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Antimicrobial Agents and Chemotherapy

Antimicrobial Agents and Chemotherapy is an ASM journal focused on antimicrobial chemotherapy, antimicrobial resistance, mycology, and related infectious disease research. The journal publishes article formats including research articles, minireviews, brief reports, letters, and case reports.

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Subject Pharmacology & Pharmacy
Impact Factor 4.5
Quartile Q1
Open Access Type Hybrid
ISSN 0066-4804
eISSN 1098-6596
Invitation Only No
Cost Range Publication fees apply, with member and nonmember publication fees for ASM journals.

Submission Instructions

Antimicrobial Agents and Chemotherapy accepts the following article types. Click on an article type to view submission instructions.

Research Articles

Cover Letter A cover letter is required for initial submission. Cover letter must explain the paper's scientific importance and its interest to the journal’s readers.
Abstract An abstract is required. Abstract must be limited to 250 words. Abstract structure is not specified.
Manuscript Manuscript must include the sections Abstract, Introduction, Results, Discussion, Materials and Methods, and Acknowledgments, although Results and Discussion may be combined in short papers. Manuscript must include a running title not exceeding 54 characters and spaces and a paragraph headed "Data availability" at the end of Materials and Methods for new accession numbers for specified data types.
References References must be numbered in citation order, cited parenthetically by number in sequential order, list all authors and editors without using "et al.," use PubMed journal abbreviations, omit periods in abbreviated words, and include URLs for accession numbers.
Figures & Tables Place figure legends and tables after the References section, and for initial submission include tables in the main text file while figures may be included in the manuscript file or uploaded separately. Appendix equations, tables, and figures must be labeled with the letter "A" preceding the numeral.
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Short-Form Papers

Cover Letter A cover letter is required for initial submission. Cover letter must explain the paper's scientific importance and its interest to the journal’s readers.
Abstract An abstract is required. Abstract must not exceed 75 words. Abstract structure is not specified.
Manuscript Manuscript must not exceed 1,000 words exclusive of references. Body text must not use section headings and must combine methods, results, and discussion in a single section. Manuscript must include a running title not exceeding 54 characters and spaces, and materials and methods must be described in the text rather than in figure legends or table footnotes.
References References must be numbered in citation order, cited parenthetically by number, list all authors and editors without using “et al.,” and use PubMed journal abbreviations.
Figures & Tables Figures and tables should be kept to a minimum. At initial submission, tables must be included with the main text in a single combined file, while figures may be included in that file or uploaded separately. Figure legends and tables must appear after the References section, and methods information must be presented in the text rather than in figure legends or table footnotes.
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Minireviews

Cover Letter A cover letter is required for initial submission. For Minireviews, the cover letter must state whether the article was solicited and by whom.
Abstract Minireviews must include an abstract. The abstract must be 250 words or fewer.
Manuscript Minireviews must be limited to 6,000 words exclusive of references. Minireview biographical text must be included after the References section in the same file, and author bios are limited to 150 words for each author.
References References must be numbered in the order cited, cited parenthetically by number in sequential order, include all authors and editors without using "et al.," and use PubMed journal abbreviations.
Figures & Tables At initial submission, tables must be included with the main text in a single combined file, figures may be included in that file or uploaded separately, and figure legends and tables should appear after the References section. Minireview bio photos must be black-and-white passport-size head shots uploaded as "Minireview Bio Photo" files, with filenames that include the author's name or enough of it for identification.
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Challenging Clinical Cases In Antimicrobial Resistance

Cover Letter A cover letter is required for initial submission. Cover letter must explain the paper's scientific importance and its interest to the journal’s readers.
Abstract A brief abstract is required. Abstract must be limited to 75 words. Abstract structure type is not specified. Mandatory abstract headings are not specified.
Manuscript The case presentation and strategy/outcome sections combined must not exceed 1,200 words. Manuscript must include a case section describing a single clinical case up to organism isolation, characterization of the organism, susceptibility testing information when appropriate, a single multiple-choice therapeutic question, and a description of the treatment strategy and patient outcome. Manuscript must include a single multiple-choice question addressing the most relevant therapeutic issues with several possible answers as choices.
References Reference list must contain no more than 10 references. References must be cited by number in sequential order. References must be numbered in citation order, cited parenthetically by number, include all authors and editors without using “et al.,” and use PubMed journal abbreviations.
Figures & Tables Photos, figures, and tables are limited to a combined total of two. At initial submission, figures may be included in the manuscript file or uploaded separately, while tables must be included in the combined manuscript file and not uploaded separately. Interesting photos, figures, and/or tables must be included.
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Letters To The Editor

Cover Letter A cover letter is required for initial submission. Cover letter must explain the paper's scientific importance and its interest to the journal’s readers.
Abstract Abstract is not required because Letters do not have abstracts.
Manuscript Letter must be no more than 500 words, exclusive of references. Letter must include a title on the manuscript with authors and affiliations listed below the title.
References References must be numbered in the order cited and cited parenthetically by number in sequential order.
Figures & Tables Figures and tables should be kept to a minimum. Figures can be included in the manuscript file or uploaded separately at initial submission, and tables must be included in the manuscript file at initial submission.
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Comment Letter

