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Journal of Clinical and Translational Hepatology

Journal of Clinical and Translational Hepatology publishes peer-reviewed studies in the translational and clinical human health sciences of liver diseases. It publishes original research, review articles, editorials, correspondence, and invited commentaries, and covers topics including liver disease mechanisms, novel techniques in research and management of liver diseases, epidemiological and environmental factors, immune system function in liver diseases, hepatitis, cirrhosis, genetic and metabolic liver diseases, hepatobiliary diseases, liver cancer, drug metabolism, and biliary disease. The journal is indexed in Science Citation Index Expanded, PubMed, and Scopus and is published by Xia & He Publishing Inc. in association with the Second Affiliated Hospital of Chongqing Medical University.

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Subject Gastroenterology & Hepatology
Impact Factor 4.2
Quartile Q1
Open Access Type Open
ISSN 2225-0719
eISSN 2310-8819
Invitation Only No
Cost Range USD 3280 for full articles; USD 2130 for short articles; editorials waived.

Submission Instructions

Journal of Clinical and Translational Hepatology accepts the following article types. Click on an article type to view submission instructions.

Original Article

Cover Letter A cover letter is required. Cover letter must briefly outline current knowledge in the research area, identify the key gaps addressed by the study, highlight the novel contributions and conceptual advancements of the findings, and emphasize the significance of the work to a broad audience.
Abstract A structured abstract is required. Abstract must not exceed 250 words. Abstract must be structured. Abstract must use the headings Background and objective(s), Methods, Results, and Conclusions.
Manuscript Manuscript must not exceed 5000 words. Manuscript must be organized as Title page, structured Abstract, Keywords, Introduction, Methods, Results, Discussion, Conclusions, Declarations, References, Tables, Figures Legends/Figures, and Supplementary materials if any. Manuscript should include 6 to 12 keywords, must state in the Methods section which reporting guideline was applied, and must submit the corresponding reporting guideline checklist with the manuscript.
References Manuscript must include no more than 50 references. References must follow the International Committee of Medical Journal Editors and NLM style. References must be numbered consecutively in the order of first appearance using superscript Arabic numerals.
Figures & Tables Manuscript must include no more than 8 figures and tables combined. Tables must be included in the manuscript file rather than submitted as separate files, and figure legends must be placed on a separate page in the manuscript. Figure panels must be labeled with uppercase letters such as A, B, and C.
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Review

Cover Letter Cover letter should briefly outline current knowledge in the field, identify key gaps addressed, highlight novel contributions and conceptual advancements, and emphasize the work’s significance to a broad audience.
Abstract An abstract is required for Review articles. Review abstracts must not exceed 250 words. Review abstracts must be unstructured and presented as a single paragraph with no subheadings.
Manuscript Review manuscripts must not exceed 10,000 words. Review manuscripts must be organized as Title page, unstructured Abstract, Keywords, Introduction, Viewpoints (one-by-one), Conclusions, Declarations, References, Tables, Figures Legends/Figures, and Supplementary materials if any. Review manuscripts are recommended to include 6 to 12 keywords.
References Review manuscripts must include no more than 300 references. References must follow the International Committee of Medical Journal Editors and NLM style. References must be numbered consecutively in the order of first appearance using superscript Arabic numerals.
Figures & Tables Review manuscripts must include no more than 10 figures and tables combined. Tables must be included in the manuscript file rather than submitted separately, and figure legends must be placed on a separate page in the manuscript. Figure panels must be labeled with uppercase letters such as A, B, and C.
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Mini-Reviews

Cover Letter A cover letter should be included. Cover letter should briefly outline current knowledge in the research area, identify key gaps addressed, highlight novel contributions and conceptual advancements, and emphasize significance to a broad audience.
Abstract An abstract is required. Abstract must be unstructured and presented as a single paragraph with no subheadings.
Manuscript Mini-Reviews must not exceed 3000 words. Mini-Reviews must not include unpublished material, including unpublished or original data, submitted manuscripts, or personal communications.
References References must follow the International Committee of Medical Journal Editors and National Library of Medicine style. References must be numbered consecutively in the order of first appearance using superscript Arabic numerals.
Figures & Tables Mini-Reviews may contain no more than 2 figures and tables combined. Tables must be included in the manuscript file rather than submitted separately. Figure panels must be labeled with uppercase letters (A, B, C, etc.).
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Systematic Review And Meta-Analysis

