AJ

American Journal of Ophthalmology

American Journal of Ophthalmology is a peer-reviewed monthly scientific journal published since 1884 for ophthalmologists and visual science specialists. It welcomes original, previously unpublished manuscripts describing clinical investigations, clinical observations, and clinically relevant laboratory investigations, and publishes Full-Length Articles, Perspectives, Editorials, and Correspondences.

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Subject Ophthalmology
Impact Factor 4.2
Quartile Q1
Open Access Type Hybrid
ISSN 0002-9394
eISSN 1879-1891
Invitation Only No
Cost Range USD 4380 APC for open access articles; no open access publication fee for subscription publication.

Submission Instructions

American Journal of Ophthalmology accepts the following article types. Click on an article type to view submission instructions.

Full-Length Articles

Cover Letter A cover letter is required for Full-Length Articles. The cover letter must address manuscript originality, justify any deletion of a required abstract section, confirm permission from all acknowledged individuals, and for manuscripts with original data include a statement from the principal investigator or corresponding author accepting responsibility for data access, integrity, analysis accuracy, and the decision to submit.
Abstract A structured abstract is required for Full-Length Articles and must be uploaded separately from the manuscript text file. The abstract must not exceed 350 words. The abstract must be structured into 7 sections. The abstract must include Objective or Purpose, Design, Subjects, Participants and/or Controls, Methods, Intervention or Testing, Main Outcome Measures, Results, and Conclusions.
Manuscript The manuscript text file must include the title page, manuscript text, Acknowledgement/Disclosure section, appendices if required, references, and a figure captions or legend page. The submission must include 1 to 7 keywords, 3 to 5 highlights submitted as a separate editable file, a completed declarations tool with competing interest information, an Acknowledgement section between the text and references, CRediT author contribution roles, and if applicable a generative AI declaration in a new section before the references.
References References must follow current AMA format. References must include a DOI if available and any source cited in the article must appear in the reference list and vice versa.
Figures & Tables Tables and figures must be uploaded individually as separate files, and figure captions or legends must be provided separately rather than on the figure while table titles and legends must appear with the corresponding table file. Tables must be submitted as editable text and all figures and tables must be cited and numbered consecutively in the manuscript with captions or legends provided.
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Systematic Reviews

Cover Letter A cover letter is required for Systematic Reviews and Meta-Analyses. The cover letter should explain why the review question is important to clinicians or users, including patients and policymakers, and present the expertise of team members with clinical, systematic review methods, and statistical expertise.
Abstract An abstract is required for Systematic Reviews and Meta-Analyses. The abstract must not exceed 350 words. The abstract must be structured into 5 sections following PRISMA guidelines. The abstract must include 5 sections following PRISMA guidelines, and the registration number should be included in the abstract.
Manuscript The manuscript should be divided into clearly defined sections covering all essential elements using headings. The manuscript must include 1 to 7 keywords, article highlights of 3 to 5 bullet points submitted as a separate editable file, a declaration of generative AI use in a section before the references if applicable, and the registration number in the text.
References References must be in current AMA format and include DOI. Any reference cited in the article must appear in the reference list and vice versa.
Figures & Tables Figures and other artwork must be supplied as separate files, while tables must be submitted as editable text. All figures and tables must be cited in the manuscript text, numbered according to appearance, and accompanied by captions.
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Meta-Analyses

Cover Letter A cover letter is required and, for Meta-Analyses, it should accompany the submission. The cover letter should explain why the review question is important to clinicians or users, including patients and policymakers, and present the expertise of team members with clinical, systematic review, and statistical expertise.
Abstract An abstract is required for Meta-Analyses. The abstract must not exceed 350 words. The abstract must be structured into five sections following PRISMA guidelines. The abstract must include five sections following PRISMA guidelines, but the specific headings are not stated.
Manuscript Meta-Analyses must have predefined protocol and eligibility criteria before the review or meta-analysis is conducted. The manuscript must include 1 to 7 keywords, article highlights of 3 to 5 bullet points, a declaration of generative AI use in a section before the references if applicable, and the registration number in both the abstract and text.
References References must be in current AMA format and include DOI. Any reference cited in the text must appear in the reference list and vice versa.
Figures & Tables Tables must be submitted as editable text and figures must be supplied as separate files along with the manuscript. All tables and figures must be cited in the text, numbered in order of appearance, and accompanied by captions.
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Correspondence

