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Metabolism-clinical And Experimental

Metabolism - Clinical and Experimental publishes original research, reviews, editorials and commentaries related to all aspects of human metabolism. It considers studies in humans, animal and cellular models, and prioritizes work with strong translational potential.

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Impact Factor 11.9
Quartile Q1
Open Access Type Hybrid
ISSN 0026-0495
eISSN 1532-8600
Invitation Only No
Cost Range Open access options are available. For open access articles, authors are responsible for payment of the article publishing charge (APC) if the manuscript is accepted.

Submission Instructions

Metabolism-clinical And Experimental accepts the following article types. Click on an article type to view submission instructions.

Original Research Papers

Cover Letter Cover Letter requirements are not specified.
Abstract A structured abstract is required. Abstract must not exceed 250 words. Abstract must be structured.
Manuscript Manuscript must be no longer than 5000 words excluding the title page, abstract, references, tables, and figure legends but including the abbreviation list, acknowledgements, funding, disclosure statement, and author contributions. Manuscript must be divided into clearly defined and numbered sections. Manuscript must include 1 to 7 keywords, submission highlights consisting of 3 to 5 bullet points, a competing interests declaration, and an AI-use declaration section before the references if generative AI was used in manuscript preparation.
References Reference list must contain no more than 60 references. References must be cited as numbers in square brackets and listed in numerical order of appearance, with the first 6 authors followed by 'et al.' when there are more than 6 authors.
Figures & Tables Original Research Papers must contain no more than 10 tables and figures combined. Tables must be provided as editable text and figures must be supplied as separate files along with the manuscript. Tables must be cited and numbered consecutively in the text with captions, and all figures must be cited, numbered in sequence, and accompanied by captions.
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Meta-Analyses

Cover Letter Cover Letter requirements are not specified.
Abstract A structured abstract is required. Abstract must not exceed 250 words. Abstract must be structured.
Manuscript Articles must be divided into clearly defined and numbered sections. Include 1 to 7 keywords, submit 3 to 5 article highlights as a separate editable file, complete the declarations tool, and add an AI-use declaration section before the references if generative AI was used in manuscript preparation.
References References must be cited by numbers in square brackets. Reference list entries must be numbered in citation order and for works with more than 6 authors list the first 6 followed by 'et al.'.
Figures & Tables Tables must be included as editable text and figures must be uploaded as separate files alongside the manuscript. Tables must be cited in the text, numbered consecutively, and include captions, and all figures must be cited in the text, numbered in sequence, and include captions.
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Review Articles

Cover Letter Cover Letter requirements are not specified.
Abstract An unstructured summary is required for Review Articles. The summary must not exceed 200 words. The summary must be unstructured.
Manuscript Review Articles must be no more than 5000 words excluding the title page, abstract, references, tables, and figure legends but including the abbreviation list, acknowledgements, funding, disclosure statement, and author contributions. Review Articles may use subheadings to highlight the content of different sections. The manuscript must include article highlights and, if generative AI was used in manuscript preparation, a declaration statement in a new section before the references.
References Review Articles must contain no more than 150 references. References must be cited as numbers in square brackets and listed in the reference list in the order of first appearance, with more than 6 authors shortened to the first 6 followed by 'et al.'.
Figures & Tables Review Articles must contain no more than 10 tables and figures combined. Figures must be uploaded as separate files, whereas tables are submitted as editable text within the submission. Tables must be editable text with captions and consecutive numbering, and each figure must be submitted as a separate file with a caption and cited in the text.
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Fast-Track Publications

Cover Letter Cover Letter requirements are not specified.
Abstract An abstract is required for Fast-Track brief reports as a single paragraph of fewer than 150 words, while Fast-Track regular reports follow the general requirement for a concise factual abstract not exceeding 250 words. Fast-Track brief report abstracts must be fewer than 150 words, while other Fast-Track abstracts must not exceed 250 words. Fast-Track brief report abstracts must be unstructured in a single paragraph.
Manuscript Fast-Track brief reports must be no longer than 15,000 characters including spaces, approximately 1,500–1,800 words, including the abstract but excluding references, while Fast-Track regular reports may be up to 4,000 words. Fast-Track Publications may be submitted as either a brief report or a regular report, and articles must be divided into clearly defined and numbered sections. The submission must include 1 to 7 keywords and separate article highlights of 3 to 5 bullet points, and if generative AI was used in manuscript preparation, a declaration statement must appear in a new section before the references.
References Fast-Track brief reports may include up to 30 references, while Fast-Track regular reports may include up to 100 references. References must be cited as numbers in square brackets and listed in the reference list in the order of first appearance, with more than 6 authors shortened to the first 6 followed by 'et al.'.
Figures & Tables Fast-Track brief reports may contain no more than 2 display items, Fast-Track regular reports normally have no more than 5 display items, and supplementary figures and tables must not exceed the total number of main-text displays. Tables must appear as editable text and figures must be supplied as separate files along with the manuscript. All tables and figures must be cited in the text, numbered consecutively in order of appearance, and provided with captions.
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Brief Reports

Cover Letter Cover Letter requirements are not specified.
Abstract A structured abstract is required. Abstract must not exceed 250 words. Abstract must be structured.
Manuscript Brief Reports must be no longer than 1500 words, excluding the title page, abstract, references, tables, and figure legends, but including the abbreviation list, acknowledgements, funding, disclosure statement, and author contributions. Articles must be divided into clearly defined and numbered sections. The manuscript must include 1 to 7 keywords, separate article highlights of 3 to 5 bullet points, and an AI-use declaration section before the references if generative AI was used in manuscript preparation.
References Brief Reports must contain no more than 20 references. References must be cited as numbers in square brackets and listed in the reference list in the order of first appearance, with more than 6 authors shortened to the first 6 followed by 'et al.'.
Figures & Tables Brief Reports must contain no more than 2 tables and figures combined. Tables must be submitted as editable text and figures must be supplied as separate files along with the manuscript. All tables and figures must be cited in the text, numbered consecutively in order of appearance, and provided with captions.
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Mini-Reviews