Cover Letter Cover Letter requirements are not specified.
Abstract A structured abstract is required for Systematic Review and Meta-Analysis submissions. The abstract must not exceed 250 words. The abstract must be structured. The abstract must use the headings Background and objective(s), Methods, Results, and Conclusions.
Manuscript The manuscript must not exceed 5000 words. The manuscript must follow the structure Title page, structured Abstract, Keywords, Introduction, Methods, Results, Discussion, Conclusions, Declarations, References, Tables, Figures Legends/Figures, and Supplementary materials if any. The manuscript must identify the report as a systematic review in the title and is recommended to include 6 to 12 keywords.
References The manuscript must include no more than 70 references. References must follow the International Committee of Medical Journal Editors and NLM style. References must be numbered consecutively in the order first cited using superscript Arabic numerals.
Figures & Tables The manuscript must include no more than 8 figures and tables combined. Tables must not be submitted as separate files and figure legends must be listed on a separate page immediately after the reference list. Figure panels must be labeled with uppercase letters such as A, B, and C.
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Illuminating And Instructive Clinical Case

Cover Letter Cover letter should briefly summarize current knowledge, identify the key gap addressed, highlight the novel contribution and conceptual advance, and emphasize significance to a broad audience. Cover letter must briefly outline current knowledge in the area, identify key gaps addressed, highlight the novel contributions and conceptual advancements, and emphasize the work's significance to a broad audience.
Abstract Abstract is required and must be unstructured as a single paragraph with no subheadings. Abstract must not exceed 250 words. Abstract must be unstructured and presented as a single paragraph with no subheadings. Abstract must include what is unique about the case and its contribution to the literature, the main symptoms or clinical findings, the main diagnoses, interventions and outcomes, and the main take-away lesson(s) as the conclusion.
Manuscript Manuscript must not exceed 3000 words. Manuscript should include one or two introductory paragraphs on why the case is unique, de-identified case presentation details with a timeline, diagnostic assessment, therapeutic interventions, outcomes and follow-up, a scientific discussion, a one-paragraph conclusion, and a one- to two-paragraph patient perspective. Include 2 to 5 keywords including "case report," and state whether informed consent was given by the patient.
References Manuscript must include no more than 30 references. References must follow the International Committee of Medical Journal Editors and NLM style with numbered citations. References must be numbered consecutively in the order first cited and cited in the text using superscript Arabic numerals.
Figures & Tables Manuscript must include no more than 5 figures and tables combined. Tables must be included in the manuscript file rather than submitted separately, and figure legends must be listed on a separate page immediately after the reference list. Figure panels must be labeled with uppercase letters such as A, B, and C.
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Research Letter

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must not be included.
Manuscript Manuscript must not exceed 1500 words. Section headings such as Introduction, Methods, Results, Conclusion, or Discussion must not be used.
References Reference list must contain no more than 15 references. References must follow the International Committee of Medical Journal Editors and NLM style. References must be numbered consecutively in the order of first appearance using superscript Arabic numerals.
Figures & Tables A maximum of 3 figures and tables combined is permitted. Tables must be included within the manuscript file rather than submitted separately. Figure panels must be labeled with uppercase letters such as A, B, and C.
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Letter To The Editor

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract is not required for Letter To The Editor manuscripts.
Manuscript Letter To The Editor manuscripts must not exceed 800 words. Letter To The Editor manuscripts must present substantive and analytical comments on a specific article recently published in the journal, address comments and conclusions to the Editor, reference the article in the text, and support comments and conclusions with data or references.
References Letter To The Editor manuscripts must include no more than 10 references. References must follow the International Committee of Medical Journal Editors and NLM style. References must be numbered consecutively in the order of first appearance using superscript Arabic numerals.
Figures & Tables Letter To The Editor manuscripts may include no more than 2 figures and tables combined. Tables must be included in the manuscript file rather than submitted as separate files. Figure panels must be labeled with uppercase letters such as A, B, and C.
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Recent Publications

