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Aging and Disease

Aging and Disease publishes research and review content on aging, age-related diseases, and related biomedical topics. The journal website includes current issues, early edition articles, collections, editorial board information, journal metrics, open access information, author guidelines, templates, policies, and online submission.

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Subject Geriatrics & Gerontology
Impact Factor 6.9
Quartile Q1
Open Access Type Open
ISSN 2152-5250
eISSN 2152-5250
Invitation Only No
Cost Range Article Processing Charge upon acceptance: $3,000 USD for Research Articles and Reviews; $2,000 USD for Perspectives, Opinions, Correspondence, and Letters, effective May 1, 2025.

Submission Instructions

Aging and Disease accepts the following article types. Click on an article type to view submission instructions.

Original Articles

Cover Letter A cover letter is required. Cover letter must include the corresponding author’s contact details, manuscript title, manuscript type, a brief paragraph on the work’s significance, a statement of originality, any conflict of interest, the names and affiliations and contact information of at least three qualified reviewers, and any AI-assistance disclosure with the tool name, version, and prompt used.
Abstract An abstract is required. Abstract must not exceed 300 words. Abstract must be unstructured. Abstract must include keywords and be followed by no more than six keywords.
Manuscript Original Articles must be organized as Title page, Abstract including Keywords, Introduction, Materials and Methods, Results, Discussion, Acknowledgments optional, References, Tables, Figure legends, and Figures. Manuscript must include a conflict of interest statement and disclose any AI-assisted tools in the Methods section and Acknowledgments section with the tool name, version, and prompt used.
References References must follow the Uniform Requirements style based largely on an American National Standards Institute style adapted by the NLM. References must be numbered consecutively in order of first mention, cited in the text with Arabic numerals in parentheses, use MEDLINE journal title abbreviations, list all authors when there are six or fewer, and list the first six authors followed by et al when there are seven or more.
Figures & Tables Tables may be embedded in the manuscript after the References section or submitted as separate .doc files, while figures must be submitted as separate files. Tables must be numbered consecutively and include a brief title, and figure legends must be provided on a separate page after the tables and numbered to match figures cited consecutively in the text.
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Reviews

Cover Letter A cover letter is required. Cover letter must include the corresponding author’s contact details, manuscript title, manuscript type, a brief statement of significance, an originality statement, any conflict of interest, details for at least three qualified reviewers, and disclosure of any AI-assisted tools used including the tool name, version, and prompt.
Abstract An abstract is required. Abstract must not exceed 300 words.
Manuscript Review manuscripts must not exceed 20,000 words excluding references. Manuscript must include a title page, abstract, text, references, tables, and figure legends, and the abstract must be followed by no more than six keywords.
References References must follow the Uniform Requirements style based largely on an American National Standards Institute style adapted by the NLM. References must be numbered consecutively by first mention, cited in Arabic numerals in parentheses, use MEDLINE journal title abbreviations, list all authors when there are six or fewer, and list the first six authors followed by et al. when there are seven or more.
Figures & Tables Figures must be submitted as separate files, while tables may be placed within the manuscript or submitted separately as .doc files. Tables must be numbered consecutively and, if included in the manuscript, placed after the references with one table per page, while figures must be numbered consecutively and figure legends provided on a separate page after the tables.
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Short Communication

Cover Letter A cover letter is required. Cover letter must include the corresponding author’s contact details, manuscript title, manuscript type, a brief paragraph explaining the significance of the work, a statement that the manuscript is original, unpublished, and not under consideration elsewhere, any conflict of interest, details for at least three qualified reviewers, and disclosure of any AI-assisted tools used including the tool name, version, and prompt.
Abstract An abstract is required. Abstract must not exceed 300 words.
Manuscript Short Communication manuscripts must not exceed 2,000 words. Short Communication manuscripts must include an introductory paragraph highlighting the significance of the findings and a concluding paragraph summarizing the key outcomes and suggesting future directions. Abstract must be followed by no more than six keywords, and the manuscript must include a conflict of interest statement with funding or related interests disclosed within the manuscript and AI use disclosed in the Acknowledgments and Methods sections.
References References must follow the Uniform Requirements style based largely on an American National Standards Institute style adapted by the NLM. References must be numbered consecutively in order of first mention, cited in the text with Arabic numerals in parentheses, use MEDLINE journal title abbreviations, list all authors when there are six or fewer, and list the first six authors followed by et al. when there are seven or more.
Figures & Tables Figures must be submitted as separate files, while tables may be placed within the manuscript or submitted as separate .doc files. If tables are included in the manuscript they must appear after the references with one table per page, and figures and tables must be numbered consecutively in the order first cited.
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Letters To The Editor

