Overview
Submission Instructions
Recent Publications
Frequently Asked Questions
Research Topics
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Aging and Disease publishes research and review content on aging, age-related diseases, and related biomedical topics. The journal website includes current issues, early edition articles, collections, editorial board information, journal metrics, open access information, author guidelines, templates, policies, and online submission.
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Subject
Geriatrics & Gerontology
Impact Factor
6.9
Quartile
Q1
Open Access Type
Open
ISSN
2152-5250
eISSN
2152-5250
Invitation Only
No
Cost Range
Article Processing Charge upon acceptance: $3,000 USD for Research Articles and Reviews; $2,000 USD for Perspectives, Opinions, Correspondence, and Letters, effective May 1, 2025.
Submission Instructions
Aging and Disease accepts the following article types. Click on an article type to view submission instructions.
Original Articles
Cover Letter
A cover letter is required. Cover letter must include the corresponding author’s contact details, manuscript title, manuscript type, a brief paragraph on the work’s significance, a statement of originality, any conflict of interest, the names and affiliations and contact information of at least three qualified reviewers, and any AI-assistance disclosure with the tool name, version, and prompt used.
Abstract
An abstract is required. Abstract must not exceed 300 words. Abstract must be unstructured. Abstract must include keywords and be followed by no more than six keywords.
Manuscript
Original Articles must be organized as Title page, Abstract including Keywords, Introduction, Materials and Methods, Results, Discussion, Acknowledgments optional, References, Tables, Figure legends, and Figures. Manuscript must include a conflict of interest statement and disclose any AI-assisted tools in the Methods section and Acknowledgments section with the tool name, version, and prompt used.
References
References must follow the Uniform Requirements style based largely on an American National Standards Institute style adapted by the NLM. References must be numbered consecutively in order of first mention, cited in the text with Arabic numerals in parentheses, use MEDLINE journal title abbreviations, list all authors when there are six or fewer, and list the first six authors followed by et al when there are seven or more.
Figures & Tables
Tables may be embedded in the manuscript after the References section or submitted as separate .doc files, while figures must be submitted as separate files. Tables must be numbered consecutively and include a brief title, and figure legends must be provided on a separate page after the tables and numbered to match figures cited consecutively in the text.
Reviews
Cover Letter
A cover letter is required. Cover letter must include the corresponding author’s contact details, manuscript title, manuscript type, a brief statement of significance, an originality statement, any conflict of interest, details for at least three qualified reviewers, and disclosure of any AI-assisted tools used including the tool name, version, and prompt.
Abstract
An abstract is required. Abstract must not exceed 300 words.
Manuscript
Review manuscripts must not exceed 20,000 words excluding references. Manuscript must include a title page, abstract, text, references, tables, and figure legends, and the abstract must be followed by no more than six keywords.
References
References must follow the Uniform Requirements style based largely on an American National Standards Institute style adapted by the NLM. References must be numbered consecutively by first mention, cited in Arabic numerals in parentheses, use MEDLINE journal title abbreviations, list all authors when there are six or fewer, and list the first six authors followed by et al. when there are seven or more.
Figures & Tables
Figures must be submitted as separate files, while tables may be placed within the manuscript or submitted separately as .doc files. Tables must be numbered consecutively and, if included in the manuscript, placed after the references with one table per page, while figures must be numbered consecutively and figure legends provided on a separate page after the tables.
Short Communication
Cover Letter
A cover letter is required. Cover letter must include the corresponding author’s contact details, manuscript title, manuscript type, a brief paragraph explaining the significance of the work, a statement that the manuscript is original, unpublished, and not under consideration elsewhere, any conflict of interest, details for at least three qualified reviewers, and disclosure of any AI-assisted tools used including the tool name, version, and prompt.
Abstract
An abstract is required. Abstract must not exceed 300 words.
Manuscript
Short Communication manuscripts must not exceed 2,000 words. Short Communication manuscripts must include an introductory paragraph highlighting the significance of the findings and a concluding paragraph summarizing the key outcomes and suggesting future directions. Abstract must be followed by no more than six keywords, and the manuscript must include a conflict of interest statement with funding or related interests disclosed within the manuscript and AI use disclosed in the Acknowledgments and Methods sections.
References
References must follow the Uniform Requirements style based largely on an American National Standards Institute style adapted by the NLM. References must be numbered consecutively in order of first mention, cited in the text with Arabic numerals in parentheses, use MEDLINE journal title abbreviations, list all authors when there are six or fewer, and list the first six authors followed by et al. when there are seven or more.
Figures & Tables
Figures must be submitted as separate files, while tables may be placed within the manuscript or submitted as separate .doc files. If tables are included in the manuscript they must appear after the references with one table per page, and figures and tables must be numbered consecutively in the order first cited.
Letters To The Editor
Cover Letter
A cover letter is required. Cover letter must include the corresponding author’s contact details, the manuscript title and type, a brief paragraph on the work’s significance, any conflict of interest, names and contact information for at least three qualified reviewers, a statement that the manuscript is original, unpublished, and not under simultaneous consideration elsewhere, and any AI-assistance disclosure including tool name, version, and prompt used.
