Overview Submission Instructions Recent Publications Frequently Asked Questions Research Topics

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Clinical Gastroenterology and Hepatology

Clinical Gastroenterology and Hepatology publishes clinical gastroenterology and hepatology content covering diagnostic, endoscopic, interventional, and therapeutic advances in cancer, inflammatory diseases, functional gastrointestinal disorders, nutrition, absorption, and secretion.

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Subject Gastroenterology & Hepatology

Impact Factor 12

Quartile Q1

Open Access Type Hybrid

ISSN 1542-3565

eISSN 1542-7714

Invitation Only No

Cost Range Hybrid open access option available for $4,600 after acceptance. Images and Videos submissions require a non-refundable $25 submission fee.

Submission Instructions

Clinical Gastroenterology and Hepatology accepts the following article types. Click on an article type to view submission instructions.

Original Articles

Cover Letter Cover letter is required. Cover letter must state that the paper is not under consideration elsewhere, none of its contents have been published previously, all authors have read and approved the manuscript, and any potential conflicts of interest are disclosed or that none exist.

Abstract Structured abstract is required. Abstract must be 260 words. Abstract must be structured. Abstract must include the headings Background and Aims, Methods, Results, and Conclusion, plus 4 to 5 keywords.

Manuscript Manuscript must not exceed 6,000 words including figure and table legends and references. Manuscript must include a title page and a structured abstract, and it must be submitted as a Microsoft Word document. Manuscript must include a 'What You Need to Know' box with 25 to 30 words under BACKGROUND, FINDINGS, and IMPLICATIONS FOR PATIENT CARE, and it must include a declaration of generative AI and AI-assisted technologies in the writing process before the references.

References References must be cited in order of appearance using superscript Arabic numerals, journal abbreviations must follow Index Medicus, and shared co-first authors must be shown in bold with the phrase 'Author names in bold designate shared co-first authorship' added at the end when applicable.

Figures & Tables Original Articles may include no more than six figures and/or tables in total, and each figure may have up to six panels labeled A-F. Figures must be submitted as separate attachments. Figures must be provided in JPEG, TIFF, EPS, or PDF format at 300 PPI resolution, and figure legends must appear in the manuscript body immediately before the references or be submitted in a .doc or .rtf file.

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Narrative Reviews

Cover Letter Cover letter is required and must include statements that the paper is not under consideration elsewhere, its contents have not been published previously, all authors approved the manuscript, and conflicts of interest are disclosed or absent. Cover letter must state that the paper is not under consideration elsewhere, its contents have not been published previously, all authors have read and approved the manuscript, and any conflicts of interest are disclosed or absent.

Abstract Structured abstracts must be 260 words or less. Abstract must be structured. Structured abstract must include Background and Aims, Methods, Results, Conclusions, and Keywords.

Manuscript Narrative Reviews are typically 6,000 words including references. Manuscript must include three to four keywords and a declaration of generative AI or AI-assisted technologies in the writing process at the end of the manuscript before the references if such tools were used.

References References must be cited in order of appearance using superscript Arabic numerals, and journal titles must use Index Medicus abbreviations.

Figures & Tables Narrative Reviews may include a maximum combined total of six tables and/or figures. Figure legends must be included in the manuscript body immediately before the references or submitted in a separate document, figures must not be embedded in Word and must be uploaded as separate files, and supplementary material must be uploaded separately from the manuscript. Tables must be created in a Word document rather than as images, and all abbreviations used in tables must be spelled out in a footnote.

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Systematic Reviews

Cover Letter Cover letter is required. Cover letter must include statements that all authors approved the manuscript and any potential conflicts of interest are disclosed or that none exist.

Abstract A structured abstract is required. Abstract must be 260 words. Abstract must be structured. Abstract must include the headings Background and Aims, Methods, Results, and Conclusion, plus 4 to 5 keywords.

Manuscript Manuscript must not exceed 6,000 words including references. Manuscript must include a title page and a 'What You Need to Know' box with BACKGROUND, FINDINGS, and IMPLICATIONS FOR PATIENT CARE sections containing 25 to 30 words each. Manuscript must include a Declaration of Generative AI and AI-assisted technologies in the writing process before the references if such tools were used.

References References must be cited in order of appearance using superscript Arabic numerals, and shared co-first authors must be shown in bold with the phrase 'Author names in bold designate shared co-first authorship' added at the end of the references when applicable.

