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JAMA Oncology

JAMA Oncology is a JAMA Network journal focused on oncology research, opinion, and clinical review and education content. The journal publishes article types including Research, Research Letters, Brief Reports, Viewpoints, Invited Commentaries, Reviews, and Clinical Challenges, and offers author resources, editorial information, podcasts, and subscription access.

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Subject Oncology
Impact Factor 20.1
Quartile Q1
Open Access Type Closed
ISSN 2374-2437
eISSN 2374-2445
Invitation Only No
Cost Range Buy article access: $45.00; subscription required for full journal access.

Submission Instructions

JAMA Oncology accepts the following article types. Click on an article type to view submission instructions.

Original Investigation

Cover Letter A cover letter is required. The cover letter must include complete contact information for the corresponding author and disclose whether related papers from the same study have been published, posted, or submitted.
Abstract A structured abstract is required. The abstract must be structured.
Manuscript Text must not exceed 3000 words, excluding the abstract, tables, figures, acknowledgments, references, and online-only material. The manuscript must include a study type and a structured abstract. The manuscript must include 3 Key Points and must include an AI disclosure in the Acknowledgment section if artificial intelligence assisted with writing or content creation.
References References must follow AMA style. References must be numbered in order of appearance, cited with superscript Arabic numerals, use PubMed journal abbreviations, list up to 6 authors in full, and for more than 6 list the first 3 followed by "et al.".
Figures & Tables The manuscript may include no more than 5 tables and/or figures total. Figures must be uploaded as separate files, while all tables must be included at the end of the manuscript file. Each table and figure must be numbered, titled, cited in the text, and limited to material needed to support the article.
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Systematic Review (Without Meta-Analysis)

Cover Letter A cover letter is required and must include complete contact information for the corresponding author. The cover letter must provide complete contact information for the corresponding author.
Abstract A structured abstract is required. The abstract must not exceed 350 words. The abstract must be structured. The abstract must use the headings Importance, Objective, Evidence Review, Findings, and Conclusions and Relevance.
Manuscript The manuscript text must not exceed 3000 words, excluding abstract, tables, figures, acknowledgments, references, and online-only material. The manuscript must include Introduction, Methods, Results, Discussion, and Conclusions sections, with Introduction and Methods each 150-250 words, Results 1000-1250 words, Discussion approximately 1000 words, and Conclusions 2-3 sentences. The manuscript must include Key Points of no more than 100 words, a table rating the quality of the studies or evidence, a reproducible literature search description, and disclosure of any AI-generated or AI-assisted content.
References The manuscript must include 50-75 references. References must follow AMA style. References must be numbered in order of appearance using superscript arabic numerals, journal names must use PubMed abbreviations, and references with more than 6 authors must list the first 3 followed by "et al.".
Figures & Tables The manuscript must include no more than 5 tables and/or figures total. Figures must be uploaded as separate files, while all tables must be included at the end of the manuscript file. Each table and figure must be numbered, given a descriptive title, and cited in the text, and data must not be duplicated between tables and figures.
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Narrative Review

Cover Letter A cover letter is required. Cover letter must include complete contact information for the corresponding author and disclose whether any related papers from the same study have been published, posted, or submitted.
Abstract A 3-part structured abstract is required. Abstract must be no more than 300 words. Abstract must be structured in 3 parts. Abstract headings must be Importance, Observations, and Conclusions and Relevance.
Manuscript Manuscript must be 2000-3500 words. Manuscript must include an Introduction of 150-250 words, may include a Methods section of 150-250 words, a Discussion/Observations section of 1000-1250 words, Conclusions of 2-3 sentences, and the subtitle "A Review." Narrative Reviews must not include Key Points and must include an AI disclosure in the manuscript if artificial intelligence or similar technologies assisted with content creation or manuscript preparation.
References Manuscript must include 50-75 references. References must follow AMA style. References must be numbered in order of appearance, cited with superscript Arabic numerals, use PubMed journal abbreviations, list all authors or editors up to 6, and for more than 6 list the first 3 followed by "et al."
Figures & Tables Narrative Reviews may include no more than 5 tables and/or figures total. Figures must be uploaded as separate files and not embedded in the manuscript text, while all tables must be placed at the end of the manuscript file. Each table and figure must be numbered, titled, cited in the text, and included only as needed to support the article without duplicating data between tables and figures.
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Clinical Trial

