CI

Chemico-biological Interactions

Chemico-Biological Interactions is a journal of molecular, cellular and biochemical toxicology that publishes research reports and review articles on the molecular, cellular, and biochemical basis of toxicologically relevant outcomes. It emphasizes toxicological mechanisms arising from interactions between chemicals and biological systems, including endpoints such as carcinogenesis, mutagenesis, respiratory toxicology, neurotoxicology, reproductive and developmental toxicology, and immunotoxicology.

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Subject Pharmacology & Pharmacy, Toxicology
Impact Factor 5.4
Quartile Q1
Open Access Type Hybrid
ISSN 0009-2797
eISSN 1872-7786
Invitation Only No
Cost Range USD 3490 APC for open access; no open access publication fee for subscription articles.

Submission Instructions

Chemico-biological Interactions accepts the following article types. Click on an article type to view submission instructions.

Papers Reporting Results Of Original Mechanistic Research

Cover Letter Cover Letter requirements are not specified.
Abstract An abstract is required. Abstract must not exceed 250 words. Abstract must be unstructured.
Manuscript Article must be divided into clearly defined and numbered sections. The manuscript must include 1 to 7 keywords in English, provide article highlights as a separate editable file with 3 to 5 bullet points, and include an AI declaration section before the references if generative AI was used in manuscript preparation.
References References must be cited using numbered square-bracket citations. References must be numbered in order of appearance and include author names, source title information, year, and volume, article number, or page range where applicable.
Figures & Tables Figures must be uploaded as separate files with the manuscript, while tables are submitted as editable text. Tables must be editable text with captions and citation in the text, and figures must be numbered, cited in the text, and supplied with captions.
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Review Articles

Cover Letter Cover Letter requirements are not specified.
Abstract An abstract not exceeding 250 words must be provided. Abstract must not exceed 250 words. Abstract should be concise and factual and is presented as unstructured.
Manuscript Article must be divided into clearly defined and numbered sections. Manuscript must include 1 to 7 keywords, provide 3 to 5 highlights as a separate editable file, and include an AI declaration section before the references if generative AI was used in manuscript preparation.
References References must be cited as numbers in square brackets and listed in the order they appear in the article.
Figures & Tables Figures must be uploaded as separate files and tables must be submitted as editable text. Tables must be cited in the text, numbered consecutively, and include captions, and figures must be cited in the text, numbered by appearance, and include captions.
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Letters To The Editor

Cover Letter Cover Letter requirements are not specified.
Abstract An abstract not exceeding 250 words must be provided. Abstract must not exceed 250 words. Abstract must be unstructured and concise.
Manuscript Article must be divided into clearly defined and numbered sections. The manuscript must include 1 to 7 keywords, provide article highlights of 3 to 5 bullet points, and include an AI declaration section before the references if generative AI was used in manuscript preparation.
References References must be cited by number in square brackets. References may be in any consistent style at submission and must be numbered in the order of appearance in the text.
Figures & Tables Figures must be supplied as separate files, and tables must be submitted as editable text. All figures and tables must be cited in the text, numbered consecutively, and provided with captions.
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Recent Publications

5-Ethynyl-2′-deoxyuridine (EdU) regulates apoptosis, autophagy, and cell cycle dynamics in 2D and 3D U87-MG glioma cells

Ceren Gencel Güler, Evren Önay Uçar

10.1016/j.cbi.2026.112140
View Publication

Response to “Reflection about articaine: in vitro studies and clinical data” by Branco & Santos, Chemico-Biological Interactions 2026, Jan 26; 423: 111816

Gustavo Henrique Rodrigues da Silva, Eneida de Paula

10.1016/j.cbi.2026.112174
View Publication

Erratum to “Interactions of hop xanthohumols with model membranes and their toxicity to cancer and erythrocytes cells” [Chem. Biol. Interact. (2026) 112119]

Monika Stompor-Gorący, Aleksandra Włoch, Priti Sengupta, Agata Bajek-Bil, Anna Nasulewicz-Goldeman, Magdalena Domanská, Joanna Wietrzyk, Maciej Machaczka

10.1016/j.cbi.2026.112169
View Publication

Elaidic acid induces hepatic lipid accumulation by inhibiting chaperone-mediated autophagy via the GAS5/miR-27b-3p/SNX10 axis

Yuelin Chen, Junzhu Feng, Lingxi Lang, Huanhuan Peng, Jin Guo, Shuang Guan, Jing Lu

10.1016/j.cbi.2026.112175
View Publication

The pivotal regulatory factor circ_0006956 promotes arsenic-induced lung carcinogenesis by enhancing the Warburg effect

Deqing Li, Xiaodong Zhou, Dunyu Cai, Haotian Xu, Xingcai Chen, Shengyi Yuan, Taoran Ning, Xiangyu Dong, Mengyao Li, Qiumei Liu, Ruirui Zhang, Wenyi Peng, Gang Li, Aruo Nan

10.1016/j.cbi.2026.112170
View Publication

Frequently asked questions

How long does it take to publish?

7 days submission to first decision; 37 days submission to decision after review; 96 days submission to acceptance; 2 days acceptance to online publication.

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What are the publication costs?

USD 3490 APC for open access; no open access publication fee for subscription articles.

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Research Topics

Carcinogens and Genotoxicity Assessment Pharmacogenetics and Drug Metabolism Cholinesterase and Neurodegenerative Diseases Pesticide Exposure and Toxicity Genomics, phytochemicals, and oxidative stress Drug Transport and Resistance Mechanisms Diverse Scientific and Economic Studies Human auditory perception and evaluation Educational Robotics and Engineering DNA and Nucleic Acid Chemistry Computational Drug Discovery Methods DNA Repair Mechanisms Drug-Induced Hepatotoxicity and Protection Trace Elements in Health Effects and risks of endocrine disrupting chemicals Glutathione Transferases and Polymorphisms Metal complexes synthesis and properties Toxic Organic Pollutants Impact Free Radicals and Antioxidants Heavy Metal Exposure and Toxicity Sulfur Compounds in Biology Environmental Toxicology and Ecotoxicology Alcohol Consumption and Health Effects Aldose Reductase and Taurine Bioactive Compounds and Antitumor Agents

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