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JAMA Ophthalmology

JAMA Ophthalmology is a JAMA Network journal focused on ophthalmology and publishes research, opinion, and clinical review and education content.

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Subject Ophthalmology
Impact Factor 9.2
Quartile Q1
Open Access Type Hybrid
ISSN 2168-6165
eISSN 2168-6173
Invitation Only No
Cost Range Specialty JAMA Network journals have an open access option with fee waiver and discount policies.

Submission Instructions

JAMA Ophthalmology accepts the following article types. Click on an article type to view submission instructions.

Original Investigation

Cover Letter A cover letter is required. The cover letter must include the corresponding author's complete contact information.
Abstract A structured abstract is required. The abstract must not exceed 350 words. The abstract must be structured. The abstract must use the headings Importance, Objective, Design, Setting, Participants, Intervention(s) or Exposure(s), Main Outcome(s) and Measure(s), Results, Conclusions and Relevance, and Trial Registration when applicable.
Manuscript The manuscript text must not exceed 3000 words. The manuscript must specify a study type. The manuscript must include 3 Key Points and a Data Sharing Statement.
References References must follow AMA style. References must be numbered in the order of appearance, cited with superscript Arabic numerals, use PubMed journal abbreviations, and list all authors up to 6 or the first 3 followed by "et al." if more than 6.
Figures & Tables The manuscript may include no more than 5 tables and/or figures in total. Figures may be uploaded as separate files or appended to the end of the manuscript for initial submission, but tables must be included at the end of the manuscript file and not uploaded separately. Each table and figure must be numbered, cited in the text, and accompanied by a descriptive title.
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Systematic Review (Without Meta-Analysis)

Cover Letter A cover letter is required. The cover letter must include the corresponding author's complete contact information.
Abstract A structured abstract is required. The abstract must not exceed 350 words. The abstract must be structured.
Manuscript The manuscript must not exceed 3000 words of text. The title subtitle must be "A Systematic Review," and the manuscript should include an Introduction of 150-250 words, a Methods section of 150-250 words, a Results section of 1000-1250 words, a Discussion section of 1000 words, and Conclusions of 2-3 sentences. The manuscript must include Key Points, and content created with artificial intelligence or similar technologies must be clearly described with the tool name, version details, and manufacturer.
References The manuscript must include 50-75 references. References must follow AMA style. References must be numbered in order of appearance using superscript Arabic numerals, journal names must be abbreviated according to PubMed, and up to 6 authors or editors should be listed before using "et al." for additional names.
Figures & Tables No more than a total of 5 tables and/or figures may be included. Figures must be submitted as separate files rather than included in the manuscript text, while tables must be included at the end of the manuscript file. The manuscript must include a table with ratings of the quality of the studies or evidence.
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Narrative Review

Cover Letter A cover letter is required. Cover letter must include the corresponding author's complete contact information.
Abstract A structured abstract is required. Abstract must not exceed 300 words. Abstract must be structured in 3 parts. Abstract headings must be Importance, Observations, and Conclusions and Relevance.
Manuscript Manuscript must be 2000 to 3500 words. Manuscript should include an Introduction of 150 to 250 words, may include a Methods section of 150 to 250 words, should include a Discussion/Observations section of 1000 to 1250 words, and should end with Conclusions of 2 to 3 sentences. Manuscript must not include Key Points and AI-generated content must be clearly described with the tool name, version, extension numbers, and manufacturer.
References Manuscript must include 50 to 75 references. References must follow AMA style. References must be numbered in order of appearance using superscript arabic numerals, not alphabetized, list up to 6 authors or editors and if more than 6 list the first 3 followed by "et al.," and use PubMed journal abbreviations.
Figures & Tables Manuscript may include no more than 5 tables and/or figures in total. Figures must be submitted as separate files and not included in the manuscript text, while tables must be included at the end of the manuscript file. Each table and figure must be numbered, titled, cited in the text, and not duplicate data presented elsewhere.
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Brief Report

Cover Letter A cover letter is required.
Abstract A structured abstract is required. Abstract must not exceed 350 words. Abstract must be structured. Abstract must use the headings Importance, Objective, Design, Setting, Participants, Intervention(s) or Exposure(s), Main Outcome(s) and Measure(s), Results, Conclusions and Relevance, and Trial Registration when applicable.
Manuscript Manuscript should be 1200 words. Manuscript must specify a study type. Manuscript must include 3 Key Points.
References Manuscript must include no more than 15 references. References must follow AMA style. References must be numbered in order of appearance, cited with superscript Arabic numerals, use PubMed journal abbreviations, and list up to 6 authors or the first 3 followed by et al if more than 6.
Figures & Tables Manuscript may include no more than a total of 3 tables and/or figures. Figures must be submitted as separate files and not included in the manuscript text, while tables must be included at the end of the manuscript file. Each table and figure must be numbered, titled, and cited in the text, and primary outcome data must not be presented only in figures.
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Research Letter

