicated in the cover letter.

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What are the publication costs?

Research Topics

Helicobacter pylori-related gastroenterology studies Inflammatory Bowel Disease Liver Disease Diagnosis and Treatment Microscopic Colitis Eosinophilic Esophagitis Gastrointestinal motility and disorders Gastroesophageal reflux and treatments Gastric Cancer Management and Outcomes Pancreatitis Pathology and Treatment Esophageal and GI Pathology Pancreatic and Hepatic Oncology Research Colorectal Cancer Screening and Detection Liver Disease and Transplantation Diet and metabolism studies Gastrointestinal disorders and treatments Hepatitis C virus research Esophageal Cancer Research and Treatment Digestive system and related health Genetic factors in colorectal cancer Clinical Nutrition and Gastroenterology Diverticular Disease and Complications Celiac Disease Research and Management Hepatitis B Virus Studies Liver Diseases and Immunity Gut microbiota and health

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