Cover Letter A cover letter is required. Cover letter must include the corresponding author’s contact details, the manuscript title and type, a brief paragraph on the work’s significance, any conflict of interest, names and contact information for at least three qualified reviewers, a statement that the manuscript is original, unpublished, and not under simultaneous consideration elsewhere, and any AI-assistance disclosure including tool name, version, and prompt used.
Abstract Abstract must not exceed 300 words.
Manuscript Letter must pertain to an article recently published in the journal. Abstract must be followed by no more than six keywords, and AI-assisted tool use must be disclosed in the Acknowledgments and Methods sections including the tool name, version, and prompt used.
References References must follow the Uniform Requirements style based largely on an American National Standards Institute style adapted by the NLM. References must be numbered consecutively by first mention, cited in Arabic numerals in parentheses, use MEDLINE journal title abbreviations, list all authors when there are six or fewer and the first six followed by et al. when there are seven or more, with unpublished data and website data excluded from the reference list.
Figures & Tables Figures must be submitted as separate files, while tables may be embedded in the manuscript after the references or submitted separately as .doc files. Tables must be numbered consecutively and have brief titles, and figures must be numbered consecutively with legends provided on a separate page after the tables.
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Correspondence

Cover Letter A cover letter is required. The cover letter must include the corresponding author’s contact details, manuscript title, manuscript type, a brief paragraph explaining the significance of the work, a statement of originality and exclusive submission, any conflict of interest, the names and affiliations and contact information of at least three qualified reviewers, and disclosure of any AI-assisted tools used including the tool name, version, and prompt.
Abstract An abstract is required. Abstract must not exceed 300 words.
Manuscript The manuscript must include a title page, abstract, text, references, tables, figure legends, no more than six keywords after the abstract, a conflict of interest statement, funding disclosures, and disclosure of any AI-assisted tools used in the Methods and Acknowledgments sections including the tool name, version, and prompt.
References References must follow the Uniform Requirements style based largely on an American National Standards Institute style adapted by the NLM. References must be numbered consecutively in order of first mention, cited with Arabic numerals in parentheses, use MEDLINE journal title abbreviations, list all authors when there are six or fewer and the first six followed by et al. when there are seven or more, and exclude unpublished data, personal communications, and website data from the reference list.
Figures & Tables Figures must be submitted as separate files, and tables may be embedded in the manuscript after the References section or submitted separately as .doc files. Tables must be numbered consecutively and have brief titles, and figure legends must be provided on a separate page after the tables and numbered to match figures.
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Recent Publications

F-box Protein-Mediated Regulation of Cell Fate in Skeletal Homeostasis and Orthopedic Degenerative Diseases: Integrated Mechanisms and Targeted Translation

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10.14336/ad.2026.1155
View Publication

Ceruloplasmin in Disorders of the Nervous System

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10.14336/ad.2026.0988
View Publication

Corrigendum to “Neuropsychological Profiles in Genetic Frontotemporal Dementia: A Meta-Analysis and Systematic Review”

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10.14336/ad.2026.0920-c
View Publication

PARP-CD38-Driven NAD+ Loss in Immune Aging: An Emerging Mechanistic Framework

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10.14336/ad.2026.0890
View Publication

Aging Intestinal Niche: Regulation of Stem Cells and Disease

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10.14336/ad.2026.0844
View Publication

Frequently asked questions

How long does it take to publish?

Early edition articles are posted after acceptance. Examples listed include accepted dates of 2026-04-17, 2026-04-20, 2026-04-23, and 2026-04-24 before publication in a 2026 issue.

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Is a cover letter required?

A cover letter must be provided with every manuscript and should include the corresponding author’s contact details, manuscript title and brief significance statement, manuscript type, originality statement, any conflict of interest, and the names and contact information of 3 or more qualified reviewers.

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What are the publication costs?

Article Processing Charge upon acceptance: $3,000 USD for Research Articles and Reviews; $2,000 USD for Perspectives, Opinions, Correspondence, and Letters, effective May 1, 2025.

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Research Topics

Neuroinflammation and Neurodegeneration Mechanisms Alzheimer's disease research and treatments Genetics, Aging, and Longevity in Model Organisms Mitochondrial Function and Pathology Neurological Disease Mechanisms and Treatments Diet and metabolism studies Telomeres, Telomerase, and Senescence Parkinson's Disease Mechanisms and Treatments Tryptophan and brain disorders Nutrition and Health in Aging Acute Ischemic Stroke Management Autophagy in Disease and Therapy Long-Term Effects of COVID-19 Adipose Tissue and Metabolism Dementia and Cognitive Impairment Research MicroRNA in disease regulation Epigenetics and DNA Methylation Frailty in Older Adults COVID-19 Clinical Research Studies Extracellular vesicles in disease Gut microbiota and health Neuroscience and Neuropharmacology Research Mesenchymal stem cell research Cancer-related molecular mechanisms research Immune cells in cancer

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