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Journal of Hepatology

Journal of Hepatology publishes original papers, reviews, case reports and letters to the editor in hepatology. The journal is published in English, supplements may be accepted after editorial review, and full text is available online through institutional access and the journal website.

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Subject Gastroenterology & Hepatology
Impact Factor 33
Quartile Q1
Open Access Type Hybrid
ISSN 0168-8278
eISSN 1600-0641
Invitation Only No
Cost Range Submission and publication are free of charge; optional open access fee is US $5320 after acceptance; uninvited Letters to the Editor have a €50 submission fee effective November 15th 2025; fast-track handling requires a submission fee.

Submission Instructions

Journal of Hepatology accepts the following article types. Click on an article type to view submission instructions.

Original Manuscripts

Cover Letter Cover Letter requirements are not specified.
Abstract A structured abstract is required for Original Manuscripts. Abstract must not exceed 275 words. Abstract must be structured using the headings Background & Aims, Methods, Results, and Conclusions. Abstract must use the headings Background & Aims, Methods, Results, and Conclusions.
Manuscript Original Manuscripts must not exceed 6000 words including the abstract, references, tables, and figure legends. Manuscript must be arranged as Title page, Abstract, Impact and Implications, Introduction, Materials and methods or Patients and methods, Results, Discussion, Abbreviations, Acknowledgements, References, Tables, Figure legends, and Figures. Manuscript must include Impact and Implications of 3 to 4 sentences, a methods section highlighting key methods, 3 to 12 keywords on the title page, an author contributions statement and AI declaration before the references if applicable, and revised Original Manuscripts must include 3 to 5 highlights submitted in a separate editable file with each bullet no longer than 85 characters including spaces.
References Original Manuscripts must not exceed 100 references. References must be ordered as they appear in the text, include article titles, include all authors unless there are more than three in which case the first three are followed by et al., and web references must include the full URL and access date.
Figures & Tables Original Manuscripts may include a maximum of 8 tables and/or figures. Tables must be included as a separate section at the end of the manuscript, figure legends must be listed in the text document separate from the figure files, and figures are uploaded separately. Figure legends must not exceed 100 words.
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Review Articles

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must not exceed 275 words. Abstract does not need to be structured.
Manuscript Review article text must not exceed 5000 words. Manuscript order is title page, abstract, impact and implications, introduction, materials and methods or patients and methods, results, discussion, abbreviations, acknowledgements, references, tables, figure legends, and figures. Review articles should include 5 to 10 key points, 3 to 4 Impact and Implications sentences, 3 to 12 keywords on the title page, and an AI-use declaration before the references if generative AI was used.
References Review articles must not exceed 150 references. References must be numbered in the order cited in the text, include article titles, list all authors unless there are four or more in which case only the first three are followed by et al., and web references must include the full URL and access date.
Figures & Tables Review articles should include no more than 8 tables and/or colored figures. Tables must appear as a separate section at the end of the manuscript, and figure legends must be included in the text document separate from the figure files.
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Case Reports

Cover Letter Cover Letter requirements are not specified.
Abstract Abstract must not exceed 275 words. Abstract does not need to be structured.
Manuscript Manuscript must not exceed 3000 words. Manuscript order is Title page, Abstract, Impact and Implications, Introduction, Materials and methods or Patients and methods, Results, Discussion, Abbreviations, Acknowledgements, References, Tables, Figure legends, and Figures. Manuscript must include 3 to 4 sentences of Impact and Implications, 3 to 12 keywords on the title page, and an AI-use declaration before the references if generative AI was used in manuscript preparation.
References References must not exceed 10. References must be ordered as they appear in the text, include article titles, cite all listed references in the text, list all authors unless there are more than three, and for four or more authors list the first three followed by et al.
Figures & Tables A combined total of tables and figures must not exceed 2. Tables must appear as a separate section at the end of the manuscript and figure legends must be included in the text document separate from the figure files. Figure legends must not exceed 100 words.
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Letters To The Editor

