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Nature Reviews Gastroenterology & Hepatology

Nature Reviews Gastroenterology & Hepatology publishes review and comment content in gastroenterology and hepatology, including Review Articles, Perspectives, Comments, Editorials, Research Highlights and Expert Recommendations covering topics such as inflammatory bowel disease, liver disease, microbiome research, cancer and clinical management.

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Subject Gastroenterology & Hepatology
Impact Factor 51
Quartile Q1
Open Access Type Hybrid
ISSN 1759-5045
eISSN 1759-5053
Invitation Only Yes
Cost Range We do not charge a fee for publication.

Submission Instructions

Nature Reviews Gastroenterology & Hepatology is an invitation-only journal. Submissions are accepted by invitation from the editorial board only. The following article types are accepted:

Review-Type

Cover Letter Cover letter is optional.
Abstract Abstract should ideally be a maximum of 200 words. Abstract must be unstructured.
Manuscript Article must open with background explaining the topic’s importance, have an introduction ending with a guiding paragraph on what will be discussed, and end with a brief summary section without subheadings that discusses implications and future research directions. Manuscript must include 4–6 key points of 30 words or fewer and must document any use of a Large Language Model in the Methods section or a suitable alternative part of the manuscript if no Methods section is available.
References References should be approximately 25 per 1,000 words. References must use Nature Reviews style. References must be cited sequentially as superscript numbers, listed in the order main text, tables, figures, and boxes, include article titles, and list only the first author followed by 'et al.' when there are six or more authors.
Figures & Tables No more than 7 display items, including tables, figures, and boxes, are allowed. Tables and boxes should be provided as part of the article document. Display items must be cited in the main text in order as (FIG. 1), tables must have a short title with no legend and all cells and abbreviations defined, and each figure must be fully labelled with a short title and a concise legend defining all abbreviations.
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Perspective

Cover Letter Cover letter is optional. Cover letter should briefly explain the importance of the work and why it is appropriate for the journal.
Abstract Abstract is required. Abstract should ideally be no more than 200 words. Abstract must be unstructured. Abstract must contain minimal specialist details and must not include references or display item citations.
Manuscript Manuscript must include an introduction without subheadings, may use up to three heading levels in the main text, and must end with a brief concluding summary section without subheadings. Manuscript must document any use of a Large Language Model in the Methods section or another suitable section, include a statement of individual author contributions and a competing interests statement, and provide 4–6 key point bullets of no more than 30 words each.
References References must use Nature Reviews style. References must be cited as sequential superscript numbers in the order of main text, tables, figures, and boxes, and the reference list must include article titles.
Figures & Tables No more than 5 display items in total, including tables, figures, and boxes, are allowed. Tables and boxes must be provided as part of the article document, and manuscript text must be submitted as a Word or LaTeX file rather than as a PDF. Figures must be fully labelled with a short title and concise legend defining abbreviations, while tables must have a short title and define all abbreviations.
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Articles

Cover Letter Cover letter is optional. Cover letter should briefly explain the importance of the work and why it is appropriate for the journal.
Abstract Abstract requirements are not specified.
Manuscript Manuscript must include a statement of each co-author’s individual contributions, a competing interests statement, documentation of any Large Language Model use in the Methods or another suitable section, and up to ten multi-panel Extended Data display items containing data integral to the work.
References References must include article or dataset titles and list only one publication under each reference number.
Figures & Tables Articles may include up to ten multi-panel Extended Data display items. For initial submission, figures may be embedded within the manuscript text or grouped at the end, and Extended Data items may appear in the manuscript body or as Supplementary Information. Each figure legend must appear on the same page as its figure and be fewer than 250 words, and each table must have a short title sentence describing what it shows.
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Consensus Statement

Cover Letter Cover letter is optional. Cover letter should briefly explain the importance of the work and why it is appropriate for the journal.
Abstract Abstract is required and must be unstructured. Abstract should ideally be a maximum of 200 words. Abstract must be unstructured. Abstract must contain minimal specialist details and must not include references or display item citations.
Manuscript Manuscript must include an introductory section without subheadings, a Methods section describing methodology and stakeholders with search strategy and decision-making details where relevant, and end with a brief summary section without subheadings, with no more than three heading levels overall. Competing interests must be declared within the text, and any use of a Large Language Model must be documented in the Methods section or another suitable manuscript section if no Methods section is available.
References References must use Nature Reviews style. References must be cited as sequential superscript numbers in the order main text, tables, figures, then boxes, and for works with six or more authors only the first author should be listed followed by 'et al.'.
Figures & Tables A maximum of 7 display items, including tables, figures and boxes, is allowed. Tables must be provided as part of the article document, tables containing graphical content must be supplied as separate image files, and figures may be embedded within the manuscript file. Figures must be fully labelled with brief legends of about 200 words that include a short title, descriptions of all components and definitions of all abbreviations, and tables must have a short title with all abbreviations defined.
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Evidence-Based Guidelines

