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JAMA Cardiology

JAMA Cardiology is a cardiology journal in the JAMA Network that publishes research, opinion, and clinical review and education content in cardiovascular medicine.

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Subject Cardiac & Cardiovascular Systems

Impact Factor 14.1

Quartile Q1

Open Access Type Closed

ISSN 2380-6583

eISSN 2380-6591

Invitation Only No

Cost Range Subscription journal; individual article access is available for $45.00.

Submission Instructions

JAMA Cardiology accepts the following article types. Click on an article type to view submission instructions.

Original Investigation

Cover Letter A cover letter is required. The cover letter must state whether the authors have published, posted, or submitted any related papers from the same study.

Abstract A structured abstract is required. The abstract must not exceed 350 words. The abstract must be structured. The abstract must use the headings Importance, Objective, Design, Setting, Participants, Intervention(s) or Exposure(s), Main Outcome(s) and Measure(s), Results, Conclusions and Relevance, and Trial Registration for clinical trials.

Manuscript The manuscript text must not exceed 3000 words, excluding abstract, tables, figures, acknowledgments, references, and online-only material. The manuscript must include a study type and include Key Points before the abstract. Key Points are required, must follow the headings Question, Findings, and Meaning, be limited to 75 to 100 words, and any use of artificial intelligence to create content or assist with writing or editing must be disclosed in the Acknowledgment or Methods section with the specified tool details and author responsibility statement.

References References must follow AMA style. References must be numbered in order of appearance using superscript Arabic numerals, not alphabetized, list up to 6 authors or editors before using the first 3 followed by "et al." for more than 6, and use PubMed journal abbreviations with issue numbers in parentheses after volume numbers.

Figures & Tables No more than 5 tables and/or figures are permitted. Figures must not be included in the manuscript text and must be submitted as separate files, while tables must be included at the end of the manuscript file. Each table and figure must be numbered, titled, and cited in the text, data must not be duplicated between tables and figures, figures must not contain more than 4 panels unless justified, and primary outcome data must not be presented only in figures.

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Systematic Review (Without Meta-Analysis)

Cover Letter A cover letter is required. The cover letter must state whether the authors have published, posted, or submitted any related papers from the same study.

Abstract A structured abstract is required. Abstract must be limited to 350 words. Abstract must be structured. Abstract must use the headings Importance, Objective, Evidence Review, Findings, and Conclusions and Relevance.

Manuscript Manuscript text must not exceed 3000 words, excluding abstract, tables, figures, acknowledgments, references, and online-only material. Manuscript should include the subtitle "A Systematic Review" and use sections including Introduction, Methods, Results, Discussion, and a 2- to 3-sentence Conclusions section. Manuscript must include Key Points before the abstract with the headings Question, Findings, and Meaning limited to 100 words, include a table with ratings of study or evidence quality, and clearly describe any AI-generated content if used.

References Manuscript must include 50 to 75 references. References must follow AMA style. References must be numbered in order of appearance using superscript Arabic numerals, not alphabetized, list up to 6 authors or editors before using "et al.," and use PubMed journal abbreviations with issue numbers in parentheses after volume numbers.

Figures & Tables Manuscript must include no more than 5 tables and/or figures. Tables must be included at the end of the manuscript file, and figures must not be included in the manuscript text and should be uploaded separately for submission. Each table and figure must be numbered, titled, and cited in the text, and data must not be duplicated across tables and figures.

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Narrative Review

Cover Letter A cover letter is required. The cover letter must state whether the authors have published, posted, or submitted any related papers from the same study.

Abstract A 3-part structured abstract is required. The abstract must be limited to 300 words. The abstract must be structured. The abstract must use the headings Importance, Observations, and Conclusions and Relevance.

Manuscript The manuscript must be 2000 to 3500 words. The manuscript should include an Abstract, Introduction, Methods if included, Discussion/Observations, and Conclusions, and the subtitle should be "A Review." Key Points must not be included, and the manuscript should include tables summarizing epidemiology, diagnostic tools, therapies available for the disease, and a fourth table comparing the review findings with current clinical practice recommendations or diagnostic and therapeutic uncertainty or controversies.