Figures & Tables Systematic Reviews and Meta-Analyses may include a maximum combined total of six tables and/or figures. Figures must be submitted as separate attachments. Figures must be provided in JPEG, TIFF, EPS, or PDF format.

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Meta-Analyses

Cover Letter Cover letter is required. Cover letter must include statements that all authors have read and approved the manuscript and disclose any potential conflicts of interest or state that none exist.

Manuscript Manuscript must not exceed 6,000 words including references. Manuscript must include a title page and a 'What You Need to Know' box with 25 to 30 words under each of the headings BACKGROUND, FINDINGS, and IMPLICATIONS FOR PATIENT CARE. Manuscript must include a declaration of generative AI or AI-assisted technologies used in writing at the end of the manuscript before the references under the specified heading.

References References must be cited in order of appearance using superscript Arabic numerals, and when applicable shared co-first authors must be shown in bold with the phrase 'Author names in bold designate shared co-first authorship' at the end of the references section.

Figures & Tables A maximum combined total of six tables and/or figures is allowed. Figures must be submitted as separate attachments. Figures must be provided in JPEG, TIFF, EPS, or PDF format.

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Full Length Original Research

Abstract Abstract is required. Structured abstract must be 260 words or less. Abstract must be structured. Abstract must include Background and Aims, Methods, Results, Conclusions, and Keywords.

Manuscript Manuscript must include a conflict of interest statement and a Declaration of Generative AI and AI-assisted technologies in the writing process placed at the end before the references.

References References must be cited in order of appearance using superscript Arabic numerals, and journal abbreviations must follow Index Medicus.

Figures & Tables Figures must be uploaded as separate files rather than embedded in Word, and figure legends must appear in the manuscript body immediately before the references or be submitted in a separate document. Figures and tables with captions must be included if applicable, and tables must be created in a Word document rather than as image files.

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Reviews

Cover Letter Cover letters must include statements that the paper is not under consideration elsewhere, its contents have not been published previously, all authors approved the manuscript, and any potential conflicts of interest are disclosed or explicitly absent.

Abstract An abstract is required for AGA QuickSubmit Reviews submissions. Structured abstracts must be 260 words or less. The abstract must be structured. Structured abstracts must include Background and Aims, Methods, Results, Conclusions, and Keywords.

Manuscript Narrative Reviews are typically 6,000 words including references. AGA QuickSubmit Reviews submissions must include manuscript text and a conflict of interest statement, and any use of generative AI in writing must be disclosed at the end of the manuscript before the references under the specified heading.

References References must be cited in order of appearance using superscript Arabic numerals, and journal abbreviations must follow Index Medicus abbreviations.

Figures & Tables Narrative Reviews may include a maximum combined total of six tables and/or figures. Figures must not be embedded in Word, each figure must be saved as a separate file, and figure legends must appear in the manuscript body immediately before the references or be submitted in a separate document file. Tables must be created in a Word document rather than as image files, and AGA QuickSubmit Reviews submissions must include captions for figures and tables if applicable.

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Images

Cover Letter Cover letter is required and must include statements that all authors approved the manuscript and disclose any potential conflicts of interest or state that none exist. Cover letter must state that all authors have read and approved the manuscript and must disclose any potential conflicts of interest or state that none exist.

Abstract Abstract must not be included.

Manuscript Manuscript text must be a brief description of no more than 200 words. Manuscript must consist of a brief clinical description presenting the patient's history, relevant findings, clinical course, response to treatment, and condition at last follow-up. Submission must not include figure legends or references and must include a declaration of generative AI use at the end of the manuscript before the references if such technologies were used in writing.

References References must not be included.

Figures & Tables Submission may include no more than four images and up to one supplemental video. Figures must be submitted as separate attachments rather than embedded in the manuscript. Images must be submitted as separate JPEG, TIFF, EPS, or PDF files at 300 PPI resolution, and endoscopy images must be free of lettering, words, or numbering.

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Videos

Cover Letter Cover letter is required and must include the four ICMJE statements. Cover letter must state that the work is not under consideration elsewhere, has not been published previously, has been read and approved by all authors, and discloses potential conflicts of interest or states that none exist.

Abstract Abstract must not be included.

Manuscript A brief description of no more than 200 words must be included in a Word document. Text must present relevant clinical information including a short description of the patient's history, relevant findings, clinical course, response to treatment, and condition at last follow-up. No figure legends or references may be included.

References References must not be included.