Cover Letter Cover letter is optional. Cover letter should briefly explain the importance of the work and why it is appropriate for the journal.
Abstract Abstract is required and must be unstructured. Abstract should ideally be a maximum of 200 words. Abstract must be unstructured. Abstract must provide a general introduction, a brief non-technical summary of the main results and their implication, contain minimal specialist details, and must not include references or display item citations.
Manuscript Manuscript must include an introductory section without subheadings, a Methods section describing methodology and stakeholders, no more than three heading levels, and end with a brief summary section without subheadings. Manuscript must include a statement specifying each co-author's contributions, a competing interests declaration within the text, and any use of a Large Language Model must be documented in the Methods section or another suitable section if no Methods section is available.
References References should be approximately 25 per 1,000 words. References must use Nature Reviews style. References must be cited as sequential superscript numbers in the order of main text, tables, figures, and boxes, include article or dataset titles, and list the first author followed by 'et al.' when there are six or more authors.
Figures & Tables A maximum of 7 display items, including tables, figures and boxes, is allowed. Tables must be provided as part of the article document, tables with graphical content as separate image files, and figures may be inserted in the text at appropriate positions or grouped at the end. Figures must be fully labelled with brief legends of approximately 200 words including a short title, descriptions of all components and abbreviation definitions, and tables must have a short title with all abbreviations defined.
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Correspondence

Cover Letter Cover letter is optional. Cover letter should briefly explain the importance of the submission and its suitability for the journal.
Abstract Abstract requirements are not specified.
Manuscript Main text must not exceed 500 words. First paragraph must cite the original article, and no more than two levels of headings are allowed. Competing interests must be declared within the text of the article, and any use of a Large Language Model must be documented in the Methods section or another suitable part of the manuscript if no Methods section is present.
References Article may include a maximum of 10 references. References must use the Nature Reviews reference style. References must be cited as sequential superscript numbers, and if a reference has six or more authors, only the first author should be listed followed by 'et al.'.
Figures & Tables Only one display item can be included. Manuscript file must be submitted as a Microsoft Word or LaTeX file rather than a PDF, with boxes provided as part of the article document. Each figure must be fully labelled with a short title and concise legend, tables must have a short title and no legend, and all abbreviations used in figures or tables must be defined.
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Recent Publications

Heart–liver co-management in MASLD: expert perspectives and recommendations from a multidisciplinary cardiometabolic framework

Xiao-Dong Zhou, Seogsong Jeong, Qin-Fen Chen, Giovanni Targher, Christopher D. Byrne, Nicholas W. S. Chew, Zobair M. Younossi, Gregory Y. H. Lip, Herbert Tilg, Jacob George, Norbert Stefan, Laurence S. Sperling, Hung N. Luu, Marat Fudim, Rohit Loomba, Ming-Hua Zheng

10.1038/s41575-026-01255-z
View Publication

Beyond inflammation: the residual burden as the next target in inflammatory bowel disease

Brigida Barberio, Shaji Sebastian, Alexander C. Ford, Beatriz Gros, Alessandro Armuzzi, Fernando Magro, Vipul Jairath, Edoardo V. Savarino

10.1038/s41575-026-01259-9
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Building and regenerating intestines by manipulating intestinal stem cells

Calvin J. Kuo, Sarah Blutt, Mark Donowitz, Mary K. Estes, Chandan Guha, Ophir D. Klein, Linheng Li, Joyce C. Niland, António J. M. Santos, Ramesh A. Shivdasani, Jason R. Spence, Carol J. Swanson, Timothy C. Wang, Kelley S. Yan, Nicholas C. Zachos, Michael A. Helmrath

10.1038/s41575-026-01242-4
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Challenges and opportunities in combining radiotherapy and immunotherapy for localized pancreatic cancer

Gilles Colin, Sylvie Streel, Eric Deutsch, Lorenzo Galluzzi, Pierre Foidart

10.1038/s41575-026-01250-4
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Long non-coding RNAs in colorectal cancer: shaping the tumour microenvironment and advancing precision oncology

M. Bartolini, F. Battaglin, S. Soni, S. Algaze, K. Ashouri, L. Torres-Gonzalez, P. Mittal, U. Shah, W. Zhang, J. Millstein, A. Puccini, H.-J. Lenz

10.1038/s41575-026-01243-3
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Frequently asked questions

How long does it take to publish?

Editorial process runs from commissioning to publication.

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Is a cover letter required?

Cover letter is optional and may be used to explain the importance of the work, its suitability for the journal, conflicts of interest, and related work in press or submitted elsewhere.

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What are the publication costs?

Research Topics

Liver Disease Diagnosis and Treatment Gut microbiota and health Inflammatory Bowel Disease Gastrointestinal motility and disorders Hepatitis C virus research Microscopic Colitis Helicobacter pylori-related gastroenterology studies Liver Disease and Transplantation Pancreatic and Hepatic Oncology Research Hepatitis B Virus Studies Diet and metabolism studies Gastric Cancer Management and Outcomes Eosinophilic Esophagitis Gastroesophageal reflux and treatments Clostridium difficile and Clostridium perfringens research Colorectal Cancer Screening and Detection Celiac Disease Research and Management Diet, Metabolism, and Disease Liver physiology and pathology Digestive system and related health Hepatocellular Carcinoma Treatment and Prognosis Pancreatitis Pathology and Treatment Organ Transplantation Techniques and Outcomes Esophageal Cancer Research and Treatment Esophageal and GI Pathology

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