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JACC Basic to Translational Science

JACC: Basic to Translational Science is an open access specialist journal in the JACC family that serves as a forum for translational cardiovascular medicine and aims to accelerate the translation of scientific discoveries into therapies that improve outcomes for patients with or at risk for cardiovascular disease. Areas of interest include pre-clinical research, clinical trials, personalized medicine, novel drugs, devices and biologics, proteomics, genomics and metabolomics, and early phase clinical trial methodology.

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Subject Cardiac & Cardiovascular Systems
Impact Factor 7.2
Quartile Q1
Open Access Type Open
ISSN 2452-302X
eISSN 2452-302X
Invitation Only No
Cost Range Article Publishing Charge: USD 4750 for full length articles (Clinical Research, Preclinical Research, Unsolicited Review Papers); USD 1900 for Short Communications (Research Letter), excluding taxes.

Submission Instructions

JACC Basic to Translational Science accepts the following article types. Click on an article type to view submission instructions.

Original Research Paper

Cover Letter A cover letter is required. The cover letter must state that the paper is not under consideration elsewhere, that its contents have not been previously published, that all authors have read and approved the manuscript, disclose any potential conflicts of interest including any AI contributions, identify the corresponding author, and substantiate each author's contribution if there are more than 4 authors.
Abstract A structured abstract is required. The structured abstract must not exceed 250 words. The abstract must be structured. The abstract must be presented in 5 paragraphs with the headings Objectives, Background, Methods, Results, and Conclusions.
Manuscript The manuscript must not exceed 5,500 words including references and figure legends. The manuscript must be arranged as title page, structured abstract and key words, condensed abstract, abbreviations list, text, acknowledgments if applicable, Funding Sources, references, figure titles and legends, and tables, with the text structured as Introduction, Methods, Results, and Discussion. The manuscript must include key words, a condensed abstract, an abbreviations list, clinical implications and translational outlook recommendations after the text and before the acknowledgments and references, 3 to 5 highlights on the title page, individual author contribution disclosures, and any required AI declaration statement immediately before the references.
References References must be identified in the text by Arabic numerals in parentheses and listed consecutively in order of mention, using Index Medicus journal abbreviations, inclusive page numbers, no periods after authors' initials, and listing all authors if 6 or fewer or the first 3 followed by et al if more than 6.
Figures & Tables Figure legends must be provided on separate pages from the text and tables must be on separate sheets, while figure titles and legends and tables are included at the end of the manuscript arrangement. Every figure and table must be cited in the text in numerical order, all figures must have a title and legend, and all tables must have a title.
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State-Of-The-Art Papers

Cover Letter A cover letter is required. The cover letter must state that the paper is not under consideration elsewhere, that its contents have not been previously published, that all authors have read and approved the manuscript, disclose any potential conflicts of interest including a statement if none exist, specify the corresponding author, substantiate each author's contribution if there are more than 4 authors, disclose any artificial intelligence contributions, and explain how the submission differs from existing reviews on the subject.
Abstract An abstract is required. The abstract must be unstructured and must not exceed 5000 words. The abstract must be unstructured. No mandatory abstract headings are specified.
Manuscript The text should be structured as Introduction, Methods, Results, and Discussion, with headings and subheadings in the Methods, Results, and particularly Discussion sections. The manuscript must include clinical implications and translational outlook recommendations after the text and before the acknowledgments and references, and if AI tools were used in manuscript preparation, a declaration section must be placed immediately above the references.
References References must be cited by Arabic numerals in parentheses and numbered consecutively in order of mention, with all authors listed if 6 or fewer or the first 3 followed by et al if more than 6.
Figures & Tables Figure legends should be provided on pages separate from the text and tables should be prepared on separate sheets. All figures and tables must be cited in numerical order in the text, figures must include a title and legend, and tables must include a title.
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Leading Edge Translational Research

Cover Letter A cover letter is required. The cover letter must state that the paper is not under consideration elsewhere, that none of the paper's contents have been previously published, that all authors have read and approved the manuscript, disclose any potential conflicts of interest including any AI contributions, identify the corresponding author, and substantiate each author's contribution if there are more than 4 authors.
Abstract A structured abstract is required. The abstract must be no more than 250 words. The abstract must be structured in 5 paragraphs. The abstract must use the headings Objectives, Background, Methods, Results, and Conclusions.
Manuscript The manuscript must be 3,500 words or fewer in length. The text must be structured as Introduction, Methods, Results, and Discussion. The manuscript must include clinical implications and translational outlook recommendations after the text and before the acknowledgments and references, and if AI tools were used in manuscript preparation, a declaration statement must appear in a new section immediately before the references.
References References must be cited in the text by Arabic numerals in parentheses and listed consecutively in order of first mention, with all authors listed if 6 or fewer or the first 3 followed by et al if 7 or more.
Figures & Tables Figure legends must be provided on separate pages from the text and tables must be submitted on separate sheets. All figures and tables must be cited in the text in numerical order, and all figures must include a title and legend while all tables must include a title.
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Leading Edge Translational Science

Cover Letter A cover letter is required. The cover letter must state that the paper is not under consideration elsewhere, that its contents have not been previously published, that all authors have read and approved the manuscript, disclose any potential conflicts of interest, identify the corresponding author, substantiate each author’s contribution if there are more than 4 authors, and disclose any AI contributions and their nature.
Abstract An abstract is required. The abstract must not exceed 250 words. The abstract must be structured in 5 paragraphs. The abstract must use the headings Objectives, Background, Methods, Results, and Conclusions.
Manuscript Leading Edge Translational Science articles must be 3,500 words or fewer in length. The text should be structured as Introduction, Methods, Results, and Discussion. The manuscript must include clinical implications and translational outlook recommendations after the text and before the acknowledgments and references, 3 to 5 highlights on the title page, and if AI tools were used in manuscript preparation, a declaration statement in a new section immediately before the references.
References References must be numbered consecutively in order of mention, cited in the text as Arabic numerals in parentheses, list all authors if 6 or fewer or the first 3 followed by et al if more than 6, use Index Medicus journal abbreviations, and provide inclusive page numbers without periods after authors’ initials.
Figures & Tables Figure legends must be on separate pages from the text and tables must be provided on separate sheets. All figures and tables must be cited in numerical order in the text, all figures must have a title and legend, and all tables must have a title.
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Letters To The Editor