Figures & Tables Submission may contain no more than four images and may include up to one supplemental video. Figures must be submitted as separate attachments, and the submission must be provided as a Microsoft Word document. Images must be in JPEG, TIFF, EPS, or PDF format at 300 PPI, and endoscopy images must be free of lettering, words, or numbering.

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Letters To The Editor

Cover Letter Cover letter must include a statement that all authors have read and approved the manuscript and full disclosure of any potential conflicts of interest or a statement that none exist. Cover letter must include author approval of the manuscript and a conflict of interest disclosure or statement of no conflicts.

Abstract Abstract is not permitted for Letters To The Editor.

Manuscript Letters To The Editor must not exceed 750 words. Letter must be written in response to a full-length original research article or Research Letter and must include on the title page the title and corresponding author, or complete reference or URL, of the original paper being referenced. A statement disclosing the use of generative AI or AI-assisted technologies in the writing process must appear at the end of the manuscript before the references under the specified heading.

References Letters To The Editor may include no more than 8 references, which are not included in the word count. References must omit the article title and list only the first author unless citing manuscripts with joint first authors, formatted like 'Jones RS, et al. Gastroenterology 2011;2:373-380'.

Figures & Tables Figures and tables are not permitted in Letters To The Editor.

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Research Letters

Cover Letter Cover letter is required and must include the four ICMJE statements. Cover letter must state that the paper is not under consideration elsewhere, none of its contents have been published previously, all authors have read and approved the manuscript, and any potential conflicts of interest are disclosed or declared absent.

Abstract Abstract must not be included.

Manuscript Article text must not exceed 1,000 words excluding table, figure, or references, and supplementary methods text may include up to 500 additional words. Research Letter must not include section headers such as Introduction, Methods, Results, and Discussion. Manuscript must include a declaration of generative AI or AI-assisted writing use at the end before the references, and QuickSubmit submissions must include a conflict of interest statement.

References Research Letters may include up to 10 references. References must be cited in order of appearance using superscript Arabic numerals and formatted with only the first author listed unless joint first authors are cited, without the article title, in the style 'Jones RS, et al. Gastroenterology 2011; 2: 373-380'.

Figures & Tables Research Letters may include up to 1 table, figure, or video, with 1 to 2 additional supplementary figures or tables allowed, and any single figure may contain up to 6 panels. Figures must be submitted as separate attachments, and QuickSubmit submissions must include figures and tables with captions if applicable. Research Letters figures must be provided in JPEG, TIFF, EPS, or PDF format at 300 PPI resolution.

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Recent Publications

Complete immunosuppression withdrawal after liver transplantation: An International Multicenter Study

Roberta Angelico, Bruno Sensi, Giuseppe Tisone, Sandy Feng, Garrett R. Roll, Ignacio Herrero, Eliano Bonaccorsi-Riani, José Antonio Pons, Pablo Ruíz, Marina Berenguer, Caroline Den Hoed, George Mazariegos, Rachel Smith, Alessandro Parente, Varuna Aluvihare, Alberto Sanchez-Fueyo, Eunice Tan, Suzana Calretas, Jacopo Lanari, Marco Spada, Aldo J. Montano-Loza, Vincent E. De Meijer, Jacques Pirenne, Callum Riley, Daljeet Chahal, Eleonora De Martin, Stefano Di Sandro, Damiano Patrono, Ignacio García-Juárez, Alba Cachero, Gupse Adali, Davide Ghinolfi, Stefania Camagni, Ana Arias Milla, Nuru Bayramov, Osama Elbahr, Tommaso Maria Manzia, Rodney Rogers, Tavakhol Mehdi, Dana Jakoubek, María Pascual, Mercedes Iñarrairaegui, Maxime Foguenne, Olga Ciccarelli, Alberto Baroja Mazo, Pablo Ramírez Romero, Jordi Colmenero, María Victoria Aguilera, Wojciech Polak, Ellina Lytvyak, Ewan Glassey, Neil Rajoriya, Mark Muthiah, Patrizia Boccagni, Hans Blokzijl, Manuel Rodriguez-Perálvarez

10.1016/j.cgh.2026.05.027

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Anxiety severity and PPI non-response association across GERD phenotypes defined by the Lyon 2.0 classification

Mentore Ribolsi, Lorenzo Marchetti, Laura Galdi, Chiara Catamo, Marco Distefano, Martina Pelle, Michele Cicala

10.1016/j.cgh.2026.05.028

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Clinical Features and Outcomes of Lean Metabolic Dysfunction Associated Steatotic Liver Disease with Increased Alcohol Intake

