AJ

American Journal of Physiology-Endocrinology and Metabolism

American Journal of Physiology-Endocrinology and Metabolism is a physiology journal of the American Physiological Society that publishes research and review content in endocrinology and metabolism, features current issues and articles in press, and highlights collections and calls for papers in areas such as clinical metabolism, exercise metabolism, immunometabolism, and liver metabolism.

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Subject Endocrinology & Metabolism
Impact Factor 3.1
Quartile Q2
Open Access Type Hybrid
ISSN 0193-1849
eISSN 1522-1555
Invitation Only No

Submission Instructions

American Journal of Physiology-Endocrinology and Metabolism accepts the following article types. Click on an article type to view submission instructions.

Research Articles

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract is required for Research Articles. Abstract must not exceed 250 words. Abstract must be a one-paragraph unstructured summary.
Manuscript Manuscript must include Introduction, Methods, Results, and Discussion sections. Manuscript must include up to 5 keywords and a New & Noteworthy summary limited to 75 words.
References References must use Vancouver style. References must be listed in numerical order as cited in the text, include only published or accepted articles and preprints, and exclude unpublished observations and personal communications from the reference list.
Figures & Tables Figures and tables must be included with the new submission. A graphical abstract is required and must be unique from the other figures.
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Review Articles

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract is required for Review Articles. Abstract must not exceed 250 words. Abstract must be a one-paragraph unstructured summary.
Manuscript Review Articles must not exceed 6,000 words. Manuscript must include up to 5 keywords and author contributions for all authors.
References References must use Vancouver style. References must be listed in numerical order as cited in the text, include only published or accepted articles plus preprints, and exclude unpublished observations and personal communications from the reference list.
Figures & Tables Review Articles may include up to 6 figures. Tables must be submitted in Word table format rather than tabbed text or embedded images.
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Systematic Review

Cover Letter Cover Letter requirements are not specified.
Abstract An abstract is required for a Systematic Review. The abstract must not exceed 250 words. The abstract must be one paragraph.
Manuscript The title must identify the article as a systematic review or meta-analysis, and the manuscript must state the search strategy, inclusion and exclusion criteria, characteristics of extracted information, any meta-analysis methods with confidence intervals and consistency measures, and risk of bias and search or analysis limitations. Include up to 5 keywords and include author contributions in the manuscript.
References References must use Vancouver style. References must be listed in numerical order of citation, include only published or accepted articles plus preprints, and exclude unpublished observations and personal communications from the reference list.
Figures & Tables Tables must be submitted in Word table format rather than as tabbed text or embedded images.
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Short Reports

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract is required. Abstract must not exceed 250 words.
Manuscript Manuscript must be limited to 4,000 words excluding references and figure legends. Manuscript must include up to 5 keywords and a link to repository-hosted supplemental material files.
References References must use Vancouver style. References must be listed in numerical order as cited in the text, include only published or accepted articles and preprints, and exclude unpublished observations and personal communications from the reference list.
Figures & Tables Short Reports may include up to 4 figures or tables, excluding additional online materials.
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Mini-Reviews

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract is required. Abstract must not exceed 250 words. Abstract should be a one-paragraph unstructured summary.
Manuscript Manuscript must not exceed 3,000 words. Include up to 5 keywords and provide author contributions for all authors in the manuscript.
References References may include up to 50 entries. References must use Vancouver style. References must be listed in numerical order as cited in the text, and only published, accepted, or preprint articles may appear in the reference list.
Figures & Tables Mini-Reviews may include 1-3 figures and/or tables. Previously published figures are allowed only with copyright-holder permission and acknowledgment of the source.
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Review: Guidelines

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract is required. Abstract must not exceed 250 words. Abstract must be a one-paragraph unstructured abstract.
Manuscript Manuscript must be 10,000–25,000 words. Include up to 5 keywords and author contributions in the manuscript.
References References must use Vancouver style. References must be listed in numerical order as cited in the text, include only published or accepted articles and preprints, and exclude unpublished observations and personal communications from the reference list.
Figures & Tables Figures and tables must be included with the new submission. Tables must be submitted in Word table format rather than as tabbed text or embedded images.
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Letters To The Editor

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract is not required for Letters To The Editor.
Manuscript Letters To The Editor are limited to 1,000 words, excluding references. Letters To The Editor must respond to work previously published in the journal and, if new data are exceptionally permitted, must include the appropriate methods.
References Letters To The Editor may include up to 10 references, including the highlighted article. References must use Vancouver style. References must be listed in numerical order as cited in the text, and only published, accepted, or preprint items may appear in the reference list.
Figures & Tables Letters To The Editor may not include figures or tables.
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Recent Publications

Single-cell dissection of cholesterol metabolism reveals cell-type-specific genes and hypercholesterolemia-associated remodeling

Jian Chu, Jing Zhuang, Shuwen Han, Yujiu Liang, Jing Mao, Zian Zhang, Caiyun Chu, Xi Yang

10.1152/ajpendo.00090.2026
View Publication

Differential impact of cancer- and chemotherapy-induced cachexia: a comparative analysis in a pre-clinical model of colorectal cancer by biological sex

Ana Regina Cabrera, Eleanor R. Schrems, Ruqaiza Muhyudin, Francielly Morena, Stavroula Tsitkanou, Ronald G. Jones, Kaitlyn Parker, Morghan Relich, Kevin A. Murach, Timothy J. Muldoon, Tyrone A. Washington, Nicholas P. Greene

10.1152/ajpendo.00131.2026
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Hypothalamic-Pituitary-Gonadal Axis Programming and Disrupted Ovarian-Endocrine Function in Female Offspring of the Preeclamptic-Like BPH/5 Mouse

Victoria N. Bailey, Kendall R. Ball, Kalynn E. Grandberry, Linda A. Nduwimana, Bryce M. Borne, Viviane C.L. Gomes

10.1152/ajpendo.00543.2025
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The Role of β-Klotho in FGF Signaling: From Molecular Insights to Therapeutic Innovations

Fang Yan, Chen Yang, ShiYuan Huang, Li Yuan, Yi Qiu, Tao Liu, Xi Peng, Yang Yang

10.1152/ajpendo.00042.2026
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Bridging the gap: Multi-omic Insights into Exercise Responses in Post-Menopausal Women

Rushali Kullachanda Aiyanna, Sisi Wang, Robin Grolaux, Elizabeth Reisman, Bernadette Jones-Freeman, Nir Eynon

10.1152/ajpendo.00172.2026
View Publication

Frequently asked questions

How long does it take to publish?

Average time to first decision is 38 days, average time to ahead-of-print publication is 16.4 days, and average time to final publication is 1.7 months.

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What are the publication costs?

Hybrid publishing model with open access articles available in 2026.

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Research Topics

Adipose Tissue and Metabolism Muscle metabolism and nutrition Pancreatic function and diabetes Diet and metabolism studies Metabolism, Diabetes, and Cancer Regulation of Appetite and Obesity Growth Hormone and Insulin-like Growth Factors Adipokines, Inflammation, and Metabolic Diseases Metabolism and Genetic Disorders Diabetes Management and Research Birth, Development, and Health Receptor Mechanisms and Signaling Muscle Physiology and Disorders Cardiovascular and exercise physiology Diabetes Treatment and Management Neuropeptides and Animal Physiology Liver Disease Diagnosis and Treatment Exercise and Physiological Responses Stress Responses and Cortisol Hormonal Regulation and Hypertension Diabetes and associated disorders Diet, Metabolism, and Disease Peroxisome Proliferator-Activated Receptors Neuroendocrine regulation and behavior Mitochondrial Function and Pathology

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