Cover Letter A cover letter is required. The cover letter must state that the paper is not under consideration elsewhere, that none of its contents have been previously published, that all authors have read and approved the manuscript, disclose any potential conflicts of interest, identify the corresponding author, and substantiate each author's contribution if there are more than four authors.
Abstract Abstract requirements are not specified.
Manuscript Letters to the Editor must not exceed 500 words. Letters to the Editor should focus on a specific article that has appeared in the journal and may not include original data. The manuscript must include the cited article as a reference, and if AI tools were used in manuscript preparation, a declaration statement must be placed in a new section immediately before the references.
References The cited article must be included as a reference, and references must be numbered consecutively in order of mention using Arabic numerals in parentheses, with all authors listed if there are 6 or fewer or the first 3 followed by et al if there are more than 6.
Figures & Tables Figures & Tables requirements are not specified.
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Recent Publications

Left Ventricular Structural, Physiological, and Transcriptomic Abnormalities in a Novel Porcine Hypertrophic Cardiomyopathy Model

Eric M. Green, Carlos del Rio, Kamel Shibbani, David K. Meyerholz, Joshua Gorham, Seong Kim, Daniel M. DeLaughter, Marcus P. Henze, Christopher S. Rogers, Lindsey M. Gifford, Melissa Kafa, Frank Rohret, J. Adam Goeken, Jared M. McLendon, Ryan L. Boudreau, Christine E. Seidman, Jessica C. Sieren, Robert M. Weiss, Jonathan G. Seidman, Abhay Divekar, Ferhaan Ahmad

10.1016/j.jacbts.2026.101696
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Identifying Cardiac Autoantibody Biomarkers that Predict the Severity of Chagas Cardiomyopathy

Heriks Ribeiro, Anton Dmitriev, Antonia Pereira Rosa Neta, Meena Fatah, Diptendu Chatterjee, Lea Campos de Oliveira, Fabiano Castro Albrecht, Hui Tzu Lin Wang, Juliana de Assis S. Gomes, Olgierd Woźniak, Karolina Borowiec, Elżbieta Katarzyna Biernacka, Antonia Claudia Jácome da Câmara, Luciana Sacilotto, Francisco Carlos da Costa Darrieux, Maurício Ibrahim Scanavacca, José Eduardo Krieger, Lúcia Maria da Cunha Galvão, Walderez Dutra, Antonio Luiz Pinho Ribeiro, Edecio Cunha-Neto, Maria Carmo Pereira Nunes, Ester Cerdeira Sabino, Igor Cestari, Andre Ducati Luchessi, Vivian Nogueira Silbiger, Robert M. Hamilton

10.1016/j.jacbts.2026.101709
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Histone Demethylase KDM5A Is Activated and Pathogenic in a Mouse Model of LMNA-Cardiomyopathy

Manisha Deogharia, Chitra Lekha Reddy, Ritapa Chaudhuri, Manogna Sai Chirasani, Abhinav K. Jain, Leila Rouhi, A.J. Marian, Priyatansh Gurha

10.1016/j.jacbts.2026.101714
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Beyond Atherosclerosis

Raúl Nicolas Jamin, Sebastian Zimmer

10.1016/j.jacbts.2026.101726
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Vitamin A Uses Its Superpowers to Combat Vascular Malformations

Zaneta Markowska, Karen K. Hirschi

10.1016/j.jacbts.2026.101725
View Publication

Frequently asked questions

How long does it take to publish?

Leading Edge Translational Research and Leading Edge Translational Science submissions are reviewed for interest within seven days of submission. Expedited review requests receive a decision on suitability within 2 days and an initial decision within 14 days.

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Is a cover letter required?

A cover letter is required. It must state that the paper is not under consideration elsewhere, that its contents have not been previously published, that all authors have read and approved the manuscript, and disclose any potential conflicts of interest or state that none exist. The corresponding author must be specified. If there are more than 4 authors, each author's contribution must be substantiated in the cover letter. Authors requesting expedited review must include the request and rationale in the cover letter.

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What are the publication costs?

Article Publishing Charge: USD 4750 for full length articles and USD 1900 for Short Communications (Research Letter), excluding taxes.

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Research Topics

Cardiovascular Function and Risk Factors Cardiac Fibrosis and Remodeling Diverse Scientific and Economic Studies Human auditory perception and evaluation Educational Robotics and Engineering Cardiac Valve Diseases and Treatments Cardiomyopathy and Myosin Studies Heart Failure Treatment and Management Cardiac electrophysiology and arrhythmias Cardiac Ischemia and Reperfusion Cardiac Structural Anomalies and Repair Mechanical Circulatory Support Devices Health and Medical Research Impacts Lipoproteins and Cardiovascular Health Viral Infections and Immunology Research Tissue Engineering and Regenerative Medicine Atherosclerosis and Cardiovascular Diseases Cardiovascular Effects of Exercise Diabetes Treatment and Management Signaling Pathways in Disease Mitochondrial Function and Pathology Pulmonary Hypertension Research and Treatments Cardiac Imaging and Diagnostics Cardiac pacing and defibrillation studies Aortic Disease and Treatment Approaches

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