Binu V. John, Samuel Soon, Ashwani Singal, Kaley Schwartz, Suthat Liangpunsakul, Naim Alkhouri, Robert J. Wong, Ponni Perumalswami, Basile Njei, Mazen Noureddin, Bassam Dahman

10.1016/j.cgh.2026.05.023

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RECOMPENSATION FOLLOWING ALCOHOL-RELATED HEPATITIS IS ASSOCIATED WITH INCREASED SURVIVAL: RESULTS FROM A MULTICENTER STUDY

Jordi Gratacós-Ginès, Pilar Ruz-Zafra, Queralt Herms, Miriam Celada-Sendino, Ares Villagrasa, Federico Cáceres, Rosa Martín-Mateos, Víctor Echavarría, Jordi Sánchez, Sonia García, Mónica Barreales, Javier Tejedor-Tejada, Sergio Vázquez-Rodríguez, Nuria Cañete, Carlos Fernández-Carrillo, María Valenzuela, David Marti-Aguado, Diana Horta, Marta Quiñones, Vanesa Bernal-Monterde, Silvia Acosta, Tomás Artaza, José Pinazo, Carmen Villar-Lucas, María Prieto De la Torre, Ana Clemente-Sánchez, Ester Badia-Aranda, Carlos Alventosa-Mateu, Álvaro Giráldez-Gallego, Jesús Rivera-Esteban, Pablo Solís-Muñoz, Edilmar Alvarado-Tapias, Joaquín Cabezas, Meritxell Ventura-Cots, Conrado Fernández-Rodríguez, Manuel Rodríguez, Victoria Aguilera, Santiago Tomé, Juan Caballería, Ramon Bataller, Elisa Pose, Alba Ardèvol, María Del Barrio, Inmaculada Fernández-Vázquez, Luis Enrique Frisancho, Montserrat García-Retortillo, Concepción Gómez-Medina, Lorena Jara, Esther Maderuelo, Aina Martí-Carretero, Dalia Morales, Olga Ramos Barriga, Manuel Luís Rodríguez-Perálvarez, Mercè Roget, Germán Soriano, Joana Villaverde

10.1016/j.cgh.2026.05.019

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Comparing Onset of Efficacy of Biologic and Small Molecule Therapies in Biologic-Naïve Ulcerative Colitis: A Post-hoc Analysis

Emily C.L. Wong, Vipul Jairath, Parambir S. Dulai, John K. Marshall, Christopher Ma, Walter Reinisch, Neeraj Narula

10.1016/j.cgh.2026.05.020

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Frequently asked questions

How long does it take to publish?

Median 3 days from submission to first decision and 43 days from acceptance to online publication.

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Is a cover letter required?

A cover letter is required. It should suggest three to four referees and an Associate Editor, state reasons for deviations from standard format, clarify potential conflicts related to exclusive publication, and include 4 ICMJE statements: the paper is not under consideration elsewhere, the contents have not been published previously, all authors have read and approved the manuscript, and all potential conflicts of interest are fully disclosed or none exist.

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What are the publication costs?

Hybrid open access sponsorship costs $4,600 after acceptance. Images and Videos submissions require a non-refundable $25 submission fee.

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Research Topics

Liver Disease Diagnosis and Treatment Inflammatory Bowel Disease Microscopic Colitis Liver Disease and Transplantation Colorectal Cancer Screening and Detection Gastric Cancer Management and Outcomes Diverse Scientific and Economic Studies Helicobacter pylori-related gastroenterology studies Eosinophilic Esophagitis Gastroesophageal reflux and treatments Esophageal and GI Pathology Gastrointestinal disorders and treatments Gastrointestinal motility and disorders Hepatitis C virus research Pancreatic and Hepatic Oncology Research Pancreatitis Pathology and Treatment Hepatitis B Virus Studies Liver Diseases and Immunity Esophageal Cancer Research and Treatment Gallbladder and Bile Duct Disorders Genetic factors in colorectal cancer Human auditory perception and evaluation Educational Robotics and Engineering Pediatric Hepatobiliary Diseases and Treatments Diverticular Disease and Complications

Related Journals

The Lancet Neurology Elsevier BV

United European Gastroenterology Journal WILEY

Environmental Research Elsevier BV

Liver Transplantation LIPPINCOTT WILLIAMS & WILKINS

International Journal of Hygiene and Environmental Health Elsevier BV

Seminars in Nephrology Elsevier BV