Cover Letter A cover letter is required. The cover letter must include the corresponding author's complete contact information and state whether related papers from the same study have been published, posted, or submitted.
Abstract Abstract must not be included.
Manuscript Text must not exceed 800 words. Manuscript should generally be divided into Introduction, Methods, Results, and Discussion sections and must specify a study type. Key Points must not be included, and the manuscript must include a Data Sharing Statement.
References No more than 10 references are permitted. References must follow AMA style. References must be numbered in order of appearance using superscript arabic numerals, journal names must be abbreviated according to PubMed, and up to 6 authors should be listed before using the first 3 followed by et al.
Figures & Tables No more than 2 small tables or figures may be included. Figures should be submitted as separate files rather than included in the manuscript text, while tables must be included at the end of the manuscript file. Each table and figure must be numbered, titled, and cited in the text, and data must not be duplicated between figures and tables.
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Letter To The Editor

Cover Letter A cover letter is required. Cover letter must include the corresponding author's complete contact information.
Abstract Abstract requirements are not specified.
Manuscript Letter to the Editor submissions must not exceed 400 words of text.
References Letter to the Editor submissions must include no more than 5 references, including 1 reference to the recent article. References must follow AMA style. References must be numbered in order of appearance using superscript Arabic numerals, not alphabetized, with journal names abbreviated according to PubMed and up to 6 authors listed before using the first 3 followed by "et al."
Figures & Tables Figures must be submitted as separate files rather than included in the manuscript text, while tables must be included at the end of the manuscript file.
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Observation

Cover Letter A cover letter is required. The cover letter must include the corresponding author's complete contact information.
Abstract Abstract requirements are not specified.
Manuscript Observation manuscripts must not exceed 600 words of text. Online supplementary material must not be included.
References Observation manuscripts must include no more than 6 references. References must follow AMA style. References must be numbered in the order cited, identified by superscript Arabic numerals, use PubMed journal abbreviations, and list up to 6 authors or the first 3 followed by "et al." when there are more than 6.
Figures & Tables Observation manuscripts may include up to 2 tables or figures. Tables must be included at the end of the manuscript file, and figures may be uploaded as separate files or appended to the end of the manuscript for initial submission. Each table and figure must be numbered, titled, cited in the text, and not duplicate data presented elsewhere.
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Recent Publications

Reported Metformin Use and Age-Related Macular Degeneration in Patients With Diabetes

Can Can Xue, Miao Li Chee, Hengtong Li, Yih-Chung Tham, Ching-Yu Cheng

10.1001/jamaophthalmol.2026.1799
View Publication

Mobile-Based Artificial Intelligence and Ocular Surface Malignancies

Cyriac Manjaly, Aaron Y. Lee

10.1001/jamaophthalmol.2026.1913
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Beyond the Retina—OCT Insights Into Neurodevelopment

Bo Wang, J. Peter Campbell

10.1001/jamaophthalmol.2026.1995
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Granular Fluorescein Flow in Retinoblastoma

Wenting Zhang, Tingyi Liang, Peiquan Zhao

10.1001/jamaophthalmol.2026.1108
View Publication

Complete Resolution of Subretinal Fluid in Dome-Shaped Macula and Hypotony-Noted Acute Postvitrectomy

Juan Carlos Campos Rodriguez, Cristina Vidal Arranz

10.1001/jamaophthalmol.2026.1808
View Publication

Frequently asked questions

How long does it take to publish?

Accepted articles are generally published Online First and then again in a print/online issue.

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Is a cover letter required?

A cover letter is required and should include complete contact information for the corresponding author and whether the authors have published, posted, or submitted any related papers from the same study.

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What are the publication costs?

Specialty JAMA Network journals have an open access option with fee waiver and discount policies.

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Research Topics

Retinal Diseases and Treatments Glaucoma and retinal disorders Retinal and Optic Conditions Ophthalmology and Visual Impairment Studies Ocular Diseases and Behçet’s Syndrome Retinal and Macular Surgery Intraocular Surgery and Lenses Ocular Oncology and Treatments Retinal Imaging and Analysis Corneal surgery and disorders Cerebral Venous Sinus Thrombosis Retinopathy of Prematurity Studies Retinal Development and Disorders Ocular Infections and Treatments Ocular Surface and Contact Lens Ophthalmology and Eye Disorders Traumatic Ocular and Foreign Body Injuries Corneal Surgery and Treatments Ophthalmology and Visual Health Research Ocular Disorders and Treatments Drug-Induced Ocular Toxicity Diversity and Career in Medicine CNS Lymphoma Diagnosis and Treatment Neonatal Respiratory Health Research Cutaneous Melanoma Detection and Management

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