Cover Letter A cover letter must accompany the submission. The cover letter should include information on manuscript originality and may justify any abstract section deletions.
Abstract Abstract requirements are not specified.
Manuscript Correspondence should not exceed 500 words of text. The title must read "Comment on," followed by the article in question, and the submission must include a complete title page with author names, institutions, city, and country. Correspondence must include an Acknowledgment/Disclosure statement, and if AI tools were used in manuscript preparation, a declaration statement must be placed before the references.
References Correspondence should not exceed six references. References must be in current AMA format and include DOI. The article being commented on must be listed as the first reference in the Correspondence.
Figures & Tables Figures and tables are generally not accepted in Correspondence. Figures, images, diagrams, and other artwork must be supplied as separate files along with the manuscript. Tables must be submitted as editable text rather than images, and all figures and tables must be cited in the manuscript text and include captions.
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Recent Publications

Anti-Adalimumab Antibodies in Patients with Inflammatory Ocular Diseases: Incidence and Clinical Outcomes.

Paulina Liberman, Sophia E. Yu, Israel J. Mendez, Eugenia M. Ramos, Meghan K. Berkenstock, Bryn B. Burkholder, Jennifer E. Thorne, Douglas A. Jabs

10.1016/j.ajo.2026.06.003
View Publication

Visual Outcomes and Associated Risk Factors for Blindness in Axenfeld-Rieger Syndrome

Kasem Seresirikachorn, Warakorn Thiamthat, Elena Bitrian, Ta Chen Peter Cheng

10.1016/j.ajo.2026.06.004
View Publication

Optimized AAV5-RPGR ORF15 Gene Therapy Rescues Photoreceptor Structure and Function in XLRP Mouse Model

Xiang Chen, Xintong Xu, Shanshan Cao, Chunyan Pan, Shihui Wei, Baoke Hou, Huanfen Zhou

10.1016/j.ajo.2026.06.005
View Publication

Author Response to Comment: Imaging Biomarkers for Early Differentiation of Candida and Aspergillus Endogenous Fungal Endophthalmitis: Multicenter Optical Coherence Tomography-Based Analysis

Aniruddha Agarwal, Nitin Kumar Menia, Alessandro Invernizzi

10.1016/j.ajo.2026.05.040
View Publication

Intraocular Pressure Changes Following Intraluminal Stent Removal from the Paul Glaucoma Implant: A Systematic Review and Meta-Analysis

Chiao-Hsin Lan, Shu-I Pao, Hsiang-Lin Tseng, Wen-Wu Yang, Da-Wen Lu, Wei-Ting Yen

10.1016/j.ajo.2026.05.047
View Publication

Frequently asked questions

How long does it take to publish?

Authors of articles discussed in Correspondence are asked to reply within 14 days. Proof corrections are requested within two days.

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Is a cover letter required?

A cover letter is required for all submission types and revisions. It must address originality and any information for the Editor-in-Chief, disclose prior rejection or evaluation by another journal when applicable, justify deleted abstract sections, confirm data responsibility for manuscripts containing original data, and for revisions include a point-by-point response to reviewer comments. Systematic review submissions should also explain the importance of the review question and the team’s clinical, systematic review, and statistical expertise.

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What are the publication costs?

Open access APC: USD 4380 excluding taxes for all article types. Subscription publication has no open access publication fee.

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Research Topics

Glaucoma and retinal disorders Intraocular Surgery and Lenses Corneal surgery and disorders Retinal Diseases and Treatments Retinal and Macular Surgery Ocular Diseases and Behçet’s Syndrome Ophthalmology and Visual Impairment Studies Ocular Surface and Contact Lens Retinal and Optic Conditions Corneal Surgery and Treatments Ocular Infections and Treatments Ophthalmology and Eye Disorders Ocular Oncology and Treatments Diverse Scientific and Economic Studies Ocular Disorders and Treatments Ophthalmology and Visual Health Research Retinal Imaging and Analysis Retinal Development and Disorders Cerebral Venous Sinus Thrombosis Traumatic Ocular and Foreign Body Injuries Educational Robotics and Engineering Medical History and Innovations Medical and Biological Sciences Earthquake and Disaster Impact Studies Retinopathy of Prematurity Studies

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