Overview
Submission Instructions
Recent Publications
Frequently Asked Questions
Research Topics
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JI
JAMA Internal Medicine is a peer-reviewed medical journal in the JAMA Network focused on internal medicine, publishing research, opinion, and clinical review and education content. The journal offers a mix of open access and subscription-access articles and provides author resources, editorial information, podcasts, RSS feeds, and subscription options through the JAMA Network.
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Subject
Medicine, General & Internal
Impact Factor
23.3
Quartile
Q1
Open Access Type
Hybrid
ISSN
2168-6106
eISSN
2168-6114
Invitation Only
No
Cost Range
No author fees are charged for standard publication of research articles; authors of research articles may elect to pay for immediate open access on the day of publication.
Submission Instructions
JAMA Internal Medicine accepts the following article types. Click on an article type to view submission instructions.
Original Investigation
Cover Letter
A cover letter is required. The cover letter must state whether the authors have published, posted, or submitted any related papers from the same study.
Abstract
A structured abstract is required. The abstract must be structured.
Manuscript
Text must not exceed 3000 words, excluding abstract, tables, figures, acknowledgments, references, and online-only material. Original Investigation manuscripts must include a study type. The manuscript must include 3 Key Points and must clearly describe any artificial intelligence-generated content with the tool name, version, and manufacturer.
References
References must follow AMA style. References must be numbered in the order of appearance, cited with superscript Arabic numerals, use PubMed journal abbreviations, and list up to 6 authors or editors before using the first 3 followed by "et al.".
Figures & Tables
The manuscript must include no more than 5 tables and/or figures. Figures must be submitted as separate files rather than included in the manuscript text, while tables must be included at the end of the manuscript file. Each table and figure must be numbered, given a descriptive title, and cited in the text without duplicating data across tables and figures.
Systematic Review (Without Meta-Analysis)
Cover Letter
A cover letter is required.
Abstract
A structured abstract is required. Abstract must not exceed 350 words. Abstract must be structured. Abstract headings must be Importance, Objective, Evidence Review, Findings, and Conclusions and Relevance.
Manuscript
Manuscript text must not exceed 3000 words, excluding abstract, tables, figures, acknowledgments, references, and online-only material. Manuscript should be organized as Abstract, Introduction, Methods, Results, Discussion, and Conclusions. Manuscript must include Key Points of 75-100 words under the headings Question, Findings, and Meaning, include a table with ratings of study or evidence quality, and disclose any AI-generated or AI-assisted content with the tool details and author responsibility.
References
Manuscript must include 50-75 references. References must follow AMA style. References must be numbered in order of appearance using superscript arabic numerals, not alphabetized, list up to 6 authors or editors before using 3 followed by "et al.," use PubMed journal abbreviations, and include the issue number after the volume number for journal articles.
Figures & Tables
Manuscript may include no more than 5 tables and/or figures. Figures must be submitted as separate files rather than embedded in the manuscript text, while tables must be included at the end of the manuscript file. Each table and figure must be numbered, titled, and cited in the text, and primary outcome data must not be presented only in figures.
Narrative Review
Cover Letter
A cover letter is required, and Narrative Review submissions also require a presubmission inquiry. The cover letter or presubmission materials must state whether related papers from the same study exist and should summarize the topic, provide a detailed outline, briefly summarize the extent and quality of the evidence, summarize the authorship group's expertise and publication record, and provide relevant financial conflicts of interest.
Abstract
A 3-part structured abstract is required for Narrative Review manuscripts. The abstract must not exceed 300 words. The abstract must be structured. The abstract must use the headings Importance, Observations, and Conclusions and Relevance.
Manuscript
Narrative Review manuscripts must be 2000-3500 words. The manuscript should be organized as Abstract, Introduction, Methods if included, Discussion/Observations, and Conclusions. Key Points must not be included, and any AI-generated or AI-assisted content must be clearly disclosed in the manuscript or acknowledgment with the tool details and authors accepting responsibility.
References
Narrative Review manuscripts must include 50-75 references. References must follow AMA style. References must be numbered in order of appearance, cited as superscript Arabic numerals, journal names abbreviated according to PubMed, and list up to 6 authors or editors before using "et al." after the first 3 if more than 6 are listed.