Cover Letter Cover Letter requirements are not specified.
Abstract Letters To The Editor do not require a structured abstract. Letters To The Editor must not exceed 800 words. Letters To The Editor do not require a structured abstract.
Manuscript Letters To The Editor must not exceed 800 words. Keywords are not required for Letters To The Editor.
References Letters To The Editor must not exceed 10 references. References must be ordered as they appear in the text, include article titles, cite all listed references in the text, and list the first three authors followed by et al. when there are four or more authors.
Figures & Tables Letters To The Editor may include a maximum of 1 table or figure. Tables must be included as a separate section at the end of the manuscript, and figure legends must be listed in the text document separate from the figure files.
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Recent Publications

Difficult diagnoses: Quando è notte, è notte per tutti

Madlin Walther, Juerg Vosbeck, Corina Kim-Fuchs, Annalisa Berzigotti, Christine Bernsmeier

10.1016/j.jhep.2026.05.021
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In vivo base editing alleviates hepatic iron accumulation and fibrosis in models of HFE-related hereditary hemochromatosis

Vanessa Hamann, Sebastian Hook, Pimpan Sujariyakul, Rajesvaran Ramalingam, Malte Sgodda, Isabel Klefenz, Amelie Stalke, Qinggong Yuan, Lars Steinbrück, Alice Rovai, Marie Ruhe, Bo Mee Chung, Doris Steinemann, Amar Deep Sharma, Tobias Cantz, Paulo J.C. Lin, Heiner Wedemeyer, Michael Ott, Simon Alexander Krooss

10.1016/j.jhep.2026.05.022
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Updates in clinical science: Alcohol-related hepatitis

Alexandre Louvet, Line Carolle Ntandja Wandji, Philippe Mathurin

10.1016/j.jhep.2026.04.016
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Dysregulated transcription in core- and pol-specific CD8 T cells can be targeted by HDAC inhibition to improve T-cell function in chronic hepatitis B

Camilla Ceccatelli Berti, Ilaria Montali, Sara Doselli, Benedetta Farina, Simona Schivazappa, Andrea Vecchi, Marzia Rossi, Valentina Reverberi, Anna Montali, Dana Sambarino, Alessio Pelagatti, Francesca Ferraglia, Valeria Barili, Floriana Facchetti, Elisabetta Degasperi, Diletta Laccabue, Amalia Penna, Marie-Laure Plissonnier, Fabien Zoulim, Pietro Lampertico, Carolina Boni, Gabriele Missale, Marco Morselli, Carlo Ferrari, Paola Fisicaro

10.1016/j.jhep.2026.05.020
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Beyond the Emperor’s Clothes: Reframing When Steatosis Constitutes Disease

Giovanni Ragozzino, Edi Mattera

10.1016/j.jhep.2026.05.016
View Publication

Frequently asked questions

How long does it take to publish?

Median time from submission to first decision is 5 days.

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Is a cover letter required?

A cover letter is required for revised manuscripts and should state that the manuscript has been revised according to the comments of the editor and reviewers. A separate point-by-point response to reviewers must be included with the covering letter.

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What are the publication costs?

Submission and publication are free of charge. Authors may choose optional open access after acceptance for US $5320. Uninvited Letters to the Editor carry a €50 submission fee effective November 15th 2025.

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Research Topics

Liver Disease Diagnosis and Treatment Hepatitis C virus research Hepatitis B Virus Studies Liver Disease and Transplantation Liver Diseases and Immunity Hepatocellular Carcinoma Treatment and Prognosis Liver physiology and pathology Organ Transplantation Techniques and Outcomes Hepatitis Viruses Studies and Epidemiology Drug-Induced Hepatotoxicity and Protection Systemic Lupus Erythematosus Research Alcohol Consumption and Health Effects Diet, Metabolism, and Disease Drug Transport and Resistance Mechanisms Pediatric Hepatobiliary Diseases and Treatments Diabetes and associated disorders Diet and metabolism studies Cholangiocarcinoma and Gallbladder Cancer Studies HIV/AIDS drug development and treatment Pancreatic function and diabetes Metabolism and Genetic Disorders Pancreatitis Pathology and Treatment Gallbladder and Bile Duct Disorders Immune Cell Function and Interaction Cancer, Hypoxia, and Metabolism

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