Cover Letter A cover letter is required. The cover letter must include complete contact information for the corresponding author.
Abstract A structured abstract is required. The abstract must be structured. The abstract must list the trial registry name, trial ID, and URL at the end of the abstract.
Manuscript The manuscript text must not exceed 3000 words, excluding abstract, tables, figures, acknowledgments, references, and supplemental material. The manuscript must include a structured abstract and 3 Key Points. The manuscript must include 3 Key Points and, if artificial intelligence or similar technologies assisted with writing or content creation, an AI disclosure describing the tool and generated content.
References The manuscript must include 50-75 references. References must follow AMA style. References must be numbered in order of appearance, cited with superscript Arabic numerals, list all names for up to 6 authors or editors and the first 3 followed by "et al" for more than 6, use PubMed journal abbreviations, and include the issue number after the volume number for journal references.
Figures & Tables The manuscript must include no more than 5 tables and/or figures total. Figures must be uploaded as separate files, while all tables must be included at the end of the manuscript file. Each table and figure must be numbered, given a descriptive title, and cited in the text, and figures should not contain more than 4 panels unless justified.
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Randomized Clinical Trial

Cover Letter A cover letter is required. The cover letter must include complete contact information for the corresponding author.
Abstract A structured abstract is required. The abstract must be structured. The abstract must list the trial registry name, trial ID, and URL at the end of the abstract.
Manuscript The manuscript text must not exceed 3000 words, excluding the abstract, tables, figures, acknowledgments, references, and supplemental material. The subtitle should include the phrase "A Randomized Clinical Trial." The manuscript must include 3 Key Points and an AI use declaration if artificial intelligence or similar technologies created content or assisted with writing or manuscript preparation.
References The manuscript must include 50 to 75 references. References must follow AMA style. References must be numbered in order of appearance, cited with superscript Arabic numerals, list all authors when there are 6 or fewer and the first 3 followed by "et al" when there are more than 6, use PubMed journal abbreviations, and include the issue number after the volume number for journal articles.
Figures & Tables The manuscript must include no more than 5 tables and/or figures total. Figures must be uploaded as separate files, while all tables must be included at the end of the manuscript file. Each table and figure must be numbered, given a descriptive title, and cited in the text, and figures should not contain more than 4 panels unless otherwise justified.
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Meta-Analysis

Cover Letter A cover letter is required. Cover letter must include complete contact information for the corresponding author.
Abstract A structured abstract is required. Abstract must be structured with the specified headings. Abstract must use the headings Importance, Objective, Data Sources, Study Selection, Data Extraction and Synthesis, Main Outcome(s) and Measure(s), Results, and Conclusions and Relevance.
Manuscript Manuscript text must not exceed 3000 words excluding abstract, tables, figures, acknowledgments, references, and online-only material. Manuscript title subtitle must include the phrase "A Meta-analysis." Manuscript must include 3 Key Points and a Data Sharing Statement, and any AI-assisted content must be disclosed in the manuscript.
References Manuscript must include 50 to 75 references. References must follow AMA style. References must be numbered in order of appearance using superscript arabic numerals, not alphabetized, with up to 6 authors listed in full and more than 6 listed as the first 3 followed by "et al.".
Figures & Tables Manuscript must include no more than 5 tables and/or figures total. Figures must be uploaded as separate files, while all tables must be placed at the end of the manuscript file. Each table and figure must be numbered, given a descriptive title, and cited in the text, and data must not be duplicated between tables and figures.
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Brief Report

Cover Letter Cover letter is required and must include complete contact information for the corresponding author. Cover letter must include complete contact information for the corresponding author.
Abstract Structured abstract is required. Abstract must be structured.
Manuscript Manuscript text must not exceed 1200 words, excluding abstract, tables, figures, acknowledgments, references, and online-only material. Manuscript must include a title page, structured abstract, text, references, and as appropriate figure legends and tables. Manuscript must include 3 Key Points and must disclose any use of artificial intelligence in the manuscript or acknowledgment as applicable.
References Reference list must contain no more than 15 references. References must follow AMA style. References must be numbered in order of appearance using superscript arabic numerals, list all authors if there are up to 6 and the first 3 followed by "et al" if there are more than 6, and use PubMed journal abbreviations with issue numbers in journal citations.
Figures & Tables Brief Reports must include no more than 3 tables and/or figures total. Figures must be uploaded as separate files and not embedded in the manuscript text, whereas tables must be included at the end of the manuscript file rather than uploaded separately. Each table and figure must be numbered, titled, cited in the text, and used only as needed to support the article without duplicating data between tables and figures.
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Research Letter

Cover Letter Cover letter is required. Cover letter must include complete contact information for the corresponding author and disclose whether related papers from the same study have been published, posted, or submitted.
Abstract Abstract is not required.
Manuscript Text must not exceed 800 words. Text should be divided into Introduction, Methods, Results, and Discussion sections. Key Points must not be included, and any AI-assisted content must be disclosed in the manuscript with the tool details and author responsibility statement.
References No more than 10 references may be included. References must follow AMA style. References must be numbered in order of appearance, cited with superscript Arabic numerals, list all authors when there are 6 or fewer and the first 3 followed by "et al" when there are more than 6, and use PubMed journal abbreviations.
Figures & Tables Up to 2 small tables or figures may be included. Figures must be uploaded as separate files, while all tables must be placed at the end of the manuscript file. Each table or figure must be numbered, titled, and cited in the text, and figures should not contain more than 4 panels unless justified.
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Clinical Challenge