Abstract
Abstract must not exceed 300 words.
Manuscript
Letter must pertain to an article recently published in the journal. Abstract must be followed by no more than six keywords, and AI-assisted tool use must be disclosed in the Acknowledgments and Methods sections including the tool name, version, and prompt used.
References
References must follow the Uniform Requirements style based largely on an American National Standards Institute style adapted by the NLM. References must be numbered consecutively by first mention, cited in Arabic numerals in parentheses, use MEDLINE journal title abbreviations, list all authors when there are six or fewer and the first six followed by et al. when there are seven or more, with unpublished data and website data excluded from the reference list.
Figures & Tables
Figures must be submitted as separate files, while tables may be embedded in the manuscript after the references or submitted separately as .doc files. Tables must be numbered consecutively and have brief titles, and figures must be numbered consecutively with legends provided on a separate page after the tables.
Correspondence
Cover Letter
A cover letter is required. The cover letter must include the corresponding author’s contact details, manuscript title, manuscript type, a brief paragraph explaining the significance of the work, a statement of originality and exclusive submission, any conflict of interest, the names and affiliations and contact information of at least three qualified reviewers, and disclosure of any AI-assisted tools used including the tool name, version, and prompt.
Abstract
An abstract is required. Abstract must not exceed 300 words.
Manuscript
The manuscript must include a title page, abstract, text, references, tables, figure legends, no more than six keywords after the abstract, a conflict of interest statement, funding disclosures, and disclosure of any AI-assisted tools used in the Methods and Acknowledgments sections including the tool name, version, and prompt.
References
References must follow the Uniform Requirements style based largely on an American National Standards Institute style adapted by the NLM. References must be numbered consecutively in order of first mention, cited with Arabic numerals in parentheses, use MEDLINE journal title abbreviations, list all authors when there are six or fewer and the first six followed by et al. when there are seven or more, and exclude unpublished data, personal communications, and website data from the reference list.
Figures & Tables
Figures must be submitted as separate files, and tables may be embedded in the manuscript after the References section or submitted separately as .doc files. Tables must be numbered consecutively and have brief titles, and figure legends must be provided on a separate page after the tables and numbered to match figures.
Recent Publications
Hepatic FoxO3 Supports Metabolic Resilience, Attenuates Age-Associated Obesity and Metabolic Dysfunction, and Mitigates Diet-Induced Steatohepatitis
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10.14336/ad.2026.0477
View Publication
Targeting the Microbiota-Butyrate-BHB Axis As a Potential Metabolic Therapeutic Strategy for Alzheimer’s Disease
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10.14336/ad.2026.0606
View Publication
Glial Scar Stiffness Affects NSCs Differentiated Direction via Piezo1 Post-Stroke
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10.14336/ad.2026.0347
View Publication
Cognitive Impairment after Aneurysmal Subarachnoid Hemorrhage: Temporal Patterns and Electrophysiological Risk Stratification
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10.14336/ad.2026.10505
View Publication
Intestinal Organoids from Alzheimer’s Disease Transgenic Mice Reveal Structural and Molecular Gut Pathology
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10.14336/ad.2026.0233
View Publication
Frequently asked questions
How long does it take to publish?
Early edition articles are posted after acceptance. Examples listed include accepted dates of 2026-04-17, 2026-04-20, 2026-04-23, and 2026-04-24 before publication in a 2026 issue.
Reformat to Aging and Disease using Livewrite PremiumIs a cover letter required?
A cover letter must be provided with every manuscript and should include the corresponding author’s contact details, manuscript title and brief significance statement, manuscript type, originality statement, any conflict of interest, and the names and contact information of 3 or more qualified reviewers.
Reformat to Aging and Disease using Livewrite PremiumWhat are the publication costs?
Article Processing Charge upon acceptance: $3,000 USD for Research Articles and Reviews; $2,000 USD for Perspectives, Opinions, Correspondence, and Letters, effective May 1, 2025.
Reformat to Aging and Disease using Livewrite PremiumResearch Topics
Neuroinflammation and Neurodegeneration Mechanisms
Alzheimer's disease research and treatments
Genetics, Aging, and Longevity in Model Organisms
Mitochondrial Function and Pathology
Neurological Disease Mechanisms and Treatments
Diet and metabolism studies
Telomeres, Telomerase, and Senescence
Parkinson's Disease Mechanisms and Treatments
Tryptophan and brain disorders
Nutrition and Health in Aging
Acute Ischemic Stroke Management
Autophagy in Disease and Therapy
Long-Term Effects of COVID-19
Adipose Tissue and Metabolism
Dementia and Cognitive Impairment Research
MicroRNA in disease regulation
Epigenetics and DNA Methylation
Frailty in Older Adults
COVID-19 Clinical Research Studies
Extracellular vesicles in disease
Gut microbiota and health
Neuroscience and Neuropharmacology Research
Mesenchymal stem cell research
Cancer-related molecular mechanisms research
Immune cells in cancer