Figures & Tables
Narrative Review manuscripts must include no more than 5 tables and/or figures. Figures must be submitted as separate files rather than embedded in the manuscript text, while tables must be included at the end of the manuscript file. Each table and figure must be numbered, given a descriptive title, and cited in the text, and figures should not have more than 4 panels unless justified.
Randomized Clinical Trial
Cover Letter
A cover letter is required. The cover letter must state whether the authors have published, posted, or submitted any related papers from the same study.
Abstract
A structured abstract is required. The abstract must be structured.
Manuscript
The manuscript must not exceed 3000 words. The title should use the subtitle "A Randomized Clinical Trial." The manuscript must include Key Points, trial registration and ID, the trial protocol, and a Data Sharing Statement.
References
The manuscript must include 50 to 75 references. References must follow AMA style. References must be numbered in the order of appearance, cited with superscript arabic numerals, use PubMed journal abbreviations, and list up to 6 authors or editors before using "et al.".
Figures & Tables
The manuscript must include no more than 5 tables and/or figures, including a CONSORT flow diagram. Figures must be submitted as separate files and not included in the manuscript text, while tables must be included at the end of the manuscript file. Each table and figure must be numbered, titled, cited in the text, and not duplicate data presented elsewhere.
Meta-Analysis
Cover Letter
A cover letter is required.
Abstract
A structured abstract is required. Abstract must not exceed 350 words. Abstract must be structured. Abstract headings must be Importance, Objective, Data Sources, Study Selection, Data Extraction and Synthesis, Main Outcome(s) and Measure(s), Results, and Conclusions and Relevance.
Manuscript
Text must not exceed 3000 words, excluding abstract, tables, figures, acknowledgments, references, and online-only material. Text must describe the methods used for data sources, study selection, data extraction, and data synthesis, and the subtitle should include "A Meta-analysis." Manuscript must include 3 Key Points and a Data Sharing Statement.
References
Manuscript must include 50 to 75 references. References must follow AMA style. References must be numbered in order of appearance using superscript Arabic numerals, not alphabetized, with journal names abbreviated according to PubMed and up to 6 authors listed before using "et al."
Figures & Tables
Manuscript must include no more than 5 tables and/or figures. Figures must be submitted as separate files and not included in the manuscript text, while tables must be included at the end of the manuscript file. Each table and figure must be numbered, cited in the text, and given a descriptive title.
Clinical Trial
Cover Letter
A cover letter is required.
Abstract
A structured abstract is required. Abstract must be structured and include trial registration information with registry name, trial ID, and URL at the end.
Manuscript
Text must not exceed 3000 words, excluding abstract, tables, figures, acknowledgments, references, and supplemental material. Manuscript must clearly state an objective or hypothesis, design and methods, essential features of interventions, primary and secondary outcome measures, main results, discussion of study limitations, and conclusions. Manuscript must include 3 Key Points and disclose any use of artificial intelligence in the Acknowledgment or Methods section with the tool details and description of its use.
References
Manuscript must include 50 to 75 references. References must follow AMA style. References must be numbered in order of appearance, cited with superscript Arabic numerals, use PubMed journal abbreviations, and list up to 6 authors or editors before using "et al."
Figures & Tables
Manuscript must include no more than 5 tables and/or figures. Figures must be submitted as separate files rather than embedded in the manuscript text, while tables must be included at the end of the manuscript file. Each table and figure must be numbered, titled, cited in the text, and limited to material needed to support the article without duplicating data.
Research Letter
Cover Letter
A cover letter is required. The cover letter must state whether any related papers from the same study have been published, posted, or submitted.
Abstract
Abstract must not be included.
Manuscript
Text must not exceed 800 words. Research Letters should generally be divided into Introduction, Methods, Results, and Discussion sections and must include the study type. Key Points must not be included, and a Data Sharing Statement must be included.
References
No more than 10 references may be included. References must follow AMA style. References must be numbered in order of appearance, cited with superscript Arabic numerals, and list up to 6 authors or editors before using the first 3 followed by "et al."
