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JACC Heart Failure

JACC: Heart Failure is a specialist journal in the Journal of the American College of Cardiology family. It publishes findings on the pathophysiology, diagnosis, treatment, and care of heart failure patients, with a goal of improving understanding of the disease, clinical trials, clinical outcomes, and advances in therapies through timely scientific communication. The journal also covers interdisciplinary topics related to neuroscience, pulmonary medicine, nephrology, electrophysiology, surgery, pharmacogenetics, biomarkers, and metabolomics.

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Subject Cardiac & Cardiovascular Systems
Impact Factor 11.8
Quartile Q1
Open Access Type Hybrid
ISSN 2213-1779
eISSN 2213-1787
Invitation Only No
Cost Range USD 5250 excl. taxes for open access articles; no open access publication fee for subscription publication.

Submission Instructions

JACC Heart Failure accepts the following article types. Click on an article type to view submission instructions.

Original Research Papers

Cover Letter Cover letter is required. Cover letter must state that the paper is not under consideration elsewhere, has not been previously published, all authors approved the manuscript, disclose conflicts of interest or their absence, disclose any use of artificial intelligence, substantiate each author's contribution if there are more than 4 authors, and denote proper ethical oversight.
Abstract A structured abstract is required. Abstract must not exceed 250 words. Abstract must be structured and written in complete sentences. Abstract must use the headings Background, Objectives, Methods, Results, and Conclusions.
Manuscript Manuscript must be 5,000 words or fewer including text, references, and figure legends. Manuscript text must be structured as Introduction, Methods, Results, Discussion, and Conclusions, and Original Research Papers must include hypothesis and purpose and implications for clinical practice. Manuscript must include key words, an abbreviations list, Clinical Perspectives placed after the text and before the acknowledgments and references, and a Central Illustration called out in the body with a title-and-caption legend listed last among figure legends.
References References must be cited by numerals in parentheses in order of first mention, list all authors if 6 or fewer or the first 3 followed by "et al." if more than 6, use Index Medicus journal abbreviations, and exclude personal communications, manuscripts in preparation, unpublished data, and abstracts older than 2 years.
Figures & Tables Original Research Papers must include a Central Illustration. Figures and the Central Illustration must be submitted separately from the manuscript file. Central Illustration must summarize the manuscript or a major section, be labeled "Central Illustration" rather than as a numbered figure, not duplicate other figures, include a legend with a title and caption listed last among figure legends, be original rather than adapted or reprinted, and trial logos must not appear.
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State Of The Art Reviews

Cover Letter Cover letter is required. Cover letter must state that the paper is not under consideration elsewhere, that its contents have not been previously published, that all authors approved the manuscript, disclose conflicts of interest or their absence, explain any disclosure exceptions, detail how the submission differs from existing reviews on the subject, and disclose any use of artificial intelligence in manuscript compilation.
Abstract Abstract is required. Abstract must be unstructured and no more than 150 words. Abstract must be unstructured.
Manuscript Manuscript must not exceed 7,500 words including text, references, and figure legends. Manuscript must include key words, an abbreviations list, 3 to 4 Highlights bullets with specified content and each bullet no more than 15 words, and a Central Illustration called out in the text with a title-and-caption legend listed last that is original, labeled "Central Illustration," summarizes the manuscript or a major section, and does not duplicate other figures.
References References must be cited by numerals in parentheses in order of appearance, numbered consecutively in the reference list, list all authors when there are 6 or fewer and the first 3 followed by "et al." when there are more than 6, use Index Medicus journal abbreviations without periods after author initials, and exclude unpublished data and abstracts older than 2 years.
Figures & Tables State Of The Art Reviews must include one Central Illustration. Figures and the Central Illustration must be submitted separately from the manuscript file. Central Illustration must be original, labeled "Central Illustration" rather than as a numbered figure, called out in the article body, accompanied by a legend with a title and caption listed last among figure legends, must not duplicate other figures, and must not contain trial logos.
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Review Topic Of The Month

Cover Letter Any use of artificial intelligence in compiling the manuscript must be disclosed in the cover letter, and if there are more than 4 authors the cover letter must substantiate each author's contribution.
Abstract An abstract is required. The abstract must be unstructured and no more than 150 words. The abstract must be unstructured.
Manuscript The manuscript must be 3,000 words or fewer from the introduction to the conclusion, including references and figure legends. The manuscript must include key words, an abbreviations list, Highlights with 3 to 4 brief bullet points following the specified content sequence, and a Central Illustration.
References The manuscript may include no more than 50 references. References must be numbered in order of first mention, cited in the text as numerals in parentheses, list all authors when there are 6 or fewer and the first 3 followed by et al. when there are more than 6, and use Index Medicus journal abbreviations.
Figures & Tables The manuscript must include one Central Illustration. Figures and the Central Illustration must be submitted separately from the manuscript file.
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Research Letters

Cover Letter Cover letter is required. Cover letter must denote proper ethical oversight and include statements that the paper is not under consideration elsewhere, has not been previously published, all authors have approved the manuscript, any potential conflicts are disclosed or absent, and any use of artificial intelligence is disclosed.
Abstract Abstract must not be included.
Manuscript Manuscript must be 1,000 words or fewer including text, references, and figure legend. Manuscript must omit an abstract, Central Illustration, Clinical Perspectives, and supplemental material and include two first-page bullets totaling no more than 40 words, one stating the clinical question and one stating the main finding. Manuscript must include two first-page bullets totaling no more than 40 words and, if artificial intelligence was used, disclose its contribution in the acknowledgments section.
References References are limited to no more than 5. References must be numbered consecutively in order of mention, cited in the text as numerals in parentheses, list all authors if there are 6 or fewer or the first 3 followed by et al if there are more than 6, use Index Medicus journal abbreviations, and exclude unpublished data and abstracts older than 2 years.
Figures & Tables Submission may include no more than 1 simple figure in no more than 2 parts or 1 simple table. Figures must be submitted separately from the manuscript file. Research Letters must not include a Central Illustration.
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Letters To The Editor