Cover Letter A cover letter is required. Cover letter must include complete contact information for the corresponding author.
Abstract Abstract requirements are not specified.
Manuscript Case presentation, question, and 4 one-sentence answers must not exceed 250 words, and the maximum text length is 850 words. Submission must present the question "What Is Your Diagnosis?" with a case presentation and 4 single-phrase plausible diagnosis options, 1 of which is the most correct response. Manuscript must use a short title describing the disease entity or case presentation without including the diagnosis, and any AI-generated or AI-assisted content must be disclosed in the manuscript.
References References must not exceed 10. References must follow AMA style. References must be numbered in order of appearance, cited with superscript Arabic numerals, use PubMed journal abbreviations, list all authors for up to 6 and the first 3 followed by "et al" for more than 6, and include the journal issue number in parentheses after the volume.
Figures & Tables Submissions may include no more than 2 small figures totaling 3 image components. Figures must be submitted as separate files rather than embedded in the manuscript, and tables must be included at the end of the manuscript file. Clinical Challenge images must be from the same patient, submitted as high-quality .jpg or .tif files in an original unlabeled version, with a separate labeled version provided if labels or markers are desired.
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Diagnostic Test Interpretation

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract requirements are not specified.
Manuscript Manuscript must not exceed 850 words overall. Manuscript must include a Case Presentation section of 200 words, a Test Characteristics section of approximately 200 words, an Application of Test Result to This Patient section of 200 words, a Patient Outcome section of 100 words with the most recent follow-up possible, a Clinical Bottom Line section with 3 to 5 bullet points, and a What Are Alternative Diagnostic Testing Approaches? section of 100 words if different testing strategies can be used to establish a diagnosis. Manuscript must include a short title describing the disease entity or case presentation without the diagnosis, the multiple-choice question "How do you interpret these test results?" or "What would you do next?" with 4 plausible alphabetized options and a single correct or best answer, the diagnostic test results with related tests and reference ranges after the case, and an AI disclosure if AI-assisted content or writing was used.
References References must not exceed 10. References must follow AMA style. References must be numbered in order of appearance, cited with superscript Arabic numerals, use PubMed journal abbreviations, list up to 6 authors in full, and for more than 6 list the first 3 followed by "et al.".
Figures & Tables Figures must be uploaded as separate files rather than embedded in the manuscript text, while tables must be included at the end of the manuscript file. Tables and figures must be limited to those necessary to support the article, each must be numbered, titled, and cited in the text, figures should not contain more than 4 panels unless justified, and tables must not be submitted as images or separate files.
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Letter To The Editor

Cover Letter A cover letter is required. Cover letter must include complete contact information for the corresponding author.
Abstract Abstract requirements are not specified.
Manuscript Letter must not exceed 400 words of text.
References Letter must include no more than 5 references. References must follow AMA style. References must be numbered in order of appearance using superscript Arabic numerals, and the recent article being discussed must be cited as one of the references.
Figures & Tables Figures must be uploaded as separate files rather than included in the manuscript text, and tables must be included at the end of the manuscript file.
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Parallel-Design Double-Blind Trial

Cover Letter A cover letter is required. The cover letter must include complete contact information for the corresponding author and state whether the authors have published, posted, or submitted any related papers from the same study.
Abstract A structured abstract is required. The abstract must be structured. The abstract must list the trial registry name, trial ID, and URL at the end of the abstract.
Manuscript The manuscript text must not exceed 3000 words, excluding abstract, tables, figures, acknowledgments, references, and supplemental material. The manuscript must include a subtitle with the phrase "A Randomized Clinical Trial." The manuscript must include 3 Key Points and an AI disclosure describing any AI-generated or AI-assisted content, including the tool details, in the Acknowledgment section if applicable.
References The manuscript must include 50-75 references. References must follow AMA style. References must be numbered in order of appearance using superscript Arabic numerals, journal names must be abbreviated according to the PubMed journals list, and references with more than 6 authors must list the first 3 followed by "et al.".
Figures & Tables The manuscript must include no more than 5 tables and/or figures total. Figures must be uploaded as separate files, while all tables must be included at the end of the manuscript file. Each table and figure must be numbered, given a descriptive title, and cited in the text, and data must not be duplicated between figures and tables.
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Crossover Trial

