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Intensive Care Medicine Experimental

Intensive Care Medicine Experimental (ICMx) is an open access journal dedicated to translational research that bridges basic science and clinical practice in critical care and emergency medicine. The journal focuses on physiology and pathophysiology relevant to critical illness, aiming to bring novel diagnostics and therapies closer to the bedside. It seeks work that advances understanding of critical illness mechanisms, informs and supports clinical trial design, tests innovative interventions, and develops or refines experimental models pertinent to intensive care. ICMx welcomes original studies, reviews, hypothesis papers, and state‑of‑the‑art methodology papers, and serves researchers working to improve emergency care for critically ill patients. It is the official journal of the European Society of Intensive Care Medicine (ESICM).

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Subject Critical Care Medicine
Impact Factor 3.1
Quartile Q2
Open Access Type Open
ISSN 2197-425X
eISSN 2197-425X
Invitation Only No
Cost Range Article processing charge (APC); ESICM members may receive a discount.

Submission Instructions

Intensive Care Medicine Experimental accepts the following article types. Click on an article type to view submission instructions.

Research Article

Title Page Provide a title page that includes the manuscript title (include study design where appropriate), full author names and institutional addresses, any collaboration group designation (with individual members listed in Acknowledgements if desired), and the corresponding author. Any use of large language models must be disclosed in the Methods.
Abstract An abstract of no more than 350 words is required. It must be structured with Background, Results, and Conclusions; avoid abbreviations and do not include references.
Main Manuscript Headings Organize the manuscript with Background, Methods, Results, Discussion, and Conclusions sections; include Keywords, a List of abbreviations (if used), and a Declarations section covering ethics, data availability, competing interests, funding, contributions, and acknowledgements.
Reference Format Format references according to the Basic Springer reference style as shown in the examples. Web links/URLs should be cited as numbered references in the reference list with access dates; cite only published, in-press, or publicly accessible items.
Figures Upload each figure as a separate file; provide figure titles (≤15 words) and legends (≤300 words) within the main manuscript file. Number figures in order of first citation and ensure correct orientation; acceptable formats include EPS, PDF, TIFF, JPEG, PNG, BMP, Word (single page), PowerPoint (single page), and CDX.
Tables Include short tables within the manuscript near their first citation and place longer tables at the end of the manuscript text file with clear callouts. Create tables using the word processor’s Table function, with titles above and legends below; do not submit tables as figures.
Additional Documents All submissions must include Declarations covering: Ethics approval and consent to participate; Consent for publication (if applicable); Availability of data and materials; Competing interests; Funding; Authors’ contributions; and Acknowledgements. Provide a List of abbreviations if used and submit any supporting datasets or materials as additional files.
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Review

Abstract A structured abstract is not required for reviews. If an abstract is included, it does not need to follow a structured format.
Key Points Provide a two-sentence “Take-home message” summarizing the manuscript’s contribution and a 140-character Tweet for online promotion.
Main Manuscript Headings No specific section structure is prescribed for review articles on this page.
Reference Format Use the Basic Springer reference style. Include web links/URLs as numbered references with site title, full URL, and access date; follow the provided examples for journals, books, chapters, proceedings, patents, and online sources.
Figures Upload figures as separate files in accepted formats; provide figure titles (max 15 words) and legends (max 300 words) within the main manuscript. Number figures in order, ensure correct orientation, and keep individual files ≤10 MB.
Tables Include tables within the main manuscript (not as figures), numbered and cited in sequence. Provide titles above and legends below; large tables may be placed at the end of the document or uploaded as additional files if too large/wide.
Additional Documents Include a two-sentence Take-home message and a 140-character Tweet to accompany the article online.
Word Count Review articles must not exceed 4,000 words and 75 references; supplementary files are not limited in length.
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Hypothesis Article

Main Manuscript Headings No structured format is required. Authors may use subsections with short, informative headings to organize the text.
Reference Format Use the Basic Springer reference style. Web links and URLs should be numbered and included in the reference list with full site title, URL, and access date.
Figures Provide figure titles and legends in the main manuscript; upload figures as separate files, numbered in order of citation. Multi-panel figures should be submitted as a single composite file.
Tables Place short tables within the manuscript where first cited; larger tables may be placed at the end of the document. Do not embed tables as figures; use the word processor’s Table function with a title above and legend below.
Additional Documents Include an ‘Availability of data and materials’ section. Additional files (datasets, tables, movies) may be submitted; do not upload consent forms, language-editing certificates, or tracked-change manuscripts as additional files.
Word Count Hypothesis articles should be concise, ideally between 500 and 1500 words.
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Editorial

Reference Format Use the Basic Springer reference style. Web links/URLs must be numbered and listed in the references with the site title, full URL, and date accessed.
Figures Figures are not permitted for Editorials; do not include any figure files.
Tables Tables are not permitted for Editorials; do not include tables in the manuscript or as separate files.
Word Count Editorials must not exceed 500 words and may include a maximum of 5 references (including the cited Intensive Care Medicine Experimental article).
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Letters to the Editor