Figures & Tables
No more than 2 small tables and/or figures may be included. Figures must not be included in the manuscript text and should be submitted as separate files, while tables must be included at the end of the manuscript file. Each table or figure must be numbered, given a descriptive title, and cited in the text.
Challenges In Clinical Electrocardiography
Cover Letter
A cover letter is required.
Abstract
Abstract requirements are not specified.
Manuscript
Manuscript must not exceed 1000 words, with the case presentation limited to 200 words and the case discussion and patient course limited to 800 words. Submission must include 1 or 2 pertinent questions and an anonymized case discussion and patient course, if applicable. Submission must include 5 bulleted summary points.
References
Submission must include no more than 10 references. References must follow AMA style. References must be numbered in the order cited, identified in the text with superscript Arabic numerals, use PubMed journal abbreviations, and list up to 6 authors or editors before using the first 3 followed by "et al.".
Figures & Tables
Submission must include 1 ECG image. Figures must be submitted as separate files rather than included in the manuscript text, and original image files must also be provided.
Teachable Moment
Cover Letter
A cover letter is required. Teachable Moment manuscripts must describe the first author's training level at the time the manuscript was prepared and the trainee's role in preparing, drafting, and revising the article.
Abstract
Abstract requirements are not specified.
Manuscript
Teachable Moment manuscripts must not exceed 800 words. The manuscript must include a clinical vignette headed "Story From the Front Lines" and a summary of the clinical issues headed "Teachable Moment." The title must reflect the specific focus, and fictional or composite accounts must not be used.
References
Teachable Moment manuscripts must include no more than 5 references. References must follow AMA style. References must be numbered in order of appearance using superscript Arabic numerals, not alphabetized, with all authors listed up to 6 and the first 3 followed by "et al" when there are more than 6.
Figures & Tables
Teachable Moment manuscripts may include 1 figure or table. Figures must be submitted as separate files and not included in the manuscript text, while tables must be included at the end of the manuscript file. Each table or figure must be numbered, given a descriptive title, and cited in the text.
Letter To The Editor
Cover Letter
A cover letter is required.
Abstract
Abstract requirements are not specified.
Manuscript
Text must not exceed 400 words. The letter must include the full name, academic degrees, and a single institutional affiliation for each author and the email address for the corresponding author.
References
No more than 5 references are permitted, including 1 reference to the recent article. References must follow AMA style. References must be numbered in the order of appearance, cited with superscript Arabic numerals, use PubMed journal abbreviations, and list up to 6 authors or editors before using "et al."
Figures & Tables
Figures must be submitted as separate files rather than included in the manuscript text, while tables must be included at the end of the manuscript file. Each table and figure must be numbered, given a descriptive title, and cited in the text.
Parallel-Design Double-Blind Trial
Cover Letter
A cover letter is required.
Abstract
A structured abstract is required. The abstract must be structured.
Manuscript
The manuscript must not exceed 3000 words. The subtitle should be "A Randomized Clinical Trial." The manuscript must include Key Points, trial registration and ID, the trial protocol, and a clear description of any AI-generated content including the tool name, version, and manufacturer.
References
The manuscript must include 50 to 75 references. References must follow AMA style. References must be numbered in order of appearance, cited with superscript Arabic numerals, use PubMed journal abbreviations, and list up to 6 authors or editors before using "et al."
Figures & Tables
The manuscript may include no more than 5 tables and/or figures in total, including a CONSORT flow diagram. Figures must be submitted as separate files rather than included in the manuscript text, while tables must be included at the end of the manuscript file. Each table and figure must be numbered, titled, cited in the text, and primary outcome data must not be presented only in figures.
Crossover Trial
Cover Letter
A cover letter is required.
Abstract
A structured abstract is required. Abstract must be structured.
Manuscript
Manuscript must not exceed 3000 words. Manuscript subtitle should be “A Randomized Clinical Trial.” Manuscript must include Key Points and a clear description of any AI-generated content with the tool name, version, and manufacturer.
References
Manuscript must include 50 to 75 references. References must follow AMA style. References must be numbered in order of appearance, cited with superscript Arabic numerals, use PubMed journal abbreviations, and list up to 6 authors or editors before using “et al.”