References The manuscript must include 50 to 75 references. References must follow AMA style. References must be numbered in order of appearance, cited with superscript Arabic numerals, list all authors up to 6 or the first 3 followed by "et al." if more than 6, and use PubMed journal abbreviations.

Figures & Tables The manuscript must include no more than 5 tables and/or figures. Figures must not be included in the manuscript text and should be submitted as separate files, while tables must be included at the end of the manuscript file. Each table and figure must be numbered, titled, and cited in the text, and data must not be duplicated in both figures and tables.

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Randomized Clinical Trial

Cover Letter A cover letter is required. The cover letter must state whether the authors have published, posted, or submitted any related papers from the same study.

Manuscript The manuscript must not exceed 3000 words. The manuscript must include Key Points before the abstract and use the subtitle "A Randomized Clinical Trial." The manuscript must include Key Points, trial registration and ID, a trial protocol, a CONSORT checklist, a Data Sharing Statement, and clear disclosure of any AI-generated or AI-assisted content.

References The manuscript must include 50 to 75 references. References must follow AMA style. References must be numbered in order of appearance using superscript Arabic numerals, not alphabetized, and list up to 6 authors or editors before using the first 3 followed by "et al." for more than 6.

Figures & Tables The manuscript must include no more than 5 tables and/or figures, including a CONSORT flow diagram. Figures must not be included in the manuscript text and must be submitted as separate files, while tables must be included at the end of the manuscript file. Each table and figure must be numbered, titled, cited in the text, and primary outcome data must not be presented only in figures.

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Meta-Analysis

Cover Letter A cover letter is required. The cover letter must state whether the authors have published, posted, or submitted any related papers from the same study.

Abstract A structured abstract is required. Abstract must be limited to 350 words. Abstract must be structured. Abstract headings must be Importance, Objective, Data Sources, Study Selection, Data Extraction and Synthesis, Main Outcome(s) and Measure(s), Results, and Conclusions and Relevance.

Manuscript Manuscript text must not exceed 3000 words, excluding abstract, tables, figures, acknowledgments, references, and online-only material. Manuscript must describe methods used for data sources, study selection, data extraction, and data synthesis in the text. Manuscript must include Key Points and a Data Sharing Statement, and any artificial intelligence-generated content must be clearly described with the tool details and author responsibility.

References Manuscript must include 50 to 75 references. References must follow AMA style. References must be numbered in order of appearance using superscript arabic numerals, journal names must use PubMed abbreviations, and up to 6 authors should be listed or the first 3 followed by "et al." if more than 6.

Figures & Tables Manuscript must include no more than 5 tables and/or figures. Figures must not be included in the manuscript text and should be submitted as separate files, while tables must be included at the end of the manuscript file. Each table and figure must be numbered, titled, and cited in the text, and figures must not contain more than 4 panels unless justified.

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Brief Report

Cover Letter A cover letter is required. The cover letter must state whether the authors have published, posted, or submitted any related papers from the same study.

Abstract A structured abstract is required. Abstract must not exceed 350 words. The abstract must be structured. Abstract headings must be Importance, Objective, Design, Setting, Participants, Intervention(s) or Exposure(s), Main Outcome(s) and Measure(s), Results, Conclusions and Relevance, and Trial Registration for clinical trials.

Manuscript Manuscript should be 1200 words. The manuscript must include Key Points before the abstract and include the study type. The manuscript must include Key Points, a Data Sharing Statement, and any required disclosure of artificial intelligence-generated or assisted content.

References No more than 15 references are permitted. References must follow AMA style. References must be numbered in order of appearance, cited with superscript Arabic numerals, not alphabetized, and list up to 6 authors or editors before using the first 3 followed by "et al." if there are more than 6.

Figures & Tables No more than 3 tables and/or figures are permitted. Figures must not be included in the manuscript text and must be submitted as separate files, while tables must be included at the end of the manuscript file. Each table and figure must be numbered, titled, cited in the text, and not duplicate data presented elsewhere.

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Research Letter

Cover Letter A cover letter is required. Cover letter must state whether any related papers from the same study have been published, posted, or submitted.

Abstract Abstract must not be included.