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract requirements are not specified.
Manuscript Manuscript must not exceed 400 words including text and references.
References References are limited to no more than 5. The cited article must be listed as the first reference.
Figures & Tables Submission may include one table or one figure with up to 2 panels. Figures must be submitted separately from the manuscript file.
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Recent Publications

The Effect of Vericiguat on Recurrent Heart Failure Hospitalization and Death in Ambulatory HFrEF

Yogesh N.V. Reddy, Javed Butler, Irina Barash, Justin A. Ezekowitz, Carolyn S.P. Lam, Robert J. Mentz, Christopher O’Connor, Michele Senni, Adriaan A. Voors, Faiez Zannad

10.1016/j.jchf.2026.103171
View Publication

Withdrawal of Guideline-Directed Medical Therapy in Heart Failure With Improved Ejection Fraction

Amira Mohamed Taha, Dang Nguyen, Marwa Muhammed Abdeljawad, Mohammed Tarek Hasan, Tam Tran, Phat K. Huynh, Chau Dang, Dat Ngo, Jacques Kpodonu, Louise Y. Sun

10.1016/j.jchf.2026.103172
View Publication

A Randomized Clinical Implementation Trial Testing a Digital Strategy to Increase SGLT2 Inhibitor Initiation in Heart Failure

Mariam Elmegaard, Lars Køber, Mads Kristian Ersbøll, Theis Lange, Christian Ditlev Tuxen, Mette Rauhe Mouridsen, Trine Kiilerich Lauridsen, Jens Jakob Thune, Peter Godsk Jørgensen, Morten Lamberts, Nadia Paarup Dridi, Peter Bonfils, Morten Petersen, Nis Ottesen Stride, Anders Barasa, Jesper Jensen, Caroline Hartwell Garred, Emil Fosbøl, Emil Wolsk, John J.V. McMurray, Mark C. Petrie, Morten Schou

10.1016/j.jchf.2026.103176
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Genotype Predicts Heart Failure Independent of LVEF, Peak VO2, and NT-proBNP Levels in Hypertrophic Cardiomyopathy

Athanasios Bakalakos, Alexandros Protonotarios, Menelaos Pavlou, Douglas E. Cannie, Rebeca Lorca, Caroline J. Coats, Emanuele Monda, Konstantinos Savvatis, Luis R. Lopes, Constantinos O’Mahony, Juan Pablo Kaski, Massimiliano Lorenzini, Petros Syrris, Perry Mark Elliott

10.1016/j.jchf.2026.103149
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Heart Failure Duration, Cardiac Remodeling, Dysfunction, and Hemodynamic Severity in HFpEF and HFmrEF

Shunichi Doi, Sho Kazui, Naoyuki Akashi, Ravi B. Patel, Jan Komtebedde, Uma Mylavarapu, Vijay Swarup, Sebastian Winkler, Sören J. Backhaus, Sheldon E. Litwin, Rajeev C. Mohan, Rami Kawash, Aaron L. Sverdlov, Eugene S. Chung, David M. Kaye, Elke Hoendermis, Scott L. Hummel, Maja Cikes, Christopher S. Hayward, Randall Starling, Deepak K. Gupta, Andreas Zirlik, Scott McKenzie, Ajith Nair, Andreas Rieth, Donald E. Cutlip, Scott D. Solomon, Dirk J. van Veldhuisen, Martin B. Leon, Frank E. Silvestry, Sanjiv J. Shah, Barry A. Borlaug

10.1016/j.jchf.2026.103167
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Frequently asked questions

How long does it take to publish?

Expedited review provides a decision regarding suitability for expedited publication processing within 2 days and an initial decision within 14 days.

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Is a cover letter required?

A cover letter is required for most submissions and is not required for Editorial Comments. It should identify the corresponding author and include the 4 ICMJE statements on exclusive consideration, prior publication, author approval, and conflict of interest disclosure; it may also explain the paper's merit, suggest reviewers, and request expedited review. Ethical oversight and AI program disclosure must be included in the cover letter when applicable.

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What are the publication costs?

Open access APC: USD 5250 excluding taxes for all articles. Subscription publication has no open access publication fee.

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Research Topics

Heart Failure Treatment and Management Cardiovascular Function and Risk Factors Mechanical Circulatory Support Devices Cardiac pacing and defibrillation studies Cardiac Structural Anomalies and Repair Diabetes Treatment and Management Cardiovascular and exercise physiology Transplantation: Methods and Outcomes Cardiac Arrest and Resuscitation Cardiomyopathy and Myosin Studies Atrial Fibrillation Management and Outcomes Cardiac Fibrosis and Remodeling Cardiac Valve Diseases and Treatments Cardiac electrophysiology and arrhythmias Cardiac Imaging and Diagnostics Acute Myocardial Infarction Research Health Systems, Economic Evaluations, Quality of Life Electrolyte and hormonal disorders Pulmonary Hypertension Research and Treatments Blood Pressure and Hypertension Studies Cardiac Health and Mental Health Renal Transplantation Outcomes and Treatments Hormonal Regulation and Hypertension Cardiovascular Issues in Pregnancy Human auditory perception and evaluation

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