Cover Letter Cover Letter requirements are not specified.
Abstract An unstructured summary is required for Mini-Reviews. The summary must be no more than 200 words. The summary must be unstructured.
Manuscript Mini-Reviews must be a maximum of 3500 words excluding the title page, abstract, references, tables, and figure legends but including the abbreviation list, acknowledgements, funding, disclosure statement, and author contributions. Subheadings are recommended to highlight the content of different sections. Article highlights are required and must be submitted as a separate editable file containing 3 to 5 bullet points, and any use of generative AI in manuscript preparation must be declared in a section placed before the references.
References Mini-Reviews must contain no more than 100 references. References must be cited as numbers in square brackets and listed in the reference list in the order of appearance, with more than 6 authors shortened to the first 6 followed by 'et al.'.
Figures & Tables Mini-Reviews must contain no more than 6 tables and figures combined. Figures must be supplied as separate files, while tables are included as editable text. Tables must be editable text rather than images and both tables and figures must be cited in the manuscript and provided with captions.
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Letters

Cover Letter Cover Letter requirements are not specified.
Abstract Letters must be no longer than 500 words all inclusive, which supersedes any separate abstract word limit.
Manuscript Letters must be no longer than 500 words all inclusive. Article highlights are required at submission as a separate editable file containing 3 to 5 bullet points of no more than 85 characters each, 1 to 7 keywords in English must be provided, competing interest declarations must be uploaded, and any generative AI use in manuscript preparation must be declared in a new section before the references if used.
References Letters must contain no more than 15 references. References must be cited by numbers in square brackets and listed in numerical order of appearance. Reference formatting may be in any consistent style at submission, and references with more than 6 authors should list the first 6 followed by 'et al.'.
Figures & Tables Letters must contain no more than 1 table or figure. Figures must be supplied as separate files, while tables must be submitted as editable text rather than images. All figures and tables must be cited in the text, numbered in order of appearance, and include captions.
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Recent Publications

When the proteome meets the metabolome observational and Mendelian randomization analyses

Rui Zheng, Mario Delgado-Velandia, Johan Ärnlöv, Johan Sundström, Gunnar Engström, J. Gustav Smith, Koen F. Dekkers, Per Lundmark, Tove Fall, Lars Lind

10.1016/j.metabol.2026.156602
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Metformin suppresses β-cell apoptosis under ER stress by inhibiting protein translation

Ryota Inoue, Kazuki Tajima, Tomoko Okuyama, Chisato Sakai, Tamaki Kanno, Meng Zou, Mayu Kyohara, Kohichi Matsunaga, Takahiro Tsuno, Junyu Luo, Emi Ishida, Shin-ichi Horike, Tohko Hirano, Noriaki Arakawa, Tatsuya Kin, A.M. James Shapiro, Yasuo Terauchi, Hideru Obinata, Hisashi Hirano, Jun Shirakawa

10.1016/j.metabol.2026.156607
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Loss of cardiomyocyte AKT signaling causes deterioration of lipid metabolism and cellular atrophy

Stefanie Gödecke, André Heinen, Tim Appel, Phil-Torben Müller, Tim Stemmer, Daniela Müller, Uli Flögel, Diran Herebian, Fiorella A. Solari, Rene Deenen, Karl Köhrer, Albert Sickmann, Axel Gödecke

10.1016/j.metabol.2026.156619
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6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3: A potential target in the development of diabetes and its complications

Minmin Jiang, Xiaofei An

10.1016/j.metabol.2026.156621
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Hepatocyte DDIT4 aggravates MASH progression through GPX4-mediated ferroptosis

Huiying Wang, Wen-Yue Liu, Feng Zhang, Wei Chen, Jinying Hu, Ruitang Cheng, Zhinan Chen, Dan Wu, Lijun Xie, Yongguang Tao, Ming-Hua Zheng, Fang Hu

10.1016/j.metabol.2026.156622
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Frequently asked questions

How long does it take to publish?

Median 1 day from submission to first decision and median 4 days from acceptance to online publication.

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What are the publication costs?

For open access articles, authors are responsible for payment of the article publishing charge (APC) if the manuscript is accepted.

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Research Topics

Adipose Tissue and Metabolism Diet and metabolism studies Pancreatic function and diabetes Metabolism, Diabetes, and Cancer Diabetes, Cardiovascular Risks, and Lipoproteins Muscle metabolism and nutrition Adipokines, Inflammation, and Metabolic Diseases Liver Disease Diagnosis and Treatment Regulation of Appetite and Obesity Diet, Metabolism, and Disease Diabetes Management and Research Diabetes Treatment and Management Growth Hormone and Insulin-like Growth Factors Diabetes and associated disorders Metabolism and Genetic Disorders Lipoproteins and Cardiovascular Health Diverse Scientific and Economic Studies Peroxisome Proliferator-Activated Receptors Human auditory perception and evaluation Lipid metabolism and disorders Hormonal and reproductive studies Thyroid Disorders and Treatments Fatty Acid Research and Health Cholesterol and Lipid Metabolism Hormonal Regulation and Hypertension