Manuscript Manuscript text must not exceed 800 words. Manuscript should generally be divided into Introduction, Methods, Results, and Discussion sections. Key Points must not be included, and any online supplementary material is allowed only for brief additional and absolutely necessary methods and not for additional results or discussion.

References No more than 10 references may be included. References must follow AMA style. References must be numbered in order of appearance using superscript Arabic numerals, not alphabetized, and list up to 6 authors or editors before using the first 3 followed by "et al." for more than 6.

Figures & Tables No more than 2 small tables and/or figures may be included. Figures must not be included in the manuscript text and should be submitted as separate files, while tables must be included at the end of the manuscript file. Each table and figure must be numbered, titled, and cited in the text, and data must not be duplicated in both figures and tables.

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Clinical Challenge

Cover Letter A cover letter is required. The cover letter must state whether the authors have published, posted, or submitted any related papers from the same study.

Abstract Abstract requirements are not specified.

Manuscript Case presentations must be 250 words and discussions must be 500 to 600 words. Manuscripts must include a case presentation, a discussion, and 4 single-phrase plausible treatment options for the question "What Would You Do Next?" with 1 option identified as preferred.

References Manuscripts must include no more than 10 references. References must follow AMA style. References must be numbered in the order they appear in the text, cited with superscript Arabic numerals, and list all authors up to 6 or the first 3 followed by "et al." if there are more than 6.

Figures & Tables Manuscripts must include 1 to 2 small figures. Figures must be submitted as separate files and not included in the manuscript text. Images must be submitted as high-quality unlabeled .jpg or .tif files, and a separate labeled version may be included for reference if desired.

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Letter To The Editor

Cover Letter A cover letter is required. Cover letter must state whether the authors have published, posted, or submitted any related papers from the same study.

Abstract Abstract requirements are not specified.

Manuscript Letter to the Editor submissions must not exceed 400 words of text.

References Letter to the Editor submissions must include no more than 5 references, including 1 reference to the recent article discussed. References must follow AMA style. References must be numbered in the order cited using superscript Arabic numerals and list all authors up to 6, or the first 3 followed by "et al" if there are more than 6.

Figures & Tables Figures must not be included in the manuscript text and should be submitted as separate files, while tables must be included at the end of the manuscript file. Each table and figure must be numbered, titled, and cited in the text.

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Parallel-Design Double-Blind Trial

Cover Letter A cover letter is required. The cover letter must state whether the authors have published, posted, or submitted any related papers from the same study.

Manuscript The manuscript must not exceed 3000 words. The manuscript must include Key Points before the abstract and use the subtitle “A Randomized Clinical Trial.” The manuscript must include Key Points, trial registration and ID, a trial protocol, a CONSORT checklist, a Data Sharing Statement, and clear disclosure of any artificial intelligence-generated content.

References The manuscript must include 50 to 75 references. References must follow AMA style. References must be numbered in order of appearance, cited with superscript Arabic numerals, not alphabetized, list up to 6 authors or editors before using “et al,” and use PubMed journal abbreviations with issue numbers in parentheses after volume numbers.

Figures & Tables The manuscript may include no more than 5 tables and/or figures, including a CONSORT flow diagram. Figures must not be included in the manuscript text and must be submitted as separate files, while tables must be included at the end of the manuscript file. Each table and figure must be numbered, titled, cited in the text, and limited to material necessary to support the article without duplicating data between tables and figures.

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Crossover Trial

Cover Letter A cover letter is required. The cover letter must state whether the authors have published, posted, or submitted any related papers from the same study.

Manuscript The manuscript must not exceed 3000 words. The manuscript must include Key Points before the abstract and use the subtitle "A Randomized Clinical Trial." The manuscript must include Key Points, trial registration and ID, a trial protocol, a CONSORT checklist, and a Data Sharing Statement, and any AI-generated or AI-assisted content must be clearly disclosed with the tool details and author responsibility.

References The manuscript must include 50 to 75 references. References must follow AMA style. References must be numbered in order of appearance using superscript arabic numerals, not alphabetized, with all authors or editors listed up to 6 and the first 3 followed by "et al." if there are more than 6.