Main Manuscript Headings Begin with “To the Editor.” The body must not exceed 500 words and may be divided into brief subsections with short, informative headings.
Reference Format Use the Basic Springer reference style. Web links and URLs should be assigned a reference number and included in the reference list with the site title, full URL, and date accessed.
Figures Upload figures as separate files, ensuring each is closely cropped and under 10 MB. Provide figure titles (max 15 words) and legends (max 300 words) within the main manuscript. Multi‑panel figures should be submitted as a single composite file; no more than two figures or tables in total are allowed.
Tables Include tables within the main manuscript file. Short tables can appear at the appropriate location in the text; longer tables may be placed at the end of the document. Do not submit tables as figures; prepare them using the word processor’s table function. A maximum of two figures or tables in total applies.
Additional Documents Include an ‘Availability of data and materials’ section. Additional files (e.g., datasets, large tables, multimedia) may be provided and will be published with the article; do not upload consent forms, editing certificates, or tracked‑changes files. Authors may be asked to detail each author’s contribution.
Word Count Maximum 500 words, up to 5 references, and no more than two total figures or tables. Limit authorship to five or fewer.
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Recent Publications

Bioactive adrenomedullin dynamics and microcirculatory changes in a porcine model of hemorrhagic shock

Carolin Vekla, Oliver Hartmann, Sebastian O. Decker, Maik von der Forst, Florian Uhle, Alexander Studier-Fischer, Berkin Özdemir, Felix Nickel, Stephan Katzenschlager, Frank Weilbacher, Thorsten Brenner, Erik Popp, Markus A. Weigand, Karsten Schmidt, Maximilian Dietrich, Daniel Gruneberg

10.1186/s40635-026-00976-4
View Publication

The effect of preload on Doppler systolic time in a large emergency department cohort with suspected sepsis

Sarah Atwi, Jared Nunnally, Kristen Ugale, So Mi Ko, Jaclyn Bond, Kimberly Boozer, Raymond J. Bautista, Catalina Torres, Matthew Sedillo, Daniel Lachner-Piza, Tracy Savery, Melissa Hebscher, Joseph K. Eibl, Jon-Emile S. Kenny, Korbin Haycock

10.1186/s40635-026-00987-1
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Frontal cortical neuroinflammation and circulating biomarkers following cardiopulmonary bypass in sheep

Taku Furukawa, Alemayehu H. Jufar, Anton L. Trask-Marino, Clive N. May, Roger G. Evans, Andrew D. Cochrane, Bruno Marino, Peter R. McCall, Sally G. Hood, Jaishankar Raman, Connie Pei Chen Ow, Lars I. P. Snel, Scott Ayton, Ashenafi Betrie, Linda Cornthwaite, Munenori Kusunoki, Angela Connelly Huf, Dawoud AlMekhled, Emily Hadzajlic, Adam Southon, Rinaldo Bellomo, Lachlan F. Miles, Lindsea Booth, Yugeesh R. Lankadeva

10.1186/s40635-026-00986-2
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Effect of vasopressin and its analogues on microcirculatory perfusion: a systematic review

Judith van Zwol, J. G. Kruijsse, A. A. Vidal Itriago, S. N. T. Hemmes, C. E. van den Brom

10.1186/s40635-026-00983-5
View Publication

The impact of ventilation mode on systemic inflammation and organ dysfunction in a porcine model of abdominal sepsis-associated acute respiratory distress syndrome

James G. Williams, Michaela Kollisch-Singule, Nirmeen Elmadany, Nader M. Habashi, Gary F. Nieman, Brian M. Varisco

10.1186/s40635-026-00985-3
View Publication

Frequently asked questions

Is Intensive Care Medicine Experimental open access?

Yes, Intensive Care Medicine Experimental is a fully open access journal. All articles are freely available to read, download, and share immediately upon publication.

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What is the impact factor of Intensive Care Medicine Experimental?

The 2024 Journal Impact Factor (JIF) for Intensive Care Medicine Experimental is 3.1. The impact factor is a measure of the frequency with which the average article in a journal has been cited in a particular year, and is often used as a proxy for the relative importance of a journal within its field.

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What is the time to publication for Intensive Care Medicine Experimental?

The journal reports a median time of 6 days from submission to first editorial decision and a median of 82 days from submission to acceptance.

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Does Intensive Care Medicine Experimental require a cover letter?

Yes. A cover letter is required and must explain why the manuscript should be published in Intensive Care Medicine Experimental, address any issues related to journal policies, declare potential competing interests, and confirm the content has not been previously published or submitted elsewhere. If submitting to a special issue, name it in the letter, and indicate if you have selected the “No Revisions” option.

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How much does it cost to publish in Intensive Care Medicine Experimental?

The journal is fully open access and uses an Article Processing Charge (APC). Members of the European Society of Intensive Care Medicine (ESICM) may be eligible for a discount. Specific fee amounts are not listed on this page.

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Research Topics

Respiratory Support and Mechanisms Sepsis Diagnosis and Treatment Cardiac Arrest and Resuscitation Intensive Care Unit Cognitive Disorders Hemodynamic Monitoring and Therapy

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