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Regulatory Toxicology and Pharmacology

Regulatory Toxicology and Pharmacology publishes peer reviewed articles involving the generation, evaluation, and interpretation of experimental animal and human data relevant to regulatory authorities in toxicological and pharmacological regulation. The journal focuses on improving protection of human health and the environment and welcomes reviews and discussions addressing legal or regulatory decisions related to risk assessment and management of toxicological and pharmacological compounds. It serves an international readership of scientists, risk assessors and managers, and other professionals in human and environmental health.

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Subject Medicine, Legal, Pharmacology & Pharmacy, Toxicology
Impact Factor 3.5
Quartile Q1
Open Access Type Hybrid
ISSN 0273-2300
eISSN 1096-0295
Invitation Only No
Cost Range USD 4100 APC for open access articles; no open access publication fee for subscription articles.

Submission Instructions

Regulatory Toxicology and Pharmacology accepts the following article types. Click on an article type to view submission instructions.

Original Research Articles

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must not exceed 200 words.
Manuscript Manuscript must contain no more than 5000 words, excluding references. Manuscript must be divided into clearly defined and numbered sections and contain clear conclusions and/or recommendations for regulatory aspects. Manuscript must include 1 to 7 English keywords, article highlights submitted as a separate editable file with 3 to 5 bullet points, and an end-of-manuscript generative AI declaration section before the references if such tools were used.
References Text citations must use author name and year of publication. References may be submitted in any consistent style but must be arranged alphabetically and then chronologically if necessary.
Figures & Tables Original Research Articles must contain no more than a total of 5 figures and/or tables. Figures must be supplied as separate files, while tables with predominantly negative information must be placed in the supplementary information and only summarized in the Results text. All figures and tables must be cited in the text, numbered in order of appearance, and accompanied by captions.
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Contemporary Reviews

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must not exceed 200 words.
Manuscript Manuscript must contain no more than 2500 words. Manuscript must be divided into clearly defined and numbered sections and contain clear conclusions and/or recommendations for regulatory aspects. Submission must include 1 to 7 English keywords, article highlights of 3 to 5 bullet points in a separate editable file, and a generative AI declaration section before the references if such tools were used in manuscript preparation.
References Reference list must contain no more than 50 references. Citations must use author names and year of publication. References may be submitted in any consistent style, must include core bibliographic details, and the reference list must be arranged alphabetically and then chronologically if necessary.
Figures & Tables Manuscript must contain no more than 2 figures and/or tables. Figures must be supplied as separate files, while tables must be submitted as editable text. All figures and tables must be cited in the text, numbered consecutively in order of appearance, and accompanied by captions.
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Comprehensive Reviews

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must be no longer than 200 words.
Manuscript Manuscript must be divided into clearly defined and numbered sections and contain clear conclusions and/or recommendations for regulatory aspects. Manuscript must include 1 to 7 keywords in English, required article highlights submitted as a separate editable file with 3 to 5 bullet points, and a generative AI declaration section before the references if such tools were used in manuscript preparation.
References Text citations must use author name and year, and the reference list must be arranged alphabetically and then chronologically if necessary.
Figures & Tables Figures must be supplied as separate files, while tables must be submitted as editable text. All figures and tables must be cited in the text, numbered according to their order of appearance, and provided with captions.
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Letters To The Editor

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must not exceed 200 words.
Manuscript Letters To The Editor must not exceed 1000 words. Manuscript must be divided into clearly defined and numbered sections. Submission must include article highlights as a separate editable file containing 3 to 5 bullet points, and any use of generative AI in manuscript preparation must be declared in a statement placed before the references.
References Letters To The Editor must not exceed 5 references. Citations in the text must use author name and year, and the reference list must be arranged alphabetically and then chronologically if necessary.
Figures & Tables Letters To The Editor may include a maximum of one table or one figure if needed. Figures must be supplied as separate files, while table placement is not explicitly stated. Tables must be submitted as editable text with captions, and all figures and tables must be cited in the manuscript text.
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Recent Publications

Simultaneous LC-MS/MS screening of 222 drugs of abuse in eight solid food matrices using a unified QuEChERS-Based approach

Eunbin Ryu, Jae Ui Park, Jin Ah Lee, Sangeun Lee, Wonhee Koo, Yoon Hee Lee, Jungmin Shin, Jihyun Lee, Jaewoo Song, Hangji Ok, Mi Jeong Oh, Jae-Sung Pyo, Tae Woong Na, Su Jeong Park, Han Bin Oh, Youngmin Hong, Eunyoung Han

10.1016/j.yrtph.2026.106141
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AI-enhanced cardiac digital twins extend drug proarrhythmic risk assessment through experimental data uncertainty propagation and overdose exploration: A loperamide case study

Paula Dominguez-Gomez, Alberto Zingaro, Caterina Balzotti, Michael Leitner, Noelia Jacobo-Piqueras, Mariano Vazquez, Georg Rast, Jazmin Aguado-Sierra

10.1016/j.yrtph.2026.106138
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Toxic trace elements in fish and seafood from North African coasts: A systematic review and meta-analysis of contamination levels and health risk assessment

Amir Nahal, Fetta Mehouel

10.1016/j.yrtph.2026.106156
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Anti-inflammatory and antinociceptive properties of Handroanthus heptaphyllus (Vell.) Mattos hydroethanolic extract bark in mice

Joyce dos Santos Lencina, Paloma Kênia de Moraes Berenguel Losavaro, Dalila dos Santos Lencina, Gabriel Silvino de Oliveira Venâncio, Mila Marluce Lima Fernandes, Josyelen Lousada Felipe, Iluska Senna Bonfá, Lucas Luiz Machado, Djacelli Sampaio de Oliveira Dembogurski, Kamylla Fernanda Souza de Souza, Edgar Julian Paredes-Gamero, Flávio Macedo Alves, Denise Brentan Silva, Mônica Cristina Toffoli-Kadri, Saulo Euclides Silva-Filho

10.1016/j.yrtph.2026.106159
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To blink or not to blink, that is the question: Reassessing rabbit eyeblink conditioning for learning and memory evaluation in nonclinical safety studies

Dilshan S. Harischandra, Sarah Beck, Paul B. Bushdid

10.1016/j.yrtph.2026.106154
View Publication

Frequently asked questions

How long does it take to publish?

Proof corrections are requested within two days after proofs are sent.

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What are the publication costs?

Open access APC: USD 4100 excluding taxes for all article types. Subscription publication has no open access publication fee.

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Research Topics

Carcinogens and Genotoxicity Assessment Effects and risks of endocrine disrupting chemicals Animal testing and alternatives Pesticide Exposure and Toxicity Toxic Organic Pollutants Impact Diverse Scientific and Economic Studies Air Quality and Health Impacts Contact Dermatitis and Allergies Computational Drug Discovery Methods Human auditory perception and evaluation Chemical Safety and Risk Management Educational Robotics and Engineering Agricultural safety and regulations Pesticide Residue Analysis and Safety Environmental Toxicology and Ecotoxicology Immunotoxicology and immune responses Occupational exposure and asthma Smoking Behavior and Cessation Heavy Metal Exposure and Toxicity Pharmacogenetics and Drug Metabolism Indoor Air Quality and Microbial Exposure Pharmaceutical studies and practices Pesticide and Herbicide Environmental Studies Occupational and environmental lung diseases Genetically Modified Organisms Research

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