Figures & Tables The manuscript must include no more than 5 tables and/or figures, including a CONSORT flow diagram. Figures must not be included in the manuscript text and must be submitted as separate files, while tables must be included at the end of the manuscript file. Each table and figure must be numbered, titled, cited in the text, and limited to material needed to support the article without duplicating data between tables and figures.

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Equivalence And Noninferiority Trial

Cover Letter A cover letter is required. The cover letter must state whether the authors have published, posted, or submitted any related papers from the same study.

Abstract A structured abstract is required. Abstract must not exceed 350 words. The abstract must be structured. The abstract must use the headings Importance, Objective, Design, Setting, Participants, Intervention(s) or Exposure(s), Main Outcome(s) and Measure(s), Results, Conclusions and Relevance, and Trial Registration.

Manuscript The manuscript must not exceed 3000 words. The manuscript must include Key Points before the abstract, use the subtitle "A Randomized Clinical Trial," and include a prespecified noninferiority margin consistent with relevant studies and within which the new intervention can be assumed to be no worse than the active control. The manuscript must include Key Points, trial registration and ID, a trial protocol, a Data Sharing Statement, and clear disclosure of any artificial intelligence-generated or assisted content with the tool details and author responsibility statement.

References The manuscript must include 50 to 75 references. References must follow AMA style. References must be numbered in order of appearance using superscript Arabic numerals, not alphabetized, list up to 6 authors or editors before using "et al." after the first 3 if more than 6, and use PubMed journal abbreviations.

Figures & Tables The manuscript may include no more than 5 tables and/or figures, including a CONSORT flow diagram. Figures must be submitted as separate files and not included in the manuscript text, while tables must be included at the end of the manuscript file. Each table and figure must be numbered, titled, cited in the text, and primary outcome data must not be presented only in figures.

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Cluster Trial

Cover Letter A cover letter is required. The cover letter must state whether the authors have published, posted, or submitted any related papers from the same study.

Abstract A structured abstract is required. Abstract must not exceed 350 words. The abstract must be structured. Abstract must use the headings Importance, Objective, Design, Setting, Participants, Intervention(s) or Exposure(s), Main Outcome(s) and Measure(s), Results, Conclusions and Relevance, and Trial Registration.

Manuscript Manuscript must not exceed 3000 words. Manuscript must include Key Points before the abstract, use the subtitle "A Randomized Clinical Trial," and include a trial protocol. Manuscript must include Key Points, trial registration and ID, a Data Sharing Statement, and disclosure of any artificial intelligence-generated content in the Acknowledgment or Methods section with the specified tool details and author responsibility statement.

Figures & Tables Manuscript must include no more than 5 tables and/or figures, including a CONSORT flow diagram. Figures must not be included in the manuscript text and should be submitted as separate files, while all tables must be included at the end of the manuscript file. Each table and figure must be numbered, titled, and cited in the text, and figures must not contain more than 4 panels unless justified.

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Nonrandomized Clinical Trial

Cover Letter A cover letter is required. Cover letter must state whether the authors have published, posted, or submitted any related papers from the same study.

Abstract A structured abstract is required. Abstract must not exceed 350 words. Abstract must be structured. Abstract must use the headings Importance, Objective, Design, Setting, Participants, Intervention(s) or Exposure(s), Main Outcome(s) and Measure(s), Results, Conclusions and Relevance, and Trial Registration.

Manuscript Manuscript must not exceed 3000 words. Manuscript must include Key Points before the abstract and use the subtitle “A Nonrandomized Clinical Trial.” Manuscript must include Key Points, trial registration and ID, a trial protocol, a Data Sharing Statement, and a study protocol with statistical analysis plan submitted as a supplemental file.

References Manuscript must include 50 to 75 references. References must follow AMA style. References must be numbered in order of appearance using superscript arabic numerals, not alphabetized, with journal names abbreviated per PubMed and all authors listed up to 6 or the first 3 followed by “et al.” if more than 6.

Figures & Tables Manuscript must include no more than 5 tables and/or figures, including a trial flow diagram. Figures must not be included in the manuscript text and must be submitted as separate files, while tables must be included at the end of the manuscript file. Each table and figure must be numbered, titled, and cited in the text, and data must not be duplicated between tables and figures.