Cover Letter A cover letter is required and must include complete contact information for the corresponding author. The cover letter must include complete contact information for the corresponding author.
Abstract A structured abstract is required. The abstract must be structured. The abstract must list the trial registry name, trial ID, and URL at the end of the abstract.
Manuscript The manuscript text must not exceed 3000 words, excluding abstract, tables, figures, acknowledgments, references, and supplemental material. The subtitle should include the phrase "A Randomized Clinical Trial." The manuscript must include 3 Key Points and an AI disclosure in the Acknowledgment section if artificial intelligence or similar technologies were used to create, review, revise, edit, or assist with writing or manuscript preparation.
References The manuscript must include 50-75 references. References must follow AMA style. References must be numbered in order of appearance, cited with superscript Arabic numerals, list all authors when there are 6 or fewer and the first 3 followed by "et al" when there are more than 6, use PubMed journal abbreviations, and include the issue number after the volume number for journal articles.
Figures & Tables The manuscript must include no more than 5 tables and/or figures total. Figures must be uploaded as separate files and not included in the manuscript text, while all tables must be included at the end of the manuscript file. Each table and figure must be numbered, given a descriptive title, and cited in the text, and data must not be duplicated between tables and figures.
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Recent Publications

Notice of Retraction: Lei Z. Rethinking End Points in Modern Oncology Trials—Beyond the P Value. JAMA Oncol . 2025;11(12):1553-1554.

Zhihao Lei

10.1001/jamaoncol.2026.2245
View Publication

Hypernatremia and Polyuria in a Patient With Metastatic Breast Cancer

Rushabh Shah, Ty Carroll, Lubna N. Chaudhary

10.1001/jamaoncol.2026.1592
View Publication

Prostate Imaging Standards for Screening Magnetic Resonance Imaging (PRISM)

Nikhil Mayor, Alexander Light, Archana Gopalakrishnan, Emma Cullen, Francesca Rawlins, Varsha Sonigra-Patel, Natasha Thorley, Tristan Barrett, Ola Bratt, Tim Dudderidge, Mark Emberton, Francesco Giganti, Aiman Haider, Masoom A. Haider, Oliver Hulson, Amish Lakhani, Caroline Moore, Tobias Nordstrom, Anwar R. Padhani, Ivo G. Schoots, Andrew Smith, Henry Tam, Massimo Valerio, Sadhna Verma, Samuel J. Withey, Shonit Punwani, Taimur T. Shah, Jan van der Meulen, Hashim U. Ahmed

10.1001/jamaoncol.2026.1711
View Publication

Avelumab Plus Methotrexate for Gestational Trophoblastic Tumors

Benoit You, Jean-Pierre Lotz, Pierre Descargues, Florence Joly, Thibault De La Motte Rouge, Coriolan Lebreton, Laurence Gladieff, Philippe Follana, Mathieu Jamelot, Jerome Massardier, Touria Hajri, Adrien Msika, Marine Alves-Ferreira, Sylvie Bin, Carole Langlois-Jacques, Fabien Subtil, Adeline Roux, Christophe Desauw, Magali Provansal, Verane Schwiertz, Francois Golfier, Pierre-Adrien Bolze

10.1001/jamaoncol.2026.1697
View Publication

Treatment Delays in Early Age–Onset Colorectal Cancer

Ryan T. Heslin, Zachary A. Whitham, Morgan F. Pettigrew, Gilbert Z. Murimwa, Lauren A. Tyler, Leah W. Ding, Matthew R. Porembka, Patricio M. Polanco, Herbert J. Zeh, Adam C. Yopp, Cecilia G. Ethun, Sam C. Wang, Alex C. Kim

10.1001/jamaoncol.2026.1335
View Publication

Frequently asked questions

How long does it take to publish?

Median time to first decision is 3 days without external peer review and 33 days with review. All major articles are published Online First.

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Is a cover letter required?

A cover letter is required and must include complete contact information for the corresponding author and whether the authors have published, posted, or submitted any related papers from the same study.

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What are the publication costs?

Buy article access: $45.00; subscription required for full journal access.

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Research Topics

Lung Cancer Treatments and Mutations Cancer Immunotherapy and Biomarkers Cancer Genomics and Diagnostics Economic and Financial Impacts of Cancer Health Systems, Economic Evaluations, Quality of Life Breast Cancer Treatment Studies Global Cancer Incidence and Screening Prostate Cancer Treatment and Research Childhood Cancer Survivors' Quality of Life BRCA gene mutations in cancer Palliative Care and End-of-Life Issues Pancreatic and Hepatic Oncology Research Lung Cancer Research Studies Prostate Cancer Diagnosis and Treatment Genetic factors in colorectal cancer Lung Cancer Diagnosis and Treatment Colorectal Cancer Treatments and Studies Cancer survivorship and care Gastric Cancer Management and Outcomes Cancer Risks and Factors Brain Metastases and Treatment Lymphoma Diagnosis and Treatment Colorectal Cancer Screening and Detection CAR-T cell therapy research Head and Neck Cancer Studies

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