Figures & Tables
Manuscript must include no more than 5 tables and/or figures. Figures must be submitted as separate files rather than embedded in the manuscript text, while tables must be included at the end of the manuscript file. Each table and figure must be numbered, titled, cited in the text, and figures with multiple panels must not exceed 4 panels unless justified.
Equivalence And Noninferiority Trial
Cover Letter
A cover letter is required. The cover letter must state whether the authors have published, posted, or submitted any related papers from the same study.
Abstract
A structured abstract is required. The abstract must be structured.
Manuscript
The manuscript must not exceed 3000 words. The subtitle should be "A Randomized Clinical Trial." The manuscript must include Key Points, and any use of artificial intelligence to create content or assist with writing or editing must be disclosed in the Acknowledgment or Methods section with the tool details and author responsibility.
References
The manuscript must include 50 to 75 references. References must follow AMA style. References must be numbered in order of appearance using superscript Arabic numerals, journal names must use PubMed abbreviations, and up to 6 authors or editors are listed before using the first 3 followed by "et al."
Figures & Tables
The manuscript must include no more than 5 tables and/or figures in total. Figures must not be included in the manuscript text and should be submitted as separate files, while tables must be included at the end of the manuscript file. Each table and figure must be numbered, titled, cited in the text, and limited to material needed to support the article without duplicating data.
Recent Publications
Changes in US Life Expectancy From 2019 to 2024
Deborah Dowell, Fang Xu, Xinyi Jiang, Gery Guy, Nisha Nataraj, Jean Ko, Grant Baldwin
10.1001/jamainternmed.2026.4589
View Publication
Comparative Effectiveness of Phenobarbital vs Diazepam for Alcohol Withdrawal Syndrome
Tess Bradley, Megan Feeney, Anica C. Law, Alyssa F. Peterkin, Kathryn L. Fantasia, Allan J. Walkey, Nicholas A. Bosch
10.1001/jamainternmed.2026.4939
View Publication
Clinical Framework for Durable Genomic Interventions
Eric D. Smith, Venkatesh L. Murthy
10.1001/jamainternmed.2026.4690
View Publication
Morning Stiffness as a Sentinel Symptom—Refining Inflammatory Arthritis Screening in Older Adults
Qingfei Kong, Wen Xiao
10.1001/jamainternmed.2026.4681
View Publication
The Growing Role of Phenobarbital in Managing Inpatient Alcohol Withdrawal Syndrome
Timothy M. Dempsey, Timothy S. Anderson
10.1001/jamainternmed.2026.4946
View Publication
Frequently asked questions
How long does it take to publish?
Median time to first decision is 1 day without external peer review and 35 days with review. All articles are published Online First. Research articles are made free access online 12 months after publication.
Reformat to JAMA Internal Medicine using Livewrite PremiumIs a cover letter required?
A cover letter is required and must include complete contact information for the corresponding author and whether the authors have published, posted, or submitted any related papers from the same study.
Reformat to JAMA Internal Medicine using Livewrite PremiumWhat are the publication costs?
No author fees are charged for standard publication of research articles. Authors of research articles may elect to pay for immediate open access on the day of publication.
Reformat to JAMA Internal Medicine using Livewrite PremiumResearch Topics
Health Systems, Economic Evaluations, Quality of Life
Healthcare cost, quality, practices
Healthcare Policy and Management
Primary Care and Health Outcomes
Palliative Care and End-of-Life Issues
Pharmaceutical Economics and Policy
Pharmaceutical industry and healthcare
Cardiac, Anesthesia and Surgical Outcomes
Cardiac Arrhythmias and Treatments
Geriatric Care and Nursing Homes
Pharmaceutical Practices and Patient Outcomes
Health and Medical Research Impacts
Hospital Admissions and Outcomes
Atrial Fibrillation Management and Outcomes
Global Cancer Incidence and Screening
Opioid Use Disorder Treatment
Cardiac Imaging and Diagnostics
Diversity and Career in Medicine
Blood Pressure and Hypertension Studies
Emergency and Acute Care Studies
Acute Myocardial Infarction Research
Cardiac electrophysiology and arrhythmias
Obesity, Physical Activity, Diet
Pharmaceutical studies and practices
Cardiovascular Syncope and Autonomic Disorders