Molecular Basis and Clinical Significance of the High-risk Phenotype of Hepatitis B Virus Genotype C

Chenchen Huang, Zhongjian Liu, Jingyao Zhang, Tao Shen, Lei Sang

10.14218/jcth.2026.00247
View Publication

qHBsAg Trajectories with Peg-IFNα-2b Add-on Therapy in Nucleos(t)ide Analog-experienced HBeAg-positive Chronic Hepatitis B

Kezhen Hu, Yanzhen Bi, Xiaoying Li, Xiangzhong Liu, Haoxi Wang, Yong Zhou, Yongning Xin

10.14218/jcth.2026.00175
View Publication

Comparative Efficacy of Promising Targets in the Treatment of Metabolic Dysfunction-associated Steatotic Liver Disease and Steatohepatitis: A Systematic Review and Network Meta-analysis

Wenjing Ni, Jie Li, Xue Bai, Sisi Zhou, Xiangyu Wu, Leyao Jia, Zhuoru Jiang, Jiali Wu, Ming Li, Connie Wong, Chao Wu, Junping Shi, Mindie H. Nguyen

10.14218/jcth.2025.00596
View Publication

Berberine Attenuates Hepatic Sinusoidal Obstruction Syndrome by Inhibiting Endothelial-mediated Neutrophil Recruitment and Activation

Yiken Lin, Wenjia Tian, Weiming Dai, Ning Chen, Huifeng Hao, Yulan Liu

10.14218/jcth.2026.00024
View Publication

Baseline Liver Fibrosis Severity Predicts Superior HBeAg Clearance and Fibrosis Reversal following Peg-IFNα plus Nucleos(t)ide Analog Therapy in HBeAg-positive Chronic Hepatitis B Patients

Yaqin Zhang, Fengxin Chen, Shuojie Wang, Xin Wei, Shiyu Wang, Linmei Yao, Zixuan Gao, Wen Deng, Minghui Li

10.14218/jcth.2026.00093
View Publication

Frequently asked questions

How long does it take to publish?

Fast-track approval decisions are provided within 2 working days, and a decision is made within 2 weeks after fast-track approval. In the standard process, peer reviewers are allotted 14 days, revised manuscripts are allotted 2 months, and proof corrections are requested within 48 hours.

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Is a cover letter required?

A cover letter should briefly outline current knowledge in the research area, identify the key gaps addressed by the study, highlight the novel contributions and conceptual advancements, emphasize significance to a broad audience, and may suggest up to three suitable reviewers and exclusions.

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What are the publication costs?

Journal of Clinical and Translational Hepatology charges USD 3280 for full articles, USD 2130 for short articles, and waives charges for editorials. There are no fees for submission, triage, or peer review.

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Research Topics

Liver Disease Diagnosis and Treatment Liver Disease and Transplantation Hepatitis C virus research Hepatitis B Virus Studies Hepatocellular Carcinoma Treatment and Prognosis Liver Diseases and Immunity Organ Transplantation Techniques and Outcomes Drug-Induced Hepatotoxicity and Protection Liver physiology and pathology Hepatitis Viruses Studies and Epidemiology Diet, Metabolism, and Disease Pediatric Hepatobiliary Diseases and Treatments Cholangiocarcinoma and Gallbladder Cancer Studies Alcohol Consumption and Health Effects Gallbladder and Bile Duct Disorders Drug Transport and Resistance Mechanisms Ferroptosis and cancer prognosis COVID-19 Clinical Research Studies Diabetes, Cardiovascular Risks, and Lipoproteins Pancreatitis Pathology and Treatment Gut microbiota and health HIV/AIDS drug development and treatment Endoplasmic Reticulum Stress and Disease MicroRNA in disease regulation Cancer Immunotherapy and Biomarkers

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