Cover Letter A cover letter is required for Comment Letters. For Comment Letters on published articles, the cover letter must state the article DOI, the article title, and the last name of the first author.
Abstract Abstract is not required for Letters.
Manuscript Letters may be no more than 500 words long, exclusive of references. Letters must be double-spaced and include a title with authors and affiliations listed below the title. Comment Letters must cite published references to support the writer's argument.
References References must be numbered in the order cited, cited parenthetically by number in sequential order, include all authors and editors without using et al., and use PubMed journal abbreviations.
Figures & Tables Figures and tables in Letters should be kept to a minimum. For initial submission, figures may be included in the manuscript file or uploaded separately, and tables must be included in the combined manuscript file rather than uploaded separately.
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New-Data Letter

Cover Letter A cover letter is required for initial submission. The cover letter must explain the paper's scientific importance and its interest to the journal’s readers.
Abstract Abstract is not required for this article type.
Manuscript Letters may be no more than 500 words long, exclusive of references. Letters must include a title on the manuscript, with authors and affiliations listed below the title.
References References must be numbered in the order cited in the text and cited parenthetically by number in sequential order.
Figures & Tables Figures and tables should be kept to a minimum. For initial submission, tables must be included with the main text file and cannot be uploaded separately, while figures may be included in the manuscript file or uploaded separately.
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Recent Publications

The β-lactam adjuvant guanosine potentiates anti-folate antibiotics and pyrimidine synthesis inhibitors by depleting thymidine in methicillin-resistant Staphylococcus aureus

Aaron C. Nolan, Jessica B. Kelly, Jongsam Ahn, Dhananjay Shinde, Vinai C. Thomas, Merve S. Zeden, James P. O'Gara

10.1128/aac.00377-26
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Pharmacokinetic-pharmacodynamic modeling using combined time-kill data for meropenem and colistin or polymyxin B combination effects in Acinetobacter baumannii

Hiie Soeorg, Sihong Lyu, Frank Kloprogge, Joseph F. Standing

10.1128/aac.00274-26
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A French national observatory of people with HIV initiating lenacapavir-based treatment after regulatory approval

Charlotte Charpentier, Thomas Montrouge, Marc Wirden, Véronique Avettand-Fenoel, Camille Tumiotto, Pantxika Bellecave, Audrey Rodallec, Elisabeth Garnier, Djeneba Fofana, Sidonie Lambert-Niclot, Brigitte Montès, Marie-Laure Chaix, Caroline Charre, Pierre Gantner, Magali Bouvier-Alias, Enagnon Kazali Alidjinou, Pauline Coulon, Gilbert Mchantaf, Agnès Beby-Defaux, Elodie Alessandri-Gradt, Alice Moisan, Quentin Le Hingrat, Minh Lê, Constance Delaugerre, Anne-Geneviève Marcelin, Gilles Peytavin, Vincent Calvez, Diane Descamps, Kevin Alexandre, Clotilde Allavena, Antoine Bachelard, Fabrice Bonnet, Charles Cazanave, Violaine Esnault, Sébastien Gallien, Jade Ghosn, Laurent Hocqueloux, Christine Jacomet, Karine Lacombe, Estibalitz Lazaro, Gwenael Le Moal, Alain Makinson, Corinne Merle de Boever, Jean-Michel Molina, Bao Phung, Valérie Pourcher, Carolien Proux, Mayda Rahi, Christophe Rioux, Olivier Robineau, Axel Ursenbach

10.1128/aac.00228-26
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Why intrinsic reduced susceptibility in rare fungal pathogens should be differentiated from intrinsic resistance: an ISHAM conceptual framework and narrative review

Cornelia Lass-Flörl, Stephan Steixner, Angelika Bauer, Jacques F. Meis, Arnaldo L. Colombo, Oliver A. Cornely, Arunaloke Chakrabarti, Ferry Hagen, Amanda Ribeiro dos Santos, Amir Seyedmousavi, Shivaprakash M. Rudramurthy, Roya Vahedi-Shahandashti

10.1128/aac.00263-26
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The protective effect of Schisandrin C against methicillin-resistant Staphylococcus aureus -induced otitis media

Weifang Sun, Meihui Tian, Xingye Wang, Shuang Jiang, Mengli Jin, Yan Wang, Yating Tang, Shuyue Zhu, Wenlu Liao, Xueying Ding, Xuanyu Lv, Huan Liu, Wu Song, Lin Wei, Yong Tang

10.1128/aac.00095-26
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Frequently asked questions

How long does it take to publish?

Revised manuscripts must be submitted within two months. Resubmission links remain active for 180 days, and once opened, the resubmission must be completed within 30 days.

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Is a cover letter required?

A cover letter is uploaded at initial submission. For resubmissions, a cover letter stating that the manuscript is a resubmission is required.

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What are the publication costs?

Member and nonmember publication fees apply for ASM journals.

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Research Topics

Antibiotic Resistance in Bacteria Antibiotics Pharmacokinetics and Efficacy Antimicrobial Resistance in Staphylococcus Antifungal resistance and susceptibility Pneumonia and Respiratory Infections Bacterial Identification and Susceptibility Testing HIV/AIDS drug development and treatment Bacterial biofilms and quorum sensing Tuberculosis Research and Epidemiology Mycobacterium research and diagnosis Pneumocystis jirovecii pneumonia detection and treatment HIV Research and Treatment Fungal Infections and Studies Bacterial Genetics and Biotechnology Cancer therapeutics and mechanisms Malaria Research and Control Drug Transport and Resistance Mechanisms Antimicrobial Peptides and Activities Pharmaceutical and Antibiotic Environmental Impacts Bacterial Infections and Vaccines Streptococcal Infections and Treatments Bacteriophages and microbial interactions Antibiotic Use and Resistance Clostridium difficile and Clostridium perfringens research Herpesvirus Infections and Treatments

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