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Recent Publications

Neurofilament Light Chain in Atrial Fibrillation—Reply

Geethan Baskaran, David Conen

10.1001/jamacardio.2026.2152

View Publication

Atrial Dyssynchrony and Bachmann Bundle Pacing

Jin Un Kim, Nandita Kaza, Mohamed Zuhair, Akriti Naraen, Ahran D. Arnold, Matthew J. Shun-Shin, Darrel P. Francis, Kevin Vernooy, Justin G. L. M. Luermans, Carsten Israel, Zachary I. Whinnett, Daniel Keene

10.1001/jamacardio.2026.2226

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Exercise Testing and the Evolving Management of Asymptomatic Severe Aortic Stenosis

Erwan Donal, Florent Le Ven, Laurie Soulat-Dufour

10.1001/jamacardio.2026.2570

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Treadmill Stress Test in Patients With Asymptomatic Severe Aortic Stenosis

Philippe Généreux, Allan Schwartz, Brian R. Lindman, Adnan Chhatriwalla, Stephen Ramee, Vasilis Babaliaros, Richard Schwartz, Tej Sheth, William F. Fearon, Paul Sorajja, Thomas Beaver, J. Bradley Oldemeyer, Andrei Pop, Santiago Garcia, Jeffrey Southard, Stephen H. Bailey, Wenhao Li, David J. Cohen, Philippe Pibarot, Martin B. Leon, E L Robinson, Y Zhao

10.1001/jamacardio.2026.2527

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Digitally Enabled Quality Improvement Intervention and LDL-C Control in Atherosclerotic Cardiovascular Disease

M. Julia Machline-Carrion, Karla Santo, Alysson Nathan Girotto, Priscila Raupp, Pedro Marton Pereira, Frederico Monfardini, Renato Hideo Nakagawa Santos, Mariane Pereira, Bruna dos Santos Sampaio, Diogo Moia, Gabriela de Oliveira Farias, Frederico Toledo Campo Dall’Orto, Ricardo Pavanello, Carisi Anne Polanczyk, Odilson Marcos Silvestre, Marcelo Heitor Vieira Assad, Maria Sanali Moura de Oliveira Paiva, Mayler Olombrada Nunes dos Santos, Marina Politi Okoshi, Carlos Eduardo da Costa Nunes Bosso, Leandro Andrade de Azeredo Bastos, Rodrigo de Moura Joaquim, José Airton Arruda, Gustavo Ferreira Araujo, Barbara Riquena, Vania Rezende, Lenio Alvarenga, Kausik Ray, Christopher P. Cannon, Raul D. Santos, Otávio Berwanger

10.1001/jamacardio.2026.2510

View Publication

Frequently asked questions

How long does it take to publish?

Median time to first decision is 8 days without external peer review and 51 days with review. All articles are published online first.

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Is a cover letter required?

A cover letter is required and must include complete contact information for the corresponding author and whether the authors have published, posted, or submitted any related papers from the same study.

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What are the publication costs?

Subscription journal; individual article access is available for $45.00.

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Research Topics

Atrial Fibrillation Management and Outcomes Cardiovascular Function and Risk Factors Cardiac Imaging and Diagnostics Heart Failure Treatment and Management Acute Myocardial Infarction Research Lipoproteins and Cardiovascular Health Cardiac Valve Diseases and Treatments Health Systems, Economic Evaluations, Quality of Life Cardiac pacing and defibrillation studies Cardiac Arrhythmias and Treatments Coronary Interventions and Diagnostics Cardiac Structural Anomalies and Repair Blood Pressure and Hypertension Studies Antiplatelet Therapy and Cardiovascular Diseases Cardiac electrophysiology and arrhythmias Infective Endocarditis Diagnosis and Management Cardiomyopathy and Myosin Studies Cardiovascular Effects of Exercise Cardiac, Anesthesia and Surgical Outcomes Cardiac Arrest and Resuscitation Cardiac Health and Mental Health Congenital Heart Disease Studies Cardiovascular Health and Risk Factors Cardiovascular Issues in Pregnancy Diabetes, Cardiovascular Risks, and Lipoproteins

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