JO

Journal of Allergy and Clinical Immunology

The Journal of Allergy and Clinical Immunology publishes high-impact, cutting-edge basic, clinical and translational research papers in allergy, asthma and immunology. Articles cover asthma, food allergy, allergic rhinitis, atopic dermatitis, primary immune deficiencies, occupational and environmental allergy, and other allergic and immunologic diseases, including clinical trials and mechanistic studies reporting novel therapies, insights into underlying mechanisms, and discoveries intended to improve diagnosis and management of patients.

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Subject Allergy, Immunology
Impact Factor 11.2
Quartile Q1
Open Access Type Hybrid
ISSN 0091-6749
eISSN 1097-6825
Invitation Only No
Cost Range Subscription publication is available, and gold open access is offered.

Submission Instructions

Journal of Allergy and Clinical Immunology accepts the following article types. Click on an article type to view submission instructions.

Original Articles

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract is required for Original Articles. Abstract must not exceed 250 words. Abstract must be structured. Abstract must use the headings Background, Objective, Methods, Results, and Conclusion.
Manuscript Manuscript text must not exceed 3500 words, excluding the abstract, figure legends, and references. Text must be organized into Introduction, Methods, Results, and Discussion. Manuscript must include clinical implications or key messages, a capsule summary, up to ten keywords, a list of abbreviations after the keywords, and a declaration of generative AI use before the references if generative AI was used.
References References must be numbered consecutively in the order cited in the text and listed in numeric sequence at the end of the article.
Figures & Tables No more than 8 graphic presentations, including figures and tables combined, are allowed. Figures must be uploaded as separate files, figure legends must be placed after the references, and figures must not contain embedded legends. Each figure legend must be 200 words or less.
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Review Articles

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must be structured.
Manuscript Manuscript must include Abstract, Keywords, Introduction, Materials and Methods, Results, Conclusions, Artwork, and Tables with Captions. A declaration of generative AI use must be included in a new section before the references list if generative AI was used in manuscript preparation.
References References must be numbered consecutively in the order cited in the text and listed in numeric sequence at the end of the article.
Figures & Tables In a single submission file, figures and tables must be placed next to the relevant text and the corresponding caption must appear directly below each figure or table. Tables must be submitted in an editable black-and-white format, one table per page and numbered with Roman numerals, while figure legends must be provided in the manuscript on a separate page after the references and any tables.
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Correspondence

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must not be included.
Manuscript Manuscript must not exceed 1,000 words. Main text must begin with the salutation "To the Editor:", contain no headers, and end with the authors’ names, academic degrees, institutions, and locations. Manuscript must include a maximum of 5 keywords and, if generative AI was used, a declaration in a new section before the references list.
References Reference list must not exceed 10 references. References must be numbered consecutively as cited in the text and presented as complete bibliographic citations after the letter’s closing.
Figures & Tables No more than 2 display items, including tables or figures, are allowed; tables must not exceed one page, and figures must not have more than six panels. In a single submission file, figures and tables must be placed next to the relevant text with the corresponding caption directly below each item. Tables must be submitted in editable black-and-white format.
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Replies

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must not be included.
Manuscript Manuscript must not exceed 1,000 words. Main text must begin with the salutation "To the Editor:", have no headers, and end with the authors’ names, academic degrees, institutions, and locations. Manuscript must include no more than 5 keywords, and any generative AI use declaration must appear in a section before the references list if applicable.
References References must not exceed 10. References must be provided as complete bibliographic citations after the closure of the letter and be numbered in consecutive order of citation with the reference list in numeric sequence.
Figures & Tables No more than 2 display items, including figures or tables, may be included, with tables limited to one page each and figures limited to six panels each. If submitted as a single file, figures and tables must be placed next to the relevant text with captions directly below, while revised submissions must upload figures separately. Tables must be submitted in editable black-and-white format.
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Recent Publications

Scientific Advances from Sharing URECA Data in Collaborative Analyses

James E. Gern, Leonard B. Bacharier, Meyer Kattan, Katherine Rivera-Spoljarik, Robert A. Wood, Carole Ober, Cynthia M. Visness, Lisa Gagalis, Alkis Togias, Patrice M. Becker, Daniel J. Jackson, William W. Busse, George T. O’Connor

10.1016/j.jaci.2026.09.020
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SERPINE1 promoter variants and differential airway responses to virus and biological therapy

Ariel Helms Thames, Madeline Schutt, Samantha Gadd, Leonardo Barrera, Seong Cho, William Wentworth-Sheilds, Jacqueline Pongracic, Andrew H. Liu, Rebecca Gruchalla, Carolyn Kercsmar, Gurjit Khurana Hershey, Edward Zoratti, Christine Johnson, Stephen Teach, Meyer Kattan, Michael Nodzenski, Courtney Gaberino, Leonard Bacharier, George T. O’Connor, James Gern, Cynthia Visness, Amaziah Coleman, Peter Gergen, Patrice Becker, Carole Ober, Daniel Jackson, Matthew Altman, Rajesh Kumar

10.1016/j.jaci.2026.08.020
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Hyperactive STAT1 Promotes T Follicular Helper Type 1 Cell Differentiation to Trigger Autoimmunity

Ran Chen, Xuemei Chen, Jigui Yang, Huilin Mu, Shengqiao Mao, Siyu Chen, Rui Gan, Qinglv Wei, Wenjing Tang, Junfeng Wu, Wuyang He, Satoshi Okada, Lina Zhou, Yunfei An, Xiaodong Zhao, Yanjun Jia

10.1016/j.jaci.2026.08.030
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Functional evaluation of CAR-T anti-CD123 from immune-mediated inflammatory diseases patients for novel pDCs-targeted immunotherapy

Blandine Caël, Elodie Bôle-Richard, Imane Belakri, Ludivine Dal Zuffo, Jérémy Mazars, Sebastien Humbert, Fabiane Sônego, Florent Creusat, Kader Thiam, Jeanne Galaine, François Aubin, Francine Garnache-Ottou

10.1016/j.jaci.2026.08.031
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Prostaglandin E2 Protects Against MRGPRX2/b2-mediated and Aspirin-aggravated Anaphylaxis via modulation of Mast Cell Activation

Payam Morakabati, Philipp Globig, Magda Babina, Margitta Worm

10.1016/j.jaci.2026.07.028
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Frequently asked questions

How long does it take to publish?

Median time from submission to first decision is 3 days.

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Is a cover letter required?

A cover letter is required for animal-model studies to explain how the study meets the journal's criteria. Reviewer suggestions and opposed reviewers may also be provided during submission.

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What are the publication costs?

Gold open access is offered alongside subscription publication.

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Research Topics

Asthma and respiratory diseases Allergic Rhinitis and Sensitization Food Allergy and Anaphylaxis Research Contact Dermatitis and Allergies Dermatology and Skin Diseases Respiratory and Cough-Related Research Urticaria and Related Conditions Drug-Induced Adverse Reactions Immunodeficiency and Autoimmune Disorders Mast cells and histamine Eosinophilic Esophagitis Pediatric health and respiratory diseases Immune Cell Function and Interaction IL-33, ST2, and ILC Pathways Inhalation and Respiratory Drug Delivery Diverse Scientific and Economic Studies Coagulation, Bradykinin, Polyphosphates, and Angioedema Human auditory perception and evaluation Occupational exposure and asthma T-cell and B-cell Immunology Eosinophilic Disorders and Syndromes Chronic Obstructive Pulmonary Disease (COPD) Research Neonatal Respiratory Health Research Sinusitis and nasal conditions Respiratory viral infections research

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